Active research studies

Details of all our active research studies which are looking for volunteers, with more information about what each project entails and what kind of volunteers would be most suitable.

Epidemiology and prognosis in acute myocarditis

Myocarditis is a disease heart muscle caused by inflammation. This study aims to provide a contemporary, population-level assessment of the true clinical burden of myocarditis and how this may have changed over the last 20 years.


Active research studies

DeVENT

Study
Decision support system to evaluate VENTilation in ARDS (DeVENT)

IRAS no
266521 

Study contact information
Name: Mahitha Gummadi
Email: m.gummadi@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel


GenOMICC

Study
Genetics of susceptibility and mortality in critical care

IRAS no
269326

Study contact information
Name: Natalie Dormand (Royal Brompton), Paula Rogers (Harefield)
Email: N.Dormand@rbht.nhs.uk, p.rogers@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


ISARIC CCP

Study
WHO ISARIC Clinical Characterisation Protocol for Severe Emerging Infection UK (CCP-UK) / Novel Coronavirus Observational Study

IRAS no
126600

Study contact information
Name: Natalie Dormand (Royal Brompton), Paula Rogers (Harefield)
Email: N.Dormand@rbht.nhs.uk, p.rogers@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


RECOVERY

Study
Randomised Evaluation of COVID-19 Therapy (RECOVERY)

IRAS no
281712

Study contact information
Name: Jessica Wallen (Royal Brompton), Claire Prendergast (Harefield)
Email: J.Wallen@rbht.nhs.ukC.Prendergast2@rbht.nhs.uk

Principal investigator
Dr Anand Shah (Royal Brompton), Dr Anna Reed (Harefield)

Click here for more information


REMAP-CAP

Study
Randomised, Embedded, Multifactorial Adaptive Platform trial for Community-Acquired Pneumonia

IRAS no
237150

Study contact information
Name: Debra Dempster (Royal Brompton), Claire Prendergast (Harefield)
Email: D.Dempster@rbht.nhs.ukC.Prendergast2@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


Heart-ACS COVID-19

Study
COVID-19 as a Trigger/Risk Factor in Acute Coronary Syndromes

IRAS no
259087

Study contact information
Name: Laura Barker
Email: l.barker2@rbht.nhs.uk

Principal investigator
Dr Miles Dalby

Click here for more information


Coagulation markers in patients with severe COVID-19

Study
Coagulation markers on discarded plasma samples from patients with severe COVID-19

IRAS no
283525

Study contact information
Name: Deepa Arachchillage
Email: D.JayakodyArachchillage@rbht.nhs.uk

Principal investigator
Dr Deepa Arachchillage

Click here for more information


PROSAIC-19

Study
PROSAIC-19 – Prospective longitudinal assessment in a COVID-19 infected cohort    

IRAS no
282739

Study contact information
Name: Katherine Rhatigan
Email: K.Rhatigan@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Click here for more information


RECOVERY - Respiratory Support

Study
Ventilation Strategies in COVID-19; CPAP, High-flow, and standard care  

IRAS no
282338

Study contact information
Name: Ashraf Hussain
Email: A.Hussain@rbht.nhs.uk

Principal investigator
Professor Anita Simonds

Click here for more information


Thrombosis and organ ischemia/inflammation in ICU admitted COVID-19

Study
Computer Tomography findings of vascular thrombosis, and abdominal organ ischemia and inflammation in Critically ill COVID-19 patients

IRAS no
286154

Study contact information
Name: Dr Saeed Mirsadraee
Email: S.Mirsadraee@rbht.nhs.uk

Principal investigator
Dr Saeed Mirsadraee


UNITE-COVID

Study
European Society of Intensive Care Medicine Covid-19 Project (Unite-Covid-19)

IRAS no
284289

Study contact information
Name: Dr Giulia Crapelli
Email: G.Crapelli@rbht.nhs.uk

Principal investigator
Dr Giulia Crapelli


Coagulopathy associated with COVID 19 (CA-COVID19) A Multi-Centre observational study in UK

Study
Coagulopathy associated with COVID 19 (CA-COVID19) A Multi-Centre observational study in UK

IRAS no
282298

Study contact information
Name: Dr Deepa Arachchillage
Email: D.JayakodyArachchillage@rbht.nhs.uk

Principal investigator
Dr Deepa Arachchillage


CLASSIC

Study
The Clinical and psychosocial impact of COVID-19 on patients with neuromuscular and neurological disorders

IRAS no
286495

Study contact information
Name: Dr Lydia Spurr
Email: L.Spurr@rbht.nhs.uk

Principal investigator
Professor Anita Simonds


CLUE (COVID-19 Flu ECMO)

Study
A retrospective cohort study comparing the differences in baseline characteristics and outcomes in patients with influenza and COVID-19 treated with veno-venous extracorporeal membrane oxygenation (ECMO)

IRAS no
285452

Study contact information
Name: Dr Benjamin Garfield
Email: B.Garfield@rbht.nhs.uk

Principal investigator
Dr Stephane Ledot

Click here for more information


COACHED Study

Study
COVID-19 infection and Congenital Heart Disease Study (COACHeD Study)

IRAS no
283054

Study contact information
Name: Professor Piers Daubeney
Email: P.Daubeney@rbht.nhs.uk

Principal investigator
Professor Piers Daubeney

Click here for more information


Narratives of NHS nurses working in ICUs during the COVID-19 pandemic

Study
Narratives of NHS nurses working in ICUs during the COVID-19 pandemic

IRAS no
284812

Study contact information
Name: Dr Melissa Sanchez
Email: M.Sanchez@rbht.nhs.uk

Principal investigator
Dr Melissa Sanchez

Click here for more information


PHOSP-COVID

Study
Post-hospitalisation COVID-19 study: a national consortium to understand and improve long-term health outcomes.

IRAS no
285439

Study contact information
Name: Merriel Woodruff
Email: M.Woodruff@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


COVID-HEART study

Study
Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: the COVID-HEART study

IRAS no
285147

Study contact information
Name: Kevin Kirby
Email: K.Kirby@rbht.nhs.uk

Principal investigator
Professor Sanjay Prasad

Click here for more information


CAPACITY-COVID

Study
Cardiac complicAtions in Patients with SARS Corona vIrus 2 regisTrY (CAPACITY)

IRAS no
282872

Study contact information
Name: Professor Sanjay Prasad
Email: S.Prasad@rbht.nhs.uk

Principal investigator
Professor Sanjay Prasad

Click here for more information


Identifying incidence and nature of Fatigue in Individuals infected with COVID-19 (SARS-Cov-2) in the UK

Study
Identifying incidence and nature of Fatigue in Individuals infected with COVID-19 (SARS-Cov-2) in the United Kingdom

IRAS no
284760

Study contact information
Name: Avantika Tailor
Email: A.Tailor@rbht.nhs.uk

Principal investigator
Avantika Tailor

Click here for more information


UKILD-Long COVID

Study
The UK Interstitial Lung Disease Long-COVID19 study (UKILD-Long COVID): understanding the burden of Interstitial Lung Disease in Long COVID

IRAS no
297891

Study contact information
Name: David Smith
Email: d.smith22@rbht.nhs.uk

Principal investigator
Dr Peter George

Click here for more information


Cardiovascular burden in COVID-19 patients

Study
Clinical utility of non-invasive cardiac investigations following infection with COVID-19: a retrospective observational study

IRAS no
311937

Study contact information
Name: Dr Sundeep Kaul
Email: s.kaul@rbht.nhs.uk

Principal investigator
Dr Sundeep Kaul


Concorde Study

Study
Acute Respiratory Syndome coronavirus and ACE-2 study

IRAS no
296463

Study contact information
Name: James Tonkin
Email: j.tonkin@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


GEMINI

Study
Assessment of clinical practice of mechanical ventilation after COVID-19 pandemic among 55 countries: A systematic analysis for the Global Burden of Mechanical Ventilation (GEMINI study) 2022

IRAS no
317449

Study contact information
Name: Dr Brijesh Patel
Email: b.patel4@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel


PROTECT V

Study
 PROphylaxis for paTiEnts at risk of COVID-19 infecTion   

IRAS no
288652

Study contact information
Name: Deirdre Flannery
Email: d.flannery@rbht.nhs.uk

Principal investigator
Professor Philip Molyneaux

Click here for more information


Heart health survey of adults with congenital heart conditions following the COVID-19 pandemic

Study
Heart health survey of adults with congenital heart conditions following the COVID-19 pandemic; a questionnaire-based study of patient experience and psychological health needs

IRAS no
302040

Study contact information
Name: Dr Anne-Marie Doyle
Email: a.doyle2@rbht.nhs.uk

Principal investigator
Dr Anne-Marie Doyle

Click here for more information

Treatment in adults with severe bilateral nasal polyps

Study
A randomised, double-blind, parallel group PhIII study to assess the clinical efficacy and safety of 100 mg SC Mepolizumab as an add on to maintenance treatment in adults with severe bilateral nasal polyps.

IRAS no
220783

Study contact information
Name: Aarif Eifan
Email: A.Eifan@rbht.nhs.uk

Principal investigator
Dr Guy Scadding

Click here for more information


Pollen food allergy syndrome in adults with IBS

Study
A prospective observational cohort study to determine the prevalence of pollen food allergy syndrome (PFS) in adults with Irritable Bowel Syndrome (IBS)

IRAS no
229644

Study contact information
Name: Dr Isabel Skypala
Email: i.skypala@rbht.nhs.uk

Principal investigator
Dr Isabela Skypala

Click here for more information


Nasal allergen challenge: standardisation as a surrogate for hay fever

Study
Nasal Allergen Challenge: standardisation as a surrogate for hay fever

IRAS no
266165

Study contact information
Name: Aarif Eifan
Email: A.Eifan@rbht.nhs.uk

Principal investigator
Professor Stephen Durham

Click here for more information


Grass Immunotherapy plus Dupilumab for Tolerance Evaluation

Study
Grass Pollen Sublingual Tablet Immunotherapy plus Dupilumab for Induction of Tolerance in Adults with Moderate to Severe Seasonal Allergic Rhinitis.

IRAS no
275309

Study contact information
Name: Aarif Eifan
Email: A.Eifan@rbht.nhs.uk

Principal investigator
Professor Stephen Durham

Click here for more information


Safety and allegenicity of new vaccine for cat allergy

Study
An open label, safety and allergenicity Phase 0 study of a new hypoallergenic plant-derived cat dander vaccine in adult cat allergic subjects

IRAS no
1006294

Study contact information
Name: Gil Jimenez
Email: A.Eifan@rbht.nhs.uk

Principal investigator
Dr Guy Scadding

Click here for more information

Cardiac Resynchronisation Therapy in non-responders and previously untreatable patients

Study
Stimulation of the left ventricular endocardium for Cardiac Resynchronisation Therapy in non-responders and previously untreatable patients

IRAS no
288696

Study contact information
Name: Paula Rogers
Email: P.Rogers@rbht.nhs.uk

Principal investigator
Dr Mark Mason


Role of ganglionated plexus ablation for catheter ablation of paroxysmal and persistent atrial fibrillation

Study
A pilot study on the role of ganglionated plexus ablation for catheter ablation of paroxysmal and persistent atrial fibrillation

IRAS no
133593

Study contact information
Name: Dr Sabine Ernst
Email: s.ernst@rbht.nhs.uk

Principal investigator
Dr Sabine Ernst

Click here for more information


WATCHMAN device in patients unsuitable for oral anticoagulation

Study
Assessment of the WATCHMAN device in patients unsuitable for oral anticoagulation

IRAS no
222284

Study contact information
Name: Carmen Chan
Email: L.Chan2@rbht.nhs.uk

Principal investigator
Dr Tom Wong


EndoCRT study

Study
A randomised double-blinded cross over study to evaluate the improvement of left ventricular systolic failure using targeted left ventricular endocardial lead placement in cardiac resynchronisation therapy (EndoCRT)

IRAS no
138184

Study contact information
Name: Lisa Jones
Email: l.jones2@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


Immediate coronary angiography after out of hospital cardiac arrest (ARREST)

Study
ImmediAte CoRonary AngiogRaphy aftEr Ventricular Fibrillation OutOfHospital Cardiac ArreST (ARREST)

IRAS no
125842

Study contact information
Name: Dr Miles Dalby
Email: M.Dalby@rbht.nhs.uk

Principal investigator
Dr Miles Dalby

Click here for more information


NOAH - AFNET 6

Study
Non-vitamin K antagonist Oral anticoagulants in patients with Atrial High rate episodes

IRAS no
194491

Study contact information
Name: Dr Shouvik Haldar
Email: S.Haldar@rbht.nhs.uk

Principal investigator
Dr Shouvik Haldar

Click here for more information


VIVOTM mapping protocol

Study
VIVOTM non-invasive mapping of ventricular arrhythmia

IRAS no
257755

Study contact information
Name: Dr Ilaria Cazzoli
Email: I.Cazzoli@rbht.nhs.uk

Principal investigator
Dr Ilaria Cazzoli


SPOT - FRAILTY

Study
A Pilot Study to exPlOre the exisTence and impact of FRAILTY in patients over the age of 70 undergoing cardiac interventions.

IRAS no
264744

Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk

Principal investigator
Paula Rogers


Long Term Outcomes in CASA AF LSPAF

Study
Long--term Outcomes in Long Standing Persistent Atrial Fibrillation Following Catheter Or Thoracoscopic Surgical Ablation : Extended Follow-Up Of CASA-AF Randomised Controlled Trial

IRAS no
271930

Study contact information
Name: Dr Tom Wong
Email: T.Wong2@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


LEADLESS II

Study
The LEADLESS Pacemaker IDE Study

IRAS no
282749

Study contact information
Name: Annelise Catelan Zborowski
Email: A.CatelanZborowski@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


PACESIM

Study
A Basic Science Study of Optimised Temporary Pacing in Patients following Cardiac Surgery in Order to Build a Pacing Simulator and Automatic Alerting Algorithm.

IRAS no
292373

Study contact information
Name: Dr Mark Mason
Email: M.Mason@rbht.nhs.uk

Principal investigator
Dr Mark Mason

Click here for more information


Analysis of electrograms in cardiac arrhythmia

Study
Analysis of electrograms in cardiac arrhythmia to aid diagnosis and patient stratification

IRAS no
293374

Study contact information
Name: Dr Haseeb Valli
Email: h.valli@rbht.nhs.uk

Principal investigator
Dr Tom Wong


AVEIR DR i2i Study

Study
Aveir Dual-Chamber Leadless i2i IDE Study

IRAS no
308539

Study contact information
Name: Sara Salmi
Email: s.salmi@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


Rhythm or rate control for CRT: the RHYTHMIC study

Study
Rhythm or rate control for CRT: the RHYTHMIC study   

IRAS no
265388

Study contact information
Name: Sara Salmi
Email: s.salmi@rbht.nhs.uk

Principal investigator
Dr Vias Markides

Click here for more information

Heterogeneity of asthma

Study
Heterogeneity of asthma: a pilot study to investigate its microbiome and how it relates to asthma severity

IRAS no
163724

Study contact information
Name: Cai Sim
Email: c.sim@rbht.nhs.uk

Principal investigator
Professor Kian Fan Chung

Click here for more information


Adherence to inhaled corticosteroids in young people with problematic severe asthma

Study
Adherence to inhaled corticosteroids in young people with problematic severe asthma

IRAS no
188453

Study contact information
Name: Dr Louise Fleming 
Email: l.fleming@rbht.nhs.uk

Principal investigator
Dr Louise Fleming

Click here for more information


Fluctuation of airway function in children with asthma phenotype as a predictor of outcome

Study
Fluctuation of airway function in children with asthma phenotype as a predictor of outcome

IRAS no
154768

Study contact information
Name: Dr Louise Fleming 
Email: l.fleming@rbht.nhs.uk

Principal investigator
Dr Louise Fleming

Click here for more information


A randomised pragmatic trial of corticosteriod optimisation in severe asthma

Study
A randomised pragmatic trial of corticosteroid optimisation in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care 

IRAS no
182421

Study contact information
Name: Maria Martins
Email: M.Martins@rbht.nhs.uk

Principal investigator
Dr Andrew Menzies-Gow

Click here for more information


Severe wheeze and asthma validation study

Study
Pulmonary epithelial barrier and immunological functions at birth and in early life: key determinants of the development of asthma? Severe wheeze and asthma validation study

IRAS no
216021

Study contact information
Name: Mindy Gore
Email: s.saglani@imperial.ac.uk

Principal investigator
Professor Sejal Saglani

Click here for more information


Do patterns of airway infection and inflammation distinguish pathophys and asthma? 

Study
Do patterns of airway infection and inflammation distinguish pathophysiological phenotypes in children with wheeze and asthma?

IRAS no
187435

Study contact information
Name: Yvonne Bingham
Email: Y.Bingham@rbht.nhs.uk

Principal investigator
Professor Sejal Saglani

Click here for more information


Targets of bronchial thermoplasty in severe asthma

Study
Targets of bronchial thermoplasty in severe asthma

IRAS no
150245

Study contact information
Name: Dr Karthikan Srikanthan
Email: K.Srikanthan@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


Th2-low endotype biomarkers in exercise-induced asthma

Study
Th2-low endotype biomarkers in exercise-induced asthma

IRAS no
203756

Study contact information
Name: Sally Meah
Email: sally.meah@imperial.ac.uk

Principal investigator
Dr Omar Usmani

Click here for more information


The use of home-monitoring and mHealth systems to predict asthma control and asthma

Study
The use of home-monitoring and mHealth systems to predict asthma control and asthma exacerbations

IRAS no
185603

Study contact information
Name: Paolo Paredi
Email: P.Paredi@rbht.nhs.uk

Principal investigator
Dr Omar Usmani

Click here for more information


National Validation and Sensitivity to Change of the SAQ

Study
National Validation and Sensitivity to Change of a scale to measure quality of life in patients with severe asthma.

IRAS no
250167

Study contact information
Name: Rachel Stead
Email: R.Stead@rbht.nhs.uk

Principal investigator
Dr Andrew Menzies-Gow 

Click here for more information


Phase IIA study of PC945 in Aspergillosis on Asthmatic subjects

Study
A double-blind, placebo-controlled study to assess the effects of inhaled PC945 in the treatment of culture-positive Aspergillus fumigatus infection in subjects with moderate to severe asthma

IRAS no
246673

Study contact information
Name: Najwa Soussi
Email: n.soussi@rbht.nhs.uk

Principal investigator
Dr Darius Armstrong-James

Click here for more information


DPI Airflow Resistance

Study
Patient’s Perception of Dry Powder Inhaler Airflow Resistance

IRAS no
235776

Study contact information
Name: Sally Meah
Email: S.Meah@rbht.nhs.uk

Principal investigator
Dr Omar Usmani


INHALE study

Study
INHALE: Personal pollution exposure and effects on the lungs in healthy and asthmatic individuals

IRAS no
270153

Study contact information
Name: Sally Meah
Email: S.Meah@rbht.nhs.uk

Principal investigator
Professor Fan Chung

Click here for more information


PRISM: Precision medicine in severe asthma

Study
PRISM: Molecular phenotyping of participants with severe asthma to determine response to biologic therapies and stability

IRAS no
273192

Study contact information
Name: Sally Meah
Email: S.Meah@rbht.nhs.uk

Principal investigator
Professor Fan Chung


P-CLESA

Study
Phenotyping circulating and lung resident eosinophils in severe asthma

IRAS no
152907

Study contact information
Name: Sally Meah
Email: S.Meah@rbht.nhs.uk

Principal investigator
Dr Pankaj Bhavsar


Prospective Study of Cellular & Clinical Aspects of Mod-Severe Asthma

Study
Prospective Study of Cellular & Clinical Aspects of Moderate to Severe Asthma

IRAS no
254003

Study contact information
Name: Lola Loewenthal
Email: L.Loewenthal@rbht.nhs.uk

Principal investigator
Professor Andrew Menzies-Gow

Click here to find out more


Measuring hydrogen peroxide in exhaled breath condensate in HV

Study
Assessment and validation of a device for measuring hydrogen peroxide in exhaled breath condensate in Healthy Volunteers

IRAS no
289549

Study contact information
Name: Sally Meah
Email: S.Meah@rbht.nhs.uk

Principal investigator
Dr Omar Usmani

Click here for more information


MODESA

Study
Mitochondrial dysfunction of eosinophils as a driving force for its activation in eosinophilic severe asthma

IRAS no
293693

Study contact information
Name: Sally Meah
Email: S.Meah@rbht.nhs.uk

Principal investigator
Professor Fan Chung

Click here for more information


Benralizumab Exacerbation Study

Study
Asthma Exacerbation Profile in patients on open label treatment with Benralizumab for severe eosinophilic asthma - an exploratory cohort study

IRAS no
256756

Study contact information
Name: Ashraf Hussain
Email: a.hussain@rbht.nhs.uk

Principal investigator
Dr Pujan Patel

Click here for more information


WAYFINDER

Study
A Multicentre, Single-arm, Phase 3b Efficacy and Safety Study of Tezepelumab 210 mg Administered Subcutaneously to Reduce Oral Corticosteroid Use in Adult Participants with Severe Asthma on High-dose Inhaled Corticosteroid plus Long-acting ß2 Agonist

IRAS no
1004972

Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk

Principal investigator
Professor Andrew Menzies-Gow

Click here for more information


601-0018

Study
A Randomized, Double-Blind, Multicenter, Placebo-Controlled Study to Evaluate the Effect of Dose and Duration of Treatment of Itraconazole Administered as a Dry Powder for Inhalation (PUR1900) on Safety, Tolerability, and Measures of Effectiveness in Adult Patients with Asthma and Allergic Bronchopulmonary Aspergillosis   

IRAS no
1006803

Study contact information
Name: Deirdre Flannery
Email: d.flannery@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Click here for more information


EAR-FEMOS

Study
EAR-FEMOS  

IRAS no
264005

Study contact information
Name: Zander Williams
Email: z.williams@rbht.nhs.uk

Principal investigator
Dr James Hull

Click here for more information


TRECOS

Study
A 12 week double-blind, multicentre, randomised, active-controlled, 2-arm, parallel-group clinical trial to evaluate the safety of CHF5993 pMDI 200/6/12.5 µg HFA-152a, compared to CHF5993 pMDI 200/6/12.5 µg HFA-134a, in subjects with asthma

IRAS no
1008211

Study contact information
Name: Dr David Watchorn
Email: d.watchorn@rbht.nhs.uk 

Principal investigator
Dr David Watchorn

Click here for more information

Utilising novel dipole density capabilities to objectively visualise the etiology of recurrent atrial fibrillation following a failed AF ablation

Study
Utilising novel dipole density capabilities to objectively visualize the etiology of recurrent atrial fibrillation following a failed AF ablation

IRAS no
239296

Study contact information
Name: Debra Dempster
Email: D.Dempster@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


Concomitant epicardial ledt atrial appendage closure and catheter ablation

Study
A study of concomitant epicardial left atrial appendage closure and catheter ablation in treating recurrent persistent atrial fibrillation after failed previous ablation

IRAS no
229383

Study contact information
Name: Peng Zhang
Email: p.zhang@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


Catheter versus thoracoscopic surgical ablation in long standing persistent Atrial Fibrillation

Study
Catheter versus thoracoscopic surgical ablation in long standing persistent Atrial Fibrillation - multicentre randomised control trial

IRAS no
155944

Study contact information
Name: Paula Rogers
Email: P.Rogers@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


VITAL - The VyronUS Image Then Ablate study

Study
Clinical investigation of the VytronUS Ablation System for Treatment of Symptomatic Drug-refractory Paroxysmal Atrial Fibrillation (VITAL)

IRAS no
230460

Study contact information
Name: Dr Tom Wong
Email: T.Wong2@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


Map Registry of Procedural Long-term Clinical Outcomes

Study
AcQMap® Global Registry of Procedural and Long-term Clinical Outcomes.

IRAS no
258348

Study contact information
Name: Mathew Varghese
Email: M.Varghese@rbht.nhs.uk

Principal investigator
Dr Tom Wong

Click here for more information


High density mapping guided ablation for Persistent AF

Study
High density substrate evaluation and guided ablation therapy for atrial fibrillation: Heat-AF

IRAS no
263083

Study contact information
Name: Dr Haseeb Valli
Email: H.Valli@rbht.nhs.uk

Principal investigator
Dr Haldar Shouvik

Click here for more information


ReCETT-AF

Study
Realistic Computational Electrophysiology Simulations for Targeted Treatment of Atrial Fibrillation

IRAS no
285221

Study contact information
Name: Dr Shouvik Haldar
Email: s.haldar@rbht.nhs.uk

Principal investigator
Dr Shouvik Haldar

Click here for more information


REMEDY-PILOT

Study
Reducing microvascular dysfunction in patients with angina, ischaemia and unobstructed coronary arteries – a pilot study (REMEDY-PILOT)

IRAS no
295523

Study contact information
Name: Carmen Chan
Email: l.chan2@rbht.nhs.uk

Principal investigator
Dr Ranil De Silva

Click here for more information


ANT-010

Study
A Phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of abelacimab in high-risk patients with atrial fibrillation who have been deemed unsuitable for oral anticoagulation.

IRAS no
1007115

Study contact information
Name: Deirdre Flannery
Email: d.flannery@rbht.nhs.uk

Principal investigator
Dr John Foran

The gut microbiome in rheumatoid arthritis and bronchiectasis 

Study
The gut microbiome in rheumatoid arthritis and bronchiectasis

IRAS no
222542

Study contact information
Name: Cheyanne Kailla
Email: c.kailla@rbht.nhs.uk

Principal investigator
Dr Rosemary Boyton

Click here for more information


Observational cohort and Biobank UK Study

Study
Observational cohort and Biobank UK Study

IRAS no
173303

Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


Efficacy and safety of 12 months of therapy with inhaled Promixin (colistimethate sodium)

Study
A double-blind, placebo controlled, multicentre, clinical trial to investigate the efficacy and safety of 12 months of therapy with inhaled Promixin (colistimethate sodium) in the treatment of subjects with non-cystic fibrosis bronchiectasis

IRAS no
213606

Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


The Clear study

Study
A 2x2 factorial randomised single blind open labelled trial to determine the clinical and cost -effectiveness of hypertonic saline (HTS 6%) and carbocysteine versus usual care over 12 months in non-cystic fibrosis bronchiectasis (BE): The Clear study

IRAS no
214254

Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


BronchUK: Clinimetric properties of outcome measures in bronchiectasis in the UK

Study
BronchUK: Clinimetric properties of outcome measures in bronchiectasis in the UK

IRAS no 
166832

Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


The EMBARC European Bronchiectasis Registry

Study
The EMBARC European Bronchiectasis Registry

IRAS no
165833

Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


The Willow Study

Study
A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center Study to Assess the Efficacy, Safety and Tolerability, and Pharmacokinetics of INS1007 Administered Once Daily for 24 Weeks in Subjects with Non-Cystic Fibrosis Bronchiectasis

IRAS no
233267

Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


The BRIDGE study

Study
The BRIDGE study- Bronchiectasis Research Involving Databases, Genomics and Endotyping to match the right treatment to the right patient

IRAS no
228760

Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


VITAL-BE

Study
A Trial of the Safety, Tolerability and Efficacy of 2 doses of Cayston (Aztreonam Lysine) compared to placebo in participants with bronchiectasis

IRAS no
252929

Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


Efficacy of domiciliary non-invasive ventilation in patients with respiratory failure due to non-CF bronchiectasis

Study
Efficacy of domiciliary non-invasive ventilation in patients with respiratory failure due to non-CF bronchiectasis

IRAS no
288577

Study contact information
Name: Dr Ricardo Jose
Email: R.Jose@rbht.nhs.uk

Principal investigator
Dr Ricardo Jose


Efficacy of domiciliary non-invasive ventilation in patients with respiratory failure due to non-CF bronchiectasis

Study
A randomised, subject- and investigator-blinded, placebo controlled, parallel group study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of QBW251 in patients with bronchiectasis

IRAS no
287333

Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger


Efficacy and Safety of Dupilumab in Participants with ABPA

Study
A randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of dupilumab in patients with allergic bronchopulmonary aspergillosis

IRAS no
282605

Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Click here for more information


MAHALE

Study
A Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled, 52-Week, Phase III Study With an Open-label Extension to Evaluate the Efficacy and Safety of Benralizumab in Patients With Non-Cystic Fibrosis Bronchiectasis With Eosinophilic

IRAS no
1003536

Study contact information
Name: Selvy Raju
Email: S.Raju@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


Phase III clinical trials in patients with Non-Cystic Fibrosis Bronchiectasis (NCFBE)

Study
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center Study to Assess the Efficacy, Safety and Tolerability of INS1007 Administered Once Daily for 52 Weeks in Subjects with Non-Cystic Fibrosis Bronchiectasis INS1007-301

IRAS no
1003433

Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Dr Michael Loebinger

Click here for more information


Safety and efficacy of PC945 for the treatment of refractory invasive pulmonary aspergillosis

Study
A double-blind, randomized, placebo-controlled study to assess  the safety and efficacy of nebulized PC945 when added to  systemic antifungal therapy for the treatment of refractory  invasive pulmonary aspergillosis

IRAS no
1004474

Study contact information
Name: Dr Anna Reed
Email: a.reed@rbht.nhs.uk

Principal investigator
Dr Anna Reed

Click here for more information


GREAT-2 -GRemubamab ErAdication Trial

Study
GRemubamab ErAdication Trial (GREAT-2) A phase 2 trial of Gremubamab compared to placebo in participants with bronchiectasis and chronicPseudomonas aeruginosa infection

IRAS no
1005993

Study contact information
Name: Vladimir Domi
Email: v.domi@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger

Click here for more information


EMILE

Study
Evaluation of the effect of Microbial dysbiosis upon anti-viral Immunity in bronchiEctasis

IRAS no
330984

Study contact information
Name: Dr Justin Garner
Email: j.garner@rbht.nhs.uk

Principal investigator
Dr Justin Garner

Click here for more information 


ERS-AMR-CRC

Study
Mapping antimicrobial resistance in chronic infectious lung disease: A European Respiratory Society Antimicrobial Resistance Clinical Research Collaborative

IRAS no
327747

Study contact information
Name: Dr Anand Shah
Email: a.shah2@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Click here for more information

Circulating cells in advanced cancer

Study
Sample collection study to explore CIrCulating tumour cells, cell free DNA and leucocytes with ImagesTReam analysis in patients with various cancers

IRAS no
198179

Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk

Principal investigator
Paula Rogers

Click here for more information


ATX-TBL-001 Tissue Research Protocol

Study
Prospective collection of donor tissue and blood or leukapheresis product from patients with solid tumours to enable development of methods for the manufacturing of clonal neoantigen T cell products (cNeT).

IRAS no
233696

Study contact information
Name: Professor Eric Lim
Email: E.Lim@rbht.nhs.uk

Principal investigator
Professor Eric Lim

CHILO

Study
Inhalation challenge to assess Inducible Laryngeal Obstruction CHILO.

IRAS no
250025

Study contact information
Name: Dr James Hull
Email: j.hull@rbht.nhs.uk

Principal investigator
Dr James Hull

Click here for more information


Study to Evaluate Efficacy and Safety of BLU-593 in Adults with RCC

Study
A Randomized, Adaptive, Double-Blind, Placebo-Controlled, Parallel Arm, Phase 2b Study to Evaluate the Efficacy and Safety of Multiple Doses of BLU-5937 in Adult Participants With Refractory Chronic Cough

IRAS no
289963

Study contact information
Name: Dr James Hull
Email: j.hull@rbht.nhs.uk

Principal investigator
Dr James Hull

Click here for more information


A Phase 2 Study of Efficacy and Safety of AX-8 in Chronic Cough  

Study
A Phase 2 Study of Efficacy and Safety of AX-8 in Chronic Cough

IRAS no
297718

Study contact information
Name: Dr James Hull
Email: j.hull@rbht.nhs.uk

Principal investigator
Dr James Hull

Click here for more information


NEuroCOUGH 

Study
NEw Understanding of the tReatment Of COUGH (NEUROCOUGH); European Chronic Cough Registry and Bio-Resource Protocol.

IRAS no
279797

Study contact information
Name: Sally Meah
Email: sally.meah@imperial.ac.uk

Principal investigator
Dr James Hull

Click here for more information


ATP and P2X3 receptor in chronic cough

Study
Neuroinflammatory interactions of ATP and P2X3 receptor in the airways of chronic cough patients: an exploratory study

IRAS no
271140

Study contact information
Name: Maria Nunez
Email: m.nunez@rbht.nhs.uk

Principal investigator
Professor Kian Fan Chung

Click here for more information


CALM-1

Study
A Phase 3, 52-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel-Arm Efficacy and Safety Study with Open-Label Extension of BLU-5937 in Adult Participants with Refractory Chronic Cough, Including Unexplained Chronic Cough (CALM-1)

IRAS no
1006707

Study contact information
Name: Maria Nunez
Email: m.nunez@rbht.nhs.uk

Principal investigator
Dr James Hull

Click here for more information

UK lung volume reduction

Study
UK lung volume reduction - multicentre observational

IRAS no
190196

Study contact information
Name: Sara  Buttery
Email: S.Buttery@rbht.nhs.uk

Principal investigator
Dr Nicholas Hopkinson

Click here for more information


Impact of smoking cessation on skeletal muscle atrophy and hypertrophy pathways in COPD

Study
Impact of smoking cessation on skeletal muscle atrophy and hypertrophy pathways in COPD

IRAS no
5020

Study contact information
Name: Ahmad Sadaka
Email: A.Sadaka@rbht.nhs.uk

Principal investigator
Dr Nicholas Hopkinson


Microbiome of the lung in patients treated with endobronchial lung volume reduction coils for emphysema

Study
Studying the microbiome of the lung in patients treated with endobronchial lung volume reduction coils for emphysema

IRAS no
215696

Study contact information
Name: Dr Justin Garner
Email: J.Garner@rbht.nhs.uk

Principal investigator
Dr Samuel Kemp

Click here for more information


RePneu lung volume reduction coil - European registry

Study
RePneu lung volume reduction coil - European Registry

IRAS no
181479

Study contact information
Name: Dr Justin Garner
Email: J.Garner@rbht.nhs.uk

Principal investigator
Dr Samuel Kemp

Click here for more information


NMES in patients with COPD and quadriceps weakness

Study
Quadriceps neuromuscular electrical stimultaion (NMES) as an adjunct to pulmonary rehabilitation in patients with COPD and quadriceps weakness - a randomised double-blind placebo-controlled trial.

IRAS no
234536

Study contact information
Name: Sarah Jones
Email: S.Jones5@rbht.nhs.uk

Principal investigator
Dr William Man

Click here for more information


Iron and COPD exercise trial

Study
Iron and Chronic Obstructive Pulmonary Disease (COPD) exercise trial

IRAS no
204579

Study contact information
Name: Matt Pavitt
Email: M.Pavitt@rbht.nhs.uk

Principal investigator
Professor Michael Polkey

Click here for more information


Airway microenvironment in patients undergoing surgical and bronchoscopic interventions

Study
Studying the airway microenvironment in patients undergoing surgical and bronchoscopic interventions for COPD

IRAS no
217587

Study contact information
Name: Dr Justin Garner
Email: J.Garner@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


Lung volume reduction in severe emphysema

Study
A single arm pilot study of lung volume reduction in severe emphysema using bronchoscopic autologous blood instillation in combination with intra-bronchial valves

IRAS no
135459

Study contact information
Name: Dr Justin Garner
Email: J.Garner@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


RejuvenAir™ System metered cryospray therapy for Chronic Bronchitis patients

Study
A prospective safety and feasibility study of the RejuvenAir™ System metered cryospray therapy for Chronic Bronchitis patients

IRAS no
185214

Study contact information
Name: Dr Justin Garner
Email: J.Garner@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


The London COPD cohort RSV study

Study
The London COPD cohort respiratory syncytial virus (RSV) study

IRAS no
232292

Study contact information
Name: Dexter Wiseman
Email: D.Wiseman@rbht.nhs.uk

Principal investigator
Professor Jadwiga Wedzicha

Click here for more information


The BLF early COPD development partnership grant

Study
The BLF early COPD development partnership grant

IRAS no
206796

Study contact information
Name: Ethaar El-Emir
Email: E.El-Emir@rbht.nhs.uk

Principal investigator
Professor Jadwiga Wedzicha

Click here for more information


Relationship between patient phenotypes and exacerbations in chronic obstructive pulmonary disease

Study
Relationship between patient phenotypes and exacerbations in chronic obstructive pulmonary disease

IRAS no
13535

Study contact information
Name: Gavin Donaldson
Email: gavin.donaldson@imperial.ac.uk

Principal investigator
Professor Jadwiga Wedzicha


Mechanisms of increased susceptibility to rhinovirus infection

Study
Mechanisms of increased susceptibility to rhinovirus infection in frequent and infrequent exacerbators of Chronic Obstructive Pulmonary Disease

IRAS no
181679

Study contact information
Name: Lydia Finney
Email: L.Finney@rbht.nhs.uk

Principal investigator
Professor Jadwiga Wedzicha

Click here for more information


Oxidative metabolism and atrophy in primary human skeletal muscle cell

Study
Primary culture of human skeletal muscle cells from patients with conditions impairing muscle mitochondrial oxidative metabolism and causing muscle atrophy to investigate underlying molecular mechanisms of reduced oxidative metabolism and atrophy and potential novel therapies.

IRAS no
214624

Study contact information
Name: Dr Amanda Natanek
Email: A.Natanek@rbht.nhs.uk

Principal investigator
Dr Amanda Natanek

Click here for more information


ELEVATE

Study
A RandomisEd ControlLed Study of PnEumRx Endobronchial Coil System Versus Standard-of-Care Medical MAnagement in the Treatment of Subjects with Severe Emphysema (ELEVATE) A Postmarket Surveillance Study (PMS).

IRAS no
242606

Study contact information
Name: Professor Pallav Shah
Email: P.Shah@rbht.nhs.uk 

Principal investigator
Professor Pallav Shah

Click here for more information


Air Pollution in COPD

Study
The Effect of Air Pollution on Small Airway Lung Function in COPD.

IRAS no
260264

Study contact information
Name: Sally Meah
Email: s.meah@rbht.nhs.uk

Principal investigator
Dr Omar Usmani

Click here for more information


Inhaled SNG001 in COPD patients

Study
A randomised, double-blind, placebo-controlled study, in COPD patients with and without a confirmed respiratory virus infection assessing anti-viral biomarker responses of inhaled SNG001 compared to placebo.

IRAS no
232887

Study contact information
Name: Dexter Wiseman
Email: D.Wiseman@rbht.nhs.uk

Principal investigator
Professor Jadwiga Wedzicha

Click here for more information


SPACE FOR COPD maintenance

Study
SPACE FOR COPD© delivered as a maintenance programme on Pulmonary Rehabilitation discharge: a randomised controlled trial evaluating the long-term effects on exercise tolerance and mental well-being

IRAS no
262581

Study contact information
Name: Ruth Barker
Email: R.Barker2@rbht.nhs.uk

Principal investigator
Dr William Man


ESPRESSO

Study
Early Supported discharge with Pulmonary REhabilitation following Severe acute exacerbations of COPD – Safety and Outcomes (ESPRESSO)

IRAS no
269894

Study contact information
Name: Ruth Barker
Email: R.Barker2@rbht.nhs.uk

Principal investigator
Dr William Man


SHIELD - Singing for Health

Study
Singing for Health: Improving Experience of Lung Disease

IRAS no
259170

Study contact information
Name: Dr Keir Philip
Email: K.Philip@rbht.nhs.uk

Principal investigator
Dr Nicholas Hopkinson

Click here for more information


AIRFLOW-3

Study
A Multicenter, Randomised, Sham-controlled Study to Evaluate Safety and Efficacy After Treatment with the Nuvaira Lung Denervation System in Subjects with Chronic Obstructive Pulmonary Disease (COPD).

IRAS no
253708

Study contact information
Name: Dr Francesca Conway
Email: f.conway@rbht.nhs.uk

Principal investigator
Professor Pallav Shah 

Click here for more information


AIRFLOW-3 sub study

Study
Mechanism of action of targeted lung denervation in Chronic Obstructive Pulmonary Disease (COPD) - A basic science study linked to the AIRFLOW-3 Trial

IRAS no
269766

Study contact information
Name: Dr Francesca Conway
Email: f.conway@rbht.nhs.uk

Principal investigator
Professor Pallav Shah 


MCS MOA

Study
Characterising the Mechanism of Action of Metered Cryospray for the Treatment of Patients with Chronic Obstructive Pulmonary Disease with Chronic Bronchitis

IRAS no
260529

Study contact information
Name: Dr Christopher Orton
Email: c.orton@rbht.nhs.uk

Principal investigator
Professor Pallav Shah 

Click here for more information


Breathe Plus feasibility trial

Study
Breathe Plus: Testing the feasibility of a comprehensive geriatric assessment for people with COPD and frailty starting pulmonary rehabilitation

IRAS no
268185

Study contact information
Name: Lisa Brighton
Email: L.Brighton@rbht.nhs.uk

Principal investigator
Dr William Man


The O-COPD trial: OPEP devices in COPD

Study
The O-COPD trial: Oscillatory Positive Expiratory Pressure (OPEP) devices to improve outcome in patients with Chronic Obstructive Pulmonary Disease (COPD)

IRAS no
269494

Study contact information
Name: Dr Saeed Alghamdi
Email: S.Alghamdi@rbht.nhs.uk

Principal investigator
Dr Nicholas Hopkinson


Lobar Segmented Iodine Mapping of the Lungs using Dual Energy CT

Study
Lobar Segmented Iodine Mapping of the Lungs using Dual Energy Computed Tomography in Advanced Chronic Obstructive Pulmonary Disease.

IRAS no
265630

Study contact information
Name: Dr Carole Ridge
Email: C.Ridge@rbht.nhs.uk

Principal investigator
Dr Carole Ridge


EON-Lung: Nitrate levels in Lung Disease

Study
EON-Lung: Nitrate levels in Lung Disease - an observational study

IRAS no
266682

Study contact information
Name: Dr Nicholas Hopkinson
Email: n.hopkinson@rbht.nhs.uk

Principal investigator
Dr Nicholas Hopkinson

Click here for more information


CONVERT Trial

Study
Fissure Closure with the AeriSeal® System for Converting Collateral Ventilation Status in Patients with Severe Emphysema; a Multicenter, Prospective Trial

IRAS no
285414

Study contact information
Name: Najwa Soussi
Email: n.soussi@rbht.nhs.uk

Principal investigator
Dr Samuel Kemp


Mobilise-D - Clinical Validation Study

Study
Validating digital mobility assessment using wearable technology – The Mobilise-D Clinical Validation Study.

IRAS no
289543

Study contact information
Name: Dr Nicholas Hopkinson
Email: n.hopkinson@rbht.nhs.uk

Principal investigator
 Dr Nicholas Hopkinson

Click here for more information


The WHAM Study

Study
Randomised controlled feasibility study of Maintaining the benefits of Pulmonary Rehabilitation with Harmonies and Melodies via Singing for Lung Health.

IRAS no
293580

Study contact information
Name: Peter Jung
Email: p.jung@rbht.nhs.uk

Principal investigator
Dr Adam Lewis

Click here for more information


Drive- BX

Study
Co-Design of a Pulmonary Rehabilitation intervention to Improve outcomes post-Exacerbation in Bronchiectasis

IRAS no
314196

Study contact information
Name: Jennifer Kilduff
Email: j.kilduff@rbht.nhs.uk

Principal investigator
Jennifer Kilduff


The ON-PACE trial

Study
Dietary nitrate supplementation to enhance daily physical activity in hypoxic COPD: a randomised controlled trial   

IRAS no
315107

Study contact information
Name: Alexis Perkins
Email: a.perkins@rbht.nhs.uk

Principal investigator
Dr Nicholas Hopkinson

Click here for more information


The RheSolve Study

Study
A Clinical Evaluation of the RheOx Bronchial Rheoplasty System for the Treatment of the Symptoms of Chronic Bronchitis in Adult Patients with COPD

IRAS no
312382

Study contact information
Name: Dr Anand Tana
Email: a.tana@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


European Alpha 1 Registry (EARCO)

Study
A Pan-European Multi-Centre Observational Study To Determine The Natural History Of Patients With Alpha-1 Antitrypsin Deficiency And The Impact Of Augmentation Therapy

IRAS no
265728

Study contact information
Name: Maria Nunez
Email: m.nunez@rbht.nhs.uk

Principal investigator
Dr Nicholas Hopkinson

Click here for more information


SPRAY-CB

Study
A Sham Controlled Prospective Randomized Clinical Trial of the RejuvenAir System for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease with Chronic Bronchitis

IRAS no
304514

Study contact information
Name: Professor Pallav Shah
Email: p.shah@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


AB1MALT

Study
Assessment of the Safety and Performance of the AB1 Electrosurgical System for Bronchoscopic Microwave Ablation of Lung Tissue

IRAS no
307228

Study contact information
Name: Dr Ley Taing Chan
Email: l.chan3@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


AI in PRImary Care spirometry for diagnosis of Lung Disease (APRIL)

Study
Real-world evaluation of an Artificial-Intelligence support software (ArtiQ.Spiro) in Primary Care spirometry pathways for the detection of Lung Disease.

IRAS no
324175

Study contact information
Name: Dr William Man
Email: w.man@rbht.nhs.uk

Principal investigator
Dr William Man


Hybrid Pulmonary Rehabilitation Trial

Study
Real-world evidence feasibility trial, in both community and hospital-based settings, for a technology-enabled hybrid service delivery model for Pulmonary Rehabilitation: assessing patient uptake and adherence, and impact on patient outcomes and service capacity.

IRAS no
325028

Study contact information
Name: Timothy Jenkins
Email: t.jenkins@rbht.nhs.uk

Principal investigator
Dr William Man


BREATH-2

Study
Bronchoscopic Release of Air Trapped in Hyperinflated Emphysematous Lung

IRAS no
326148

Study contact information
Name: Dr Christopher Orton
Email: c.orton@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

Click here for more information


Breathing Vigilance in a COPD population with hyperinflation

Study
Breathing Vigilance in a COPD population with hyperinflation

IRAS no
321477

Study contact information
Name: Dr Justin Garner
Email: j.garner@rbht.nhs.uk

Principal investigator
Dr Justin Garner


ATHLOSS

Study
A Double-Blind, Multicentre, Randomized, Three-Period, Three-Treatment, Cross-Over Study to Evaluate the Effect of BGF MDI, BFF MDI, and Placebo MDI on Exercise Parameters in Participants with Chronic Obstructive Pulmonary Disease

IRAS no
1007637

Study contact information
Name: Camilla Goulsbra
Email: c.goulsbra@rbht.nhs.uk

Principal investigator
Professor Michael Polkey

Click here for more information

FREAL

Study
Understanding susceptibility to fungal infection and evolution of antimicrobial resistance in chronic respiratory disease

IRAS no
244685

Study contact information
Name: Dr Anand Shah
Email: A.Shah2@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Click here for more information


Endothelial senescence in chronic lung disease

Study
Studying endothelial senescence and dysfunction in chronic lung disease

IRAS no
284894

Study contact information
Name: Dr Koralia Paschalaki
Email: K.Paschalaki@rbht.nhs.uk

Principal investigator
Professor Jadwiga Wedzicha


FADE UK

Study
Analysing Fungal Disease Epidemiology in the UK

IRAS no
300045

Study contact information
Name: Dr Anand Shah
Email: A.Shah2@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Heterotaxy and abnormalities in intestinal rotation

Study
Heterotaxy and abnormalities in intestinal rotation

IRAS no
170433

Study contact information
Name: Anastasia Fotaki
Email: a.fotaki@rbht.nhs.uk

Principal investigator
Dr Julene Carvalho

Click here for more information


Pharmacokinetics and pharmacodynamics of edoxaban in paediatric patients

Study
A phase 1, open-label, single-dose, non-randomised study to evaluate pharmacokinetics and pharmacodynamics of edoxaban in pediatric patients 

IRAS no
200445

Study contact information
Name: Neil West
Email: N.West@rbht.nhs.uk

Principal investigator
Dr Zdenek Slavik

Click here for more information


Pedometer walking program for ACHD patients

Study
Does a pedometer-based walking programme affect exercise capacity and quality of life in sedentary adults with congenital heart disease?

IRAS no
232271

Study contact information
Name: Ms Lynda Shaughnessy
Email: L.Shaughnessy@rbht.nhs.uk

Principal investigator
Ms Lynda Shaughnessy

Click here for more information


Clinical Artificial Intelligence Fetal Echocardiography (CAIFE)

Study
Development of Clinical Artificial Intelligence Models in Fetal Echocardiography for the Detection of Congenital Heart Defects

IRAS no
317510

Study contact information
Name: Julene Carvalho
Email: j.carvalho@rbht.nhs.uk

Principal investigator
Dr Olga Patey

Click here for more information

Outcome validation in noses of subjects with CF and non-CF volunteers

Study
Outcome validation in noses of subjects with cystic fibrosis and non-CF volunteers

IRAS no
215047

Study contact information
Name: Aarash Saleh
Email: a.saleh@rbht.nhs.uk

Principal investigator
Professor Eric Alton

Click here for more information


Living with cystic fibrosis

Study
Living with Cystic fibrosis

IRAS no
196567

Study contact information
Name: Olga Archangelidi
Email: o.archangelidi@rbht.nhs.uk

Principal investigator
Dr Siobhan Carr

Click here for more information


CF start

Study
The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF

IRAS no
211995

Study contact information
Name: Dr Siobhan Carr
Email: s.carr@rbht.nhs.uk

Principal investigator
Dr Siobhan Carr

Click here for more information


MAGIC

Study
Managing abnormal glucose in cystic fibrosis (MAGIC)- the development of a self-management education programme for people with CFRD

IRAS no
215946

Study contact information
Name: Sarah Collins
Email: s.collins@rbht.nhs.uk

Principal investigator
Ms Sarah Collins

Click here for more information


Safety and pharmacodynamics of long-term Ivacaftor treatment for CF

Study
A Phase 3, 2-Arm, open-label study to evaluate the safety and pharmacodynamics of long-term Ivacaftor treatment in subjects with Cystic Fibrosis who are less than 24 Months of age at treatment initiation and have a CFTR gating mutation

IRAS no
228921

Study contact information
Name: Nicole Westrupp
Email: n.westrupp@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


CLIMB-CF

Study
Clinical monitoring and biomarkers to stratify severity and predict outcomes in children with cystic fibrosis (CLIMB-CF).

IRAS no
207718

Study contact information
Name: Nicole Westrupp
Email: n.westrupp@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Non-invasive detection of pseudomonas aeruginosa lower airway infection in patients with CF

Study
Non-invasive detection of Pseudomonas aeruginosa lower airway infection in patients with Cystic Fibrosis

IRAS no
233578

Study contact information
Name: Claire Edmondson
Email: C.Edmondson@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Safety and efficacy of long-term treatment with VX 661 in combination with Ivacaftor

Study
A Phase 3, open label, rollover study to evaluate the safety and efficacy of long term treatment with VX 661 in combination with Ivacaftor in subjects aged 12 years and older with Cystic Fibrosis , homozygous or heterozygous for the F508del CFTR mutation

IRAS no
186033

Study contact information
Name: Sandra Scott
Email: S.Scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Multiple breath washout in paediatric chronic airways disease

Study
Multiple Breath Washout in paediatric chronic airways disease: Building a clinimetrics dataset

IRAS no
204190

Study contact information
Name: Clare Saunders
Email: C.Saunders2@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Screening tools for drug-induced ototoxicity in adults with CF

Study
A prospective cross-sectional study analysing the utility of novel tablet-based audiometry and an interactive web-based hearing app as screening tools for drug-induced ototoxicity in adults with cystic fibrosis.

IRAS no
230986

Study contact information
Name: Anitha Vijayasingam
Email: A.Vijayasingam@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Click here for more information


Improving outcome measures for physiotherapy trials of airway clearance in adults in CF

Study
Improving outcome measures for physiotherapy trials of airway clearance in adults with CF

IRAS no
154635

Study contact information
Name: Gemma Stanford
Email: G.Stanford@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds

Click here for more information


Finger-prick capillary blood sampling in chronic lung disease

Study
Single-centre validation of finger-prick capillary blood sampling for remote monitoring in chronic lung disease including antifungal therapeutic drug monitoring.

IRAS no
239814

Study contact information
Name: Professor Michael Loebinger 
Email: M.Loebinger@rbht.nhs.uk

Principal investigator
Professor Michael Loebinger 

Click here for more information


VX17-661-116

Study
A Phase 3, Open-label, Rollover Study to Evaluate the Safety and Efficacy of Long-term Treatment With Tezacaftor in Combination With Ivacaftor in Subjects With Cystic Fibrosis Aged 6 Years and Older, Homozygous or Heterozygous for the F508del-CFTR Mutation.

IRAS no
241643

Study contact information
Name: Professor Jane Davies
Email: J.Davies@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


VX17-659-105 Open-label Safety and Efficacy of VX-659 in CF

Study
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-659 Combination Therapy in Subjects with Cystic Fibrosis Who Are Homozygous or Heterozygous for the F508del Mutation.

IRAS no
241641

Study contact information
Name: Dr Nicholas Simmonds
Email: N.Simmonds@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds

Click here for more information


MR assessment of shunt fraction in CF patients before and after BAE

Study
A prospective pilot study: Magnetic Resonance Imaging (MRI) derived measures of bronchial arterial flow in the assessment and follow-up of patients with Cystic fibrosis (CF) who undergo bronchial artery embolisation.

IRAS no
256039

Study contact information
Name: Bhavin Rawal
Email: B.Rawal@rbht.nhs.uk

Principal investigator
Professor Simon Padley


Organoid Study (HIT-CF)

Study
Stratifying Cystic Fibrosis Patients Based on Intestinal Organoid Response To Different CFTR-modulators

IRAS no
255704

Study contact information
Name: Maria Nunez
Email: M.Nunez@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds


Phase IIa study of PC945 in Aspergillosis in Cystic Fibrosis patients

Study
An open-label study to assess the safety, pharmacokinetics and pharmacodynamics of inhaled PC945 in adult Cystic Fibrosis (CF) patients with persistent pulmonary Aspergillus fumigatus infection

IRAS no
248009

Study contact information
Name: Dr Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds

Click here for more information


Exercise behaviours in children and young people with cystic fibrosis

Study
Identifying predictors for maintenance of exercise participation in children and young people with cystic fibrosis.

IRAS no
246187

Study contact information
Name: Nicky Murray
Email: N.Murray@rbht.nhs.uk

Principal investigator
Nicky Murray

Click here for more information


Measurement of novel indices of lung function in respiratory disease

Study
Measurement of novel indices of lung function in respiratory disease

IRAS no
208382

Study contact information
Name: Clare Saunders
Email: C.Saunders2@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


A study of the combined effects of three CFTR modulator medicines in people with cystic fibrosis aged 12 and older

Study
A Phase 3 study of the long-term safety of a triple combination therapy of VX-445, tezacaftor and ivacaftor in people with cystic fibrosis aged 12 and older.

IRAS no
269907

Study contact information
Name: Dr Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds


A study to learn more about a combination of CFTR modulator medicines in people with Cystic Fibrosis (VX 18 445 104)

Study
A study to evaluate the effectiveness and safety of VX 445/Tezacaftor/Ivacaftor in people with Cystic Fibrosis who are heterozygous for the F508del mutation and a gating or residual function mutation.

IRAS no
268820

Study contact information
Name: Dr Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies


A Phase 2 study of ABBV-3067 alone and in combination with ABBV-2222

Study
A Phase 2 study of ABBV-3067 alone and in combination with ABBV-2222 in Cystic Fibrosis subjects who are homozygous for the F508del mutation.

IRAS no
268446

Study contact information
Name: Dr Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


VX18-445-110 VX-445/TEZ/IVA Open-label in CF (F/G and F/RF)

Study
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for the F508del Mutation and a Gating or Residual Function Mutation (F/G and F/RF Genotypes)

IRAS no
268821

Study contact information
Name: Dr Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Phase 3 Open-label Study of VX-445/TEZ/IVA in subjects 6 years & older

Study
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-445/TEZ/IVA Combination Therapy in Subjects With Cystic Fibrosis Who Are 6 Years of Age and Older

IRAS no
274499

Study contact information
Name: Dr Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Clinical Outcomes With Novel Modifier Therapy Combinations in CF

Study
Clinical Outcomes With Novel Modifier Therapy Combinations in CF

IRAS no
279116

Study contact information
Name: Dr Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Targeting Immunotherapy for Fungal Infection in Cystic Fibrosis

Study
TrIFIC: Targeting Immunotherapy for Fungal Infection in Cystic Fibrosis

IRAS no
270828

Study contact information
Name: Maria Nunez
Email: M.Nunez@rbht.nhs.uk

Principal investigator
Dr James Darius-Armstrong


VX20-445-119

Study
A Phase 3b Open-label Study Evaluating the Long-term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor Combination Therapy in Cystic Fibrosis Subjects Ages 6 Years and Older Who Are Heterozygous for the F508del Mutation and a Minimal Function Mutation (F/MF)"

IRAS no
1003390

Study contact information
Name: Dr Sandra Scott
Email:  s.scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies


Clinical Outcomes With Novel Modifier Therapy Combination (RECOVER)

Study
Real World Clinical Outcomes With Novel Modifier Therapy Combinations in People with CF

IRAS no
296928

Study contact information
Name: Clare Saunders
Email:  c.saunders2@rbht.nhs.uk

Principal investigator
Professor Jane Davies


Clinimetric properties of Oxygen-Enhanced MRI

Study
Determining the clinimetric properties of structural and functional outputs of oxygen-enhanced magnetic resonance imaging in children and adults with cystic fibrosis (CF) and chronic suppurative lung disease (CSLD)

IRAS no
294686

Study contact information
Name: Cristopher Short
Email: C.Short@rbht.nhs.uk

Principal investigator
Professor Jane Davies


The Effects of Planned Intravenous Antibiotics on Activity and Sleep Quality in Cystic Fibrosis During the Post COVID-19 Lockdown Period.   

Study
The Effects of Planned Intravenous Antibiotics on Activity and Sleep Quality in Cystic Fibrosis During the Post COVID-19 Lockdown Period   

IRAS no
223350

Study contact information
Name: Dr Rishi Pabary
Email: R.Pabary@rbht.nhs.uk

Principal investigator
Dr Rishi Pabary


COVID-19 antibody responses in Cystic Fibrosis patients   

Study
COVID-19 antibody responses in Cystic Fibrosis patients      

IRAS no
294037

Study contact information
Name: Jessie Matthews
Email: J.Matthews@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds

Click here for more information


Video game hearing tests for remote monitoring of ototoxicity

Study
Development and validation of the use of Video games and virtual reality to enable Autonomous Remote monitoring of OTotoxicity in high-risk population groups (VAROT).

IRAS no
298372

Study contact information
Name: Jamie Cheong
Email: j.cheong@rbht.nhs.uk

Principal investigator
Dr Anand Shah

Click here for more information


Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Subjects

Study
A Phase 3 Open-label Study Evaluating the Long‑term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor Triple Combination Therapy in Cystic Fibrosis Subjects 2 Years and Older

IRAS no
1004766

Study contact information
Name: Jessie Matthews
Email: j.matthews@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


A Phase 3 Study of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Heterozygous

Study
 A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for F508del and a Minimal Function Mutation (F/MF)

IRAS no
1003950

Study contact information
Name: Jessie Matthews
Email: j.matthews@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds

Click here for more information


RExA-CF

Study
Reproducibility of virtual exercise assessments versus face-to-face exercise testing in adults with cystic fibrosis – a pilot feasibility study

IRAS no
314914

Study contact information
Name: Gemma Stanford
Email: g.stanford@rbht.nhs.uk

Principal investigator
Gemma Stanford

Click here for more information


A Phase 1/2 Dose-escalation Study Evaluating the  Safety, Tolerability, and Efficacy of VX-522 in  Subjects 18 Years of Age and Older With Cystic  Fibrosis and a CFTR Genotype Not Responsive to  CFTR Modulator Therapy

Study
A Phase 1/2 Dose-escalation Study Evaluating the  Safety, Tolerability, and Efficacy of VX-522 in  Subjects 18 Years of Age and Older With Cystic  Fibrosis and a CFTR Genotype Not Responsive to  CFTR Modulator Therapy

IRAS no
1005878

Study contact information
Name: Clare Saunders
Email: c.saunders2@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Skyline Open label Extension - VX20-121-104

Study
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy in Subjects With Cystic Fibrosis

IRAS no
1005889

Study contact information
Name: Dr Nicholas Simmonds
Email: n.simmonds@rbht.nhs.uk

Principal investigator
Dr Nicholas Simmonds

Click here for more information


A Randomised, Double-Blind, Placebo Controlled, Two-Part Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of a Repeat Dose of Inhaled ETD001 in People with Cystic Fibrosis
 

Study
A Randomised, Double-Blind, Placebo Controlled, Two-Part Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of a Repeat Dose of Inhaled ETD001 in People with Cystic Fibrosis

IRAS no
1008079

Study contact information
Name: Yasmine Needham
Email: y.needham@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


CFTR c.3874-4522A>G's impact on cystic fibrosis severity
 

Study
Investigating the possible association between expression of the CFTR: c.3874-4522A>G deep intronic variant and phenotype severity in patients with Cystic Fibrosis 

IRAS no
335624

Study contact information
Name: Anna Lockhart
Email: a.lockhart@rbht.nhs.uk

Principal investigator
Dr Deborah Morris-Rosendahl


ENHANCE
 

Study
Establishing Natural History in an Advanced New CF Care Era

IRAS no
332109

Study contact information
Name: Clare Saunders
Email: c.saunders2@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


YOGA-CF
 

Study
Yoga Outcomes Get Assessed in Cystic Fibrosis (YOGA-CF)

IRAS no
303898

Study contact information
Name: Gemma Stanford
Email: g.stanford@rbht.nhs.uk

Principal investigator
Gemma Stanford

Click here for more information

Ilprost (Ventavis) in patients with Eisenmenger syndrome

Study
A single-centre, placebo-controlled, double-blinded, randomised, crossover study of Iloprost (Ventavis®) in patients with Eisenmenger syndrome

IRAS no
121948

Study contact information
Name: Dr Stephen John Wort
Email: s.wort@rbht.nhs.uk

Principal investigator
Dr Stephen John Wort

Click here for more information

Molecular genetics of human birth defects

Study
Molecular genetics of human birth defects – mapping and gene identification

IRAS no
103488

Study contact information
Name: Dr Claire Hogg
Email: c.hogg@rbht.nhs.uk

Principal investigator
Dr Claire Hogg


Genetic linkage evaluation in inherited cardiac conditions

Study
Genetic linkage evaluation in inherited cardiac conditions

IRAS no
53663

Study contact information
Name: Dr Janice Till
Email: j.till@rbht.nhs.uk

Principal investigator
Dr Janice Till


Natural History Dilated Cardiomyopathy Associated with BAG3 Mutations

Study
A prospective multinational study of the natural history of participants with BAG3 mutation associated dilated cardiomyopathy

IRAS no
321187

Study contact information
Name: Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk

Principal investigator
Dr Antonis Pantazis


The SMARTER-CM Study

Study
Genetics, Imaging And Artificial Intelligence for Precision Care in Cardiomyopathy

IRAS no
313058

Study contact information
Name: Dr Upasana Tayal
Email: u.tayal@rbht.nhs.uk

Principal investigator
Dr Upasana Tayal

Click here for more information

Factors influencing physical activity among individuals living with heart failure

Study
Factors influencing physical activity among individuals living with heart failure: a mixed-methods study

IRAS no
205050

Study contact information
Name: Professor Martin Cowie
Email: m.cowie@rbht.nhs.uk

Principal investigator
Professor Martin Cowie

Click here for more information


Assessing organisational readiness for heart failure remote monitoring

Study
Assessing Organisational Readiness for Heart Failure Remote Monitoring

IRAS no
236418

Study contact information
Name: Darshan Brahmbhatt
Email: d.brahmbhatt@rbht.nhs.uk

Principal investigator
Professor Martin Cowie

Click here for more information


IRONMAN

Study
Effectiveness of intravenous iron treatment vs standard care in patients with heart failure and iron deficiency: a randomised, open-label multicentre trial (IRONMAN)

IRAS no
191168

Study contact information
Name: Peng Zhang
Email: p.zhang@rbht.nhs.uk

Principal investigator
Ms Rebecca Lane

Click here for more information


The effects of inorganic nitrite on cardiac and skeletal muscle

Study
The Effects of inorganic nitrite on cardiac and skeletal muscle: Physiology, pharmacology, and therapeutic potential in patients with Chronic Heart Failure

IRAS no
87162

Study contact information
Name: Brodie Loudon
Email: B.Loudon@rbht.nhs.uk

Principal investigator
Dr Sanjay Prasad

Click for more information


Mitraclip device in heart failure

Study
Randomised investigation of the Mitraclip device in heart failure: 2nd trial in patients with clinically significant functional mitral regurgitation

IRAS no
220456

Study contact information
Name: Joanne Benton
Email: j.benton@rbht.nhs.uk

Principal investigator
Dr Robert Smith

Click here for more information


LCZ696 in paediatric patients

Study
Multicenter, open-label, single dose study to evaluate the safety, tolerability and pharmacokinetics of LCZ696 followed by randomised, double-blind, parallel group,active-controlled study to evaluate the efficacy and safety of LCZ696 in pediatric patients

IRAS no
206351

Study contact information
Name: Dr Piers Daubeney
Email: p.daubeney@rbht.nhs.uk

Principal investigator
Dr Piers Daubeney

Click for more information


AccuCinch® Ventriculoplasty System for Functional Mitral Regurgitation

Study
Safety and performance evaluation of the AccuCinch® Ventricular Repair System for the treatment of heart failure with or without Functional Mitral Regurgitation due to Dilated Ischaemic or Non-Ischaemic Cardiomyopathy. 

IRAS no
230127

Study contact information
Name: Lauren Kelly
Email: L.Kelly2@rbht.nhs.uk

Principal investigator
Dr Robert Smith

Click for more information


The AMBITION

Study
Assessing mitochondrial bioenergetics in coronary heart disease; correlating cardiac magnetic resonance with the molecular processes that underpin myocardial dysfunction and left ventricular reverse remodelling.

IRAS no
247881

Study contact information
Name: Dr Richard Jones
Email: r.jones@rbht.nhs.uk

Principal investigator
Dr Sanjay Prasad


The REMIT-DCM study

Study
Reverse rEmodelling Markers In the serial evaluation of recenTonset Dilated CardioMyopathy

IRAS no
262962

Study contact information
Name: Dr Daniel Hammersley
Email: d.hammersley@rbht.nhs.uk

Principal investigator
Dr Sanjay Prasad

Click here for more information


PiCSO-AMI-I

Study
Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) in Acute Myocardial Infarction (PiCSO-AMI-I)

IRAS no
259683

Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk

Principal investigator
Dr Charles Ilsley

Click here for more information


Go DCM

Study
Defining the genetics, biomarkers and outcomes for dilated cardiomyopathy: a prospective multi-centre observational study

IRAS no
237880

Study contact information
Name: Teijo Palovaara
Email: T.Palovaara@rbht.nhs.uk

Principal investigator
Dr James Ware


ORBITA-2

Study
A placebo-controlled trial of percutaneous coronary intervention for the relief of stable angina

IRAS no
242451

Study contact information
Name: Meriel Woodruff
Email: M.Woodruff@rbht.nhs.uk

Principal investigator
Dr Vasileios Panoulas

Click here for more information


Sanofi Drug Utilisation Study of alirocumab

Study
A drug utilization study (DUS) of alirocumab in Europe to assess the effectiveness of the dosing recommendation to avoid very low LDL-C levels.

IRAS no
245146

Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk

Principal investigator
Dr Barbir Mahmoud

Click here for more information


HEART - ACS V1.0

Study
The HarEfield Acute MyocaRdial InfarcTion Cohort

IRAS no
259087

Study contact information
Name: Laura Barker
Email: L.Barker2@rbht.nhs.uk

Principal investigator
Dr Miles Dalby


The EURO-SHOCK Trial version 1

Study
EURO SHOCK Testing the value of novel strategy and its cost efficacy in order to improve the poor outcomes in Cardiogenic Shock

IRAS no
250403

Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk

Principal investigator
Dr Alex Rosenberg

Click here for more information


Epidemiology and Prognosis in Acute Myocarditis 

Study
Epidemiological trends and outcomes of hospital admissions for acute myocarditis and dilated cardiomyopathy in the National Health Service of England from 1998 onwards.

IGARD reference number
DARS-NIC-144568-D7G6V

Study contact information
Name: Amrit Lota
Email: A.Lota@rbht.nhs.uk

Principal investigator
Professor Sanjay Prasad

Click here for more information


Diagnosis and risk stratification in myocarditis

Study
Diagnosis and risk stratification in myocarditis using cardiovascular magnetic resonance, detailed molecular markers and gene sequencing - a personalised approach.

IRAS no
220817

Study contact information
Name: Alma Iacob
Email: A.Iacob@rbht.nhs.uk

Principal investigator
Professor Sanjay  Prasad

Click here for more information


VIDEO-HF

Study
Evaluating Outpatient Video Consultations in Heart Failure: Clinician and Patient Perspectives.

IRAS no
284625

Study contact information
Name: Dr Arvind Singhal
Email: A.Singhal@rbht.nhs.uk

Principal investigator
Professor Martin Cowie

Click here for more information


Fish and Chips

Study
FFRCT In Stable Heart disease & CTA Helps Improve Patient care and Societal costs

IRAS no
285996

Study contact information
Name: Dr Edward Nicol
Email: E.Nicol@rbht.nhs.uk

Principal investigator
Dr Edward Nicol

Click here for more information


A possible new treatment for elevated Lp(a) in CVD - HORIZON

Study
A randomised double-blind, placebo-controlled, multicenter trial assessing the impact of lipoprotein (a) lowering with TQJ230 on major cardiovascular events in patients with established cardiovascular disease (CVD).

IRAS no
267092

Study contact information
Name: Alkida Bucaj
Email: A.Bucaj@rbht.nhs.uk

Principal investigator
Professor Mahmoud Barbir

Click here for more information



Olpasiran trials of Cardiovascular Events And LipoproteiN(a) reduction – Outcomes trial

Study
A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Olpasiran on Major Cardiovascular Events in Patients with Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein (a)

IRAS no
1006924

Study contact information
Name: Sankari Nagarajan
Email: s.nagarajan@rbht.nhs.uk

Principal investigator
Dr Tina Khan


Genetic testing for DCM   

Study
Examining the use and yield of genetic testing in clinical practice for patients with dilated cardiomyopathy.

IRAS no
280916

Study contact information
Name: Dr Brian Halliday
Email: B.Halliday@rbht.nhs.uk

Principal investigator
Dr Brian Halliday


Digital-HF

Study
Digital tools in Heart failure – a survey of patient usage

IRAS no
307636

Study contact information
Name: Kyle McBeath
Email: K.McBeath@rbht.nhs.uk

Principal investigator
Professor Martin Cowie

Click here for more information


ANTHEM

Study
Autonomic Regulation Therapy to Enhance Myocardial Function and Reduce Progression of Heart Failure with Heart Failure with Reduced Ejection Fraction

IRAS no
244390

Study contact information
Name: Antonio Barbera
Email: a.barbera@rbht.nhs.uk

Principal investigator
Professor Martin Cowie

Click here for more information


Examining the effect of mitochondrial oxidative stress in DCM

Study
Examining the role of mitochondrial oxidative stress in dilated cardiomyopathy

IRAS no
286376

Study contact information
Name: Katherine Smith
Email: k.smith@rbht.nhs.uk

Principal investigator
Dr Brian Halliday

Click here for more information


CY 6031- Cytokinetics - Cardiomyopathy 0771/0042

Study
A Phase 3, Multi-Center, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy and Safety of CK­3773274 in Adults with Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction

IRAS no
1005127

Study contact information
Name: Carmen Chan
Email: l.chan2@rbht.nhs.uk

Principal investigator
Dr Antonis Pantazis

Click here for more information


CE-MARC 3

Study
A pragmatic approach to the investigation of stable chest pain: a UK, multi-centre, randomised trial to improve patient experience, outcomes and NHS cost efficiency

IRAS no
302218

Study contact information
Name: Dr Chiara Bucciarelli-Ducchi
Email: c.bucciarelli-ducci@rbht.nhs.uk

Principal investigator
Dr Ciara Bucciarelli-Ducchi

Click here for more information


Clinical Investigation of FIRE1 System in HF Patients – FUTURE HF

Study
First In Human Clinical Investigation of the FIRE1 System in Heart Failure Patients

IRAS no
316506

Study contact information
Name: Nikula Vicario
Email: n.vicario@rbht.nhs.uk

Principal investigator
Dr Ali Vazir

Click here for more information


QUAL-HF

Study
Digital tools in Heart failure – patient and clinician perspectives

IRAS no
321337

Study contact information
Name: Dr Ali Vazir
Email: a.vazir@rbht.nhs.uk

Principal investigator
Dr Ali Vazir

Click here for more information


VICTORION REAL v01

Study
An international prospective Real-world study to evaluate the Effectiveness and Adherence of incLisiran plus standard of care lipid-lowering therapy compared to standard of care therapy alone in patients with primary hypercholesterolemia or mixed dyslipidemia

IRAS no
317604

Study contact information
Name: Susshmitha Ramesh
Email: s.ramesh2@rbht.nhs.uk

Principal investigator
Dr Barbir Mahmoud

Click here for more information


BRITISH: Using CMR scar as risk indication tool in NICM and severe LVSD

Study
Using cardiovascular magnetic resonance identified scar as the Benchmark Risk Indication Tool for Implantable cardioverter defibrillators in patients with Non-Ischemic Cardiovascular and Severe systolic Heart failure

IRAS no
280862

Study contact information
Name: Annashyl West
Email: a.west@rbht.nhs.uk

Principal investigator
Professor Sanjay Prasad

Click here for more information


TRED-HF2

Study
A randomised trial examining therapy to maintain remission in dilated cardiomyopathy

IRAS no
1006543

Study contact information
Name: Saad Javed
Email: s.javed@rbht.nhs.uk 

Principal investigator
Dr Brian Halliday

Click here for more information


HER-SAFE

Study
Randomised Control Trial for the Safety of Withdrawal of Pharmacological Treatment for Recovered HER2 Targeted Therapy Related Cardiac Dysfunction

IRAS no
312432

Study contact information
Name: Dr Alexander Lyon
Email: a.lyon@rbht.nhs.uk

Principal investigator
Dr Alexander Lyon

Click here for more information


Low QRS voltages in young healthy individuals and athletes

Study
The prevalence and significance of low QRS voltages in young healthy individuals and athletes

IRAS no
283055

Study contact information
Name: Dr Nirmitha Jayaratne
Email: n.jayaratne@rbht.nhs.uk

Principal investigator
Dr Sabiha Gati

Click here for more information


TN-401-0011

Study
Seroprevalence Study of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV) in Patients with Plakophilin 2 (PKP2)-associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)

IRAS no
323224

Study contact information
Name: Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk

Principal investigator
Dr Antonis Pantazis


Cardiac cachexia in advanced heart failure – a prospective cohort study investigating prevalence and outcome

Study
Cardiac cachexia in advanced heart failure – a prospective cohort study investigating prevalence and outcome

IRAS no
334613

Study contact information
Name: Dr Mansimran Singh Dulay
Email: m.singhdulay@rbht.nhs.uk

Principal investigator
Dr Owais Dar


CY 6032

Study
A Phase 3, Multi-center, Randomized, Double-blind Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol in Adults with Symptomatic Obstructive Hypertrophic Cardiomyopathy

IRAS no
1007788

Study contact information
Name: Dr Antonis Pantazis
Email: a.pantazis@rbht.nhs.uk

Principal investigator
Dr Antonis Pantazis

Click here for more information


Euro-CRAFT Registry

Study
Prospective evaluation of the impact of coronary themodilution on clinical outcomes in chronic coronary syndromes

IRAS no
315345

Study contact information
Name: Maria Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk

Principal investigator
Dr Ranil De Silva

Click here for more information


FRACTURE

Study
ModiFication of coRonAry Calcium with Iaser based inTravascUlaR lithotripsy for coronary artEry disease (FRACTURE)

IRAS no
328394

Study contact information
Name: Laura Barker
Email: l.barker2@rbht.nhs.uk 

Principal investigator
 Dr Jonathan Hill 

GSK3008348 in IPF patients using PET imaging

Study
A study of single doses to evaluate the safety, tolerability, pharmacokinetics and target engagement of nebulised GSK3008348 in Idiopathic Pulmonary Fibrosis patients, using positron emission tomography (PET) imaging

IRAS no
221453

Study contact information
Name: Lyn Paul
Email: L.Paul@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


Muscle stimulation in advanced idiopathic pulmonary fibrosis (MUST-IPF)

Study
Neuromuscular electrical stimulation (NMES) is a portable hand-held muscle stimulator which allows the thigh muscles to be exercised whilst seated. The aims of this study are to 1) investigate whether NMES is acceptable to patients with IPF and healthcare/research staff and 2) identify if it can improve leg muscle strength and walking ability.

IRAS no
241055

Study contact information 
Name: Claire Nolan
Email: c.nolan@rbht.nhs.uk

Principal investigator
Dr William Man

Click here for more information


A study to evaluate to efficacy and safety of BG00011

Study
A randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of BG00011 in patients with Idiopathic Pulmonary Fibrosis. 

IRAS no
248312

Study contact information
Name: Lyn Paul
Email: l.paul@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


Nintedanib in PF-ILD (extension)

Study
An open-label extension trial of the long-term safety of nintedanib in patients with Progressive Fibrosing Interstitial Lung Disease (PF-ILD)

IRAS no
252018

Study contact information
Name: Lyn Paul
Email: l.paul@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


TR12 Ph 2 Study in Idiopathic Pulmonary Fibrosis-Nalbuphine ER Tablets

Study
A phase 2, double-blind, randomised, placebo-controlled, two-treatment, two-period crossover efficacy and safety study in Idiopathic Pulmonary Fibrosis (IPF) with Nalbuphine ER tablets for the treatment of cough.

IRAS no
262846

Study contact information
Name: Lyn Paul
Email: l.paul@rbht.nhs.uk

Principal investigator
Professor Toby Maher


Changes in iOS in IPF

Study
Changes in impulse oscillometry measurements and outcomes in idiopathic pulmonary fibrosis

IRAS no
282567

Study contact information
Name: Suhani Patel
Email: S.Patel1@rbht.nhs.uk

Principal investigator
Dr William Man

Click here for more information


Reliability and vailidity of iOS in IPF

Study
Reliability and validity of impulse oscillometry measurements in idiopathic pulmonary fibrosis

IRAS no
280564

Study contact information
Name: Suhani Patel
Email: S.Patel1@rbht.nhs.uk

Principal investigator
Dr William Man

Click here for more information


PACIFY Cough

Study
PAciFy Cough: A multicentre, double blind, placebo controlled, crossover trial of morphine sulfate for the treatment of PulmonAry Fibrosis Cough

IRAS no
275034

Study contact information
Name: Zhe Wu
Email: Z.Wu@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


Progressive Fibrosing Lung Disease (PROFOUND)

Study
Identifying progressive fibrosing lung disease: a study of genetic and environmental interactions: an observational cohort study.

IRAS no
279948

Study contact information
Name: Jessica Wallen
Email: j.wallen@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux


1305-0013 BI 1015550 in Idiopathic Pulmonary Fibrosis 

Study
A randomised, double-blind, placebo-controlled parallel group study in IPF patients over 12 weeks evaluating efficacy, safety and tolerability of BI 1015550 taken orally.

IRAS no
280729

Study contact information
Name: Deirdre Flannery
Email: D.Flannery@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux


Phase 2 Study of the Efficacy and Safety of BMS-986278 in IPF

Study
A Multicenter, Randomised, Double-blind, Placebo-controlled, Phase 2 Study of the Efficacy and the Safety and Tolerability of BMS-986278 in Participants with Idiopathic Pulmonary Fibrosis (IM027-040)

IRAS no
1003409

Study contact information
Name: Natalie Dwyer
Email: N.Dwyer@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


TIPAL

Study
The effectiveness and risks of Treating people with Idiopathic Pulmonary fibrosis with the Addition of Lansoprazole (TIPAL): a randomised placebo-controlled multi-centre clinical trial

IRAS no
269050

Study contact information
Name: Natalie Dwyer
Email: N.Dwyer@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


C21 in IPF

Study
A Phase 2, Multi-Centre, Open-Label, Single-Arm Trial Investigating the Safety, Efficacy and Pharmacokinetics of C21 in Subjects with Idiopathic Pulmonary Fibrosis

IRAS no
282448

Study contact information
Name: Victor Jardim
Email: V.Jardim@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


C21 in IPF

Study
A Phase 2, Multi-Centre, Open-Label, Single-Arm Trial Investigating the Safety, Efficacy and Pharmacokinetics of C21 in Subjects with Idiopathic Pulmonary Fibrosis

IRAS no
282448

Study contact information
Name: Victor Jardim
Email: V.Jardim@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


Outcomes in Idiopathic Inflammatory Myopathies

Study
Autoantibody Predictors of Long-Term Outcomes in Idiopathic Inflammatory Myopathy Associated Interstitial Lung Disease.

IRAS no
286985

Study contact information
Name: Dr Elizabeth Renzoni
Email: E.Renzoni@rbht.nhs.uk

Principal investigator
Dr Elizabeth Renzoni

Click here for more information


PLN-74809-IPF-202

Study
A randomized, double-blind, dose-ranging, placebo-controlled Phase 2a evaluation of the safety, tolerability and pharmacokinetics of PLN-74809 in participants with idiopathic pulmonary fibrosis (IPF).

IRAS no
277008

Study contact information
Name: Victor Jardim
Email: V.Jardim@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


A Phase 2 study of RXC007 in patients with IPF

Study
A Multi-Cohort, Randomized, Placebo-Controlled Phase 2a Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Ascending Doses of RXC007 in Patients with Idiopathic Pulmonary Fibrosis.

IRAS no
1005138

Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


Perspectives On Screening and early Treatment for Pulmonary Fibrosis: a qualitative study

Study
Perspectives On Screening and early Treatment for Pulmonary Fibrosis: a qualitative study

IRAS no
319409

Study contact information
Name: Dr Elizabeth Renzoni
Email: e.renzoni@rbht.nhs.uk

Principal investigator
Dr Elizabeth Renzoni

Click here for more information


Randomised, Double-Blind, Placebo-Controlled, Dose  Escalation, Safety, Tolerability & Pharmacodynamic Biomarker Study of Caveolin-1-Scaffolding-Protein-Derived Peptide (LTI-03)

Study
A Randomised, Double-Blind, Placebo-Controlled, Phase 1b, Dose Escalation, Safety, Tolerability and Pharmacodynamic Biomarker Study of Caveolin-1-Scaffolding-Protein-Derived Peptide (LTI-03) in Recently Diagnosed, Treatment Naïve Subjects with Idiopathic Pulmonary Fibrosis.

IRAS no
1006203

Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk

Principal investigator
Professor Philip Molyneaux

Click here for more information


A Study to Investigate MBS2320 Patients with IPF

Study
A Randomised, Double-Blind, Placebo-Controlled, Phase 2 Study to Investigate the Efficacy and Safety of MBS2320 in Patients With Idiopathic Pulmonary Fibrosis (IPF)

IRAS no
1007976

Study contact information
Name: Maria Fernandes
Email: m.fernandes@rbht.nhs.uk

Principal investigator
Professor Philip Molyneaux

Click here for more information


NAL03-202  - Trevi Therapeutics, Inc. - Idiopathic Pulmonary Fibrosis - 4318/0010

Study
A Randomised, Double-Blind, Placebo-Controlled, Parallel, 4-Arm Dose Ranging Study of the Safety and Efficacy of NAL ER Tablets for the Treatment of Cough in Idiopathic Pulmonary Fibrosis (IPF) 

IRAS no
1008035

Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk

Principal investigator
Professor Philip Molyneaux

Click here for more information


Efzo-Fit Study

Study
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Intravenous Efzofitimod in Patients with Pulmonary Sarcoidosis

IRAS no
1006104

Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk

Principal investigator
Dr Vasilis Kouranos

Click here for more information


IM027-068

Study
A multicenter, randomized, double-blind, placebo-controlled, Phase 3 Study to evaluate the efficacy, safety, and tolerability of BMS-986278 in participants with idiopathic pulmonary fibrosis (IPF)

IRAS no
1008043

Study contact information
Name: Deirdre Flannery
Email: d.flannery@rbht.nhs.uk

Principal investigator
Professor Philip Molyneaux

Click here for more information

CMR sequences for future clinical use

Study
Development of Cardiovascular Magnetic Resonance (CMR) sequences for future clinical use

IRAS no
33773

Study contact information
Name: Andy Scott
Email: a.scott07@imperial.ac.uk

Principal investigator
Professor David Firmin


Diffusion tensor CMR imaging of the myocardium

Study
Diffusion Tensor Cardiovascular Magnetic Resonance Imaging of the myocardium

IRAS no
136441

Study contact information
Name: Zohya Khalique
Email: Z.Khalique@rbht.nhs.uk

Principal investigator
Professor Dudley Pennell

Click here for more information


Quantitive analysis of the 4-dimensional motion of the ascending aorta

Study
Quantitive analysis of the 4-dimensional motion of the ascending aorta

IRAS no
281535

Study contact information
Name: Dr Christoph Nienaber
Email: C.Nienaber@rbht.nhs.uk

Principal investigator
Dr Christoph Nienaber


Diagnosis severity & prognosis evaluation using cardiothoracic CT & MR

Study
Diagnosis severity & prognosis evaluation using cardiothoracic CT & MR

IRAS no
296357

Study contact information
Name: Dr Anand Devaraj
Email: A.Devaraj@rbht.nhs.uk

Principal investigator
Mr Simon Padley

Transmural myocardial perfusion with hypertension, HCM and HCM phenocopies with CMR

Study
The measurement of transmural myocardial perfusion in normal subjects and patients with hypertension, hypertrophic cardiomyopathy (HCM) and HCM phenocopies with Cardiovascular Magnetic Resonance (CMR)

IRAS no
171258

Study contact information
Name: Brian Halliday
Email: B.Halliday@rbht.nhs.uk

Principal investigator
Dr Sanjay Prasad


Lifestyle and exercise in Hypertrophic Cardiomyopathy

Study
Lifestyle and exercise in Hypertrophic Cardiomyopathy

IRAS no
205294

Study contact information
Name: Carmen Chan
Email: L.Chan2@rbht.nhs.uk

Principal investigator
Dr James Ware

Click here for more information


Exploring the lived experiences of Familial Hypercholesterolaemia in childhood

Study
Exploring the lived experience of being diagnosed with genetically confirmed Familial Hypercholesterolaemia in childhood

IRAS no
269787

Study contact information
Name: Charis Browne
Email: C.Browne@rbht.nhs.uk

Principal investigator
Charis Browne

Click here for more information


CY 6022

Study
An open-label study of CK-3773274 for patients with Symptomatic Hypertrophic Cardiomyopathy (HCM)

IRAS no
1005788

Study contact information
Name: Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk

Principal investigator
Dr Antonis Pantazis

Click here for more information


Mavacamten in non-obstructive HCM

Study
A randomised, double-blind, placebo-controlled clinical study to evaluate mavacamten in adults with symptomatic non-obstructive hypertrophic cardiomyopathy

IRAS no
1006306

Study contact information
Name: Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk

Principal investigator
Dr Brian Halliday

Click here for more information

The DEPICT study

Study
Critically ill children and young people: Do national differences in access to emergency paediatric Intensive Care and care during transport affect clinical outcomes and patient experience? The DEPICT study

IRAS no
218569

Study contact information
Name: Angela Aramburo
Email: a.aramburocaragol@rbht.nhs.uk

Principal investigator
Ms Angela Aramburo


Rovaroxaban regimen in children with acute venous thromboembolism

Study
Multicentre, open-label, active-controlled, randomised study to evaluate the efficacy and safety of an age and body weight-adjusted rivaroxaban regimen in children with acute venous thromboembolism

IRAS no
155345

Study contact information
Name: Helena Sampaio
Email: m.fernandessampaio@rbht.nhs.uk

Principal investigator
Ms Angela Aramburo

Click here for more information


S-CAP study

Study
A molecular toolkit for the microbial investigation of severe community acquired pneumonia (S-CAP Study)

IRAS no
189915

Study contact information
Name: Natalie Dormand
Email: N.Dormand@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


Haemostatic markers in ECMO (HAE) study

Study
Prospective cohort study of haemostatic activation markers and correlation with bleeding and thrombotic complications in patients receiving extracorporeal membrane oxygenation(ECMO)

IRAS no
235036

Study contact information
Name: Dr Deepa Arachchillage
Email: D.JayakodyArachchillage@rbht.nhs.uk

Principal investigator
Dr Deepa Arachchillage

Click here for more information


WAVE study - Weaning Algorithms for mechanical VEntilation

Study
Weaning from mechanical ventilation: comparison of open-loop decision support system and routine care in cardiothoracic patients.

IRAS no
239144

Study contact information
Name: Dr Brijesh Patel
Email: B.Patel4@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


EAT-PK

Study
Does Extra-Corporeal Membrane Oxygenation alter anti-infectives therapy pharmacokinetics in adult critically ill patients?

IRAS no
228196

Study contact information
Name: Dr Anna Reed
Email: A.Reed@rbht.nhs.uk

Principal investigator
Dr Anna Reed

Click here for more information


Advanced echocardiography in critical care

Study
Advanced echocardiography in critical care

IRAS no
266247

Study contact information
Name: Professor Susanna Price
Email: S.Price@rbht.nhs.uk

Principal investigator
Professor Susanna Price


GenOMICC

Study
Genetics of susceptibility and mortality in critical care (GenOMICC)

IRAS no
269326

Study contact information
Name: Mahitha Gummadi
Email: M.Gummadi@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel


Evaluating the nutritional impact of changing from 1% to 2% Propofol in a Cardiothoracic Adult Critical Care Unit

Study
Evaluating the nutritional impact of changing from 1% to 2% Propofol in a Cardiothoracic Adult Critical Care Unit

IRAS no
286229

Study contact information
Name: Chris Remmington
Email: C.Remmington@rbht.nhs.uk

Principal investigator
Chris Remmington


MUSCLE-ICU Study

Study
 Acute muscle wasting in critical illness – an observational cohort study

IRAS no
285418

Study contact information
Name: Dr Brijesh Patel
Email: B.Patel4@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


Nasal High-Flow Oxygen Therapy After Cardiac Surgery (NOTACS) study

Study
Nasal High-Flow Oxygen Therapy After Cardiac Surgery (NOTACS) Study: Effect of High-Flow Nasal Therapy on Patient-Centred Outcomes in Patients at High Risk of Postoperative Pulmonary Complications After Cardiac Surgery: A Multicentre Randomised Controlled Trial.

IRAS no
278290

Study contact information
Name: Dr Nicoletta Zimbler
Email: N.Zimbler@rbht.nhs.uk

Principal investigator
Dr Nicoletta Zimbler

Click here for more information


Aspergillosis in patients with severe influenza (AspiFlu)

Study
Incidence and Pathogenesis of Invasive Aspergillosis in Intensive Care Patients with Severe Influenza (AspiFLu)

IRAS no
271269

Study contact information
Name: Anelise Catelan Zborowski
Email: A.CatelanZborowski@rbht.nhs.uk

Principal investigator
Dr Darius Armstrong-James

Click here for more information


The HITEC study

Study
Haemostasis and Immunothrombosis in Extracorporeal Circuits

IRAS no
294477

Study contact information
Name: Dr Teresa Lee
Email: t.lee@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


RASECAL-Bronchoscopic ambusampler RCT - safety and efficiency

Study
A Randomised controlled trial to Assess the Safety and Efficiency of a self-Contained sampling device /disposable bronchoscope system versus usual sAmpLing procedure.

IRAS no
289572

Study contact information
Name: Anelise Catelan Zborowski
Email: a.catelanzborowski@rbht.nhs.uk

Principal investigator
Dr Ben Garfield

Click here for more information


HERACLES

Study
HEmodynamic effects of Reducing lv Afterload with impella or intra-aortic balloon CounterpuLsation during veno-arterial Extracorporeal membrane oxygenation in cardiogenic Shock

IRAS no
300145

Study contact information
Name: Professor Susanna Price
Email: s.price@rbht.nhs.uk

Principal investigator
Professor Susanna Price & Dr Vasileios Panoulas

Click here for more information


PETRA-UK study

Study
PaEdiatric TRAnsfusion practices in PICU in UK (PETRA-UK study)

IRAS no
317209

Study contact information
Name: Dr Justin Wang
Email: q.wang@rbht.nhs.uk

Principal investigator
Dr Justin Wang

Click here for more information


GOlDilOCS: Genomic determinants of outcome in cardiogenic shock

Study
Prospective observational study investigating genomic determinants of outcome from cardiogenic shock   

IRAS no
290406

Study contact information
Name: Keir Stirrat
Email: k.stirrat@rbht.nhs.uk

Principal investigator
Dr Brijesh Patel

Click here for more information


Indications, efficacy and safety profiles of dual treatment with Levosimendan and Sildenafil in critically ill adult patients

Study
Indications, efficacy and safety profiles of dual treatment with Levosimendan and Sildenafil in critically ill adult patients

IRAS no
326729

Study contact information
Name: Dr Sundeep Kaul
Email: s.kaul@rbht.nhs.uk

Principal investigator
Dr Sundeep Kaul

"Unclassifiable" ILD

Study
Phase II study of Pirfenidone vs placebo in patients with fibrotic ILD that cannot be classified with moderate or high confidence into any other category of fibrotic IP by Multidisciplinary Team (MDT) review (“unclassifiable” ILD).

IRAS no
218417

Study contact information
Name: Vladimir Domi
Email: V.Domi@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


Systemic sclerosis associated with ILD

Study
A double blind, randomised, placebo-controlled trial evaluating efficacy and safety of oral nintedanib, 150 mg twice daily for 52 weeks (with follow up until last patient out up to a maximum of 2 years) in patients with systemic sclerosis associated interstitial lung disease

IRAS no
185104

Study contact information
Name: Deirdre Flannery
Email: D.Flannery@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


RA associated ILD with UIP pattern

Study
A 52 week, double blind, randomised, placebo-controlled trial evaluating the effect of Nintedanib, 150 mg twice daily, on annual rate of decline in Forced Vital Capacity and safety in patients with RA associated ILD with UIP pattern

IRAS no
217658

Study contact information
Name: Vladimir Domi
Email: V.Domi@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


Rituximab vs intravenous cyclophosphamide in connective tissue disease associated ILD

Study
A randomised, double blind controlled trial comparing rituximab against intravenous cyclophosphamide in connective tissue disease associated interstitial lung disease

IRAS no
98339

Study contact information
Name: Vladimir Domi
Email: V.Domi@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


Open label extension study of nintedanib in SSc-ILD

Study
An open-label extension trial to assess the long term safety of nintedanib in patients with ‘Systemic Sclerosis associated Interstitial Lung Disease’ (SSc-ILD)

IRAS no
235678

Study contact information
Name: Professor Toby Maher
Email: T.Maher@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


TRAIL1

Study
A Randomised, Double-Blind, Placebo-Controlled, Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease

IRAS no
220334

Study contact information
Name: Professor Toby Maher
Email: T.Maher@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


Deep learning for HRCT classification of fibrotic lung disease

Study
Deep learning for HRCT classification of fibrotic lung disease

IRAS no
234527

Study contact information
Name: Professor Toby Maher
Email: T.Maher@rbht.nhs.uk

Principal investigator
Professor Toby Maher

Click here for more information


Historical exposures in hypersensitivity pneumonitis

Study
A case-referent study of the exposure history of adults with hypersensitivity pneumonitis

IRAS no
245417

Study contact information
Name: Dr Johanna Feary
Email: J.Feary@rbht.nhs.uk 

Principal investigator
Dr Johanna Feary

Click here for more information


FIBRINOX

Study
Fibrotic Interstitial Lung Disease and nocturnal oxygen - An observational study of the effects of nocturnal hypoxaemia on patients with fibrotic interstitial lung disease

IRAS no
234305

Study contact information
Name: Richard Mordi
Email: R.Mordi@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


Clustering and Phenotyping Interstitial Lung Disease

Study
Clustering and Phenotyping Interstitial Lung Disease

IRAS no
270865

Study contact information
Name: Dr Philip Molyneaux
Email: P.Molyneaux@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


I-FILE

Study
An international patient-led registry in fibrotic interstitial lung diseases using eHealth technology

IRAS no
291393

Study contact information
Name: Victor Jardim
Email: v.jardim@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


IMPALA -2

Study
A randomized, double-blind, placebo-controlled clinical trial of once-daily inhaled molgramostim nebulizer solution in adult subjects with autoimmune pulmonary alveolar proteinosis (aPAP).

IRAS no
289012

Study contact information
Name: Rosemarie Bolla
Email: r.bolla@rbht.nhs.uk

Principal investigator
Dr Maria Kokosi

Click here for more information


ILD-DNA   

Study
Interstitial Lung Disease DNA Study

IRAS no
316318

Study contact information
Name: Mr Philip Molyneaux
Email: p.molyneaux@rbht.nhs.uk

Principal investigator
Mr Philip Molyneaux

Click here for more information


1305-0023: Phase III PoCC pivotal trial #1 BI 1015550 - PDE4 inhibitor in AF experienced PF-ILD

Study
Phase III PoCC pivotal trial #1 BI 1015550 - PDE4 inhibitor in AF experienced PF-ILD

IRAS no
1006258

Study contact information
Name: Maria Nunez
Email: m.nunez@rbht.nhs.uk

Principal investigator
Mr Philip Molyneaux

Click here for more information


1305-0014: Phase III PoCC pivotal trial #1 BI 1015550 - PDE4 inhibitor in AF experienced PF-ILD

Study
A double blind, randomized, placebo-controlled trial evaluating the efficacy and safety of BI 1015550 over at least 52 weeks in patients with Idiopathic Pulmonary Fibrosis (IPF).

IRAS no
1006245

Study contact information
Name: Maria Nunez
Email: m.nunez@rbht.nhs.uk

Principal investigator
Mr Philip Molyneaux

Click here for more information


DT-ILD

Study
 Specialist dietetic intervention in malnourished patients with fibrotic ILD: a randomised controlled pilot trial

IRAS no
327224

Study contact information
Name: Rasleen Kahai
Email: r.kahai@rbht.nhs.uk

Principal investigator
Dr Elizabeth Renzoni


ILD: Health Outcomes in Remote Digital Monitoring versus Usual Care

Study
Comparison of health outcomes in a remote monitoring programme versus usual care in Interstitial Lung Disease

IRAS no
301636

Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk

Principal investigator
Professor Philip Molyneaux

Click here for more information


INGENIOUS 

Study
Detecting and understanding exacerbations in patients with fibrotic lung disease; a multi-centre cohort observational study

IRAS no
331080

Study contact information
Name: Leda Yazbeck
Email: l.yazbeck@rbht.nhs.uk

Principal investigator
Professor Philip Molyneaux

Click here for more information

Genetic determinants of Kawasaki disease

Study
Genetic determinants of Kawasaki disease for susceptibility and outcome

IRAS no
115933

Study contact information
Name: Dr Rodney Franklin
Email: r.franklin@rbht.nhs.uk

Principal investigator
Dr Rodney Franklin

Click here for more information

Tracking no small cell lung cancer evaluation

Study
Tracking non small cell lung cancer evolution through therapy (Rx)

IRAS no
138871

Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk

Principal investigator
Mr Eric Lim

Click here for more information


Video assisted thoracoscopic lobectomy vs conventional Open LobEcTomy

Study
Video assisted thoracoscopic lobectomy versus conventional Open LobEcTomy for lung cancer, a multi-centre randomised controlled trial with an internal pilot

IRAS no
163516

Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk

Principal investigator
Mr Eric Lim

Click here for more information


Cancer recurrence in patients after lung cancer surgery

Study
The process of disclosure of the risk of cancer recurrence in patients following potentially curative lung cancer surgery: a multiple case study

IRAS no
168907

Study contact information
Name: Matthew Johnson
Email: M.Johnson@rbht.nhs.uk

Principal investigator
Mr Eric Lim

Click here for more information


Lung nodule Imaging Biobank for Radiomics and AI research (LIBRA)

Study
Lung nodule Imaging Biobank for Radiomics and AI research (LIBRA)

IRAS no
274775

Study contact information
Name: Professor Anand Devaraj
Email: A.Devaraj@rbht.nhs.uk

Principal investigator
Professor Anand Devaraj


2010 BTS Guideline evaluation

Study
An evaluation of surgical resection rates before and after the introduction of the 2010 British Thoracic Society Guidelines on Radical Management of Lung Cancer

IRAS no
295021

Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk

Principal investigator
Mr Eric Lim

Click here for more information


OCTAPUS AI

Study
Optimising cancer treatment surveillance and ascertaining cause of Pneumonitis using artificial intelligence

IRAS no
283611

Study contact information
Name: Dr Philip Molyneaux
Email: P.Molyneaux@rbht.nhs.uk

Principal investigator
Dr Philip Molyneaux

Click here for more information


AI-SONAR

Study
AI & radiomics for Stratification Of lung Nodules After Radically treated cancer

IRAS no
300424

Study contact information
Name: Professor Anand Devaraj
Email: A.Devaraj@rbht.nhs.uk

Principal investigator
Professor Anand Devaraj


ADAURA2

Study
Phase III, Double-blind, Randomized, Placebo-Controlled, International Study to assess the Efficacy and Safety of Adjuvant Osimertinib versus Placebo in Patients with EGFR mutation-positive Stage IA2-IA3 Non-small Cell Lung Cancer, following Complete Tumoour removal.

IRAS no
1004224

Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk

Principal investigator 
Professor Eric Lim

Click here for more information


Investigating Management of Lung Nodules

Study
Investigating management of lung nodules, and the impact of pre-diagnostic surveillance on health and economic outcomes

IRAS no
301177

Study contact information
Name: Professor Anand Devaraj
Email: A.Devaraj@rbht.nhs.uk

Principal investigator
Professor Anand Devaraj

Click here for more information

Diffusion Tensor Imaging in ST-elevation Myocardial Infarction

Study
Investigation of Post-Myocardial Infarction Left Ventricular Remodelling  By Diffusion Tensor Cardiac Magnetic Resonance

IRAS no
259868

Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk

Principal investigator
Dr Ranil De Silva


Infarction NSTEMI v1.0

Study
Non-ST-segment elevation myocardial infarction Registry.

IRAS no
261605

Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk

Principal investigator
Dr Vasileios Panoulas

Click here for more information


ORBITA-COSMIC

Study
Coronary sinus reducer Objective impact on Symptoms, MRI Ischaemia and microvascular Resistance

IRAS no
288725

Study contact information
Name: Dr Ranil De Silva
Email: r.desilva2@rbht.nhs.uk

Principal investigator
Dr Ranil De Silva

Click here for more information


SERIAL Study

Study
Systematic Evaluation by Randomisation of Intracoronary physiological techniques for Assessing tandem Lesions

IRAS no
293563

Study contact information
Name: Kevin Cheng
Email: k.cheng@rbht.nhs.uk

Principal investigator
Dr Ranil De Silva

Click here for more information


STEMI-COOL

Study
Trans Coronary cooling and dilution to reduce reperfusion injury during revascularisation for ST-Elevation Myocardial Infarction

IRAS no
315559

Study contact information
Name: Ermes Carulli
Email: e.carulli@rbht.nhs.uk

Principal investigator
Dr Miles Dalby

Click here for more information


LIBREXIA-ACS

Study
A Phase 3, Randomized, Double-blind, Placebo-controlled, Event-driven Study to Demonstrate the Efficacy and Safety of Milvexian, an Oral Factor XIa Inhibitor, After a Recent Acute Coronary Syndrome

IRAS no
1007525

Study contact information
Name: Marita Quiroz-Patel
Email: m.quiroz-patel@rbht.nhs.uk

Principal investigator
Dr Vasileios Panoulas


Assessing patients investigated or treated for chest pain or ischaemia

Study
Assessment of patients investigated and treated for chest pain or deficits in myocardial blood flow – a multi-modalitystudy

IRAS no
334655

Study contact information
Name: Dr Ranil De Silva
Email: r.desilva2@rbht.nhs.uk

Principal investigator
Dr Ranil De Silva


Unloading and Delayed Reperfusion in ST-Elevation MI (STEMI-DTU trial)

Study
Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: The STEMI-DTU Trial

IRAS no
289666

Study contact information
Name: Jasmine Griffin
Email: j.griffin@rbht.nhs.uk

Principal investigator
Dr Vasileios Panoulas

Click here for more information

Pulmonary Non-Tuberculous Mycobacterial Disease

Study
A molecular approach to the diagnosis, assessment, monitoring and treatment of pulmonary non-Tuberculous Mycobacterial Disease.

IRAS no
212193

Study contact information
Name: Huw Ellis
Email: Huw.Ellis@rbht.nhs.uk

Principal investigator
Dr Michael Loebinger

Click here for more information


LAI in adult patients with NTM lung infections caused by MAC

Study
An open-label safety extension study to a multicenter study of liposomal amikacin for inhalation (LAI) in adult patients with non-Tuberculous Mycobacterial (NTM) lung infections caused by Mycobacterium avium complex (MAC) that are refractory to treatment

IRAS no
190666

Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk

Principal investigator
Dr Michael Loebinger

Click here for more information


ENCORE - INS 416

Study
A Randomized, Double-Blind, Placebo-Controlled, Active Comparator, Multicenter Study to Evaluate the Efficacy and Safety of an Amikacin Liposome Inhalation Suspension (ALIS)-Based Regimen in Adult Subjects with Newly Diagnosed Nontuberculous Mycobacterial

IRAS no
1004406

Study contact information
Name: Camilla Goulsbra
Email: c.goulsbra@rbht.nhs.uk

Principal investigator
Dr Michael Loebinger


There are currently no active studies 

NEURO-PACK

Study
NEURO-PACK: Neurologic prognosis after cardiac arrest in kids. An observational study of neurodevelopmental outcome after cardiac arrest in children admitted to paediatric intensive care

IRAS no
223292

Study contact information
Name: Dr Sandra Gala-Peralta
Email: s.gala-peralta@rbht.nhs.uk

Principal investigator
Dr Sandra Gala-Peralta

Click here for more information


Phase 3 - Edoxaban DU-176b in children

Study
An open-label randomised, parallel-group, multicenter, observational trial to evaluate the safety and efficacy of edoxaban tosylate in children from 38 weeks gestational age to less than 18 years of age with cardiac disease at risk of thromboembolic events.

IRAS no
238090

Study contact information
Name: Dr Piers Daubeney
Email: P.Daubeney@rbht.nhs.uk

Principal investigator
Dr Piers Daubeney

Click here for more information


Remote monitoring & gaming technology for children with CF

Study
Project Fizzyo: Remote monitoring and gaming technology for improving physiotherapy prescription, adherence and prediction of clinical outcomes in children with cystic fibrosis.

IRAS no
228625

Study contact information
Name: Ms Nicky Murray
Email: N.Murray@rbht.nhs.uk

Principal investigator
Ms Nicky Murray

Click here for more information


Severe Paediatric Asthma Collaborative in Europe (SPACE)

Study
Severe Paediatric Asthma Collaborative in Europe (SPACE).

IRAS no
230893

Study contact information
Name: Dr Louise Fleming
Email: L.Fleming@rbht.nhs.uk

Principal investigator
Dr Louise Fleming

Click here for more information


Fevipiprant

Study
A multicenter, open-label, 8 day treatment study to assess the pharmacokinetics, safety and tolerability of fevipiprant delivered via a once daily chewable tablet in children aged 6 to <12 years with asthma

IRAS no
264789

Study contact information
Name: Yvonne Bingham
Email: Y.Bingham@rbht.nhs.uk

Principal investigator
Dr Louise Fleming


Microbial ecology effects relating to childhood asthma (MEERCAT)

Study
Impact of premature birth on the gastrointestinal microbiota in early infancy and respiratory health at school age: a comparison of premature and term birth cohorts.

IRAS no
251418

Study contact information
Name: Yvonne Bingham
Email: Y.Bingham@rbht.nhs.uk

Principal investigator
Professor Sejal Saglani


A Phase 3b, randomised, placebo-controlled study evaluating the efficacy and safety of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis subjects 6-11 years of age who are heterozygous for the F508del mutation and a minimal function mutation (F/MF)

Study
A Phase 3b, randomised, placebo-controlled study evaluating the efficacy and safety of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis subjects 6-11 years of age who are heterozygous for the F508del mutation and a minimal function mutation (F/MF)

IRAS no
1003047

Study contact information
Name: Sandra Scott
Email: s.scott@rbht.nhs.uk

Principal investigator
Professor Jane Davies


PRAADA1 Study - Prenatal right aortic arch and double arch study - V1

Study
National Study of prenatally diagnosed right aortic arch and double arch: Incidence; associations and outcomes. A collaboration of the United Kingdom National Foetal Cardiology Working Group.

IRAS no
262525

Study contact information
Name: Victoria Doughty
Email: V.Doughty@rbht.nhs.uk

Principal investigator
Dr Julene Carvalho


Treating severe paediatric asthma; the TREAT trial

Study
Treating severe paediatric asthma; a randomised controlled trial of mepolizumab and omalizumab (TREAT trial)

IRAS no
252084

Study contact information
Name: Professor Sejal Saglani
Email: S.Saglani@rbht.nhs.uk

Principal investigator
Professor Sejal Saglani

Click here for more information


Retrospective review of lung function data in a paediatric centre

Study
Retrospective review of lung function data in a tertiary paediatric respiratory cohort

IRAS no
292859

Study contact information
Name: Dr Samantha Irving
Email: S.Irving@rbht.nhs.uk

Principal investigator
Dr Samantha Irving


CKJX839C12301: inclisiran in adolescents with HeFH

Study
Two part (double-blind inclisiran versus placebo [Year 1] followed by open-label inclisiran [Year 2]) randomized multicenter study to evaluate safety, tolerability, and efficacy of inclisiran in adolescents (12 to less than 18 years) with heterozygous familial hypercholesterolemia and elevated LDL-cholesterol (ORION-16)

IRAS no
1003480

Study contact information
Name: Dr Mahmoud Barbir
Email: M.Barbir@rbht.nhs.uk

Principal investigator
Dr Mahmoud Barbir

Click here for more information


The SPAR Study

Study
Exploration of a novel mathematical approach -Symmetric Projection Attractor Reconstruction (SPAR), to assist with clinical decision making in critically ill children.

IRAS no
301471

Study contact information
Name: Dr Duncan Macrae
Email: D.Macrae@rbht.nhs.uk

Principal investigator
Dr Duncan Macrae


The Fetal Aorta Study

Study
Echocardiographic Z-scores for Fetal Aortic Arch Dimensions

IRAS no
264724

Study contact information
Name: Victoria Doughty
Email: v.doughty@rbht.nhs.uk

Principal investigator
Dr Julene S Carvalho

Click here for more information


Childhood Home Asthma Monitoring Project (CHAMP)

Study
Childhood Home Asthma Monitoring Project: prospective observational study to explore the use of contactless home monitoring devices and analysis to predict asthma risk

IRAS no
282335

Study contact information
Name: Angela Jamalzadeh
Email: a.jamalzadeh@rbht.nhs.uk

Principal investigator
Dr Louise Fleming

Click here for more information


Remote monitoring in preschool wheeze

Study
Remote monitoring to predict and prevent asthma attacks in preschool children

IRAS no
307300

Study contact information
Name: Yvonne Bingham
Email: y.bingham@rbht.nhs.uk

Principal investigator
Dr Sejal Saglani

Click here for more information


Predicting Progression to School Aged Asthma

Study
Pre-school Wheeze: Predicting Progression to School Aged Asthma

IRAS no
290688

Study contact information
Name: Sormeh Salehian
Email: s.salehian@rbht.nhs.uk

Principal investigator
Dr Louise Fleming

Click here for more information


ICONIK

Study
Inherited Cardiac cONditions In Kids Understanding the Genetics and Outcomes of Paediatric Inherited Cardiac Conditions

IRAS no
288514

Study contact information
Name: Dr Andres Rico-Armada
Email: a.rico-armada@rbht.nhs.uk

Principal investigator
Dr Andres Rico-Armada

Click here for more information


Connecting breath and mind for CYP with post-COVID syndrome

Study
Connecting breath and mind: Development of an online holistic treatment Programme connecting psychological wellbeing and breathing techniques in children and young people with post-COVID syndrome

IRAS no
315063

Study contact information
Name: Dr Samatha Sonnappa
Email: s.sonnappa@rbht.nhs.uk

Principal investigator
Dr Samatha Sonnappa

Click here for more information


Care at the end of life in babies and children (NICU and PICU) WS3b

Study
End of Life Care for Infants, Children and Young People: a mixed methods evaluation of current practice in England and Wales. (Workstream 3 PART B: Prospective evaluation of care at the end of life in babies and children in NICU and PICU)

IRAS no
319728

Study contact information
Name: Laura Tous Sampol
Email: l.toussampol@rbht.nhs.uk

Principal investigator
Dr Justin Wang

Click here for more information


AFRICCA

Study
Active Fluid Removal In paediatric Critical CAre (AFRICCA): a retrospective cohort study

IRAS no
317123

Study contact information
Name: Dr Justin Wang
Email: q.wang@rbht.nhs.uk

Principal investigator
Dr Justin Wang


Artificial Intelligence in paediatric ICU

Study
Development and validation of novel Artificial Intelligence (AI) algorithms in critically ill children

IRAS no
323235

Study contact information
Name: Laura Tous Sampol
Email: l.toussampol@rbht.nhs.uk

Principal investigator
Dr Justin Wang


GASTRIC-PICU

Study
A randomised controlled trial of no routine gastric residual monitoring to guide enteral feeding in paediatric intensive care units

IRAS no
322370

Study contact information
Name: Laura Tous Sampol
Email: l.toussampol@rbht.nhs.uk

Principal investigator
Dr Justin Wang


Paediatric FH Register Study

Study
Estimating appropriate lipid lowering management in the United Kingdom Paediatric Familial Hypercholesterolaemia Register

IRAS no
324246

Study contact information
Name: Emma Neves
Email: e.neves@rbht.nhs.uk

Principal investigator
Lorraine Priestley-Barnham   

Click here for more information


VX22-445-122

Study
A Phase 3, Open-label Study Evaluating the Pharmacokinetics, Safety, and Tolerability of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Subjects 12 to Less Than 24 Months of Age

IRAS no
1007349

Study contact information
Name:  Clare Saunders
Email: c.saunders2@rbht.nhs.uk

Principal investigator
Professor Jane Davies

Click here for more information


Natural History Study in Pediatric Patients with MYBPC3

Study
A Prospective and Retrospective Registry and Biomarker Study to Evaluate the Natural History of Pediatric Patients with Cardiomyopathy due to MYBPC3 Mutations

IRAS no
304240

Study contact information
Name: Annashyl West
Email: a.west@rbht.nhs.uk

Principal investigator
Dr Janice Till

Click here for more information


PDA study v 1.2

Study
A multicenter, international, prospective and retrospective, post marketing clinical follow-up study to evaluate the efficacy and safety of the occlutech patent ductus arteriosus occluder (the occlutech pda occluder) in patient with patent ductus arterios

IRAS no
318495

Study contact information
Name: Karl Evangelista
Email: k.evangelista@rbht.nhs.uk

Principal investigator
Professor Alain Fraisse

Click here for more information


VICTORION-PEDS-OLE

Study
An open-label, single arm, multicenter extension study to evaluate long-term safety and tolerability of inclisiran in participants with heterozygous or homozygous familial hypercholesterolemia who have completed the adolescent ORION-16 or ORION-13 studies

IRAS no
1007316

Study contact information
Name: Sankari Nagarajan
Email: s.nagarajan@rbht.nhs.uk

Principal investigator
Dr Mahmoud Barbir

Click here for more information


ARDS in Children and ECMO strategies impact on Neuro-Development

Study
ARDS in Children and ECMO initiation strategies impact on Neuro-Development (ASCEND)

IRAS no
292537

Study contact information
Name: Justin Wang
Email: q.wang@rbht.nhs.uk 

Principal investigator
Angela Aramburo

Click here for more information

Unexplained respiratory muscle weakness or respiratory failure

Study
Prevalence of Pompe’s disease amongst patients with unexplained respiratory muscle weakness or respiratory failure

IRAS no
184294

Study contact information
Name: Mike Apps
Email: M.Apps@rbht.nhs.uk

Principal investigator
Professor Michael Polkey

Click here for more information

MRI in the assessment of CF and primary ciliary dyskinesia

Study
Use of MRI in the assessment of cystic fibrosis and primary ciliary dyskinesia - A clinical feasibility study

IRAS no
196228

Study contact information
Name: Dr Anand Devaraj
Email: a.devaraj@rbht.nhs.uk

Principal investigator
Dr Anand Devaraj

Click here for more information


Machine learning to diagnose PCD

Study
Improving Primary Ciliary Dyskinesia diagnosis using artificial intelligence

IRAS no
259067

Study contact information
Name: Thomas Burgoyne
Email: T.Burgoyne@rbht.nhs.uk

Principal investigator
Professor Claire Hogg

Click here for more information


IN-PCD

Study
The Effects of Inhaled Corticosteroids on Inflammation and Infection in Primary Ciliary Dyskinesia.

IRAS no
256504

Study contact information
Name: Laura Gardner
Email: L.Gardner@rbht.nhs.uk

Principal investigator
Professor Jane Davies


RCT1100-101

Study
A Phase 1, Randomized, Double-Blind, Placebo Controlled, Single Ascending Dose Study in Healthy Adult Participants and Open-Label Single Ascending Dose Study in Adults with Primary Ciliary Dyskinesia Caused by Pathogenic Mutations in the DNAI1 Gene

IRAS no
1008307

Study contact information
Name: Arvin Fernando
Email: a.fernando@rbht.nhs.uk 

Principal investigator
Professor Michael Loebinger

Click here for more information

Patients with pulmonary vascular disease

Study
Prospective study in patients with pulmonary vascular disease

IRAS no
210461

Study contact information
Name: Eleanor Morris
Email: e.morris@rbht.nhs.uk

Principal investigator
Dr Stephen John Wort

Click here for more information


Idiopathic and heritable pulmonary arterial hypertension

Study
National cohort study of Idiopathic and Heritable Pulmonary Arterial Hypertension

IRAS no
123349

Study contact information
Name: Joy Pinguel
Email: A.Pinguel@rbht.nhs.uk

Principal investigator
Dr Stephen John Wort

Click here for more information


Quantitative MRI measures in PH (Version 1)

Study
Novel Quantitative Magnetic Resonance Imaging (MRI) Measures in the Assessment and Follow-up of patients with Pulmonary Hypertension (PH)

IRAS no
246688

Study contact information
Name: Mr Simon Padley
Email: S.Padley@rbht.nhs.uk

Principal investigator
Mr Simon Padley

Click here for more information


Utility of Emphasis-10 in Risk Stratification in Pulmonary Arterial Hypertension

Study
Utility of Emphasis-10 in Risk Stratification in Pulmonary Arterial Hypertension.

IRAS no
254446

Study contact information
Name: Dr John Wort
Email: S.Wort@rbht.nhs.uk

Principal investigator
Dr John Wort


Use of pulmonary arterial hypertension therapies in Fontan patients: Current practice across the UK

Study
Use of pulmonary arterial hypertension therapies in Fontan patients.

IRAS no
263589

Study contact information
Name: Dr Kostas Dimopoulos
Email: K.Dimopoulos@rbht.nhs.uk

Principal investigator
Dr Kostas Dimopoulos


PEX-NET

Study
Pulmonary Hemodynamics during Exercise - Research Network.

IRAS no
257879

Study contact information
Name: Dr Colm McCabe
Email: C.McCabe2@rbht.nhs.uk

Principal investigator
Dr Colm McCabe


ROR-PH-301 - APD811-301 A phase 3 study to evaluate ralinepag added to SOC in PAH

Study
ROR-PH-301 - A StuDy eVAluatiNg the EffiCacy and Safety of RalinEpag To Improve Treatment OUTCOMES in PAH Patients

IRAS no
255909

Study contact information
Name: Eleanor Morris
Email: e.morris@rbht.nhs.uk

Principal investigator
Dr Colm McCabe

Click here for more information


ROR-PH-303 - APD811-303-A phase 3 OLE ext to evaluate long term safety of ralinepag

Study
ROR-PH-303 - A StuDy EVAluatiNg the Long-Term EffiCacy and Safety of RalinEpag in Subjects with PAH via an Open-Label EXTENSION

IRAS no
255904

Study contact information
Name: Eleanor Morris
Email: e.morris@rbht.nhs.uk

Principal investigator
Dr Colm McCabe

Click here for more information


CPET and stress echocardiography following pulmonary embolism

Study
Utility of cardiopulmonary exercise testing and stress echocardiography in the assessment of breathlessness following pulmonary embolism: a pilot study

IRAS no
300840

Study contact information
Name: Dr Colm McCabe
Email: C.McCabe2@rbht.nhs.uk

Principal investigator
Dr Colm McCabe


GLP-1 agonist in acute pulmonary embolisms

Study
Efficacy of GLP-1 agonist Semaglutide in acute pulmonary embolisms: a biomarker-driven proof of concept open label phase II study

IRAS no
300440

Study contact information
Name: Joy Pinguel
Email: a.pinguel@rbht.nhs.uk

Principal investigator
Dr Colm McCabe


Pulmonary hypertension in CHD

Study
Pulmonary hypertension in congenital heart disease

IRAS no
273383

Study contact information
Name: Dr Andrew Constantine
Email: a.constantine@rbht.nhs.uk

Principal investigator
Professor Kostas Dimopoulos

Click here for more information


Utility of sendaway NTproBNP

Study
Assessing the utility of capillary sendaway NT-proBNP in pulmonary hypertension across the UK.

IRAS no
299472

Study contact information
Name: Eleanor Morris
Email: e.morris@rbht.nhs.uk

Principal investigator
 Dr Stephen John Wort


Acceleron

Study
An Open-Label Long-term Follow-up Study to Evaluate the Effects of Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH

IRAS no
1003791

Study contact information
Name: Joy Pinguel
Email: a.pinguel@rbht.nhs.uk

Principal investigator
 Dr Stephen John Wort

Click here for more information


Hyperion

Study
A Phase 3, Randomized, Double-blind, Placebo-controlled study to Evaluate Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy in Newly Diagnosed Intermediate-and High-risk PAH Patients

IRAS no
1003773

Study contact information
Name: Joy Pinguel
Email: a.pinguel@rbht.nhs.uk

Principal investigator
Dr Colm McCabe

Click here for more information


A011-14

Study
A Phase 3, Randomized, Double-Blind, PlaceboControlled Study to Evaluate Sotatercept When Added to Maximum Tolerated Background Therapy in Participants With Pulmonary Arterial Hypertension (PAH) World Health Organization (WHO) Functional Class (FC) III or FC IV at High Risk of Mortality.

IRAS no
1004073

Study contact information
Name: Joy Pinguel
Email: a.pinguel@rbht.nhs.uk

Principal investigator
Dr Stephen John Wort

Click here for more information


AI in Chronic Lung Disease PH

Study
The role of artificial intelligence to detect the presence and severity of pulmonary hypertension in patients with chronic lung disease using non-invasive data

IRAS no
311484

Study contact information
Name: Dr Stephen John Wort
Email: s.wort@rbht.nhs.uk

Principal investigator
Dr Stephen John Wort


IMPAHCT Phase 2b/3 Study of AV-101 for Pulmonary Arterial Hypertension

Study
A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 24-Week Dose Ranging and Confirmatory Study to Evaluate the Safety and Efficacy of AV-101 in Patients with Pulmonary Arterial Hypertension (PAH)

IRAS no
299052

Study contact information
Name: Victor Jardim
Email: v.jardim@rbht.nhs.uk

Principal investigator
Dr Colm McCabe

Click here for more information


CLTP002A12201 PAH

Study
A randomized, participant- and investigator-blinded, placebo-controlled study to investigate efficacy, safety and tolerability of LTP001 in participants with pulmonary arterial hypertension

IRAS no
1004298

Study contact information
Name: Apple Joy Pinguel
Email: a.pinguel@rbht.nhs.uk

Principal investigator
Dr John Wort Stephen

Click here for more information


Real-World Comparative Effectiveness Study of TYVASO Inhaled Treprostinil) in the Treatment of PH-ILD

Study
Real-World Comparative Effectiveness Study of TYVASO Inhaled Treprostinil) in the Treatment of PH-ILD

IRAS no
335576

Study contact information
Name: Victor Jardim
Email: v.jardim@rbht.nhs.uk

Principal investigator
Dr Laura Price


TSPO in PH

Study
Evaluation of circulating endothelial inflammatory biomarkers in response to a 18kDa Translocator Protein (TSPO) ligand in pulmonary hypertension

IRAS no
302997

Study contact information
Name: Apple Joy Pinguel 
Email: a.pinguel@rbht.nhs.uk

Principal investigator
Dr Colm McCabe

Click here for more information


Re-PHIRE

Study
A Phase IIb Randomised, Double-blind, Placebo-controlled, Multi-centre, Dose-ranging Study of AZD3427 in Participants with Heart Failure and Pulmonary Hypertension due to Left Heart Disease (WHO Group 2)

IRAS no
1007304

Study contact information
Name: Keir Stirrat
Email: k.stirrat@rbht.nhs.uk

Principal investigator
Dr Ali Vazir

Click here for more information


GB002-3101 Efficacy and Safety of Seralutinib in Adult Subjects with PAH

Study
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Inhalation of Seralutinib for the Treatment of Pulmonary Arterial Hypertension (PAH)

IRAS no
1007953

Study contact information
Name: Apple Joy Pinguel 
Email: a.pinguel@rbht.nhs.uk

Principal investigator
Dr Colm McCabe

Click here for more information


Effectiveness of inhaled treprostinil versus standard of care for the treatment of pulmonary hypertension associated with interstitial lung disease

Study
Effectiveness of inhaled treprostinil versus standard of care for the treatment of pulmonary hypertension associated with interstitial lung disease: A propensity score-matched study of the INCREASE trial and registry data from the United Kingdom

IRAS no
340955

Study contact information
Name: Ifan Jenkin
Email: i.jenkin@rbht.nhs.uk

Principal investigator
Dr Laura Price

Click here for more information


PHoenix    

Study
A multicentre randomised cross-over trial of disease specific therapy in patients with Pulmonary Arterial Hypertension (PAH) implanted with pulmonary artery pressure and cardiac rhythm monitoring devices (CardioMEMS/Confirm Rx)

IRAS no
325120

Study contact information
Name: Meriel Woodruff
Email: m.woodruff@rbht.nhs.uk

Principal investigator
Dr Stephen John Wort

Click here for more information

DeVENT

Study
Decision support system to evaluate VENTilation in ARDS (DeVENT)

IRAS no
266521

Study contact information
Name: Natalie Dormand
Email: N.Dormand@rbht.nhs.uk

Principal investigator
Dr Brij Patel

Reducer-I

Study
Reducer-I: An observational study of the Neovasc Reducer System

IRAS no
190140

Study contact information
Name: Debra Dempster
Email: D.Dempster@rbht.nhs.uk

Principal investigator
Dr Ranil De Silva

Click here for more information


PPCI

Study
Lived experiences of heart attack and primary angioplasty (PPCI)

IRAS no
224728

Study contact information
Name: Marina Nicholas
Email: m.nicholas@rbht.nhs.uk

Principal investigator
Ms Marina Nicholas

Click here for more information

EBT in sarcoidosis

Study
Measure of exhaled breath temperature (EBT) in patients with sarcoidosis. 

IRAS no
215820

Study contact information
Name: Professor Athol Wells
Email: RBHILD@rbht.nhs.uk

Principal investigator
Professor Athol Wells

Click here for more information


MAGNET-CS Version 1

Study
Improving Assessment of Diagnosis and Prognosis in Cardiac Sarcoidosis

IRAS no
287964

Study contact information
Name: Dr Alessia Azzu
Email: A.Azzu@rbht.nhs.uk

Principal investigator
Professor Dudley Pennell


The role of conventional and advanced imaging modalities in formulating an optimal risk stratification strategy in patients with suspected cardiac sarcoidosis

Study
The role of conventional and advanced imaging modalities in formulating an optimal risk stratification strategy in patients with suspected cardiac sarcoidosis

IRAS no
310314

Study contact information
Name: Raheel Ahmed
Email: r.ahmed2@rbht.nhs.uk

Principal investigator
Dr Vasilis Kouranos


A Phase II study of CMK389 in patients with pulmonary sarcoidosis

Study
A subject and investigator blinded, randomized, placebo-controlled, repeat-dose, multicenter study to investigate efficacy, safety, and tolerability of CMK389 in patients with chronic pulmonary sarcoidosis

IRAS no
279463

Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk

Principal investigator
Dr Vasilis Kouranos

Click here for more information

No studies at present

UK Mini Mitral

Study
Minimally invasive thoracoscopically-guided right minithoracotomy versus conventional sternotomy for mitral valve repair: a multicentre randomised controlled trial (UK Mini Mitral)

IRAS no
204506

Study contact information
Name: Claire Prendergast
Email: c.prendergast2@rbht.nhs.uk

Principal investigator
Mr Toufan Bahrami

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Blood flow patterns from 4D-flow MRI

Study
Can blood flow patterns from 4D-flow MRI be used to predict aortic wall degradation?

IRAS no
231355

Study contact information
Name: Yousuf Salmasi
Email: M.Salmasi@rbht.nhs.uk

Principal investigator
Professor John Pepper

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Avr Thrombosis OutcoMe study (ATOM)

Study
Can thrombosis and fibrinolysis markers in patients undergoing aortic valve replacement predict outcome

IRAS no
259805

Study contact information
Name: Michelle Rackham
Email: M.Rackham@rbht.nhs.uk

Principal investigator
Dr Vasileios Panoulas

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OSPREY-CR Version 2

Study
Optimising Secondary PRevention and quality of life following EarlY Cardiac Rehabilitation: OSPREY-CR

IRAS no
278371

Study contact information
Name: Heather Probert
Email: H.Probert@rbht.nhs.uk

Principal investigator
Heather Probert

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4D Motion-2

Study
4D Motion of the aorta in the chest and simulated wall stress distribution in relation to aortic events

IRAS no
284431

Study contact information
Name: Dr Christoph Nienaber
Email: c.nienaber@rbht.nhs.uk

Principal investigator
Dr Christoph Nienaber


RESOLVE MR

Study
Real World Study of the Tendyne™ Mitral Valve System to Treat Mitral Regurgitation (Tendyne™ PMCF Study)

IRAS no
304570

Study contact information
Name: Anelise Catelan Zborowski
Email: a.catelanzborowski@rbht.nhs.uk

Principal investigator
Dr Alison Mary Duncan

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Fingerprinting proteoglycan turnover by ADAMTS proteases

Study
Fingerprinting proteoglycan turnover by ADAMTS proteases in the cardiovasculature

IRAS no
296129

Study contact information
Name: Professor John Pepper
Email: j.pepper@rbht.nhs.uk

Principal investigator
Professor John Pepper

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STRESS-MR - Haemodynamics of Mitral Regurgitation Reduction

Study
Comparative STudy chaRacterising the physiological changEs induced by Surgical and tranScatheter Mitral Regurgitation reduction - STRESS-MR

IRAS no
293585

Study contact information
Name: Dr Robert Smith
Email: r.smith@rbht.nhs.uk

Principal investigator
Dr Robert Smith

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Acorai MLG study

Study
A Multi-Site Observational Clinical Investigation to Collect Non-invasive Sensor Data During a Right Heart Catheterization and Train Machine Learning Models to Estimate Intracardiac Hemodynamic Parameters

IRAS no
328221

Study contact information
Name: Dr Owais Dar
Email: o.dar@rbht.nhs.uk

Principal investigator
Dr Owais Dar

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APOLLO-EU study

Study
Transcatheter Mitral Valve Replacement with the Medtronic IntrepidTM TMVR Transfemoral System in patients with severe symptomatic mitral regurgitation

IRAS no
319225

Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk

Principal investigator
Dr Alison Mary Duncan

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Prevention HARP 2

Study
Prevention of post-operative complications by using HMG-CoA reductase inhibitor in patients undergoing oesophagectomy. A multicentre, randomised, double blind, placebo controlled trial (Prevention HARP 2)

IRAS no
180853

Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk

Principal investigator
Mr Eric Lim

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TOPIC 2: Thoracic Epidural and Paravertebral Blocks in reducing CPTP

Study
A randomised controlled trial to investigate the effectiveness of Thoracic Epidural and Paravertebral Blockade in reducing Chronic Post-Thoracotomy Pain: 2

IRAS no
248427

Study contact information
Name: Dr Nandor Marczin
Email: N.Marczin@rbht.nhs.uk

Principal investigator
Dr Nandor Marczin

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CYCLONE- LVAD

Study
CYtosorb modulation of surgiCal infLammatiON during LVAD insErtion (CYCLONE-LVAD) study

IRAS no
230919

Study contact information
Name: Louise Moss
Email: L.McBrearty@rbht.nhs.uk

Principal investigator
Dr Nandor Marczin

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Millipede Feasibility Study

Study
A Study to Evaluate the Feasibility and Safety of the Millipede Transcatheter Annuloplasty Ring System in Patients with Functional Mitral Regurgitation

IRAS no
285206

Study contact information
Name: Debra Dempster
Email: D.Dempster@rbht.nhs.uk

Principal investigator
Dr Robert Smith

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BigpAK-2

Study
Biomarker- guided intervention to prevent acute kidney injury after major non-cardiac surgery - the prospective multicenter randomized controlled interventional trial

IRAS no
299561

Study contact information
Name: Alessandra Verzelloni
Email: a.verzellonisef@rbht.nhs.uk

Principal investigator
Dr Nandor Marczin

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STAR Registry

Study
Safe and Timely Antithrombotic Removal (STAR REGISTRY): International registry on the use of CytoSorb for removal of antithrombotic agents in the acute hospital setting.

IRAS no
301571

Study contact information
Name: Jovile Kazileviciute
Email: j.kazileviciute@rbht.nhs.uk

Principal investigator
Dr Nandor Marczin

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Embolization coil systems: RETRACTA and HILAL

Study
Embolization coil systems: RETRACTA and HILAL

IRAS no
307387

Study contact information
Name: Dr Carole Ridge
Email: c.ridge@rbht.nhs.uk

Principal investigator
Dr Carole Ridge

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CHIP-BCIS3

Study
Controlled trial of High-risk coronary Intervention with Percutaneous left ventricular unloading

IRAS no
290599

Study contact information
Name: Laura Barker
Email: l.barker2@rbht.nhs.uk

Principal investigator
Dr Vasileios Panoulas

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EuroSCORE 3

Study
EuroSCORE 3: recalibration of the EuroSCORE cardiac surgery risk model

IRAS no
300893

Study contact information
Name: Dr Sunil Bhudia
Email: s.bhudia@rbht.nhs.uk

Principal investigator
Sunil Bhudia


The CO2 study

Study
Carbon Dioxide Insufflation and Brain Protection During Open Heart Surgery. A Randomized Controlled Trial

IRAS no
278171

Study contact information
Name: Meriel Woodruff
Email: m.woodruff@rbht.nhs.uk

Principal investigator
Mr Shahzad G Raja

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Peak cough flow and respiratory function testing (spirometry)

Study
A cross sectional feasibility study examining the relationship between peak cough flow and respiratory function testing (spirometry) post bilateral sequential single lung transplantation, at a single centre cardiothoracic transplantation unit

IRAS no
218051

Study contact information
Name: Abigail Roberts
Email: A.Roberts@rbht.nhs.uk

Principal investigator
Dr Anna Reed

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LACTATE in OHT

Study
Significance of hyperlactataemia during heart transplantation.

IRAS no
259590

Study contact information
Name: Ms Ana Doce Hurtado
Email: A.HurtadoDoce@rbht.nhs.uk

Principal investigator
Ms Ana Doce Hurtado


PRIDEHEART 1.0

Study
PRImary graft Dysfunction Evaluation in HEART Transplantation (PRIDE-HEART) study

IRAS no
241344

Study contact information
Name: Mr Andre Simon
Email: A.Simon@rbht.nhs.uk

Principal investigator
Mr Andre Simon

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4D Flow CMR in Lung Transplant Assessment

Study
4D Flow Cardiovascular Magnetic Resonance analysis of the right ventricle in lung transplant assessment

IRAS no
270554

Study contact information
Name: Dr Joyce Wong
Email: J.Wong@rbht.nhs.uk

Principal investigator
Dr Joyce Wong

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Statins for Improving Organ Outcome in Transplantation (SIGNET)

Study
An evaluation of the benefits of a single dose of Simvastatin given to potential organ donors declared dead by neurological criteria on outcomes in organ recipients

IRAS no
288722

Study contact information
Name: Kamal Liyanage
Email: k.liyanage@rbht.nhs.uk

Principal investigator
Dr Hatem Soliman Aboumarie & Dr Sian Jaggar

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E-CLAD UK

Study
Extracorporeal Photopheresis in the treatment of Chronic Lung Allograft Dysfunction: a randomised controlled trial

IRAS no
1005642

Study contact information
Name: Dr Martin Carby
Email: m.carby@rbht.nhs.uk

Principal investigator
Dr Martin Carby

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Experience and Concerns in Organ Procurement and Transplantation

Study
An Insight into Perioperative Practitioners' Learning Experience and Concerns when Assisting Heart and Lung Organ Procurement and Transplantation

IRAS no
324868

Study contact information
Name: Ms Yi Wang
Email: y.wang@rbht.nhs.uk

Principal investigator
Ms Yi Wang


Sentinel skin flap in lung transplant RCT

Study
Efficacy and mechanism of sentinel skin flap reduction of solid organ (lung) transplant rejection: A randomised controlled trial

IRAS no
318347

Study contact information
Name: Hayley Meyrick
Email: 

Principal investigator
Dr Anna Reed

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Molecular and cellular pathogenesis of bone marrow failure syndromes

Study
Investigation of the molecular and cellular pathogenesis of bone marrow failure syndromes

IRAS no
97361

Study contact information
Name: Mr Andreas Hoschtitzky
Email: A.Hoschtitzky@rbht.nhs.uk

Principal investigator
Mr Andreas Hoschtitzky


Multisystem and autonomic complications of NMD on NIV

Study
Growing up on non-invasive ventilation: assessment of multisystem and autonomic complications of neuromuscular and neurological disorders in young adults.

IRAS no
266270 

Study contact information
Name: Lydia Spurr
Email: l.spurr@rbht.nhs.uk

Principal investigator
Professor Anita Simonds


Characterisation of Large Airway Collapse during Exercise (LACE)

Study
The Feasibility of Continuous Bronchoscopy During Exercise in Healthy Adults in Assessing Large Airways Collapse

IRAS no
268188

Study contact information
Name: Alexandros Mitropoulos
Email: A.Mitropoulos@rbht.nhs.uk

Principal investigator
Dr James Hull


Grenfell Firefighters Study

Study
The Grenfell firefighters study; establishing a cohort

IRAS no
265618

Study contact information
Name: Professor Paul Cullinan
Email: p.cullinan@imperial.ac.uk

Principal investigator
Professor Paul Cullinan


University of Cambridge NHS health data consent survey

Study
University of Cambridge NHS health data consent survey. 

IRAS no
268811

Study contact information
Name: Sara Salmi
Email: S.Salmi@rbht.nhs.uk

Principal investigator
Sara Salmi


Lung Health Check Biomarker Study

Study
Lung Health Check Biomarker Study

IRAS no
258696

Study contact information
Name: Dr Benjamin Hunter
Email: B.Hunter@rbht.nhs.uk

Principal investigator
Professor Anand Devaraj

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PaD Strat Study

Study
PaD Strat Study

IRAS no
285609

Study contact information
Name: Melissa Rochon
Email: M.Rochon@rbht.nhs.uk

Principal investigator
Melissa Rochon


Measurement of ISDs and creatinine by LC-MS/MS in VAMS samples

Study
Development and validation of a method for measurement of tacrolimus, ciclosporin, and creatinine in whole blood via 2D turboflow HPLC coupled with tandem mass spectrometry, using VAMS micro sampling techniques.

IRAS no
302783

Study contact information
Name: Mr Zain Odho
Email: Z.Odho@rbht.nhs.uk

Principal investigator
Mr Zain Odho


Tool Placement in Pulmonary Nodule using a Robotic Bronchoscopy System

Study
A Prospective Investigation to Assess the Accurate Tool Placement in Pulmonary Nodule(s) using a Robotic
Navigational Bronchoscopy System with Adjunct Real-time Imaging

IRAS no
308868

Study contact information
Name: Professor Pallav Shah
Email: p.shah@rbht.nhs.uk

Principal investigator
Professor Pallav Shah

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The Physiotherapy Assessment of Breathing Pattern Dysfunction (PHAB)

Study
An evaluation of physiotherapy assessment: A mixed methods study to evaluate the physiotherapy assessment of Breathing Pattern Disorder

IRAS no
315897

Study contact information
Name: Lizzie Grillo
Email: l.grillo@rbht.nhs.uk

Principal investigator
Lizzie Grillo


Unreported secondary findings in diagnostic Next Generation Sequencing: A retrospective study

Study
Unreported secondary findings in diagnostic Next Generation Sequencing: A retrospective study

IRAS no
326738

Study contact information
Name: Dr Deborah Morris-Rosendahl
Email: d.morris-rosendahl@rbht.nhs.uk

Principal investigator
Dr Deborah Morris-Rosendahl


Patient codesign

Study
Patients as learners and codesigners: an examination of patients’ engagement and experience of codesign of an educational resource

IRAS no
328243

Study contact information
Name: Ms Melissa Rochon
Email: melissa.rochon@gstt.nhs.uk

Principal investigator
Ms Melissa Rochon


Microbiome and Metabolome in Healthy Volunteers (MATINEE Study)

Study
Investigating the stool and saliva microbiome and metabolome in healthy volunteers (The MATINEE Study). An observational cohort study

IRAS no
322270

Study contact information
Name: David Smith
Email: d.smith22@rbht.nhs.uk

Principal investigator
Professor Philip Molyneaux