Active research studies

COVID-19 research

Most of our regular research is currently on hold due to the ongoing situation with COVID-19 (coronavirus). However, as a specialist respiratory centre we are undertaking research on COVID-19, and some patients, and their families/carers, may be invited to participate over the phone.

If you are contacted, you will be provided with all the information you require to make an informed decision on whether you would like to participate or not. Some of these studies are listed below, under COVID-19.


Details of all our active research studies which are looking for volunteers, with more information about what each project entails and what kind of volunteers would be most suitable.

Early COPD cohort study

COPD is a life-long condition that makes breathing difficult because the airways have been narrowed. People living with COPD will feel out of breath doing everyday tasks such as housework or walking the dog. Though 20% of people with COPD have never smoked and not all smokers develop COPD - it is mainly caused by smoking from early adulthood. Find out more

The MISTER trial

The MISTER trial is looking at testing whether minimal equipment pulmonary rehabilitation classes are as effective as those that use specialist equipment in terms of the effect on fitness levels, breathlessness and quality of life in the short and medium term. Find out more

Epidemiology and prognosis in acute myocarditis

Myocarditis is a disease heart muscle caused by inflammation. This study aims to provide a contemporary, population-level assessment of the true clinical burden of myocarditis and how this may have changed over the last 20 years. Find out more.


See details of our performance for all clinical trials reported to the NIHR, for the Initiation and Delivery of studies in the period from 1 October 2020 to 31 March 2021.


Active research studies

DeVENT

Study
Decision support system to evaluate VENTilation in ARDS (DeVENT)

IRAS no
266521 

Study contact information
Name:
 Mahitha Gummadi
Email: m.gummadi@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel


GenOMICC

Study
Genetics of susceptibility and mortality in critical care

IRAS no
269326

Study contact information
Name: Natalie Dormand (Royal Brompton), Paula Rogers (Harefield)
Email: N.Dormand@rbht.nhs.uk, p.rogers@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


ISARIC CCP

Study
WHO ISARIC Clinical Characterisation Protocol for Severe Emerging Infection UK (CCP-UK) / Novel Coronavirus Observational Study

IRAS no
126600

Study contact information
Name:
 Natalie Dormand (Royal Brompton), Paula Rogers (Harefield)
Email: N.Dormand@rbht.nhs.uk, p.rogers@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


RECOVERY

Study
Randomised Evaluation of COVID-19 Therapy (RECOVERY)

IRAS no
281712

Study contact information
Name:
 Jessica Wallen (Royal Brompton), Claire Prendergast (Harefield)
Email: J.Wallen@rbht.nhs.ukC.Prendergast2@rbht.nhs.uk

Principal investigator
Dr Anand Shah (Royal Brompton), Dr Anna Reed (Harefield)

Click here for more information


REMAP-CAP

Study
Randomised, Embedded, Multifactorial Adaptive Platform trial for Community-Acquired Pneumonia

IRAS no
237150

Study contact information
Name:
 Debra Dempster (Royal Brompton), Claire Prendergast (Harefield)
Email: D.Dempster@rbht.nhs.ukC.Prendergast2@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


Heart-ACS COVID-19

Study
COVID-19 as a Trigger/Risk Factor in Acute Coronary Syndromes

IRAS no
259087

Study contact information
Name:
 Laura Barker
Email: l.barker2@rbht.nhs.uk

Principal investigator
Dr Miles Dalby

Click here for more information


Coagulation markers in patients with severe COVID-19

Study
Coagulation markers on discarded plasma samples from patients with severe COVID-19

IRAS no
283525

Study contact information
Name:
 Deepa Arachchillage
Email: D.JayakodyArachchillage@rbht.nhs.uk

Principal investigator
Dr Deepa Arachchillage

Click here for more information


PROSAIC-19

Study
PROSAIC-19 – Prospective longitudinal assessment in a COVID-19 infected cohort    

IRAS no
282739

Study contact information
Name:
 Katherine Rhatigan
Email: K.Rhatigan@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Click here for more information


RECOVERY - Respiratory Support

Study
Ventilation Strategies in COVID-19; CPAP, High-flow, and standard care  

IRAS no
282338

Study contact information
Name:
 Ashraf Hussain
Email: A.Hussain@rbht.nhs.uk

Principal investigator
Professor Anita Simonds

Click here for more information


Thrombosis and organ ischemia/inflammation in ICU admitted COVID-19

Study
Computer Tomography findings of vascular thrombosis, and abdominal organ ischemia and inflammation in Critically ill COVID-19 patients

IRAS no
286154

Study contact information
Name: 
Dr Saeed Mirsadraee
Email: S.Mirsadraee@rbht.nhs.uk

Principal investigator
Dr Saeed Mirsadraee


UNITE-COVID

Study
European Society of Intensive Care Medicine Covid-19 Project (Unite-Covid-19)

IRAS no
284289

Study contact information
Name: 
Dr Giulia Crapelli
Email: G.Crapelli@rbht.nhs.uk

Principal investigator
Dr Giulia Crapelli


Coagulopathy associated with COVID 19 (CA-COVID19) A Multi-Centre observational study in UK

Study
Coagulopathy associated with COVID 19 (CA-COVID19) A Multi-Centre observational study in UK

IRAS no
282298

Study contact information
Name: 
Dr Deepa Arachchillage
Email: D.JayakodyArachchillage@rbht.nhs.uk

Principal investigator
Dr Deepa Arachchillage


CLASSIC

Study
The Clinical and psychosocial impact of COVID-19 on patients with neuromuscular and neurological disorders

IRAS no
286495

Study contact information
Name: 
Dr Lydia Spurr
Email: L.Spurr@rbht.nhs.uk

Principal investigator
Professor Anita Simonds


CLUE (COVID-19 Flu ECMO)

Study
A retrospective cohort study comparing the differences in baseline characteristics and outcomes in patients with influenza and COVID-19 treated with veno-venous extracorporeal membrane oxygenation (ECMO)

IRAS no
285452

Study contact information
Name: 
Dr Benjamin Garfield
Email: B.Garfield@rbht.nhs.uk

Principal investigator
Dr Stephane Ledot

Click here for more information


COACHED Study

Study
COVID-19 infection and Congenital Heart Disease Study (COACHeD Study)

IRAS no
283054

Study contact information
Name: 
Professor Piers Daubeney
Email: P.Daubeney@rbht.nhs.uk

Principal investigator
Professor Piers Daubeney

Click here for more information


Narratives of NHS nurses working in ICUs during the COVID-19 pandemic

Study
Narratives of NHS nurses working in ICUs during the COVID-19 pandemic

IRAS no
284812

Study contact information
Name: 
Dr Melissa Sanchez
Email: M.Sanchez@rbht.nhs.uk

Principal investigator
Dr Melissa Sanchez

Click here for more information


PHOSP-COVID

Study
Post-hospitalisation COVID-19 study: a national consortium to understand and improve long-term health outcomes.

IRAS no
285439

Study contact information
Name: 
Merriel Woodruff
Email: M.Woodruff@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


EARSATS-19

Study
EARSATS-19: In-ear measurement of blood oxygen saturation in COVID-19 follow up

IRAS no
285603

Study contact information
Name: 
Dr Zhe Wu
Email: Z.Wu@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux 

Click here for more information


CAPACITY-COVID

Study
Cardiac complicAtions in Patients with SARS Corona vIrus 2 regisTrY (CAPACITY)

IRAS no
285603

Study contact information
Name: 
Professor Sanjay Prasad
Email: S.Prasad@rbht.nhs.uk

Principal investigator
Professor Sanjay Prasad

Click here for more information


COVID-HEART study

Study
Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: the COVID-HEART study

IRAS no
285147

Study contact information
Name: 
Kevin Kirby
Email: K.Kirby@rbht.nhs.uk

Principal investigator
Professor Sanjay Prasad

Click here for more information


CAPACITY-COVID

Study
Cardiac complicAtions in Patients with SARS Corona vIrus 2 regisTrY (CAPACITY)

IRAS no
282872

Study contact information
Name: 
Professor Sanjay Prasad
Email: S.Prasad@rbht.nhs.uk

Principal investigator
Professor Sanjay Prasad

Click here for more information


Identifying incidence and nature of Fatigue in Individuals infected with COVID-19 (SARS-Cov-2) in the UK

Study
Identifying incidence and nature of Fatigue in Individuals infected with COVID-19 (SARS-Cov-2) in the United Kingdom

IRAS no
284760

Study contact information
Name: 
Avantika Tailor
Email: A.Tailor@rbht.nhs.uk

Principal investigator
Avantika Tailor

Click here for more information


Tele-physiotherapy innovation for children with difficult asthma

Study
"Acceptability, feasibility and efficacy of tele-physiotherapy for children with difficult asthma: service innovation post
COVID-19 pandemic."

IRAS no
291850

Study contact information
Name: 
Professor Sejal Saglani
Email: S.Saglani@rbht.nhs.uk

Principal investigator
Professor Sejal Saglani


HEAL-COVID trial

Study
HElping Alleviate the Longer-term consequences of COVID-19(HEAL-COVID): a national platform trial

IRAS no
294861

Study contact information
Name:
Michelle Rackham
Email: M.Rackham@rbht.nhs.uk

Principal investigator
Dr William Man

Click here for more information

Treatment in adults with severe bilateral nasal polyps

Study
A randomised, double-blind, parallel group PhIII study to assess the clinical efficacy and safety of 100 mg SC Mepolizumab as an add on to maintenance treatment in adults with severe bilateral nasal polyps.

IRAS no
220783

Study contact information
Name: 
Aarif Eifan
Email: A.Eifan@rbht.nhs.uk

Principal investigator
Dr Guy Scadding

Click here for more information


Pollen food allergy syndrome in adults with IBS

Study
A prospective observational cohort study to determine the prevalence of pollen food allergy syndrome (PFS) in adults with Irritable Bowel Syndrome (IBS)

IRAS no
229644

Study contact information
Name: 
Dr Isabel Skypala
Email: i.skypala@rbht.nhs.uk

Principal investigator
Dr Isabela Skypala

Click here for more information


Nasal allergen challenge: standardisation as a surrogate for hay fever

Study
Nasal Allergen Challenge: standardisation as a surrogate for hay fever

IRAS no
266165

Study contact information
Name: 
Aarif Eifan
Email: A.Eifan@rbht.nhs.uk

Principal investigator
Professor Stephen Durham

Click here for more information


Grass Immunotherapy plus Dupilumab for Tolerance Evaluation

Study
Grass Pollen Sublingual Tablet Immunotherapy plus Dupilumab for Induction of Tolerance in Adults with Moderate to Severe Seasonal Allergic Rhinitis.

IRAS no
275309

Study contact information
Name: 
Aarif Eifan
Email: A.Eifan@rbht.nhs.uk

Principal investigator
Professor Stephen Durham

Click here for more information

Cardiac Resynchronisation Therapy in non-responders and previously untreatable patients

Study
Stimulation of the left ventricular endocardium for Cardiac Resynchronisation Therapy in non-responders and previously untreatable patients

IRAS no
288696

Study contact information
Name:
 Paula Rogers
Email: P.Rogers@rbht.nhs.uk

Principal investigator
Dr Mark Mason


Role of ganglionated plexus ablation for catheter ablation of paroxysmal and persistent atrial fibrillation

Study
A pilot study on the role of ganglionated plexus ablation for catheter ablation of paroxysmal and persistent atrial fibrillation

IRAS no
133593

Study contact information
Name:
 Dr Sabine Ernst
Email: s.ernst@rbht.nhs.uk

Principal investigator
Dr Sabine Ernst

Click here for more information


WATCHMAN device in patients unsuitable for oral anticoagulation

Study
Assessment of the WATCHMAN device in patients unsuitable for oral anticoagulation

IRAS no
222284

Study contact information
Name:
 Carmen Chan
Email: L.Chan2@rbht.nhs.uk

Principal investigator
Dr Tom Wong


EndoCRT study

Study
A randomised double-blinded cross over study to evaluate the improvement of left ventricular systolic failure using targeted left ventricular endocardial lead placement in cardiac resynchronisation therapy (EndoCRT)

IRAS no
138184

Study contact information
Name:
 Lisa Jones
Email: l.jones2@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


Immediate coronary angiography after out of hospital cardiac arrest (ARREST)

Study
ImmediAte CoRonary AngiogRaphy aftEr Ventricular Fibrillation OutOfHospital Cardiac ArreST (ARREST)

IRAS no
125842

Study contact information
Name:
 Dr Miles Dalby
Email: M.Dalby@rbht.nhs.uk

Principal investigator
Dr Miles Dalby

Click here for more information


NOAH - AFNET 6

Study
Non-vitamin K antagonist Oral anticoagulants in patients with Atrial High rate episodes

IRAS no
194491

Study contact information
Name:
 Dr Shouvik Haldar
Email: S.Haldar@rbht.nhs.uk

Principal investigator
Dr Shouvik Haldar

Click here for more information


VIVOTM mapping protocol

Study
VIVOTM non-invasive mapping of ventricular arrhythmia

IRAS no
257755

Study contact information
Name:
 Dr Ilaria Cazzoli
Email: I.Cazzoli@rbht.nhs.uk

Principal investigator
Dr Ilaria Cazzoli


SPOT - FRAILTY

Study
A Pilot Study to exPlOre the exisTence and impact of FRAILTY in patients over the age of 70 undergoing cardiac interventions.

IRAS no
264744

Study contact information
Name:
 Paula Rogers
Email: p.rogers@rbht.nhs.uk

Principal investigator
Paula Rogers


Long Term Outcomes in CASA AF LSPAF

Study
Long--term Outcomes in Long Standing Persistent Atrial Fibrillation Following Catheter Or Thoracoscopic Surgical Ablation : Extended Follow-Up Of CASA-AF Randomised Controlled Trial

IRAS no
271930

Study contact information
Name:
 Dr Tom Wong
Email: T.Wong2@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


LEADLESS II

Study
The LEADLESS Pacemaker IDE Study

IRAS no
282749

Study contact information
Name:
 Annelise Catelan Zborowski
Email: A.CatelanZborowski@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


PACESIM

Study
A Basic Science Study of Optimised Temporary Pacing in Patients following Cardiac Surgery in Order to Build a Pacing Simulator and Automatic Alerting Algorithm.

IRAS no
292373

Study contact information
Name:
Dr Mark Mason
Email: M.Mason@rbht.nhs.uk

Principal investigator
Dr Mark Mason

Click here for more information

Heterogeneity of asthma

Study
Heterogeneity of asthma: a pilot study to investigate its microbiome and how it relates to asthma severity

IRAS no
163724

Study contact information
Name:
 Cai Sim
Email: c.sim@rbht.nhs.uk

Principal investigator
Professor Kian Fan Chung

Click here for more information


Adherence to inhaled corticosteroids in young people with problematic severe asthma

Study
Adherence to inhaled corticosteroids in young people with problematic severe asthma

IRAS no
188453

Study contact information
Name:
 Dr Louise Fleming 
Email: l.fleming@rbht.nhs.uk

Principal investigator
Dr Louise Fleming

Click here for more information


Unwanted effects of inhaled corticosteriods in children with airway diseases

Study
Unwanted effects of inhaled corticosteroids in children with airway diseases

IRAS no
227592

Study contact information
Name:
 Louise Selby 
Email: L.Selby@rbht.nhs.uk

Principal investigator
Dr Louise Fleming

Click here for more information


Fluctuation of airway function in children with asthma phenotype as a predictor of outcome

Study
Fluctuation of airway function in children with asthma phenotype as a predictor of outcome

IRAS no
154768

Study contact information
Name:
 Dr Louise Fleming 
Email: l.fleming@rbht.nhs.uk

Principal investigator
Dr Louise Fleming

Click here for more information


A randomised pragmatic trial of corticosteriod optimisation in severe asthma

Study
A randomised pragmatic trial of corticosteroid optimisation in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care 

IRAS no
182421

Study contact information
Name:
 Maria Martins
Email: M.Martins@rbht.nhs.uk

Principal investigator
Dr Andrew Menzies-Gow

Click here for more information


Severe wheeze and asthma validation study

Study
Pulmonary epithelial barrier and immunological functions at birth and in early life: key determinants of the development of asthma? Severe wheeze and asthma validation study

IRAS no
216021

Study contact information
Name:
 Mindy Gore
Email: s.saglani@imperial.ac.uk

Principal investigator
Professor Sejal Saglani

Click here for more information


Do patterns of airway infection and inflammation distinguish pathophys and asthma? 

Study
Do patterns of airway infection and inflammation distinguish pathophysiological phenotypes in children with wheeze and asthma?

IRAS no
187435

Study contact information
Name:
 Yvonne Bingham
Email: Y.Bingham@rbht.nhs.uk

Principal investigator
Professor Sejal Saglani

Click here for more information


Targets of bronchial thermoplasty in severe asthma

Study
Targets of bronchial thermoplasty in severe asthma

IRAS no
150245

Study contact information
Name:
 Dr Karthikan Srikanthan
Email: K.Srikanthan@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


Th2-low endotype biomarkers in exercise-induced asthma

Study
Th2-low endotype biomarkers in exercise-induced asthma

IRAS no
203756

Study contact information
Name:
 Sally Meah
Email: sally.meah@imperial.ac.uk

Principal investigator
Dr Omar Usmani

Click here for more information


The use of home-monitoring and mHealth systems to predict asthma control and asthma

Study
The use of home-monitoring and mHealth systems to predict asthma control and asthma exacerbations

IRAS no
185603

Study contact information
Name:
 Paolo Paredi
Email: P.Paredi@rbht.nhs.uk

Principal investigator
Dr Omar Usmani

Click here for more information


National Validation and Sensitivity to Change of the SAQ

Study
National Validation and Sensitivity to Change of a scale to measure quality of life in patients with severe asthma.

IRAS no
250167

Study contact information
Name:
 Rachel Stead
Email: R.Stead@rbht.nhs.uk

Principal investigator
Dr Andrew Menzies-Gow 

Click here for more information


Phase IIA study of PC945 in Aspergillosis on Asthmatic subjects

Study
A double-blind, placebo-controlled study to assess the effects of inhaled PC945 in the treatment of culture-positive Aspergillus fumigatus infection in subjects with moderate to severe asthma

IRAS no
246673

Study contact information
Name:
 Najwa Soussi
Email: n.soussi@rbht.nhs.uk

Principal investigator
Dr Darius Armstrong-James

Click here for more information


DPI Airflow Resistance

Study
Patient’s Perception of Dry Powder Inhaler Airflow Resistance

IRAS no
235776

Study contact information
Name:
 Sally Meah
Email: S.Meah@rbht.nhs.uk

Principal investigator
Dr Omar Usmani


INHALE study

Study
INHALE: Personal pollution exposure and effects on the lungs in healthy and asthmatic individuals

IRAS no
270153

Study contact information
Name:
 Sally Meah
Email: S.Meah@rbht.nhs.uk

Principal investigator
Professor Fan Chung

Click here for more information


PRISM: Precision medicine in severe asthma

Study
PRISM: Molecular phenotyping of participants with severe asthma to determine response to biologic therapies and stability

IRAS no
273192

Study contact information
Name:
 Sally Meah
Email: S.Meah@rbht.nhs.uk

Principal investigator
Professor Fan Chung


P-CLESA

Study
Phenotyping circulating and lung resident eosinophils in severe asthma

IRAS no
152907

Study contact information
Name:
 Sally Meah
Email: S.Meah@rbht.nhs.uk

Principal investigator
Dr Pankaj Bhavsar


Prospective Study of Cellular & Clinical Aspects of Mod-Severe Asthma

Study
Prospective Study of Cellular & Clinical Aspects of Moderate to Severe Asthma

IRAS no
254003

Study contact information
Name:
 Lola Loewenthal
Email: L.Loewenthal@rbht.nhs.uk

Principal investigator
Professor Andrew Menzies-Gow

Click here to find out more


Measuring hydrogen peroxide in exhaled breath condensate in HV

Study
Assessment and validation of a device for measuring hydrogen peroxide in exhaled breath condensate in Healthy Volunteers

IRAS no
289549

Study contact information
Name:
Sally Meah
Email: S.Meah@rbht.nhs.uk

Principal investigator
Dr Omar Usmani


Utilising novel dipole density capabilities to objectively visualise the etiology of recurrent atrial fibrillation following a failed AF ablation

Study
Utilising novel dipole density capabilities to objectively visualize the etiology of recurrent atrial fibrillation following a failed AF ablation

IRAS no
239296

Study contact information
Name:
 Debra Dempster
Email: D.Dempster@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


Concomitant epicardial ledt atrial appendage closure and catheter ablation

Study
A study of concomitant epicardial left atrial appendage closure and catheter ablation in treating recurrent persistent atrial fibrillation after failed previous ablation

IRAS no
229383

Study contact information
Name:
 Peng Zhang
Email: p.zhang@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


Catheter versus thoracoscopic surgical ablation in long standing persistent Atrial Fibrillation

Study
Catheter versus thoracoscopic surgical ablation in long standing persistent Atrial Fibrillation - multicentre randomised control trial

IRAS no
155944

Study contact information
Name:
 Paula Rogers
Email: P.Rogers@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


VITAL - The VyronUS Image Then Ablate study

Study
Clinical investigation of the VytronUS Ablation System for Treatment of Symptomatic Drug-refractory Paroxysmal Atrial Fibrillation (VITAL)

IRAS no
230460

Study contact information
Name: Dr Tom Wong
Email: T.Wong2@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


Map Registry of Procedural Long-term Clinical Outcomes

Study
AcQMap® Global Registry of Procedural and Long-term Clinical Outcomes.

IRAS no
258348

Study contact information
Name: Mathew Varghese
Email: M.Varghese@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


REMOTE AF

Study
Remote Monitoring of AF Recurrence using mHealth Technology (REMOTE - AF)

IRAS no
283058

Study contact information
Name: Gamith Adasuriya
Email: G.Adasuriya@rbht.nhs.uk

Principal investigator
Dr Haldar Shouvik


High density mapping guided ablation for Persistent AF

Study
High density substrate evaluation and guided ablation therapy for atrial fibrillation: Heat-AF

IRAS no
263083

Study contact information
Name: Dr Haseeb Valli
Email: H.Valli@rbht.nhs.uk

Principal investigator
Dr Haldar Shouvik

Click here for more information

The gut microbiome in rheumatoid arthritis and bronchiectasis 

Study
The gut microbiome in rheumatoid arthritis and bronchiectasis

IRAS no
222542

Study contact information
Name:
 Cheyanne Kailla
Email: c.kailla@rbht.nhs.uk

Principal investigator
Dr Rosemary Boyton

Click here for more information


Observational cohort and Biobank UK Study

Study
Observational cohort and Biobank UK Study

IRAS no
173303

Study contact information
Name:
 Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


Efficacy and safety of 12 months of therapy with inhaled Promixin (colistimethate sodium)

Study
A double-blind, placebo controlled, multicentre, clinical trial to investigate the efficacy and safety of 12 months of therapy with inhaled Promixin (colistimethate sodium) in the treatment of subjects with non-cystic fibrosis bronchiectasis

IRAS no
213606

Study contact information
Name:
 Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


The Clear study

Study
A 2x2 factorial randomised single blind open labelled trial to determine the clinical and cost -effectiveness of hypertonic saline (HTS 6%) and carbocysteine versus usual care over 12 months in non-cystic fibrosis bronchiectasis (BE): The Clear study

IRAS no
214254

Study contact information
Name:
 Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


BronchUK: Clinimetric properties of outcome measures in bronchiectasis in the UK

Study
BronchUK: Clinimetric properties of outcome measures in bronchiectasis in the UK

IRAS no 
166832

Study contact information
Name:
 Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


The EMBARC European Bronchiectasis Registry

Study
The EMBARC European Bronchiectasis Registry

IRAS no
165833

Study contact information
Name:
 Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


The Willow Study

Study
A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center Study to Assess the Efficacy, Safety and Tolerability, and Pharmacokinetics of INS1007 Administered Once Daily for 24 Weeks in Subjects with Non-Cystic Fibrosis Bronchiectasis

IRAS no
233267

Study contact information
Name:
 Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


The BRIDGE study

Study
The BRIDGE study- Bronchiectasis Research Involving Databases, Genomics and Endotyping to match the right treatment to the right patient

IRAS no
228760

Study contact information
Name:
 Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


VITAL-BE

Study
A Trial of the Safety, Tolerability and Efficacy of 2 doses of Cayston (Aztreonam Lysine) compared to placebo in participants with bronchiectasis

IRAS no
252929

Study contact information
Name:
 Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


Efficacy of domiciliary non-invasive ventilation in patients with respiratory failure due to non-CF bronchiectasis

Study
Efficacy of domiciliary non-invasive ventilation in patients with respiratory failure due to non-CF bronchiectasis

IRAS no
288577

Study contact information
Name:
 Dr Ricardo Jose
Email: R.Jose@rbht.nhs.uk

Principal investigator
Dr Ricardo Jose


Efficacy of domiciliary non-invasive ventilation in patients with respiratory failure due to non-CF bronchiectasis

Study
A randomised, subject- and investigator-blinded, placebo controlled, parallel group study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of QBW251 in patients with bronchiectasis

IRAS no
287333

Study contact information
Name:
 Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger


Efficacy and Safety of Dupilumab in Participants with ABPA

Study
A randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of dupilumab in patients with allergic bronchopulmonary aspergillosis

IRAS no
282605

Study contact information
Name:
 Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Click here for more information

Circulating cells in advanced cancer

Study
Sample collection study to explore CIrCulating tumour cells, cell free DNA and leucocytes with ImagesTReam analysis in patients with various cancers

IRAS no
198179

Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk

Principal investigator
Paula Rogers

Click here for more information


ATX-TBL-001 Tissue Research Protocol

Study
Prospective collection of donor tissue and blood or leukapheresis product from patients with solid tumours to enable development of methods for the manufacturing of clonal neoantigen T cell products (cNeT).

IRAS no
233696

Study contact information
Name: Professor Eric Lim
Email: E.Lim@rbht.nhs.uk

Principal investigator
Professor Eric Lim

CHILO

Study
Inhalation challenge to assess Inducible Laryngeal Obstruction CHILO.

IRAS no
250025

Study contact information
Name: Dr James Hull
Email: j.hull@rbht.nhs.uk

Principal investigator
Dr James Hull

Click here for more information


Study to Evaluate Efficacy and Safety of BLU-593 in Adults with RCC

Study
A Randomized, Adaptive, Double-Blind, Placebo-Controlled, Parallel Arm, Phase 2b Study to Evaluate the Efficacy and Safety of Multiple Doses of BLU-5937 in Adult Participants With Refractory Chronic Cough

IRAS no
289963

Study contact information
Name: Dr James Hull
Email: j.hull@rbht.nhs.uk

Principal investigator
Dr James Hull

Click here for more information


A Phase 2 Study of Efficacy and Safety of AX-8 in Chronic Cough  

Study
A Phase 2 Study of Efficacy and Safety of AX-8 in Chronic Cough

IRAS no
297718

Study contact information
Name: Dr James Hull
Email: j.hull@rbht.nhs.uk

Principal investigator
Dr James Hull

UK lung volume reduction

Study
UK lung volume reduction - multicentre observational

IRAS no
190196

Study contact information
Name:
 Sara  Buttery
Email: S.Buttery@rbht.nhs.uk

Principal investigator
Dr Nicholas Hopkinson

Click here for more information


Impact of smoking cessation on skeletal muscle atrophy and hypertrophy pathways in COPD

Study
Impact of smoking cessation on skeletal muscle atrophy and hypertrophy pathways in COPD

IRAS no
5020

Study contact information
Name:
 Ahmad Sadaka
Email: A.Sadaka@rbht.nhs.uk

Principal investigator
Dr Nicholas Hopkinson


Microbiome of the lung in patients treated with endobronchial lung volume reduction coils for emphysema

Study
Studying the microbiome of the lung in patients treated with endobronchial lung volume reduction coils for emphysema

IRAS no
215696

Study contact information
Name:
 Dr Justin Garner
Email: J.Garner@rbht.nhs.uk

Principal investigator
Dr Samuel Kemp

Click here for more information


RePneu lung volume reduction coil - European registry

Study
RePneu lung volume reduction coil - European Registry

IRAS no
181479

Study contact information
Name:
 Dr Justin Garner
Email: J.Garner@rbht.nhs.uk

Principal investigator
Dr Samuel Kemp

Click here for more information


NMES in patients with COPD and quadriceps weakness

Study
Quadriceps neuromuscular electrical stimultaion (NMES) as an adjunct to pulmonary rehabilitation in patients with COPD and quadriceps weakness - a randomised double-blind placebo-controlled trial.

IRAS no
234536

Study contact information
Name:
 Sarah Jones
Email: S.Jones5@rbht.nhs.uk

Principal investigator
Dr William Man

Click here for more information


Iron and COPD exercise trial

Study
Iron and Chronic Obstructive Pulmonary Disease (COPD) exercise trial

IRAS no
204579

Study contact information
Name:
 Matt Pavitt
Email: M.Pavitt@rbht.nhs.uk

Principal investigator
Professor Michael Polkey

Click here for more information


Airway microenvironment in patients undergoing surgical and bronchoscopic interventions

Study
Studying the airway microenvironment in patients undergoing surgical and bronchoscopic interventions for COPD

IRAS no
217587

Study contact information
Name:
 Dr Justin Garner
Email: J.Garner@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


Lung volume reduction in severe emphysema

Study
A single arm pilot study of lung volume reduction in severe emphysema using bronchoscopic autologous blood instillation in combination with intra-bronchial valves

IRAS no
135459

Study contact information
Name:
 Dr Justin Garner
Email: J.Garner@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


RejuvenAir™ System metered cryospray therapy for Chronic Bronchitis patients

Study
A prospective safety and feasibility study of the RejuvenAir™ System metered cryospray therapy for Chronic Bronchitis patients

IRAS no
185214

Study contact information
Name:
 Dr Justin Garner
Email: J.Garner@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


The London COPD cohort RSV study

Study
The London COPD cohort respiratory syncytial virus (RSV) study

IRAS no
232292

Study contact information
Name:
 Dexter Wiseman
Email: D.Wiseman@rbht.nhs.uk

Principal investigator
Professor Jadwiga Wedzicha

Click here for more information


The BLF early COPD development partnership grant

Study
The BLF early COPD development partnership grant

IRAS no
206796

Study contact information
Name:
 Ethaar El-Emir
Email: E.El-Emir@rbht.nhs.uk

Principal investigator
Professor Jadwiga Wedzicha

Click here for more information


Relationship between patient phenotypes and exacerbations in chronic obstructive pulmonary disease

Study
Relationship between patient phenotypes and exacerbations in chronic obstructive pulmonary disease

IRAS no
13535

Study contact information
Name:
 Gavin Donaldson
Email: gavin.donaldson@imperial.ac.uk

Principal investigator
Professor Jadwiga Wedzicha


Mechanisms of increased susceptibility to rhinovirus infection

Study
Mechanisms of increased susceptibility to rhinovirus infection in frequent and infrequent exacerbators of Chronic Obstructive Pulmonary Disease

IRAS no
181679

Study contact information
Name:
 Lydia Finney
Email: L.Finney@rbht.nhs.uk

Principal investigator
Professor Jadwiga Wedzicha

Click here for more information


Oxidative metabolism and atrophy in primary human skeletal muscle cell

Study
Primary culture of human skeletal muscle cells from patients with conditions impairing muscle mitochondrial oxidative metabolism and causing muscle atrophy to investigate underlying molecular mechanisms of reduced oxidative metabolism and atrophy and potential novel therapies.

IRAS no
214624

Study contact information
Name:
 Dr Amanda Natanek
Email: A.Natanek@rbht.nhs.uk

Principal investigator
Dr Amanda Natanek

Click here for more information


ELEVATE

Study
A RandomisEd ControlLed Study of PnEumRx Endobronchial Coil System Versus Standard-of-Care Medical MAnagement in the Treatment of Subjects with Severe Emphysema (ELEVATE) A Postmarket Surveillance Study (PMS).

IRAS no
242606

Study contact information
Name: 
Professor Pallav Shah
Email: P.Shah@rbht.nhs.uk 

Principal investigator
Professor Pallav Shah

Click here for more information


Air Pollution in COPD

Study
The Effect of Air Pollution on Small Airway Lung Function in COPD.

IRAS no
260264

Study contact information
Name:
Sally Meah
Email: s.meah@rbht.nhs.uk

Principal investigator
Dr Omar Usmani

Click here for more information


Inhaled SNG001 in COPD patients

Study
A randomised, double-blind, placebo-controlled study, in COPD patients with and without a confirmed respiratory virus infection assessing anti-viral biomarker responses of inhaled SNG001 compared to placebo.

IRAS no
232887

Study contact information
Name:
Dexter Wiseman
Email: D.Wiseman@rbht.nhs.uk

Principal investigator
Professor Jadwiga Wedzicha

Click here for more information


SPACE FOR COPD maintenance

Study
SPACE FOR COPD© delivered as a maintenance programme on Pulmonary Rehabilitation discharge: a randomised controlled trial evaluating the long-term effects on exercise tolerance and mental well-being

IRAS no
262581

Study contact information
Name:
Ruth Barker
Email: R.Barker2@rbht.nhs.uk

Principal investigator
Dr William Man


ESPRESSO

Study
Early Supported discharge with Pulmonary REhabilitation following Severe acute exacerbations of COPD – Safety and Outcomes (ESPRESSO)

IRAS no
269894

Study contact information
Name:
Ruth Barker
Email: R.Barker2@rbht.nhs.uk

Principal investigator
Dr William Man


SHIELD - Singing for Health

Study
Singing for Health: Improving Experience of Lung Disease

IRAS no
259170

Study contact information
Name:
Dr Keir Philip
Email: K.Philip@rbht.nhs.uk

Principal investigator
Dr Nicholas Hopkinson

Click here for more information


AIRFLOW-3

Study
A Multicenter, Randomised, Sham-controlled Study to Evaluate Safety and Efficacy After Treatment with the Nuvaira Lung Denervation System in Subjects with Chronic Obstructive Pulmonary Disease (COPD).

IRAS no
253708

Study contact information
Name:
Dr Francesca Conway
Email: f.conway@rbht.nhs.uk

Principal investigator
Professor Pallav Shah 

Click here for more information


AIRFLOW-3 sub study

Study
Mechanism of action of targeted lung denervation in Chronic Obstructive Pulmonary Disease (COPD) - A basic science study linked to the AIRFLOW-3 Trial

IRAS no
269766

Study contact information
Name:
Dr Francesca Conway
Email: f.conway@rbht.nhs.uk

Principal investigator
Professor Pallav Shah 


MCS MOA

Study
Characterising the Mechanism of Action of Metered Cryospray for the Treatment of Patients with Chronic Obstructive Pulmonary Disease with Chronic Bronchitis

IRAS no
260529

Study contact information
Name:
Dr Christopher Orton
Email: c.orton@rbht.nhs.uk

Principal investigator
Professor Pallav Shah 

Click here for more information


Post-Market Clinical Evaluation of the Zephyr Valve 5.5-LP EBV

Study
Post-Market Clinical Evaluation of the Zephyr Valve 5.5-LP EBV for Bronchoscopic Lung Volume Reduction (BLVR) Procedures

IRAS no
262755

Study contact information
Name:
Elaine Shattock
Email: e.shattock@rbht.nhs.uk

Principal investigator
Dr Samuel Kemp


Breathe Plus feasibility trial

Study
Breathe Plus: Testing the feasibility of a comprehensive geriatric assessment for people with COPD and frailty starting pulmonary rehabilitation

IRAS no
268185

Study contact information
Name:
Lisa Brighton
Email: L.Brighton@rbht.nhs.uk

Principal investigator
Dr William Man


The O-COPD trial: OPEP devices in COPD

Study
The O-COPD trial: Oscillatory Positive Expiratory Pressure (OPEP) devices to improve outcome in patients with Chronic Obstructive Pulmonary Disease (COPD)

IRAS no
269494

Study contact information
Name:
Dr Saeed Alghamdi
Email: S.Alghamdi@rbht.nhs.uk

Principal investigator
Dr Nicholas Hopkinson


Lobar Segmented Iodine Mapping of the Lungs using Dual Energy CT

Study
Lobar Segmented Iodine Mapping of the Lungs using Dual Energy Computed Tomography in Advanced Chronic Obstructive Pulmonary Disease.

IRAS no
265630

Study contact information
Name:
Dr Carole Ridge
Email: C.Ridge@rbht.nhs.uk

Principal investigator
Dr Carole Ridge


EON-Lung: Nitrate levels in Lung Disease

Study
EON-Lung: Nitrate levels in Lung Disease - an observational study

IRAS no
266682

Study contact information
Name:
Dr Nicholas Hopkinson
Email: n.hopkinson@rbht.nhs.uk

Principal investigator
Dr Nicholas Hopkinson

Click here for more information


QBW251 in patients with Chronic Obstructive Lung disease (COPD)

Study
A randomised, patients- and investigator blinded, placebo - controlled parallel group study to assess the mode-of-action of QBW251 in patients with Chronic Obstructive Lung disease (COPD)

IRAS no
1003158

Study contact information
Name:
Professor Jadwiga Wedzicha
Email: J.Wedzicha@rbht.nhs.uk

Principal investigator
Professor Jadwiga Wedzicha


CONVERT Trial

Study
Fissure Closure with the AeriSeal® System for Converting Collateral Ventilation Status in Patients with Severe Emphysema; a Multicenter, Prospective Trial

IRAS no
285414

Study contact information
Name:
Najwa Soussi
Email: n.soussi@rbht.nhs.uk

Principal investigator
Dr Samuel Kemp


Mobilise-D - Clinical Validation Study

Study
Validating digital mobility assessment using wearable technology – The Mobilise-D Clinical Validation Study.

IRAS no
289543

Study contact information
Name:
Dr Nicholas Hopkinson
Email: n.hopkinson@rbht.nhs.uk

Principal investigator
 Dr Nicholas Hopkinson

FREAL

Study
Understanding susceptibility to fungal infection and evolution of antimicrobial resistance in chronic respiratory disease

IRAS no
244685

Study contact information
Name:
Dr Anand Shah
Email: A.Shah2@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Click here for more information


Endothelial senescence in chronic lung disease

Study
Studying endothelial senescence and dysfunction in chronic lung disease

IRAS no
284894

Study contact information
Name:
Dr Koralia Paschalaki
Email: K.Paschalaki@rbht.nhs.uk

Principal investigator
Professor Jadwiga Wedzicha


FADE UK

Study
Analysing Fungal Disease Epidemiology in the UK

IRAS no
300045

Study contact information
Name:
Dr Anand Shah
Email: A.Shah2@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Heterotaxy and abnormalities in intestinal rotation

Study
Heterotaxy and abnormalities in intestinal rotation

IRAS no
170433

Study contact information
Name:
 Anastasia Fotaki
Email: a.fotaki@rbht.nhs.uk

Principal investigator
Dr Julene Carvalho

Click here for more information


Pharmacokinetics and pharmacodynamics of edoxaban in paediatric patients

Study
A phase 1, open-label, single-dose, non-randomised study to evaluate pharmacokinetics and pharmacodynamics of edoxaban in pediatric patients 

IRAS no
200445

Study contact information
Name:
 Neil West
Email: N.West@rbht.nhs.uk

Principal investigator
Dr Zdenek Slavik

Click here for more information


Pedometer walking program for ACHD patients

Study
Does a pedometer-based walking programme affect exercise capacity and quality of life in sedentary adults with congenital heart disease?

IRAS no
232271

Study contact information
Name:
 Ms Lynda Shaughnessy
Email: L.Shaughnessy@rbht.nhs.uk

Principal investigator
Ms Lynda Shaughnessy

Click here for more information

Outcome validation in noses of subjects with CF and non-CF volunteers

Study
Outcome validation in noses of subjects with cystic fibrosis and non-CF volunteers

IRAS no
215047

Study contact information
Name:
 Aarash Saleh
Email: a.saleh@rbht.nhs.uk

Principal investigator
Professor Eric Alton

Click here for more information


Living with cystic fibrosis

Study
Living with Cystic fibrosis

IRAS no
196567

Study contact information
Name:
 Olga Archangelidi
Email: o.archangelidi@rbht.nhs.uk

Principal investigator
Dr Siobhan Carr

Click here for more information


CF start

Study
The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF

IRAS no
211995

Study contact information
Name:
 Dr Siobhan Carr
Email: s.carr@rbht.nhs.uk

Principal investigator
Dr Siobhan Carr

Click here for more information


MAGIC

Study
Managing abnormal glucose in cystic fibrosis (MAGIC)- the development of a self-management education programme for people with CFRD

IRAS no
215946

Study contact information
Name:
 Sarah Collins
Email: s.collins@rbht.nhs.uk

Principal investigator
Ms Sarah Collins

Click here for more information


Safety and pharmacodynamics of long-term Ivacaftor treatment for CF

Study
A Phase 3, 2-Arm, open-label study to evaluate the safety and pharmacodynamics of long-term Ivacaftor treatment in subjects with Cystic Fibrosis who are less than 24 Months of age at treatment initiation and have a CFTR gating mutation

IRAS no
228921

Study contact information
Name:
 Nicole Westrupp
Email: n.westrupp@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


CLIMB-CF

Study
Clinical monitoring and biomarkers to stratify severity and predict outcomes in children with cystic fibrosis (CLIMB-CF).

IRAS no
207718

Study contact information
Name:
 Nicole Westrupp
Email: n.westrupp@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Non-invasive detection of pseudomonas aeruginosa lower airway infection in patients with CF

Study
Non-invasive detection of Pseudomonas aeruginosa lower airway infection in patients with Cystic Fibrosis

IRAS no
233578

Study contact information
Name:
 Claire Edmondson
Email: C.Edmondson@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Safety, pharmacokinetics and pharmacodynamics of Ivacaftor in CF patients (less than 24 months old)

Study
A Phase 3, 2 Part, open-Label study to evaluate the safety, pharmacokinetics, and pharmacodynamics of Ivacaftor in subjects with Cystic Fibrosis who are less than 24 Months of age at treatment initiation and have a CFTR gating mutation

IRAS no
199957

Study contact information
Name:
 Nicole Westrupp
Email: n.westrupp@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Safety and efficacy of long-term treatment with VX 661 in combination with Ivacaftor

Study
A Phase 3, open label, rollover study to evaluate the safety and efficacy of long term treatment with VX 661 in combination with Ivacaftor in subjects aged 12 years and older with Cystic Fibrosis , homozygous or heterozygous for the F508del CFTR mutation

IRAS no
186033

Study contact information
Name:
 Sandra Scott
Email: S.Scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Multiple breath washout in paediatric chronic airways disease

Study
Multiple Breath Washout in paediatric chronic airways disease: Building a clinimetrics dataset

IRAS no
204190

Study contact information
Name:
 Clare Saunders
Email: C.Saunders2@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Screening tools for drug-induced ototoxicity in adults with CF

Study
A prospective cross-sectional study analysing the utility of novel tablet-based audiometry and an interactive web-based hearing app as screening tools for drug-induced ototoxicity in adults with cystic fibrosis.

IRAS no
230986

Study contact information
Name:
 Anitha Vijayasingam
Email: A.Vijayasingam@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Click here for more information


Improving outcome measures for physiotherapy trials of airway clearance in adults in CF

Study
Improving outcome measures for physiotherapy trials of airway clearance in adults with CF

IRAS no
154635

Study contact information
Name:
 Gemma Stanford
Email: G.Stanford@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds

Click here for more information


Finger-prick capillary blood sampling in chronic lung disease

Study
Single-centre validation of finger-prick capillary blood sampling for remote monitoring in chronic lung disease including antifungal therapeutic drug monitoring.

IRAS no
239814

Study contact information
Name:
 Professor Michael Loebinger 
Email: M.Loebinger@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger 

Click here for more information


VX17-661-116

Study
A Phase 3, Open-label, Rollover Study to Evaluate the Safety and Efficacy of Long-term Treatment With Tezacaftor in Combination With Ivacaftor in Subjects With Cystic Fibrosis Aged 6 Years and Older, Homozygous or Heterozygous for the F508del-CFTR Mutation.

IRAS no
241643

Study contact information
Name:
 Professor Jane Davies
Email: J.Davies@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


VX17-659-105 Open-label Safety and Efficacy of VX-659 in CF

Study
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-659 Combination Therapy in Subjects with Cystic Fibrosis Who Are Homozygous or Heterozygous for the F508del Mutation.

IRAS no
241641

Study contact information
Name:
 Dr Nicholas Simmonds
Email: N.Simmonds@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds

Click here for more information


MR assessment of shunt fraction in CF patients before and after BAE

Study
A prospective pilot study: Magnetic Resonance Imaging (MRI) derived measures of bronchial arterial flow in the assessment and follow-up of patients with Cystic fibrosis (CF) who undergo bronchial artery embolisation.

IRAS no
256039

Study contact information
Name:
 Bhavin Rawal
Email: B.Rawal@rbht.nhs.uk

Principal investigator
Professor Simon Padley


Organoid Study (HIT-CF)

Study
Stratifying Cystic Fibrosis Patients Based on Intestinal Organoid Response To Different CFTR-modulators

IRAS no
255704

Study contact information
Name:
 Maria Nunez
Email: M.Nunez@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds


Phase IIa study of PC945 in Aspergillosis in Cystic Fibrosis patients

Study
An open-label study to assess the safety, pharmacokinetics and pharmacodynamics of inhaled PC945 in adult Cystic Fibrosis (CF) patients with persistent pulmonary Aspergillus fumigatus infection

IRAS no
248009

Study contact information
Name:
 Dr Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds

Click here for more information


Exercise behaviours in children and young people with cystic fibrosis

Study
Identifying predictors for maintenance of exercise participation in children and young people with cystic fibrosis.

IRAS no
246187

Study contact information
Name:
Nicky Murray
Email: N.Murray@rbht.nhs.uk

Principal investigator
Nicky Murray

Click here for more information


Measurement of novel indices of lung function in respiratory disease

Study
Measurement of novel indices of lung function in respiratory disease

IRAS no
208382

Study contact information
Name:
Clare Saunders
Email: C.Saunders2@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


A study of the combined effects of three CFTR modulator medicines in people with cystic fibrosis aged 12 and older

Study
A Phase 3 study of the long-term safety of a triple combination therapy of VX-445, tezacaftor and ivacaftor in people with cystic fibrosis aged 12 and older.

IRAS no
269907

Study contact information
Name:
 Dr Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds


A study to learn more about a combination of CFTR modulator medicines in people with Cystic Fibrosis (VX 18 445 104)

Study
A study to evaluate the effectiveness and safety of VX 445/Tezacaftor/Ivacaftor in people with Cystic Fibrosis who are heterozygous for the F508del mutation and a gating or residual function mutation.

IRAS no
268820

Study contact information
Name:
 Dr Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies


A Phase 2 study of ABBV-3067 alone and in combination with ABBV-2222

Study
A Phase 2 study of ABBV-3067 alone and in combination with ABBV-2222 in Cystic Fibrosis subjects who are homozygous for the F508del mutation.

IRAS no
268446

Study contact information
Name:
 Dr Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


VX18-445-110 VX-445/TEZ/IVA Open-label in CF (F/G and F/RF)

Study
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for the F508del Mutation and a Gating or Residual Function Mutation (F/G and F/RF Genotypes)

IRAS no
268821

Study contact information
Name:
 Dr Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Phase 3 Open-label Study of VX-445/TEZ/IVA in subjects 6 years & older

Study
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-445/TEZ/IVA Combination Therapy in Subjects With Cystic Fibrosis Who Are 6 Years of Age and Older

IRAS no
274499

Study contact information
Name:
 Dr Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Clinical Outcomes With Novel Modifier Therapy Combinations in CF

Study
Clinical Outcomes With Novel Modifier Therapy Combinations in CF

IRAS no
279116

Study contact information
Name:
 Dr Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Targeting Immunotherapy for Fungal Infection in Cystic Fibrosis

Study
TrIFIC: Targeting Immunotherapy for Fungal Infection in Cystic Fibrosis

IRAS no
270828

Study contact information
Name:
 Maria Nunez
Email: M.Nunez@rbht.nhs.uk

Principal investigator
Dr James Darius-Armstrong


VX20-445-119

Study
A Phase 3b Open-label Study Evaluating the Long-term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor Combination Therapy in Cystic Fibrosis Subjects Ages 6 Years and Older Who Are Heterozygous for the F508del Mutation and a Minimal Function Mutation (F/MF)"

IRAS no
1003390

Study contact information
Name:
 Dr Sandra Scott
Email:  s.scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies


Clinical Outcomes With Novel Modifier Therapy Combination (RECOVER)

Study
Real World Clinical Outcomes With Novel Modifier Therapy Combinations in People with CF

IRAS no
296928

Study contact information
Name:
Clare Saunders
Email:  c.saunders2@rbht.nhs.uk

Principal investigator
Professor Jane Davies


COLONiC FITness

Study
Faecal immunochemical testing to detect advanced adenomas and colorectal carcinoma in people with cystic fibrosis

IRAS no
296774

Study contact information
Name:
 Dr Aoife Lillis
Email: A.Lillis@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds

Ilprost (Ventavis) in patients with Eisenmenger syndrome

Study
A single-centre, placebo-controlled, double-blinded, randomised, crossover study of Iloprost (Ventavis®) in patients with Eisenmenger syndrome

IRAS no
121948

Study contact information
Name:
 Dr Stephen John Wort
Email: s.wort@rbht.nhs.uk

Principal investigator
Dr Stephen John Wort

Click here for more information

Molecular genetics of human birth defects

Study
Molecular genetics of human birth defects – mapping and gene identification

IRAS no
103488

Study contact information
Name:
 Dr Claire Hogg
Email: c.hogg@rbht.nhs.uk

Principal investigator
Dr Claire Hogg


Genetic linkage evaluation in inherited cardiac conditions

Study
Genetic linkage evaluation in inherited cardiac conditions

IRAS no
53663

Study contact information
Name:
 Dr Janice Till
Email: j.till@rbht.nhs.uk

Principal investigator
Dr Janice Till


ARRY-371797 (p38 MAP Kinase Inhibitor)

Study
A Phase 3, multinational, randomised, placebo-controlled study of ARRY-371797 in patients with Symptomatic Dilated Cardiomyopathy due to a Lamin A/C Gene Mutation

IRAS no
254544

Study contact information
Name: Dr James Ware
Email: J.Ware@rbht.nhs.uk

Principal investigator
Dr James Ware

Click here for more information

CardioMEMS Heart Failure System

Study
CardioMEMS Heart Failure System 

IRAS no
219676

Study contact information
Name:
 Angela Gallagher
Email: a.gallagher2@rbht.nhs.uk

Principal investigator
Professor Martin Cowie

Click here for more information


Factors influencing physical activity among individuals living with heart failure

Study
Factors influencing physical activity among individuals living with heart failure: a mixed-methods study

IRAS no
205050

Study contact information
Name:
 Professor Martin Cowie
Email: m.cowie@rbht.nhs.uk

Principal investigator
Professor Martin Cowie

Click here for more information


Assessing organisational readiness for heart failure remote monitoring

Study
Assessing Organisational Readiness for Heart Failure Remote Monitoring

IRAS no
236418

Study contact information
Name:
 Darshan Brahmbhatt
Email: d.brahmbhatt@rbht.nhs.uk

Principal investigator
Professor Martin Cowie

Click here for more information


BAROSTIM NEO

Study
BAROSTIM NEO ® - Baroreflex Activation Therapy® for Heart Failure

IRAS no
235110

Study contact information
Name:
 Ms Rebecca Lane
Email: r.lane@rbht.nhs.uk

Principal investigator
Ms Rebecca Lane

Click here for more information


IRONMAN

Study
Effectiveness of intravenous iron treatment vs standard care in patients with heart failure and iron deficiency: a randomised, open-label multicentre trial (IRONMAN)

IRAS no
191168

Study contact information
Name:
 Peng Zhang
Email: p.zhang@rbht.nhs.uk

Principal investigator
Ms Rebecca Lane

Click here for more information


The effects of inorganic nitrite on cardiac and skeletal muscle

Study
The Effects of inorganic nitrite on cardiac and skeletal muscle: Physiology, pharmacology, and therapeutic potential in patients with Chronic Heart Failure

IRAS no
87162

Study contact information
Name:
 Brodie Loudon
Email: B.Loudon@rbht.nhs.uk

Principal investigator
Dr Sanjay Prasad

Click for more information


Mitraclip device in heart failure

Study
Randomised investigation of the Mitraclip device in heart failure: 2nd trial in patients with clinically significant functional mitral regurgitation

IRAS no
220456

Study contact information
Name:
 Joanne Benton
Email: j.benton@rbht.nhs.uk

Principal investigator
Dr Robert Smith

Click here for more information


LCZ696 in paediatric patients

Study
Multicenter, open-label, single dose study to evaluate the safety, tolerability and pharmacokinetics of LCZ696 followed by randomised, double-blind, parallel group,active-controlled study to evaluate the efficacy and safety of LCZ696 in pediatric patients

IRAS no
206351

Study contact information
Name:
 Dr Piers Daubeney
Email: p.daubeney@rbht.nhs.uk

Principal investigator
Dr Piers Daubeney

Click for more information


AccuCinch® Ventriculoplasty System for Functional Mitral Regurgitation

Study
Safety and performance evaluation of the AccuCinch® Ventricular Repair System for the treatment of heart failure with or without Functional Mitral Regurgitation due to Dilated Ischaemic or Non-Ischaemic Cardiomyopathy. 

IRAS no
230127

Study contact information
Name: Lauren Kelly
Email: L.Kelly2@rbht.nhs.uk

Principal investigator
Dr Robert Smith

Click for more information


The AMBITION

Study
Assessing mitochondrial bioenergetics in coronary heart disease; correlating cardiac magnetic resonance with the molecular processes that underpin myocardial dysfunction and left ventricular reverse remodelling.

IRAS no
247881

Study contact information
Name: Dr Richard Jones
Email: r.jones@rbht.nhs.uk

Principal investigator
Dr Sanjay Prasad


The REMIT-DCM study

Study
Reverse rEmodelling Markers In the serial evaluation of recenTonset Dilated CardioMyopathy

IRAS no
262962

Study contact information
Name: Dr Daniel Hammersley
Email: d.hammersley@rbht.nhs.uk

Principal investigator
Dr Sanjay Prasad

Click here for more information


PiCSO-AMI-I

Study
Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) in Acute Myocardial Infarction (PiCSO-AMI-I)

IRAS no
259683

Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk

Principal investigator
Dr Charles Ilsley

Click here for more information


Go DCM

Study
Defining the genetics, biomarkers and outcomes for dilated cardiomyopathy: a prospective multi-centre observational study

IRAS no
237880

Study contact information
Name: Teijo Palovaara
Email: T.Palovaara@rbht.nhs.uk

Principal investigator
Dr James Ware


ORBITA-2

Study
A placebo-controlled trial of percutaneous coronary intervention for the relief of stable angina

IRAS no
242451

Study contact information
Name: Meriel Woodruff
Email: M.Woodruff@rbht.nhs.uk

Principal investigator
Dr Vasileios Panoulas

Click here for more information


Sanofi Drug Utilisation Study of alirocumab

Study
A drug utilization study (DUS) of alirocumab in Europe to assess the effectiveness of the dosing recommendation to avoid very low LDL-C levels.

IRAS no
245146

Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk

Principal investigator
Dr Barbir Mahmoud

Click here for more information


HEART - ACS V1.0

Study
The HarEfield Acute MyocaRdial InfarcTion Cohort

IRAS no
259087

Study contact information
Name: Laura Barker
Email: L.Barker2@rbht.nhs.uk

Principal investigator
Dr Miles Dalby


The EURO-SHOCK Trial version 1

Study
EURO SHOCK Testing the value of novel strategy and its cost efficacy in order to improve the poor outcomes in Cardiogenic Shock

IRAS no
250403

Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk

Principal investigator
Dr Alex Rosenberg

Click here for more information


Epidemiology and Prognosis in Acute Myocarditis 

Study
Epidemiological trends and outcomes of hospital admissions for acute myocarditis and dilated cardiomyopathy in the National Health Service of England from 1998 onwards.

IGARD reference number
DARS-NIC-144568-D7G6V

Study contact information
Name: Amrit Lota
Email: A.Lota@rbht.nhs.uk

Principal investigator
Professor Sanjay Prasad

Click here for more information


Diagnosis and risk stratification in myocarditis

Study
Diagnosis and risk stratification in myocarditis using cardiovascular magnetic resonance, detailed molecular markers and gene sequencing - a personalised approach.

IRAS no
220817

Study contact information
Name:
 Alma Iacob
Email: A.Iacob@rbht.nhs.uk

Principal investigator
Professor Sanjay  Prasad

Click here for more information


MYK-491 in MYH7-DCM patients

Study
Open-Label, Baseline-Controlled, Two-Period, Exploratory Study of Safety, Tolerability and Pharmacodynamics of Oral MYK-491 in Stable Ambulatory Patients with Primary Dilated Cardiomyopathy Associated with MYH7 Mutation

IRAS no
277149

Study contact information
Name:
 Dr Brian Halliday
Email: B.Halliday@rbht.nhs.uk

Principal investigator
Dr Brian Halliday

Click here for more information


VIDEO-HF

Study
Evaluating Outpatient Video Consultations in Heart Failure: Clinician and Patient Perspectives.

IRAS no
284625

Study contact information
Name:
 Dr Arvind Singhal
Email: A.Singhal@rbht.nhs.uk

Principal investigator
Professor Martin Cowie

Click here for more information


Fish and Chips

Study
FFRCT In Stable Heart disease & CTA Helps Improve Patient care and Societal costs

IRAS no
285996

Study contact information
Name:
 Dr Edward Nicol
Email: E.Nicol@rbht.nhs.uk

Principal investigator
Dr Edward Nicol

Click here for more information


The DAPA-MI Study

Study
A Registry-based, Randomised, Double-blind, Placebo-Controlled Cardiovascular Outcomes Trial to Evaluate the Effect of Dapagliflozin on the Incidence of Heart Failure or Cardiovascular Death in Patients without Diabetes with Acute Myocardial Infarction at Increased Risk for Subsequent Development of Heart Failure

IRAS no
284188

Study contact information
Name:
Heather Passmore
Email: H.Passmore@rbht.nhs.uk

Principal investigator
Dr Anthony Barron

Click here for more information


A possible new treatment for elevated Lp(a) in CVD - HORIZON

Study
A randomised double-blind, placebo-controlled, multicenter trial assessing the impact of lipoprotein (a) lowering with TQJ230 on major cardiovascular events in patients with established cardiovascular disease (CVD).

IRAS no
267092

Study contact information
Name:
Alkida Bucaj
Email: A.Bucaj@rbht.nhs.uk

Principal investigator
Professor Mahmoud Barbir

Click here for more information

GSK3008348 in IPF patients using PET imaging

Study
A study of single doses to evaluate the safety, tolerability, pharmacokinetics and target engagement of nebulised GSK3008348 in Idiopathic Pulmonary Fibrosis patients, using positron emission tomography (PET) imaging

IRAS no
221453

Study contact information
Name:
 Lyn Paul
Email: L.Paul@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


Muscle stimulation in advanced idiopathic pulmonary fibrosis (MUST-IPF)

Study
Neuromuscular electrical stimulation (NMES) is a portable hand-held muscle stimulator which allows the thigh muscles to be exercised whilst seated. The aims of this study are to 1) investigate whether NMES is acceptable to patients with IPF and healthcare/research staff and 2) identify if it can improve leg muscle strength and walking ability.

IRAS no
241055

Study contact information 
Name: 
Claire Nolan
Email: c.nolan@rbht.nhs.uk

Principal investigator
Dr William Man

Click here for more information


A study to evaluate to efficacy and safety of BG00011

Study
A randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of BG00011 in patients with Idiopathic Pulmonary Fibrosis. 

IRAS no
248312

Study contact information
Name: Lyn Paul
Email: l.paul@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


Nintedanib in PF-ILD (extension)

Study
An open-label extension trial of the long-term safety of nintedanib in patients with Progressive Fibrosing Interstitial Lung Disease (PF-ILD)

IRAS no
252018

Study contact information
Name: Lyn Paul
Email: l.paul@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


TR12 Ph 2 Study in Idiopathic Pulmonary Fibrosis-Nalbuphine ER Tablets

Study
A phase 2, double-blind, randomised, placebo-controlled, two-treatment, two-period crossover efficacy and safety study in Idiopathic Pulmonary Fibrosis (IPF) with Nalbuphine ER tablets for the treatment of cough.

IRAS no
262846

Study contact information
Name: Lyn Paul
Email: l.paul@rbht.nhs.uk

Principal investigator
Professor Toby Maher


GALACTIC-1 Phase 2b study in idiopathic pulmonary fibrosis

Study
GALACTIC-1 - A randomised, double-blind, multicentre, parallel, placebo controlled Phase 2b study in subjects with idiopathic pulmonary fibrosis (IPF) investigating the efficacy and safety of TD139, an inhaled galectin-3 inhibitor administered via a dry powder.

IRAS no
257627

Study contact information
Name: Lyn Paul
Email: l.paul@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux


Changes in iOS in IPF

Study
Changes in impulse oscillometry measurements and outcomes in idiopathic pulmonary fibrosis

IRAS no
282567

Study contact information
Name: Suhani Patel
Email: S.Patel1@rbht.nhs.uk

Principal investigator
Dr William Man

Click here for more information


Reliability and vailidity of iOS in IPF

Study
Reliability and validity of impulse oscillometry measurements in idiopathic pulmonary fibrosis

IRAS no
280564

Study contact information
Name: Suhani Patel
Email: S.Patel1@rbht.nhs.uk

Principal investigator
Dr William Man

Click here for more information


PACIFY Cough

Study
PAciFy Cough: A multicentre, double blind, placebo controlled, crossover trial of morphine sulfate for the treatment of PulmonAry Fibrosis Cough

IRAS no
275034

Study contact information
Name: Zhe Wu
Email: Z.Wu@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux


Progressive Fibrosing Lung Disease (PROFOUND)

Study
Identifying progressive fibrosing lung disease: a study of genetic and environmental interactions: an observational cohort study.

IRAS no
279948

Study contact information
Name: Jessica Wallen
Email: j.wallen@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux


1305-0013 BI 1015550 in Idiopathic Pulmonary Fibrosis 

Study
A randomised, double-blind, placebo-controlled parallel group study in IPF patients over 12 weeks evaluating efficacy, safety and tolerability of BI 1015550 taken orally.

IRAS no
280729

Study contact information
Name: Deirdre Flannery
Email: D.Flannery@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux


Phase 2 Study of the Efficacy and Safety of BMS-986278 in IPF

Study
A Multicenter, Randomised, Double-blind, Placebo-controlled, Phase 2 Study of the Efficacy and the Safety and Tolerability of BMS-986278 in Participants with Idiopathic Pulmonary Fibrosis (IM027-040)

IRAS no
1003409

Study contact information
Name: Natalie Dwyer
Email: N.Dwyer@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information

CMR sequences for future clinical use

Study
Development of Cardiovascular Magnetic Resonance (CMR) sequences for future clinical use

IRAS no
33773

Study contact information
Name:
 Andy Scott
Email: a.scott07@imperial.ac.uk

Principal investigator
Professor David Firmin


Diffusion tensor CMR imaging of the myocardium

Study
Diffusion Tensor Cardiovascular Magnetic Resonance Imaging of the myocardium

IRAS no
136441

Study contact information
Name:
 Zohya Khalique
Email: Z.Khalique@rbht.nhs.uk

Principal investigator
Professor Dudley Pennell

Click here for more information


ORFAN

Study
The Oxford Risk Factors And Non-invasive imaging Study.

IRAS no
164361

Study contact information
Name:
 Dr Ciara Mahon
Email: C.Mahon@rbht.nhs.uk

Principal investigator
Dr Edward Nichol

Click here for more information


P-VECT Study

Study
Peri-Vascular adipose tissue inflammation Elevated using coronary CT angiography (P-VECT Study)

IRAS no
258745

Study contact information
Name:
 Dr Ciara Mahon
Email: C.Mahon@rbht.nhs.uk

Principal investigator
Dr Edward Nichol

Click here for more information


Quantitive analysis of the 4-dimensional motion of the ascending aorta

Study
Quantitive analysis of the 4-dimensional motion of the ascending aorta

IRAS no
281535

Study contact information
Name:
 Dr Cristoph Nienaber
Email: C.Nienaber@rbht.nhs.uk

Principal investigator
Dr Christoph Nienaber

Transmural myocardial perfusion with hypertension, HCM and HCM phenocopies with CMR

Study
The measurement of transmural myocardial perfusion in normal subjects and patients with hypertension, hypertrophic cardiomyopathy (HCM) and HCM phenocopies with Cardiovascular Magnetic Resonance (CMR)

IRAS no
171258

Study contact information
Name:
 Brian Halliday
Email: B.Halliday@rbht.nhs.uk

Principal investigator
Dr Sanjay Prasad


Lifestyle and exercise in Hypertrophic Cardiomyopathy

Study
Lifestyle and exercise in Hypertrophic Cardiomyopathy

IRAS no
205294

Study contact information
Name:
 Carmen Chan
Email: L.Chan2@rbht.nhs.uk

Principal investigator
Dr James Ware

Click here for more information


Exploring the lived experiences of Familial Hypercholesterolaemia in childhood

Study
Exploring the lived experience of being diagnosed with genetically confirmed Familial Hypercholesterolaemia in childhood

IRAS no
269787

Study contact information
Name:
 Charis Browne
Email: C.Browne@rbht.nhs.uk

Principal investigator
Charis Browne

Click here for more information

The DEPICT study

Study
Critically ill children and young people: Do national differences in access to emergency paediatric Intensive Care and care during transport affect clinical outcomes and patient experience? The DEPICT study

IRAS no
218569

Study contact information
Name:
 Angela Aramburo
Email: a.aramburocaragol@rbht.nhs.uk

Principal investigator
Ms Angela Aramburo


Rovaroxaban regimen in children with acute venous thromboembolism

Study
Multicentre, open-label, active-controlled, randomised study to evaluate the efficacy and safety of an age and body weight-adjusted rivaroxaban regimen in children with acute venous thromboembolism

IRAS no
155345

Study contact information
Name:
 Helena Sampaio
Email: m.fernandessampaio@rbht.nhs.uk

Principal investigator
Ms Angela Aramburo

Click here for more information


S-CAP study

Study
A molecular toolkit for the microbial investigation of severe community acquired pneumonia (S-CAP Study)

IRAS no
189915

Study contact information
Name:
 Natalie Dormand
Email: N.Dormand@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


Haemostatic markers in ECMO (HAE) study

Study
Prospective cohort study of haemostatic activation markers and correlation with bleeding and thrombotic complications in patients receiving extracorporeal membrane oxygenation(ECMO)

IRAS no
235036

Study contact information
Name:
 Dr Deepa Arachchillage
Email: D.JayakodyArachchillage@rbht.nhs.uk

Principal investigator
Dr Deepa Arachchillage

Click here for more information


WAVE study - Weaning Algorithms for mechanical VEntilation

Study
Weaning from mechanical ventilation: comparison of open-loop decision support system and routine care in cardiothoracic patients.

IRAS no
239144

Study contact information
Name:
 Dr Brijesh Patel
Email: B.Patel4@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


EAT-PK

Study
Does Extra-Corporeal Membrane Oxygenation alter anti-infectives therapy pharmacokinetics in adult critically ill patients?

IRAS no
228196

Study contact information
Name:
 Dr Anna Reed
Email: A.Reed@rbht.nhs.uk

Principal investigator
Dr Anna Reed

Click here for more information


Advanced echocardiography in critical care

Study
Advanced echocardiography in critical care

IRAS no
266247

Study contact information
Name:
 Professor Susanna Price
Email: S.Price@rbht.nhs.uk

Principal investigator
Professor Susanna Price


GenOMICC

Study
Genetics of susceptibility and mortality in critical care (GenOMICC)

IRAS no
269326

Study contact information
Name:
 Mahitha Gummadi
Email: M.Gummadi@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel


Evaluating the nutritional impact of changing from 1% to 2% Propofol in a Cardiothoracic Adult Critical Care Unit

Study
Evaluating the nutritional impact of changing from 1% to 2% Propofol in a Cardiothoracic Adult Critical Care Unit

IRAS no
286229

Study contact information
Name:
 Chris Remmington
Email: C.Remmington@rbht.nhs.uk

Principal investigator
Chris Remmington


MUSCLE-ICU Study

Study
 Acute muscle wasting in critical illness – an observational cohort study

IRAS no
285418

Study contact information
Name:
 Dr Brijesh Patel
Email: B.Patel4@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel


Inhale Work Package 3

Study
The Impact of using FilmArray Pneumonia Panel Molecular Diagnostics for Hospital-Acquired and Ventilator-Associated Pneumonia on Antimicrobial Stewardship and Patient Outcomes in UK Critical Care: A Multicentre Randomised Controlled Trial.

IRAS no
250289

Study contact information
Name:
 Lauren Kelly
Email: L.Kelly3@rbht.nhs.uk

Principal investigator
Dr Suveer Singh

Click here for more information


Nasal High-Flow Oxygen Therapy After Cardiac Surgery (NOTACS) study

Study
Nasal High-Flow Oxygen Therapy After Cardiac Surgery (NOTACS) Study: Effect of High-Flow Nasal Therapy on Patient-Centred Outcomes in Patients at High Risk of Postoperative Pulmonary Complications After Cardiac Surgery: A Multicentre Randomised Controlled Trial.

IRAS no
278290

Study contact information
Name:
Dr Nicoletta Zimbler
Email: N.Zimbler@rbht.nhs.uk

Principal investigator
Dr Nicoletta Zimbler


An exploration of the metabolic cost of IMT and physical rehab

Study
Measurement of the metabolic cost of inspiratory muscle training and physical rehabilitation in mechanically ventilated patients in intensive care; a feasibility study.

IRAS no
298839

Study contact information
Name:
Dr Timothy Jenkins
Email: T.Jenkins@rbht.nhs.uk

Principal investigator
Professor Michael Polkey

"Unclassifiable" ILD

Study
Phase II study of Pirfenidone vs placebo in patients with fibrotic ILD that cannot be classified with moderate or high confidence into any other category of fibrotic IP by Multidisciplinary Team (MDT) review (“unclassifiable” ILD).

IRAS no
218417

Study contact information
Name:
 Vladimir Domi
Email: V.Domi@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


Systemic sclerosis associated with ILD

Study
A double blind, randomised, placebo-controlled trial evaluating efficacy and safety of oral nintedanib, 150 mg twice daily for 52 weeks (with follow up until last patient out up to a maximum of 2 years) in patients with systemic sclerosis associated interstitial lung disease

IRAS no
185104

Study contact information
Name:
 Deirdre Flannery
Email: D.Flannery@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


RA associated ILD with UIP pattern

Study
A 52 week, double blind, randomised, placebo-controlled trial evaluating the effect of Nintedanib, 150 mg twice daily, on annual rate of decline in Forced Vital Capacity and safety in patients with RA associated ILD with UIP pattern

IRAS no
217658

Study contact information
Name:
 Vladimir Domi
Email: V.Domi@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


Rituximab vs intravenous cyclophosphamide in connective tissue disease associated ILD

Study
A randomised, double blind controlled trial comparing rituximab against intravenous cyclophosphamide in connective tissue disease associated interstitial lung disease

IRAS no
98339

Study contact information
Name:
 Vladimir Domi
Email: V.Domi@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


Pathogenesis of fibrotic lung disease

Study
Control subjects for better understanding of pathogenesis of fibrotic lung disease

IRAS no
139113

Study contact information
Name:
 Vladimir Domi
Email: V.Domi@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


Pathogenesis and clinical manifestations of pulmonary fibrosis

Study
Pathogenesis and clinical manifestations of pulmonary fibrosis in (A) Connective Tissue Diseases (CTD), (B) Granulomatous Conditions (GC), and (C) Idiopathic Interstitial Pneumonias (IIP)

IRAS no
125496

Study contact information
Name:
 Professor Athol Wells
Email: rbhild@rbht.nhs.uk

Principal investigator
Professor Athol Wells

Click here for more information


Open label extension study of nintedanib in SSc-ILD

Study
An open-label extension trial to assess the long term safety of nintedanib in patients with ‘Systemic Sclerosis associated Interstitial Lung Disease’ (SSc-ILD)

IRAS no
235678

Study contact information
Name:
 Professor Toby Maher
Email: T.Maher@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


TRAIL1

Study
A Randomised, Double-Blind, Placebo-Controlled, Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease

IRAS no
220334

Study contact information
Name:
 Professor Toby Maher
Email: T.Maher@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


Deep learning for HRCT classification of fibrotic lung disease

Study
Deep learning for HRCT classification of fibrotic lung disease

IRAS no
234527

Study contact information
Name:
 Professor Toby Maher
Email: T.Maher@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


Historical exposures in hypersensitivity pneumonitis

Study
A case-referent study of the exposure history of adults with hypersensitivity pneumonitis

IRAS no
245417

Study contact information
Name:
 Dr Johanna Feary
Email: J.Feary@rbht.nhs.uk 

Principal investigator
Dr Johanna Feary

Click here for more information


FIBRINOX

Study
Fibrotic Interstitial Lung Disease and nocturnal oxygen - An observational study of the effects of nocturnal hypoxaemia on patients with fibrotic interstitial lung disease

IRAS no
234305

Study contact information
Name:
 Richard Mordi
Email: R.Mordi@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


Clustering and Phenotyping Interstitial Lung Disease

Study
Clustering and Phenotyping Interstitial Lung Disease

IRAS no
270865

Study contact information
Name:
 Dr Philip Molyneaux
Email: P.Molyneaux@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


POSTCODE

Study
POST COvid-19 interstitial lung DiseasE (POSTCODE) A study of genetic and environmental interactions: an observational cohort study.

IRAS no
297495

Study contact information
Name:
 Dr Philip Molyneaux
Email: P.Molyneaux@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux


Genetic determinants of Kawasaki disease

Study
Genetic determinants of Kawasaki disease for susceptibility and outcome

IRAS no
115933

Study contact information
Name:
 Dr Rodney Franklin
Email: r.franklin@rbht.nhs.uk

Principal investigator
Dr Rodney Franklin

Click here for more information

Tracking no small cell lung cancer evaluation

Study
Tracking non small cell lung cancer evolution through therapy (Rx)

IRAS no
138871

Study contact information
Name:
 Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk

Principal investigator
Mr Eric Lim

Click here for more information


Video assisted thoracoscopic lobectomy vs conventional Open LobEcTomy

Study
Video assisted thoracoscopic lobectomy versus conventional Open LobEcTomy for lung cancer, a multi-centre randomised controlled trial with an internal pilot

IRAS no
163516

Study contact information
Name:
 Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk

Principal investigator
Mr Eric Lim

Click here for more information


Cancer recurrence in patients after lung cancer surgery

Study
The process of disclosure of the risk of cancer recurrence in patients following potentially curative lung cancer surgery: a multiple case study

IRAS no
168907

Study contact information
Name:
 Matthew Johnson
Email: M.Johnson@rbht.nhs.uk

Principal investigator
Mr Eric Lim

Click here for more information


Lung nodule Imaging Biobank for Radiomics and AI research (LIBRA)

Study
Lung nodule Imaging Biobank for Radiomics and AI research (LIBRA)

IRAS no
274775

Study contact information
Name:
 Professor Anand Devaraj
Email: A.Devaraj@rbht.nhs.uk

Principal investigator
Professor Anand Devaraj


2010 BTS Guideline evaluation

Study
An evaluation of surgical resection rates before and after the introduction of the 2010 British Thoracic Society Guidelines on Radical Management of Lung Cancer

IRAS no
295021

Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk

Principal investigator
Mr Eric Lim

Click here for more information


OCTAPUS AI

Study
Optimising cancer treatment surveillance and ascertaining cause of Pneumonitis using artificial intelligence

IRAS no
283611

Study contact information
Name:
 Dr Philip Molyneaux
Email: P.Molyneaux@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


EARL

Study
Electrocautery Ablation for the Prevention of Lung Cancer

IRAS no
263980

Study contact information
Name:
Maria Nunez
Email: M.Nunez@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


Selection of individuals for lung screening through risk models   

Study
Selection of individuals for lung cancer screening through published risk models: A modelling study

IRAS no
302774

Study contact information
Name:
Professor Anand Devaraj
Email: A.Devaraj@rbht.nhs.uk

Principal investigator
Professor Anand Devaraj

There are currently no active studies 

Diffusion Tensor Imaging in ST-elevation Myocardial Infarction

Study
Investigation of Post-Myocardial Infarction Left Ventricular Remodelling  By Diffusion Tensor Cardiac Magnetic Resonance

IRAS no
259868

Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk

Principal investigator
Dr Ranil De Silva


Infarction NSTEMI v1.0

Study
Non-ST-segment elevation myocardial infarction Registry.

IRAS no
261605

Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk

Principal investigator
Dr Vasileios Panoulas

Click here for more information


DanGer Shock

Study
Effect of mechanical circulatory support in acute myocardial infarction complicated by cardiogenic shock

IRAS no
286689

Study contact information
Name: Alcida Bucaj
Email: A.Bucaj@rbht.nhs.uk

Principal investigator
Dr Vasileios Panoulas

Click here for more information

Pulmonary Non-Tuberculous Mycobacterial Disease

Study
A molecular approach to the diagnosis, assessment, monitoring and treatment of pulmonary non-Tuberculous Mycobacterial Disease.

IRAS no
212193

Study contact information
Name:
 Huw Ellis
Email: Huw.Ellis@rbht.nhs.uk

Principal investigator
Dr Michael Loebinger

Click here for more information


LAI in adult patients with NTM lung infections caused by MAC

Study
An open-label safety extension study to a multicenter study of liposomal amikacin for inhalation (LAI) in adult patients with non-Tuberculous Mycobacterial (NTM) lung infections caused by Mycobacterium avium complex (MAC) that are refractory to treatment

IRAS no
190666

Study contact information
Name:
 Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Dr Michael Loebinger

Click here for more information


GTMAC

Study
Genomics and transmissibility of Mycobacterium avium complex

IRAS no
300657

Study contact information
Name:
 Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Dr Michael Loebinger


Metatranscriptomics in Non-Tuberculous Mycobacterial Pulmonary Disease

Study
Metatranscriptomics in Non-Tuberculous Mycobacterial Pulmonary Disease

IRAS no
296492

Study contact information
Name:
Kartik Kumar
Email: K.Kumar2@rbht.nhs.uk

Principal investigator
Dr Michael Loebinger

Click here for more information


Phase III clinical trials in patients with Non-Cystic Fibrosis Bronchiectasis (NCFBE)

Study
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center Study to Assess the Efficacy, Safety and Tolerability of INS1007 Administered Once Daily for 52 Weeks in Subjects with Non-Cystic Fibrosis Bronchiectasis INS1007-301

IRAS no
1003433

Study contact information
Name:
 Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Dr Michael Loebinger

Click here for more information

There are currently no active studies 

NEURO-PACK

Study
NEURO-PACK: Neurologic prognosis after cardiac arrest in kids. An observational study of neurodevelopmental outcome after cardiac arrest in children admitted to paediatric intensive care

IRAS no
223292

Study contact information
Name:
 Dr Sandra Gala-Peralta
Email: s.gala-peralta@rbht.nhs.uk

Principal investigator
Dr Sandra Gala-Peralta

Click here for more information


Phase 3 - Edoxaban DU-176b in children

Study
An open-label randomised, parallel-group, multicenter, observational trial to evaluate the safety and efficacy of edoxaban tosylate in children from 38 weeks gestational age to less than 18 years of age with cardiac disease at risk of thromboembolic events.

IRAS no
238090

Study contact information
Name:
 Dr Piers Daubeney
Email: P.Daubeney@rbht.nhs.uk

Principal investigator
Dr Piers Daubeney

Click here for more information


Remote monitoring & gaming technology for children with CF

Study
Project Fizzyo: Remote monitoring and gaming technology for improving physiotherapy prescription, adherence and prediction of clinical outcomes in children with cystic fibrosis.

IRAS no
228625

Study contact information
Name:
 Ms Nicky Murray
Email: N.Murray@rbht.nhs.uk

Principal investigator
Ms Nicky Murray

Click here for more information


Novel electronic monitoring devices to monitor adherence in asthma

Study
A feasibility study to assess Novel Electronic Monitoring Devices (NEDM) for monitoring adherence in children with asthma.

IRAS no
239759

Study contact information
Name:
 Dr Louise Fleming
Email: L.Fleming@rbht.nhs.uk

Principal investigator
Dr Louise Fleming

Click here for more information


Severe Paediatric Asthma Collaborative in Europe (SPACE)

Study
Severe Paediatric Asthma Collaborative in Europe (SPACE).

IRAS no
230893

Study contact information
Name:
 Dr Louise Fleming
Email: L.Fleming@rbht.nhs.uk

Principal investigator
Dr Louise Fleming

Click here for more information


Fevipiprant

Study
A multicenter, open-label, 8 day treatment study to assess the pharmacokinetics, safety and tolerability of fevipiprant delivered via a once daily chewable tablet in children aged 6 to <12 years with asthma

IRAS no
264789

Study contact information
Name:
 Yvonne Bingham
Email: Y.Bingham@rbht.nhs.uk

Principal investigator
Dr Louise Fleming


Microbial ecology effects relating to childhood asthma (MEERCAT)

Study
Impact of premature birth on the gastrointestinal microbiota in early infancy and respiratory health at school age: a comparison of premature and term birth cohorts.

IRAS no
251418

Study contact information
Name:
 Yvonne Bingham
Email: Y.Bingham@rbht.nhs.uk

Principal investigator
Professor Sejal Saglani


A Phase 3b, randomised, placebo-controlled study evaluating the efficacy and safety of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis subjects 6-11 years of age who are heterozygous for the F508del mutation and a minimal function mutation (F/MF)

Study
A Phase 3b, randomised, placebo-controlled study evaluating the efficacy and safety of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis subjects 6-11 years of age who are heterozygous for the F508del mutation and a minimal function mutation (F/MF)

IRAS no
1003047

Study contact information
Name:
 Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies


PRAADA1 Study - Prenatal right aortic arch and double arch study - V1

Study
National Study of prenatally diagnosed right aortic arch and double arch: Incidence; associations and outcomes. A collaboration of the United Kingdom National Foetal Cardiology Working Group.

IRAS no
262525

Study contact information
Name:
 Victoria Doughty
Email: V.Doughty@rbht.nhs.uk

Principal investigator
Dr Julene Carvalho


Hemodynamics in repaired type A aortic dissection

Study
Computational fluid dynamics in predicting progressive aortic dilatation following type A aortic dissection surgical repair.

IRAS no
281613

Study contact information
Name:
 Saeed Mirsadraee
Email: S.Mirsadraee@rbht.nhs.uk

Principal investigator
Dr Saeed Mirsadraee

Click here for more information


Treating severe paediatric asthma; the TREAT trial

Study
Treating severe paediatric asthma; a randomised controlled trial of mepolizumab and omalizumab (TREAT trial)

IRAS no
252084

Study contact information
Name:
 Professor Sejal Saglani
Email: S.Saglani@rbht.nhs.uk

Principal investigator
Professor Sejal Saglani

Click here for more information


Retrospective review of lung function data in a paediatric centre

Study
Retrospective review of lung function data in a tertiary paediatric respiratory cohort

IRAS no
292859

Study contact information
Name:
 Dr Samantha Irving
Email: S.Irving@rbht.nhs.uk

Principal investigator
Dr Samantha Irving


CKJX839C12301: inclisiran in adolescents with HeFH

Study
Two part (double-blind inclisiran versus placebo [Year 1] followed by open-label inclisiran [Year 2]) randomized multicenter study to evaluate safety, tolerability, and efficacy of inclisiran in adolescents (12 to less than 18 years) with heterozygous familial hypercholesterolemia and elevated LDL-cholesterol (ORION-16)

IRAS no
1003480

Study contact information
Name:
Dr Mahmoud Barbir
Email: M.Barbir@rbht.nhs.uk

Principal investigator
Dr Mahmoud Barbir

Click here for more information


Acceptability and tolerance study of Resource Thicken up Junior   

Study
Evaluation of the acceptability (including gastrointestinal tolerance, compliance) of a thickener for those aged 6 months and above.

IRAS no
280585

Study contact information
Name:
Ms Clare Russell
Email: C.Russell2@rbht.nhs.uk

Principal investigator
Ms Clare Russell

Click here for more information

Unexplained respiratory muscle weakness or respiratory failure

Study
Prevalence of Pompe’s disease amongst patients with unexplained respiratory muscle weakness or respiratory failure

IRAS no
184294

Study contact information
Name:
 Mike Apps
Email: M.Apps@rbht.nhs.uk

Principal investigator
Professor Michael Polkey

Click here for more information

MRI in the assessment of CF and primary ciliary dyskinesia

Study
Use of MRI in the assessment of cystic fibrosis and primary ciliary dyskinesia - A clinical feasibility study

IRAS no
196228

Study contact information
Name:
 Dr Anand Devaraj
Email: a.devaraj@rbht.nhs.uk

Principal investigator
Dr Anand Devaraj

Click here for more information


Machine learning to diagnose PCD

Study
Improving Primary Ciliary Dyskinesia diagnosis using artificial intelligence

IRAS no
259067

Study contact information
Name:
 Thomas Burgoyne
Email: T.Burgoyne@rbht.nhs.uk

Principal investigator
Professor Claire Hogg


IN-PCD

Study
The Effects of Inhaled Corticosteroids on Inflammation and Infection in Primary Ciliary Dyskinesia.

IRAS no
256504

Study contact information
Name:
 Laura Gardner
Email: L.Gardner@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Heart rate reduction in PH using pressure volume loop analysis

Study
Evaluation of right ventricular performance in response to heart rate reduction in pulmonary hypertension using pressure volume loop analysis at rest and on exercise

IRAS no
219677

Study contact information
Name:
 Dr Colm McCabe
Email: c.mccabe2@rbht.nhs.uk

Principal investigator
Dr Colm McCabe

Click here for more information


INOvation-1

Study
A phase 3, placebo controlled, double-blind, randomised, clinical study to determine efficacy, safety and tolerability of pulsed, inhaled nitric oxide (iNO) versus placebo in symptomatic subjects with pulmonary arterial hypertension (PAH): INOvation-1

IRAS no
202601

Study contact information
Name:
 Mahitha Gummadi
Email: M.Gummadi@rbht.nhs.uk

Principal investigator
Dr Stephen John Wort

Click here for more information


Patients with pulmonary vascular disease

Study
Prospective study in patients with pulmonary vascular disease

IRAS no
210461

Study contact information
Name:
 Mahitha Gummadi
Email: M.Gummadi@rbht.nhs.uk

Principal investigator
Dr Stephen John Wort

Click here for more information


Idiopathic and heritable pulmonary arterial hypertension

Study
National cohort study of Idiopathic and Heritable Pulmonary Arterial Hypertension

IRAS no
123349

Study contact information
Name:
 Rosa DaCosta
Email: R.DaCosta@rbht.nhs.uk

Principal investigator
Dr Stephen John Wort

Click here for more information


TRITON- Macitentan, Tadalafil and Selexipag Study in Patients with PAH

Study
The efficacy and safety of initial triple versus initial dual oral combination therapy in patients with newly diagnosed pulmonary arterial hypertension: A Multi-Centre, double-blind, placebo-controlled, Phase 3b Study

IRAS no
236384

Study contact information
Name: Dr John Wort
Email: S.Wort@rbht.nhs.uk

Principal investigator
Dr John Wort

Click here for more information


Quantitative MRI measures in PH (Version 1)

Study
Novel Quantitative Magnetic Resonance Imaging (MRI) Measures in the Assessment and Follow-up of patients with Pulmonary Hypertension (PH)

IRAS no
246688

Study contact information
Name: Mr Simon Padley
Email: S.Padley@rbht.nhs.uk

Principal investigator
Mr Simon Padley

Click here for more information


Utility of Emphasis-10 in Risk Stratification in Pulmonary Arterial Hypertension

Study
Utility of Emphasis-10 in Risk Stratification in Pulmonary Arterial Hypertension.

IRAS no
254446

Study contact information
Name: Dr John Wort
Email: S.Wort@rbht.nhs.uk

Principal investigator
Dr John Wort


Use of pulmonary arterial hypertension therapies in Fontan patients: Current practice across the UK

Study
Use of pulmonary arterial hypertension therapies in Fontan patients.

IRAS no
263589

Study contact information
Name: Dr Kostas Dimopoulos
Email: K.Dimopoulos@rbht.nhs.uk

Principal investigator
Dr Kostas Dimopoulos


SELECT: SELExipag in inoperable or persistent/recurrent CTEPH

Study
A multicentre, randomised, double-blind, placebo-controlled, parallel-group, group-sequential, adaptive, Phase 3 study with open-label extension period to assess the efficacy and safety of selexipag as an add-on to standard of care therapy in subjects with inoperable or persistent/recurrent after surgical treatment Chronic Thromboembolic Pulmonary Hypertension.

IRAS no
253601

Study contact information
Name: Rosa Da Costa
Email: r.dacosta@rbht.nhs.uk

Principal investigator
Dr John Wort


Phenotyping individuals with elevated mean pulmonary arterial pressure and elevated pulmonary vascular resistance in united kingdom

Study
Phenotyping individuals with elevated mean pulmonary arterial pressure and elevated pulmonary vascular resistance in united kingdom

IRAS no
275470

Study contact information
Name: Rosa Da Costa
Email: r.dacosta@rbht.nhs.uk

Principal investigator
Dr Colm McCabe

Click here for more information


PEX-NET

Study
Pulmonary Hemodynamics during Exercise - Research Network.

IRAS no
257879

Study contact information
Name: Dr Colm McCabe
Email: C.McCabe2@rbht.nhs.uk

Principal investigator
Dr Colm McCabe


ROR-PH-301 - APD811-301 A phase 3 study to evaluate ralinepag added to SOC in PAH

Study
ROR-PH-301 - A StuDy eVAluatiNg the EffiCacy and Safety of RalinEpag To Improve Treatment OUTCOMES in PAH Patients

IRAS no
255909

Study contact information
Name: Kevin Kirby
Email: K.Kirby@rbht.nhs.uk

Principal investigator
Dr Colm McCabe

Click here for more information


ROR-PH-303 - APD811-303-A phase 3 OLE ext to evaluate long term safety of ralinepag

Study
ROR-PH-303 - A StuDy EVAluatiNg the Long-Term EffiCacy and Safety of RalinEpag in Subjects with PAH via an Open-Label EXTENSION

IRAS no
255904

Study contact information
Name: Kevin Kirby
Email: K.Kirby@rbht.nhs.uk

Principal investigator
Dr Colm McCabe

Click here for more information


CPET and stress echocardiography following pulmonary embolism

Study
Utility of cardiopulmonary exercise testing and stress echocardiography in the assessment of breathlessness following pulmonary embolism: a pilot study

IRAS no
300840

Study contact information
Name: Dr Colm McCabe
Email: C.McCabe2@rbht.nhs.uk

Principal investigator
Dr Colm McCabe


STELLAR. A Phase 3 Study of Sotatercept for the Treatment of PAH

Study
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Compare the Efficacy and Safety of Sotatercept Versus Placebo When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH

IRAS no
1003529

Study contact information
Name: Debra Dempster
Email: D.Dempster@rbht.nhs.uk

Principal investigator
Dr John Wort

DeVENT

Study
Decision support system to evaluate VENTilation in ARDS (DeVENT)

IRAS no
266521

Study contact information
Name: Natalie Dormand
Email: N.Dormand@rbht.nhs.uk

Principal investigator
Dr Brij Patel

Reducer-I

Study
Reducer-I: An observational study of the Neovasc Reducer System

IRAS no
190140

Study contact information
Name:
 Debra Dempster
Email: D.Dempster@rbht.nhs.uk

Principal investigator
Dr Ranil De Silva

Click here for more information


PPCI

Study
Lived experiences of heart attack and primary angioplasty (PPCI)

IRAS no
224728

Study contact information
Name:
 Marina Nicholas
Email: m.nicholas@rbht.nhs.uk

Principal investigator
Ms Marina Nicholas

Click here for more information

EBT in sarcoidosis

Study
Measure of exhaled breath temperature (EBT) in patients with sarcoidosis. 

IRAS no
215820

Study contact information
Name: Professor Athol Wells
Email: RBHILD@rbht.nhs.uk

Principal investigator
Professor Athol Wells

Click here for more information


MAGNET-CS Version 1

Study
Improving Assessment of Diagnosis and Prognosis in Cardiac Sarcoidosis

IRAS no
287964

Study contact information
Name: Dr Alessia Azzu
Email: A.Azzu@rbht.nhs.uk

Principal investigator
Professor Dudley Pennell


PHASE Study

Study
A multicentre, randomised, double-blind, placebo-controlled study in participants with sarcoidosis-associated pulmonary hypertension (SAPH) to assess the efficacy and safety of oral selexipag

IRAS no
264526

Study contact information
Name: Silvia Zagalo
Email: S.Zagalo@rbht.nhs.uk

Principal investigator
Dr Vasilis Kouranos

Click here for more information

The POSA Trial

Study
Positional Therapy for Obstructive Sleep Apnoea: a Randomised Controlled Trial to assess the effect on Health and Wellbeing in Older and Younger People.

IRAS no
252494

Study contact information
Name:
 Julia Kelly
Email: J.Kelly@rbht.nhs.uk

Principal investigator
Julia Kelly

Click here for more information


The SOSAT Trial

Study
A prospective, multicentre, randomised, blinded study of obstructive sleep apnoea detection using the Sunrise solution: The Sunrise OSA Trial (SOSAT)

IRAS no
296444

Study contact information
Name:
 Julia Kelly
Email: J.Kelly@rbht.nhs.uk

Principal investigator
Professor Michael Polkey

UK Mini Mitral

Study
Minimally invasive thoracoscopically-guided right minithoracotomy versus conventional sternotomy for mitral valve repair: a multicentre randomised controlled trial (UK Mini Mitral)

IRAS no
204506

Study contact information
Name:
 Claire Prendergast
Email: c.prendergast2@rbht.nhs.uk

Principal investigator
Mr Toufan Bahrami

Click here for more information


Blood flow patterns from 4D-flow MRI

Study
Can blood flow patterns from 4D-flow MRI be used to predict aortic wall degradation?

IRAS no
231355

Study contact information
Name:
 Yousuf Salmasi
Email: M.Salmasi@rbht.nhs.uk

Principal investigator
Professor John Pepper

Click here for more information


Avr Thrombosis OutcoMe study (ATOM)

Study
Can thrombosis and fibrinolysis markers in patients undergoing aortic valve replacement predict outcome

IRAS no
259805

Study contact information
Name:
 Michelle Rackham
Email: M.Rackham@rbht.nhs.uk

Principal investigator
Dr Vasileios Panoulas

Click here for more information


OSPREY-CR Version 2

Study
Optimising Secondary PRevention and quality of life following EarlY Cardiac Rehabilitation: OSPREY-CR

IRAS no
278371

Study contact information
Name:
Heather Probert
Email: H.Probert@rbht.nhs.uk

Principal investigator
Heather Probert

Prevention HARP 2

Study
Prevention of post-operative complications by using HMG-CoA reductase inhibitor in patients undergoing oesophagectomy. A multicentre, randomised, double blind, placebo controlled trial (Prevention HARP 2)

IRAS no
180853

Study contact information
Name:
 Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk

Principal investigator
Mr Eric Lim

Click here for more information


TOPIC 2: Thoracic Epidural and Paravertebral Blocks in reducing CPTP

Study
A randomised controlled trial to investigate the effectiveness of Thoracic Epidural and Paravertebral Blockade in reducing Chronic Post-Thoracotomy Pain: 2

IRAS no
248427

Study contact information
Name: Dr Nandor Marczin
Email: N.Marczin@rbht.nhs.uk

Principal investigator
Dr Nandor Marczin

Click here for more information


CYCLONE- LVAD

Study
CYtosorb modulation of surgiCal infLammatiON during LVAD insErtion (CYCLONE-LVAD) study

IRAS no
230919

Study contact information
Name: Louise Moss
Email: L.McBrearty@rbht.nhs.uk

Principal investigator
Dr Nandor Marczin

Click here for more information

Peak cough flow and respiratory function testing (spirometry)

Study
A cross sectional feasibility study examining the relationship between peak cough flow and respiratory function testing (spirometry) post bilateral sequential single lung transplantation, at a single centre cardiothoracic transplantation unit

IRAS no
218051

Study contact information
Name:
 Abigail Roberts
Email: A.Roberts@rbht.nhs.uk

Principal investigator
Dr Anna Reed

Click here for more information


LACTATE in OHT

Study
Significance of hyperlactataemia during heart transplantation.

IRAS no
259590

Study contact information
Name:
 Ms Ana Doce Hurtado
Email: A.HurtadoDoce@rbht.nhs.uk

Principal investigator
Ms Ana Doce Hurtado


PRIDEHEART 1.0

Study
PRImary graft Dysfunction Evaluation in HEART Transplantation (PRIDE-HEART) study

IRAS no
241344

Study contact information
Name:
 Mr Andre Simon
Email: A.Simon@rbht.nhs.uk

Principal investigator
Mr Andre Simon

Click here for more information


4D Flow CMR in Lung Transplant Assessment

Study
4D Flow Cardiovascular Magnetic Resonance analysis of the right ventricle in lung transplant assessment

IRAS no
270554

Study contact information
Name:
Dr Joyce Wong
Email: J.Wong@rbht.nhs.uk

Principal investigator
Dr Joyce Wong

Molecular and cellular pathogenesis of bone marrow failure syndromes

Study
Investigation of the molecular and cellular pathogenesis of bone marrow failure syndromes

IRAS no
97361

Study contact information
Name:
 Mr Andreas Hoschtitzky
Email: A.Hoschtitzky@rbht.nhs.uk

Principal investigator
Mr Andreas Hoschtitzky


Multisystem and autonomic complications of NMD on NIV

Study
Growing up on non-invasive ventilation: assessment of multisystem and autonomic complications of neuromuscular and neurological disorders in young adults.

IRAS no
266270 

Study contact information
Name:
 Lydia Spurr
Email: l.spurr@rbht.nhs.uk

Principal investigator
Professor Anita Simonds


Characterisation of Large Airway Collapse during Exercise (LACE)

Study
The Feasibility of Continuous Bronchoscopy During Exercise in Healthy Adults in Assessing Large Airways Collapse

IRAS no
268188

Study contact information
Name: Alexandros Mitropoulos
Email: A.Mitropoulos@rbht.nhs.uk

Principal investigator
Dr James Hull


Grenfell Firefighters Study

Study
The Grenfell firefighters study; establishing a cohort

IRAS no
265618

Study contact information
Name: Professor Paul Cullinan
Email: p.cullinan@imperial.ac.uk

Principal investigator
Professor Paul Cullinan


University of Cambridge NHS health data consent survey

Study
University of Cambridge NHS health data consent survey. 

IRAS no
268811

Study contact information
Name: Sara Salmi
Email: S.Salmi@rbht.nhs.uk

Principal investigator
Sara Salmi


Lung Health Check Biomarker Study

Study
Lung Health Check Biomarker Study

IRAS no
258696

Study contact information
Name: Dr Benjamin Hunter
Email: B.Hunter@rbht.nhs.uk

Principal investigator
Professor Anand Devaraj

Click here for more information


PaD Strat Study

Study
PaD Strat Study

IRAS no
285609

Study contact information
Name: Melissa Rochon
Email: M.Rochon@rbht.nhs.uk

Principal investigator
Melissa Rochon