Details of all our active research studies which are looking for volunteers, with more information about what each project entails and what kind of volunteers would be most suitable.
Early COPD cohort study
COPD is a life-long condition that makes breathing difficult because the airways have been narrowed. People living with COPD will feel out of breath doing everyday tasks such as housework or walking the dog. Though 20% of people with COPD have never smoked and not all smokers develop COPD - it is mainly caused by smoking from early adulthood. Find out more.
The MISTER trial
The MISTER trial is looking at testing whether minimal equipment pulmonary rehabilitation classes are as effective as those that use specialist equipment in terms of the effect on fitness levels, breathlessness and quality of life in the short and medium term. Find out more.
Epidemiology and prognosis in acute myocarditis
Myocarditis is a disease heart muscle caused by inflammation. This study aims to provide a contemporary, population-level assessment of the true clinical burden of myocarditis and how this may have changed over the last 20 years. Find out more.
See details of our performance for all clinical trials reported to the NIHR, for the Initiation and Delivery of studies in the period from 1 October 2020 to 31 March 2021.
Active research studies
DeVENT
Study
Decision support system to evaluate VENTilation in ARDS (DeVENT)
IRAS no
266521
Study contact information
Name: Mahitha Gummadi
Email: m.gummadi@rbht.nhs.uk
Principal investigator
Dr Brijesh Patel
GenOMICC
Study
Genetics of susceptibility and mortality in critical care
IRAS no
269326
Study contact information
Name: Natalie Dormand (Royal Brompton), Paula Rogers (Harefield)
Email: N.Dormand@rbht.nhs.uk, p.rogers@rbht.nhs.uk
Principal investigator
Dr Brijesh Patel
Click here for more information
ISARIC CCP
Study
WHO ISARIC Clinical Characterisation Protocol for Severe Emerging Infection UK (CCP-UK) / Novel Coronavirus Observational Study
IRAS no
126600
Study contact information
Name: Natalie Dormand (Royal Brompton), Paula Rogers (Harefield)
Email: N.Dormand@rbht.nhs.uk, p.rogers@rbht.nhs.uk
Principal investigator
Dr Brijesh Patel
Click here for more information
RECOVERY
Study
Randomised Evaluation of COVID-19 Therapy (RECOVERY)
IRAS no
281712
Study contact information
Name: Jessica Wallen (Royal Brompton), Claire Prendergast (Harefield)
Email: J.Wallen@rbht.nhs.uk, C.Prendergast2@rbht.nhs.uk
Principal investigator
Dr Anand Shah (Royal Brompton), Dr Anna Reed (Harefield)
Click here for more information
REMAP-CAP
Study
Randomised, Embedded, Multifactorial Adaptive Platform trial for Community-Acquired Pneumonia
IRAS no
237150
Study contact information
Name: Debra Dempster (Royal Brompton), Claire Prendergast (Harefield)
Email: D.Dempster@rbht.nhs.uk, C.Prendergast2@rbht.nhs.uk
Principal investigator
Dr Brijesh Patel
Click here for more information
Heart-ACS COVID-19
Study
COVID-19 as a Trigger/Risk Factor in Acute Coronary Syndromes
IRAS no
259087
Study contact information
Name: Laura Barker
Email: l.barker2@rbht.nhs.uk
Principal investigator
Dr Miles Dalby
Click here for more information
Coagulation markers in patients with severe COVID-19
Study
Coagulation markers on discarded plasma samples from patients with severe COVID-19
IRAS no
283525
Study contact information
Name: Deepa Arachchillage
Email: D.JayakodyArachchillage@rbht.nhs.uk
Principal investigator
Dr Deepa Arachchillage
Click here for more information
PROSAIC-19
Study
PROSAIC-19 – Prospective longitudinal assessment in a COVID-19 infected cohort
IRAS no
282739
Study contact information
Name: Katherine Rhatigan
Email: K.Rhatigan@rbht.nhs.uk
Principal investigator
Dr Anand Shah
Click here for more information
RECOVERY - Respiratory Support
Study
Ventilation Strategies in COVID-19; CPAP, High-flow, and standard care
IRAS no
282338
Study contact information
Name: Ashraf Hussain
Email: A.Hussain@rbht.nhs.uk
Principal investigator
Professor Anita Simonds
Click here for more information
Thrombosis and organ ischemia/inflammation in ICU admitted COVID-19
Study
Computer Tomography findings of vascular thrombosis, and abdominal organ ischemia and inflammation in Critically ill COVID-19 patients
IRAS no
286154
Study contact information
Name: Dr Saeed Mirsadraee
Email: S.Mirsadraee@rbht.nhs.uk
Principal investigator
Dr Saeed Mirsadraee
UNITE-COVID
Study
European Society of Intensive Care Medicine Covid-19 Project (Unite-Covid-19)
IRAS no
284289
Study contact information
Name: Dr Giulia Crapelli
Email: G.Crapelli@rbht.nhs.uk
Principal investigator
Dr Giulia Crapelli
Coagulopathy associated with COVID 19 (CA-COVID19) A Multi-Centre observational study in UK
Study
Coagulopathy associated with COVID 19 (CA-COVID19) A Multi-Centre observational study in UK
IRAS no
282298
Study contact information
Name: Dr Deepa Arachchillage
Email: D.JayakodyArachchillage@rbht.nhs.uk
Principal investigator
Dr Deepa Arachchillage
CLASSIC
Study
The Clinical and psychosocial impact of COVID-19 on patients with neuromuscular and neurological disorders
IRAS no
286495
Study contact information
Name: Dr Lydia Spurr
Email: L.Spurr@rbht.nhs.uk
Principal investigator
Professor Anita Simonds
CLUE (COVID-19 Flu ECMO)
Study
A retrospective cohort study comparing the differences in baseline characteristics and outcomes in patients with influenza and COVID-19 treated with veno-venous extracorporeal membrane oxygenation (ECMO)
IRAS no
285452
Study contact information
Name: Dr Benjamin Garfield
Email: B.Garfield@rbht.nhs.uk
Principal investigator
Dr Stephane Ledot
Click here for more information
COACHED Study
Study
COVID-19 infection and Congenital Heart Disease Study (COACHeD Study)
IRAS no
283054
Study contact information
Name: Professor Piers Daubeney
Email: P.Daubeney@rbht.nhs.uk
Principal investigator
Professor Piers Daubeney
Click here for more information
Narratives of NHS nurses working in ICUs during the COVID-19 pandemic
Study
Narratives of NHS nurses working in ICUs during the COVID-19 pandemic
IRAS no
284812
Study contact information
Name: Dr Melissa Sanchez
Email: M.Sanchez@rbht.nhs.uk
Principal investigator
Dr Melissa Sanchez
Click here for more information
PHOSP-COVID
Study
Post-hospitalisation COVID-19 study: a national consortium to understand and improve long-term health outcomes.
IRAS no
285439
Study contact information
Name: Merriel Woodruff
Email: M.Woodruff@rbht.nhs.uk
Principal investigator
Dr Brijesh Patel
Click here for more information
EARSATS-19
Study
EARSATS-19: In-ear measurement of blood oxygen saturation in COVID-19 follow up
IRAS no
285603
Study contact information
Name: Dr Zhe Wu
Email: Z.Wu@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
CAPACITY-COVID
Study
Cardiac complicAtions in Patients with SARS Corona vIrus 2 regisTrY (CAPACITY)
IRAS no
285603
Study contact information
Name: Professor Sanjay Prasad
Email: S.Prasad@rbht.nhs.uk
Principal investigator
Professor Sanjay Prasad
Click here for more information
COVID-HEART study
Study
Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: the COVID-HEART study
IRAS no
285147
Study contact information
Name: Kevin Kirby
Email: K.Kirby@rbht.nhs.uk
Principal investigator
Professor Sanjay Prasad
Click here for more information
CAPACITY-COVID
Study
Cardiac complicAtions in Patients with SARS Corona vIrus 2 regisTrY (CAPACITY)
IRAS no
282872
Study contact information
Name: Professor Sanjay Prasad
Email: S.Prasad@rbht.nhs.uk
Principal investigator
Professor Sanjay Prasad
Click here for more information
Identifying incidence and nature of Fatigue in Individuals infected with COVID-19 (SARS-Cov-2) in the UK
Study
Identifying incidence and nature of Fatigue in Individuals infected with COVID-19 (SARS-Cov-2) in the United Kingdom
IRAS no
284760
Study contact information
Name: Avantika Tailor
Email: A.Tailor@rbht.nhs.uk
Principal investigator
Avantika Tailor
Click here for more information
HEAL-COVID trial
Study
HElping Alleviate the Longer-term consequences of COVID-19(HEAL-COVID): a national platform trial
IRAS no
294861
Study contact information
Name: Michelle Rackham
Email: M.Rackham@rbht.nhs.uk
Principal investigator
Dr William Man
Click here for more information
UKILD-Long COVID
Study
The UK Interstitial Lung Disease Long-COVID19 study (UKILD-Long COVID): understanding the burden of Interstitial Lung Disease in Long COVID
IRAS no
297891
Study contact information
Name: David Smith
Email: d.smith22@rbht.nhs.uk
Principal investigator
Dr Peter George
Click here for more information
Cardiovascular burden in COVID-19 patients
Study
Clinical utility of non-invasive cardiac investigations following infection with COVID-19: a retrospective observational study
IRAS no
311937
Study contact information
Name: Dr Sundeep Kaul
Email: s.kaul@rbht.nhs.uk
Principal investigator
Dr Sundeep Kaul
Concorde Study
Study
Acute Respiratory Syndome coronavirus and ACE-2 study
IRAS no
296463
Study contact information
Name: James Tonkin
Email: j.tonkin@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
GEMINI
Study
Assessment of clinical practice of mechanical ventilation after COVID-19 pandemic among 55 countries: A systematic analysis for the Global Burden of Mechanical Ventilation (GEMINI study) 2022
IRAS no
317449
Study contact information
Name: Dr Brijesh Patel
Email: b.patel4@rbht.nhs.uk
Principal investigator
Dr Brijesh Patel
PROTECT V
Study
PROphylaxis for paTiEnts at risk of COVID-19 infecTion
IRAS no
288652
Study contact information
Name: Deirdre Flannery
Email: d.flannery@rbht.nhs.uk
Principal investigator
Professor Philip Molyneaux
Treatment in adults with severe bilateral nasal polyps
Study
A randomised, double-blind, parallel group PhIII study to assess the clinical efficacy and safety of 100 mg SC Mepolizumab as an add on to maintenance treatment in adults with severe bilateral nasal polyps.
IRAS no
220783
Study contact information
Name: Aarif Eifan
Email: A.Eifan@rbht.nhs.uk
Principal investigator
Dr Guy Scadding
Click here for more information
Pollen food allergy syndrome in adults with IBS
Study
A prospective observational cohort study to determine the prevalence of pollen food allergy syndrome (PFS) in adults with Irritable Bowel Syndrome (IBS)
IRAS no
229644
Study contact information
Name: Dr Isabel Skypala
Email: i.skypala@rbht.nhs.uk
Principal investigator
Dr Isabela Skypala
Click here for more information
Nasal allergen challenge: standardisation as a surrogate for hay fever
Study
Nasal Allergen Challenge: standardisation as a surrogate for hay fever
IRAS no
266165
Study contact information
Name: Aarif Eifan
Email: A.Eifan@rbht.nhs.uk
Principal investigator
Professor Stephen Durham
Click here for more information
Grass Immunotherapy plus Dupilumab for Tolerance Evaluation
Study
Grass Pollen Sublingual Tablet Immunotherapy plus Dupilumab for Induction of Tolerance in Adults with Moderate to Severe Seasonal Allergic Rhinitis.
IRAS no
275309
Study contact information
Name: Aarif Eifan
Email: A.Eifan@rbht.nhs.uk
Principal investigator
Professor Stephen Durham
Click here for more information
HDM and Silver Birch NAC Standardisation
Study
Nasal Allergen Challenge: standardisation for house dust mite and silver birch allergen extracts
IRAS no
84388
Study contact information
Name: Aarif Eifan
Email: A.Eifan@rbht.nhs.uk
Principal investigator
Dr Guy Scadding
Cardiac Resynchronisation Therapy in non-responders and previously untreatable patients
Study
Stimulation of the left ventricular endocardium for Cardiac Resynchronisation Therapy in non-responders and previously untreatable patients
IRAS no
288696
Study contact information
Name: Paula Rogers
Email: P.Rogers@rbht.nhs.uk
Principal investigator
Dr Mark Mason
Role of ganglionated plexus ablation for catheter ablation of paroxysmal and persistent atrial fibrillation
Study
A pilot study on the role of ganglionated plexus ablation for catheter ablation of paroxysmal and persistent atrial fibrillation
IRAS no
133593
Study contact information
Name: Dr Sabine Ernst
Email: s.ernst@rbht.nhs.uk
Principal investigator
Dr Sabine Ernst
Click here for more information
WATCHMAN device in patients unsuitable for oral anticoagulation
Study
Assessment of the WATCHMAN device in patients unsuitable for oral anticoagulation
IRAS no
222284
Study contact information
Name: Carmen Chan
Email: L.Chan2@rbht.nhs.uk
Principal investigator
Dr Tom Wong
EndoCRT study
Study
A randomised double-blinded cross over study to evaluate the improvement of left ventricular systolic failure using targeted left ventricular endocardial lead placement in cardiac resynchronisation therapy (EndoCRT)
IRAS no
138184
Study contact information
Name: Lisa Jones
Email: l.jones2@rbht.nhs.uk
Principal investigator
Dr Tom Wong
Click here for more information
Immediate coronary angiography after out of hospital cardiac arrest (ARREST)
Study
ImmediAte CoRonary AngiogRaphy aftEr Ventricular Fibrillation OutOfHospital Cardiac ArreST (ARREST)
IRAS no
125842
Study contact information
Name: Dr Miles Dalby
Email: M.Dalby@rbht.nhs.uk
Principal investigator
Dr Miles Dalby
Click here for more information
NOAH - AFNET 6
Study
Non-vitamin K antagonist Oral anticoagulants in patients with Atrial High rate episodes
IRAS no
194491
Study contact information
Name: Dr Shouvik Haldar
Email: S.Haldar@rbht.nhs.uk
Principal investigator
Dr Shouvik Haldar
Click here for more information
VIVOTM mapping protocol
Study
VIVOTM non-invasive mapping of ventricular arrhythmia
IRAS no
257755
Study contact information
Name: Dr Ilaria Cazzoli
Email: I.Cazzoli@rbht.nhs.uk
Principal investigator
Dr Ilaria Cazzoli
SPOT - FRAILTY
Study
A Pilot Study to exPlOre the exisTence and impact of FRAILTY in patients over the age of 70 undergoing cardiac interventions.
IRAS no
264744
Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk
Principal investigator
Paula Rogers
Long Term Outcomes in CASA AF LSPAF
Study
Long--term Outcomes in Long Standing Persistent Atrial Fibrillation Following Catheter Or Thoracoscopic Surgical Ablation : Extended Follow-Up Of CASA-AF Randomised Controlled Trial
IRAS no
271930
Study contact information
Name: Dr Tom Wong
Email: T.Wong2@rbht.nhs.uk
Principal investigator
Dr Tom Wong
Click here for more information
LEADLESS II
Study
The LEADLESS Pacemaker IDE Study
IRAS no
282749
Study contact information
Name: Annelise Catelan Zborowski
Email: A.CatelanZborowski@rbht.nhs.uk
Principal investigator
Dr Tom Wong
Click here for more information
PACESIM
Study
A Basic Science Study of Optimised Temporary Pacing in Patients following Cardiac Surgery in Order to Build a Pacing Simulator and Automatic Alerting Algorithm.
IRAS no
292373
Study contact information
Name: Dr Mark Mason
Email: M.Mason@rbht.nhs.uk
Principal investigator
Dr Mark Mason
Click here for more information
Analysis of electrograms in cardiac arrhythmia
Study
Analysis of electrograms in cardiac arrhythmia to aid diagnosis and patient stratification
IRAS no
293374
Study contact information
Name: Dr Haseeb Valli
Email: h.valli@rbht.nhs.uk
Principal investigator
Dr Tom Wong
AVEIR DR i2i Study
Study
Aveir Dual-Chamber Leadless i2i IDE Study
IRAS no
308539
Study contact information
Name: Sara Salmi
Email: s.salmi@rbht.nhs.uk
Principal investigator
Dr Tom Wong
Click here for more information
Rhythm or rate control for CRT: the RHYTHMIC study
Study
Rhythm or rate control for CRT: the RHYTHMIC study
IRAS no
265388
Study contact information
Name: Sara Salmi
Email: s.salmi@rbht.nhs.uk
Principal investigator
Dr Vias Markides
Heterogeneity of asthma
Study
Heterogeneity of asthma: a pilot study to investigate its microbiome and how it relates to asthma severity
IRAS no
163724
Study contact information
Name: Cai Sim
Email: c.sim@rbht.nhs.uk
Principal investigator
Professor Kian Fan Chung
Click here for more information
Adherence to inhaled corticosteroids in young people with problematic severe asthma
Study
Adherence to inhaled corticosteroids in young people with problematic severe asthma
IRAS no
188453
Study contact information
Name: Dr Louise Fleming
Email: l.fleming@rbht.nhs.uk
Principal investigator
Dr Louise Fleming
Click here for more information
Unwanted effects of inhaled corticosteriods in children with airway diseases
Study
Unwanted effects of inhaled corticosteroids in children with airway diseases
IRAS no
227592
Study contact information
Name: Louise Selby
Email: L.Selby@rbht.nhs.uk
Principal investigator
Dr Louise Fleming
Click here for more information
Fluctuation of airway function in children with asthma phenotype as a predictor of outcome
Study
Fluctuation of airway function in children with asthma phenotype as a predictor of outcome
IRAS no
154768
Study contact information
Name: Dr Louise Fleming
Email: l.fleming@rbht.nhs.uk
Principal investigator
Dr Louise Fleming
Click here for more information
A randomised pragmatic trial of corticosteriod optimisation in severe asthma
Study
A randomised pragmatic trial of corticosteroid optimisation in severe asthma using a composite biomarker algorithm to adjust corticosteroid dose versus standard care
IRAS no
182421
Study contact information
Name: Maria Martins
Email: M.Martins@rbht.nhs.uk
Principal investigator
Dr Andrew Menzies-Gow
Click here for more information
Severe wheeze and asthma validation study
Study
Pulmonary epithelial barrier and immunological functions at birth and in early life: key determinants of the development of asthma? Severe wheeze and asthma validation study
IRAS no
216021
Study contact information
Name: Mindy Gore
Email: s.saglani@imperial.ac.uk
Principal investigator
Professor Sejal Saglani
Click here for more information
Do patterns of airway infection and inflammation distinguish pathophys and asthma?
Study
Do patterns of airway infection and inflammation distinguish pathophysiological phenotypes in children with wheeze and asthma?
IRAS no
187435
Study contact information
Name: Yvonne Bingham
Email: Y.Bingham@rbht.nhs.uk
Principal investigator
Professor Sejal Saglani
Click here for more information
Targets of bronchial thermoplasty in severe asthma
Study
Targets of bronchial thermoplasty in severe asthma
IRAS no
150245
Study contact information
Name: Dr Karthikan Srikanthan
Email: K.Srikanthan@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
Th2-low endotype biomarkers in exercise-induced asthma
Study
Th2-low endotype biomarkers in exercise-induced asthma
IRAS no
203756
Study contact information
Name: Sally Meah
Email: sally.meah@imperial.ac.uk
Principal investigator
Dr Omar Usmani
Click here for more information
The use of home-monitoring and mHealth systems to predict asthma control and asthma
Study
The use of home-monitoring and mHealth systems to predict asthma control and asthma exacerbations
IRAS no
185603
Study contact information
Name: Paolo Paredi
Email: P.Paredi@rbht.nhs.uk
Principal investigator
Dr Omar Usmani
Click here for more information
National Validation and Sensitivity to Change of the SAQ
Study
National Validation and Sensitivity to Change of a scale to measure quality of life in patients with severe asthma.
IRAS no
250167
Study contact information
Name: Rachel Stead
Email: R.Stead@rbht.nhs.uk
Principal investigator
Dr Andrew Menzies-Gow
Click here for more information
Phase IIA study of PC945 in Aspergillosis on Asthmatic subjects
Study
A double-blind, placebo-controlled study to assess the effects of inhaled PC945 in the treatment of culture-positive Aspergillus fumigatus infection in subjects with moderate to severe asthma
IRAS no
246673
Study contact information
Name: Najwa Soussi
Email: n.soussi@rbht.nhs.uk
Principal investigator
Dr Darius Armstrong-James
Click here for more information
DPI Airflow Resistance
Study
Patient’s Perception of Dry Powder Inhaler Airflow Resistance
IRAS no
235776
Study contact information
Name: Sally Meah
Email: S.Meah@rbht.nhs.uk
Principal investigator
Dr Omar Usmani
INHALE study
Study
INHALE: Personal pollution exposure and effects on the lungs in healthy and asthmatic individuals
IRAS no
270153
Study contact information
Name: Sally Meah
Email: S.Meah@rbht.nhs.uk
Principal investigator
Professor Fan Chung
Click here for more information
PRISM: Precision medicine in severe asthma
Study
PRISM: Molecular phenotyping of participants with severe asthma to determine response to biologic therapies and stability
IRAS no
273192
Study contact information
Name: Sally Meah
Email: S.Meah@rbht.nhs.uk
Principal investigator
Professor Fan Chung
P-CLESA
Study
Phenotyping circulating and lung resident eosinophils in severe asthma
IRAS no
152907
Study contact information
Name: Sally Meah
Email: S.Meah@rbht.nhs.uk
Principal investigator
Dr Pankaj Bhavsar
Prospective Study of Cellular & Clinical Aspects of Mod-Severe Asthma
Study
Prospective Study of Cellular & Clinical Aspects of Moderate to Severe Asthma
IRAS no
254003
Study contact information
Name: Lola Loewenthal
Email: L.Loewenthal@rbht.nhs.uk
Principal investigator
Professor Andrew Menzies-Gow
Measuring hydrogen peroxide in exhaled breath condensate in HV
Study
Assessment and validation of a device for measuring hydrogen peroxide in exhaled breath condensate in Healthy Volunteers
IRAS no
289549
Study contact information
Name: Sally Meah
Email: S.Meah@rbht.nhs.uk
Principal investigator
Dr Omar Usmani
Click here for more information
MODESA
Study
Mitochondrial dysfunction of eosinophils as a driving force for its activation in eosinophilic severe asthma
IRAS no
293693
Study contact information
Name: Sally Meah
Email: S.Meah@rbht.nhs.uk
Principal investigator
Professor Fan Chung
Click here for more information
Benralizumab Exacerbation Study
Study
Asthma Exacerbation Profile in patients on open label treatment with Benralizumab for severe eosinophilic asthma - an exploratory cohort study
IRAS no
256756
Study contact information
Name: Ashraf Hussain
Email: a.hussain@rbht.nhs.uk
Principal investigator
Dr Pujan Patel
Click here for more information
WAYFINDER
Study
A Multicentre, Single-arm, Phase 3b Efficacy and Safety Study of Tezepelumab 210 mg Administered Subcutaneously to Reduce Oral Corticosteroid Use in Adult Participants with Severe Asthma on High-dose Inhaled Corticosteroid plus Long-acting ß2 Agonist
IRAS no
1004972
Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk
Principal investigator
Professor Andrew Menzies-Gow
Click here for more information
Real world use of dupilumab for severe asthma (DUPIAZA)
Study
Real-world experience of dupilumab for the treatment of severe asthma in the United Kingdom: a retrospective study. An observational, retrospective multicentre medical record review to describe the post-authorisation early clinical experience of dupilumab in the treatment of adult severe asthma.
IRAS no
320583
Study contact information
Name: Pujan Patel
Email: p.patel@rbht.nhs.uk
Principal investigator
Dr Pujan Patel
Utilising novel dipole density capabilities to objectively visualise the etiology of recurrent atrial fibrillation following a failed AF ablation
Study
Utilising novel dipole density capabilities to objectively visualize the etiology of recurrent atrial fibrillation following a failed AF ablation
IRAS no
239296
Study contact information
Name: Debra Dempster
Email: D.Dempster@rbht.nhs.uk
Principal investigator
Dr Tom Wong
Click here for more information
Concomitant epicardial ledt atrial appendage closure and catheter ablation
Study
A study of concomitant epicardial left atrial appendage closure and catheter ablation in treating recurrent persistent atrial fibrillation after failed previous ablation
IRAS no
229383
Study contact information
Name: Peng Zhang
Email: p.zhang@rbht.nhs.uk
Principal investigator
Dr Tom Wong
Click here for more information
Catheter versus thoracoscopic surgical ablation in long standing persistent Atrial Fibrillation
Study
Catheter versus thoracoscopic surgical ablation in long standing persistent Atrial Fibrillation - multicentre randomised control trial
IRAS no
155944
Study contact information
Name: Paula Rogers
Email: P.Rogers@rbht.nhs.uk
Principal investigator
Dr Tom Wong
Click here for more information
VITAL - The VyronUS Image Then Ablate study
Study
Clinical investigation of the VytronUS Ablation System for Treatment of Symptomatic Drug-refractory Paroxysmal Atrial Fibrillation (VITAL)
IRAS no
230460
Study contact information
Name: Dr Tom Wong
Email: T.Wong2@rbht.nhs.uk
Principal investigator
Dr Tom Wong
Click here for more information
Map Registry of Procedural Long-term Clinical Outcomes
Study
AcQMap® Global Registry of Procedural and Long-term Clinical Outcomes.
IRAS no
258348
Study contact information
Name: Mathew Varghese
Email: M.Varghese@rbht.nhs.uk
Principal investigator
Dr Tom Wong
Click here for more information
High density mapping guided ablation for Persistent AF
Study
High density substrate evaluation and guided ablation therapy for atrial fibrillation: Heat-AF
IRAS no
263083
Study contact information
Name: Dr Haseeb Valli
Email: H.Valli@rbht.nhs.uk
Principal investigator
Dr Haldar Shouvik
Click here for more information
ReCETT-AF
Study
Realistic Computational Electrophysiology Simulations for Targeted Treatment of Atrial Fibrillation
IRAS no
285221
Study contact information
Name: Dr Shouvik Haldar
Email: s.haldar@rbht.nhs.uk
Principal investigator
Dr Shouvik Haldar
Click here for more information
REMEDY-PILOT
Study
Reducing microvascular dysfunction in patients with angina, ischaemia and unobstructed coronary arteries – a pilot study (REMEDY-PILOT)
IRAS no
295523
Study contact information
Name: Carmen Chan
Email: l.chan2@rbht.nhs.uk
Principal investigator
Dr Ranil De Silva
The gut microbiome in rheumatoid arthritis and bronchiectasis
Study
The gut microbiome in rheumatoid arthritis and bronchiectasis
IRAS no
222542
Study contact information
Name: Cheyanne Kailla
Email: c.kailla@rbht.nhs.uk
Principal investigator
Dr Rosemary Boyton
Click here for more information
Observational cohort and Biobank UK Study
Study
Observational cohort and Biobank UK Study
IRAS no
173303
Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk
Principal investigator
Professor Michael Loebinger
Click here for more information
Efficacy and safety of 12 months of therapy with inhaled Promixin (colistimethate sodium)
Study
A double-blind, placebo controlled, multicentre, clinical trial to investigate the efficacy and safety of 12 months of therapy with inhaled Promixin (colistimethate sodium) in the treatment of subjects with non-cystic fibrosis bronchiectasis
IRAS no
213606
Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk
Principal investigator
Professor Michael Loebinger
Click here for more information
The Clear study
Study
A 2x2 factorial randomised single blind open labelled trial to determine the clinical and cost -effectiveness of hypertonic saline (HTS 6%) and carbocysteine versus usual care over 12 months in non-cystic fibrosis bronchiectasis (BE): The Clear study
IRAS no
214254
Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk
Principal investigator
Professor Michael Loebinger
Click here for more information
BronchUK: Clinimetric properties of outcome measures in bronchiectasis in the UK
Study
BronchUK: Clinimetric properties of outcome measures in bronchiectasis in the UK
IRAS no
166832
Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk
Principal investigator
Professor Michael Loebinger
Click here for more information
The EMBARC European Bronchiectasis Registry
Study
The EMBARC European Bronchiectasis Registry
IRAS no
165833
Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk
Principal investigator
Professor Michael Loebinger
Click here for more information
The Willow Study
Study
A Randomised, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center Study to Assess the Efficacy, Safety and Tolerability, and Pharmacokinetics of INS1007 Administered Once Daily for 24 Weeks in Subjects with Non-Cystic Fibrosis Bronchiectasis
IRAS no
233267
Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk
Principal investigator
Professor Michael Loebinger
Click here for more information
The BRIDGE study
Study
The BRIDGE study- Bronchiectasis Research Involving Databases, Genomics and Endotyping to match the right treatment to the right patient
IRAS no
228760
Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk
Principal investigator
Professor Michael Loebinger
Click here for more information
VITAL-BE
Study
A Trial of the Safety, Tolerability and Efficacy of 2 doses of Cayston (Aztreonam Lysine) compared to placebo in participants with bronchiectasis
IRAS no
252929
Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk
Principal investigator
Professor Michael Loebinger
Click here for more information
Efficacy of domiciliary non-invasive ventilation in patients with respiratory failure due to non-CF bronchiectasis
Study
Efficacy of domiciliary non-invasive ventilation in patients with respiratory failure due to non-CF bronchiectasis
IRAS no
288577
Study contact information
Name: Dr Ricardo Jose
Email: R.Jose@rbht.nhs.uk
Principal investigator
Dr Ricardo Jose
Efficacy of domiciliary non-invasive ventilation in patients with respiratory failure due to non-CF bronchiectasis
Study
A randomised, subject- and investigator-blinded, placebo controlled, parallel group study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of QBW251 in patients with bronchiectasis
IRAS no
287333
Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk
Principal investigator
Professor Michael Loebinger
Efficacy and Safety of Dupilumab in Participants with ABPA
Study
A randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of dupilumab in patients with allergic bronchopulmonary aspergillosis
IRAS no
282605
Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk
Principal investigator
Dr Anand Shah
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MAHALE
Study
A Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled, 52-Week, Phase III Study With an Open-label Extension to Evaluate the Efficacy and Safety of Benralizumab in Patients With Non-Cystic Fibrosis Bronchiectasis With Eosinophilic
IRAS no
1003536
Study contact information
Name: Selvy Raju
Email: S.Raju@rbht.nhs.uk
Principal investigator
Professor Michael Loebinger
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Phase III clinical trials in patients with Non-Cystic Fibrosis Bronchiectasis (NCFBE)
Study
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multi-Center Study to Assess the Efficacy, Safety and Tolerability of INS1007 Administered Once Daily for 52 Weeks in Subjects with Non-Cystic Fibrosis Bronchiectasis INS1007-301
IRAS no
1003433
Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk
Principal investigator
Dr Michael Loebinger
Click here for more information
Safety and efficacy of PC945 for the treatment of refractory invasive pulmonary aspergillosis
Study
A double-blind, randomized, placebo-controlled study to assess the safety and efficacy of nebulized PC945 when added to systemic antifungal therapy for the treatment of refractory invasive pulmonary aspergillosis
IRAS no
1004474
Study contact information
Name: Dr Anna Reed
Email: a.reed@rbht.nhs.uk
Principal investigator
Dr Anna Reed
Circulating cells in advanced cancer
Study
Sample collection study to explore CIrCulating tumour cells, cell free DNA and leucocytes with ImagesTReam analysis in patients with various cancers
IRAS no
198179
Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk
Principal investigator
Paula Rogers
Click here for more information
ATX-TBL-001 Tissue Research Protocol
Study
Prospective collection of donor tissue and blood or leukapheresis product from patients with solid tumours to enable development of methods for the manufacturing of clonal neoantigen T cell products (cNeT).
IRAS no
233696
Study contact information
Name: Professor Eric Lim
Email: E.Lim@rbht.nhs.uk
Principal investigator
Professor Eric Lim
CHILO
Study
Inhalation challenge to assess Inducible Laryngeal Obstruction CHILO.
IRAS no
250025
Study contact information
Name: Dr James Hull
Email: j.hull@rbht.nhs.uk
Principal investigator
Dr James Hull
Click here for more information
Study to Evaluate Efficacy and Safety of BLU-593 in Adults with RCC
Study
A Randomized, Adaptive, Double-Blind, Placebo-Controlled, Parallel Arm, Phase 2b Study to Evaluate the Efficacy and Safety of Multiple Doses of BLU-5937 in Adult Participants With Refractory Chronic Cough
IRAS no
289963
Study contact information
Name: Dr James Hull
Email: j.hull@rbht.nhs.uk
Principal investigator
Dr James Hull
Click here for more information
A Phase 2 Study of Efficacy and Safety of AX-8 in Chronic Cough
Study
A Phase 2 Study of Efficacy and Safety of AX-8 in Chronic Cough
IRAS no
297718
Study contact information
Name: Dr James Hull
Email: j.hull@rbht.nhs.uk
Principal investigator
Dr James Hull
Click here for more information
NEuroCOUGH
Study
NEw Understanding of the tReatment Of COUGH (NEUROCOUGH); European Chronic Cough Registry and Bio-Resource Protocol.
IRAS no
279797
Study contact information
Name: Sally Meah
Email: sally.meah@imperial.ac.uk
Principal investigator
Dr James Hull
Click here for more information
Effect of upper airway rehydration on chronic cough and other laryngeal hypersensitivity symptoms: an exploratory study
Study
Effect of upper airway rehydration on chronic cough and other laryngeal hypersensitivity symptoms: an exploratory study.
IRAS no
317520
Study contact information
Name: Professor Kian Fan Chung
Email: k.chung@rbht.nhs.uk
Principal investigator
Professor Kian Fan Chung
UK lung volume reduction
Study
UK lung volume reduction - multicentre observational
IRAS no
190196
Study contact information
Name: Sara Buttery
Email: S.Buttery@rbht.nhs.uk
Principal investigator
Dr Nicholas Hopkinson
Click here for more information
Impact of smoking cessation on skeletal muscle atrophy and hypertrophy pathways in COPD
Study
Impact of smoking cessation on skeletal muscle atrophy and hypertrophy pathways in COPD
IRAS no
5020
Study contact information
Name: Ahmad Sadaka
Email: A.Sadaka@rbht.nhs.uk
Principal investigator
Dr Nicholas Hopkinson
Microbiome of the lung in patients treated with endobronchial lung volume reduction coils for emphysema
Study
Studying the microbiome of the lung in patients treated with endobronchial lung volume reduction coils for emphysema
IRAS no
215696
Study contact information
Name: Dr Justin Garner
Email: J.Garner@rbht.nhs.uk
Principal investigator
Dr Samuel Kemp
Click here for more information
RePneu lung volume reduction coil - European registry
Study
RePneu lung volume reduction coil - European Registry
IRAS no
181479
Study contact information
Name: Dr Justin Garner
Email: J.Garner@rbht.nhs.uk
Principal investigator
Dr Samuel Kemp
Click here for more information
NMES in patients with COPD and quadriceps weakness
Study
Quadriceps neuromuscular electrical stimultaion (NMES) as an adjunct to pulmonary rehabilitation in patients with COPD and quadriceps weakness - a randomised double-blind placebo-controlled trial.
IRAS no
234536
Study contact information
Name: Sarah Jones
Email: S.Jones5@rbht.nhs.uk
Principal investigator
Dr William Man
Click here for more information
Iron and COPD exercise trial
Study
Iron and Chronic Obstructive Pulmonary Disease (COPD) exercise trial
IRAS no
204579
Study contact information
Name: Matt Pavitt
Email: M.Pavitt@rbht.nhs.uk
Principal investigator
Professor Michael Polkey
Click here for more information
Airway microenvironment in patients undergoing surgical and bronchoscopic interventions
Study
Studying the airway microenvironment in patients undergoing surgical and bronchoscopic interventions for COPD
IRAS no
217587
Study contact information
Name: Dr Justin Garner
Email: J.Garner@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
Lung volume reduction in severe emphysema
Study
A single arm pilot study of lung volume reduction in severe emphysema using bronchoscopic autologous blood instillation in combination with intra-bronchial valves
IRAS no
135459
Study contact information
Name: Dr Justin Garner
Email: J.Garner@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
RejuvenAir™ System metered cryospray therapy for Chronic Bronchitis patients
Study
A prospective safety and feasibility study of the RejuvenAir™ System metered cryospray therapy for Chronic Bronchitis patients
IRAS no
185214
Study contact information
Name: Dr Justin Garner
Email: J.Garner@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
The London COPD cohort RSV study
Study
The London COPD cohort respiratory syncytial virus (RSV) study
IRAS no
232292
Study contact information
Name: Dexter Wiseman
Email: D.Wiseman@rbht.nhs.uk
Principal investigator
Professor Jadwiga Wedzicha
Click here for more information
The BLF early COPD development partnership grant
Study
The BLF early COPD development partnership grant
IRAS no
206796
Study contact information
Name: Ethaar El-Emir
Email: E.El-Emir@rbht.nhs.uk
Principal investigator
Professor Jadwiga Wedzicha
Click here for more information
Relationship between patient phenotypes and exacerbations in chronic obstructive pulmonary disease
Study
Relationship between patient phenotypes and exacerbations in chronic obstructive pulmonary disease
IRAS no
13535
Study contact information
Name: Gavin Donaldson
Email: gavin.donaldson@imperial.ac.uk
Principal investigator
Professor Jadwiga Wedzicha
Mechanisms of increased susceptibility to rhinovirus infection
Study
Mechanisms of increased susceptibility to rhinovirus infection in frequent and infrequent exacerbators of Chronic Obstructive Pulmonary Disease
IRAS no
181679
Study contact information
Name: Lydia Finney
Email: L.Finney@rbht.nhs.uk
Principal investigator
Professor Jadwiga Wedzicha
Click here for more information
Oxidative metabolism and atrophy in primary human skeletal muscle cell
Study
Primary culture of human skeletal muscle cells from patients with conditions impairing muscle mitochondrial oxidative metabolism and causing muscle atrophy to investigate underlying molecular mechanisms of reduced oxidative metabolism and atrophy and potential novel therapies.
IRAS no
214624
Study contact information
Name: Dr Amanda Natanek
Email: A.Natanek@rbht.nhs.uk
Principal investigator
Dr Amanda Natanek
Click here for more information
ELEVATE
Study
A RandomisEd ControlLed Study of PnEumRx Endobronchial Coil System Versus Standard-of-Care Medical MAnagement in the Treatment of Subjects with Severe Emphysema (ELEVATE) A Postmarket Surveillance Study (PMS).
IRAS no
242606
Study contact information
Name: Professor Pallav Shah
Email: P.Shah@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
Air Pollution in COPD
Study
The Effect of Air Pollution on Small Airway Lung Function in COPD.
IRAS no
260264
Study contact information
Name: Sally Meah
Email: s.meah@rbht.nhs.uk
Principal investigator
Dr Omar Usmani
Click here for more information
Inhaled SNG001 in COPD patients
Study
A randomised, double-blind, placebo-controlled study, in COPD patients with and without a confirmed respiratory virus infection assessing anti-viral biomarker responses of inhaled SNG001 compared to placebo.
IRAS no
232887
Study contact information
Name: Dexter Wiseman
Email: D.Wiseman@rbht.nhs.uk
Principal investigator
Professor Jadwiga Wedzicha
Click here for more information
SPACE FOR COPD maintenance
Study
SPACE FOR COPD© delivered as a maintenance programme on Pulmonary Rehabilitation discharge: a randomised controlled trial evaluating the long-term effects on exercise tolerance and mental well-being
IRAS no
262581
Study contact information
Name: Ruth Barker
Email: R.Barker2@rbht.nhs.uk
Principal investigator
Dr William Man
ESPRESSO
Study
Early Supported discharge with Pulmonary REhabilitation following Severe acute exacerbations of COPD – Safety and Outcomes (ESPRESSO)
IRAS no
269894
Study contact information
Name: Ruth Barker
Email: R.Barker2@rbht.nhs.uk
Principal investigator
Dr William Man
SHIELD - Singing for Health
Study
Singing for Health: Improving Experience of Lung Disease
IRAS no
259170
Study contact information
Name: Dr Keir Philip
Email: K.Philip@rbht.nhs.uk
Principal investigator
Dr Nicholas Hopkinson
Click here for more information
AIRFLOW-3
Study
A Multicenter, Randomised, Sham-controlled Study to Evaluate Safety and Efficacy After Treatment with the Nuvaira Lung Denervation System in Subjects with Chronic Obstructive Pulmonary Disease (COPD).
IRAS no
253708
Study contact information
Name: Dr Francesca Conway
Email: f.conway@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
AIRFLOW-3 sub study
Study
Mechanism of action of targeted lung denervation in Chronic Obstructive Pulmonary Disease (COPD) - A basic science study linked to the AIRFLOW-3 Trial
IRAS no
269766
Study contact information
Name: Dr Francesca Conway
Email: f.conway@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
MCS MOA
Study
Characterising the Mechanism of Action of Metered Cryospray for the Treatment of Patients with Chronic Obstructive Pulmonary Disease with Chronic Bronchitis
IRAS no
260529
Study contact information
Name: Dr Christopher Orton
Email: c.orton@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
Breathe Plus feasibility trial
Study
Breathe Plus: Testing the feasibility of a comprehensive geriatric assessment for people with COPD and frailty starting pulmonary rehabilitation
IRAS no
268185
Study contact information
Name: Lisa Brighton
Email: L.Brighton@rbht.nhs.uk
Principal investigator
Dr William Man
The O-COPD trial: OPEP devices in COPD
Study
The O-COPD trial: Oscillatory Positive Expiratory Pressure (OPEP) devices to improve outcome in patients with Chronic Obstructive Pulmonary Disease (COPD)
IRAS no
269494
Study contact information
Name: Dr Saeed Alghamdi
Email: S.Alghamdi@rbht.nhs.uk
Principal investigator
Dr Nicholas Hopkinson
Lobar Segmented Iodine Mapping of the Lungs using Dual Energy CT
Study
Lobar Segmented Iodine Mapping of the Lungs using Dual Energy Computed Tomography in Advanced Chronic Obstructive Pulmonary Disease.
IRAS no
265630
Study contact information
Name: Dr Carole Ridge
Email: C.Ridge@rbht.nhs.uk
Principal investigator
Dr Carole Ridge
EON-Lung: Nitrate levels in Lung Disease
Study
EON-Lung: Nitrate levels in Lung Disease - an observational study
IRAS no
266682
Study contact information
Name: Dr Nicholas Hopkinson
Email: n.hopkinson@rbht.nhs.uk
Principal investigator
Dr Nicholas Hopkinson
Click here for more information
CONVERT Trial
Study
Fissure Closure with the AeriSeal® System for Converting Collateral Ventilation Status in Patients with Severe Emphysema; a Multicenter, Prospective Trial
IRAS no
285414
Study contact information
Name: Najwa Soussi
Email: n.soussi@rbht.nhs.uk
Principal investigator
Dr Samuel Kemp
Mobilise-D - Clinical Validation Study
Study
Validating digital mobility assessment using wearable technology – The Mobilise-D Clinical Validation Study.
IRAS no
289543
Study contact information
Name: Dr Nicholas Hopkinson
Email: n.hopkinson@rbht.nhs.uk
Principal investigator
Dr Nicholas Hopkinson
Click here for more information
The WHAM Study
Study
Randomised controlled feasibility study of Maintaining the benefits of Pulmonary Rehabilitation with Harmonies and Melodies via Singing for Lung Health.
IRAS no
293580
Study contact information
Name: Peter Jung
Email: p.jung@rbht.nhs.uk
Principal investigator
Dr Adam Lewis
Click here for more information
Drive- BX
Study
Co-Design of a Pulmonary Rehabilitation intervention to Improve outcomes post-Exacerbation in Bronchiectasis
IRAS no
314196
Study contact information
Name: Jennifer Kilduff
Email: j.kilduff@rbht.nhs.uk
Principal investigator
Jennifer Kilduff
The ON-PACE trial
Study
Dietary nitrate supplementation to enhance daily physical activity in hypoxic COPD: a randomised controlled trial
IRAS no
315107
Study contact information
Name: Alexis Perkins
Email: a.perkins@rbht.nhs.uk
Principal investigator
Dr Nicholas Hopkinson
Click here for more information
The RheSolve Study
Study
A Clinical Evaluation of the RheOx Bronchial Rheoplasty System for the Treatment of the Symptoms of Chronic Bronchitis in Adult Patients with COPD
IRAS no
312382
Study contact information
Name: Dr Anand Tana
Email: a.tana@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
European Alpha 1 Registry (EARCO)
Study
A Pan-European Multi-Centre Observational Study To Determine The Natural History Of Patients With Alpha-1 Antitrypsin Deficiency And The Impact Of Augmentation Therapy
IRAS no
265728
Study contact information
Name: Maria Nunez
Email: m.nunez@rbht.nhs.uk
Principal investigator
Dr Nicholas Hopkinson
Click here for more information
SPRAY-CB
Study
A Sham Controlled Prospective Randomized Clinical Trial of the RejuvenAir System for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease with Chronic Bronchitis
IRAS no
304514
Study contact information
Name: Professor Pallav Shah
Email: p.shah@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
AB1MALT
Study
Assessment of the Safety and Performance of the AB1 Electrosurgical System for Bronchoscopic Microwave Ablation of Lung Tissue
IRAS no
307228
Study contact information
Name: Dr Ley Taing Chan
Email: l.chan3@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
AI in PRImary Care spirometry for diagnosis of Lung Disease (APRIL)
Study
Real-world evaluation of an Artificial-Intelligence support software (ArtiQ.Spiro) in Primary Care spirometry pathways for the detection of Lung Disease.
IRAS no
324175
Study contact information
Name: Dr William Man
Email: w.man@rbht.nhs.uk
Principal investigator
Dr William Man
Hybrid Pulmonary Rehabilitation Trial
Study
Real-world evidence feasibility trial, in both community and hospital-based settings, for a technology-enabled hybrid service delivery model for Pulmonary Rehabilitation: assessing patient uptake and adherence, and impact on patient outcomes and service capacity.
IRAS no
325028
Study contact information
Name: Timothy Jenkins
Email: t.jenkins@rbht.nhs.uk
Principal investigator
Dr William Man
FREAL
Study
Understanding susceptibility to fungal infection and evolution of antimicrobial resistance in chronic respiratory disease
IRAS no
244685
Study contact information
Name: Dr Anand Shah
Email: A.Shah2@rbht.nhs.uk
Principal investigator
Dr Anand Shah
Click here for more information
Endothelial senescence in chronic lung disease
Study
Studying endothelial senescence and dysfunction in chronic lung disease
IRAS no
284894
Study contact information
Name: Dr Koralia Paschalaki
Email: K.Paschalaki@rbht.nhs.uk
Principal investigator
Professor Jadwiga Wedzicha
FADE UK
Study
Analysing Fungal Disease Epidemiology in the UK
IRAS no
300045
Study contact information
Name: Dr Anand Shah
Email: A.Shah2@rbht.nhs.uk
Principal investigator
Dr Anand Shah
Heterotaxy and abnormalities in intestinal rotation
Study
Heterotaxy and abnormalities in intestinal rotation
IRAS no
170433
Study contact information
Name: Anastasia Fotaki
Email: a.fotaki@rbht.nhs.uk
Principal investigator
Dr Julene Carvalho
Click here for more information
Pharmacokinetics and pharmacodynamics of edoxaban in paediatric patients
Study
A phase 1, open-label, single-dose, non-randomised study to evaluate pharmacokinetics and pharmacodynamics of edoxaban in pediatric patients
IRAS no
200445
Study contact information
Name: Neil West
Email: N.West@rbht.nhs.uk
Principal investigator
Dr Zdenek Slavik
Click here for more information
Pedometer walking program for ACHD patients
Study
Does a pedometer-based walking programme affect exercise capacity and quality of life in sedentary adults with congenital heart disease?
IRAS no
232271
Study contact information
Name: Ms Lynda Shaughnessy
Email: L.Shaughnessy@rbht.nhs.uk
Principal investigator
Ms Lynda Shaughnessy
Outcome validation in noses of subjects with CF and non-CF volunteers
Study
Outcome validation in noses of subjects with cystic fibrosis and non-CF volunteers
IRAS no
215047
Study contact information
Name: Aarash Saleh
Email: a.saleh@rbht.nhs.uk
Principal investigator
Professor Eric Alton
Click here for more information
Living with cystic fibrosis
Study
Living with Cystic fibrosis
IRAS no
196567
Study contact information
Name: Olga Archangelidi
Email: o.archangelidi@rbht.nhs.uk
Principal investigator
Dr Siobhan Carr
Click here for more information
CF start
Study
The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF
IRAS no
211995
Study contact information
Name: Dr Siobhan Carr
Email: s.carr@rbht.nhs.uk
Principal investigator
Dr Siobhan Carr
Click here for more information
MAGIC
Study
Managing abnormal glucose in cystic fibrosis (MAGIC)- the development of a self-management education programme for people with CFRD
IRAS no
215946
Study contact information
Name: Sarah Collins
Email: s.collins@rbht.nhs.uk
Principal investigator
Ms Sarah Collins
Click here for more information
Safety and pharmacodynamics of long-term Ivacaftor treatment for CF
Study
A Phase 3, 2-Arm, open-label study to evaluate the safety and pharmacodynamics of long-term Ivacaftor treatment in subjects with Cystic Fibrosis who are less than 24 Months of age at treatment initiation and have a CFTR gating mutation
IRAS no
228921
Study contact information
Name: Nicole Westrupp
Email: n.westrupp@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
CLIMB-CF
Study
Clinical monitoring and biomarkers to stratify severity and predict outcomes in children with cystic fibrosis (CLIMB-CF).
IRAS no
207718
Study contact information
Name: Nicole Westrupp
Email: n.westrupp@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
Non-invasive detection of pseudomonas aeruginosa lower airway infection in patients with CF
Study
Non-invasive detection of Pseudomonas aeruginosa lower airway infection in patients with Cystic Fibrosis
IRAS no
233578
Study contact information
Name: Claire Edmondson
Email: C.Edmondson@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
Safety and efficacy of long-term treatment with VX 661 in combination with Ivacaftor
Study
A Phase 3, open label, rollover study to evaluate the safety and efficacy of long term treatment with VX 661 in combination with Ivacaftor in subjects aged 12 years and older with Cystic Fibrosis , homozygous or heterozygous for the F508del CFTR mutation
IRAS no
186033
Study contact information
Name: Sandra Scott
Email: S.Scott@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
Multiple breath washout in paediatric chronic airways disease
Study
Multiple Breath Washout in paediatric chronic airways disease: Building a clinimetrics dataset
IRAS no
204190
Study contact information
Name: Clare Saunders
Email: C.Saunders2@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
Screening tools for drug-induced ototoxicity in adults with CF
Study
A prospective cross-sectional study analysing the utility of novel tablet-based audiometry and an interactive web-based hearing app as screening tools for drug-induced ototoxicity in adults with cystic fibrosis.
IRAS no
230986
Study contact information
Name: Anitha Vijayasingam
Email: A.Vijayasingam@rbht.nhs.uk
Principal investigator
Dr Anand Shah
Click here for more information
Improving outcome measures for physiotherapy trials of airway clearance in adults in CF
Study
Improving outcome measures for physiotherapy trials of airway clearance in adults with CF
IRAS no
154635
Study contact information
Name: Gemma Stanford
Email: G.Stanford@rbht.nhs.uk
Principal investigator
Dr Nicholas Simmonds
Click here for more information
Finger-prick capillary blood sampling in chronic lung disease
Study
Single-centre validation of finger-prick capillary blood sampling for remote monitoring in chronic lung disease including antifungal therapeutic drug monitoring.
IRAS no
239814
Study contact information
Name: Professor Michael Loebinger
Email: M.Loebinger@rbht.nhs.uk
Principal investigator
Professor Michael Loebinger
Click here for more information
VX17-661-116
Study
A Phase 3, Open-label, Rollover Study to Evaluate the Safety and Efficacy of Long-term Treatment With Tezacaftor in Combination With Ivacaftor in Subjects With Cystic Fibrosis Aged 6 Years and Older, Homozygous or Heterozygous for the F508del-CFTR Mutation.
IRAS no
241643
Study contact information
Name: Professor Jane Davies
Email: J.Davies@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
VX17-659-105 Open-label Safety and Efficacy of VX-659 in CF
Study
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-659 Combination Therapy in Subjects with Cystic Fibrosis Who Are Homozygous or Heterozygous for the F508del Mutation.
IRAS no
241641
Study contact information
Name: Dr Nicholas Simmonds
Email: N.Simmonds@rbht.nhs.uk
Principal investigator
Dr Nicholas Simmonds
Click here for more information
MR assessment of shunt fraction in CF patients before and after BAE
Study
A prospective pilot study: Magnetic Resonance Imaging (MRI) derived measures of bronchial arterial flow in the assessment and follow-up of patients with Cystic fibrosis (CF) who undergo bronchial artery embolisation.
IRAS no
256039
Study contact information
Name: Bhavin Rawal
Email: B.Rawal@rbht.nhs.uk
Principal investigator
Professor Simon Padley
Organoid Study (HIT-CF)
Study
Stratifying Cystic Fibrosis Patients Based on Intestinal Organoid Response To Different CFTR-modulators
IRAS no
255704
Study contact information
Name: Maria Nunez
Email: M.Nunez@rbht.nhs.uk
Principal investigator
Dr Nicholas Simmonds
Phase IIa study of PC945 in Aspergillosis in Cystic Fibrosis patients
Study
An open-label study to assess the safety, pharmacokinetics and pharmacodynamics of inhaled PC945 in adult Cystic Fibrosis (CF) patients with persistent pulmonary Aspergillus fumigatus infection
IRAS no
248009
Study contact information
Name: Dr Sandra Scott
Email: s.scott@rbht.nhs.uk
Principal investigator
Dr Nicholas Simmonds
Click here for more information
Exercise behaviours in children and young people with cystic fibrosis
Study
Identifying predictors for maintenance of exercise participation in children and young people with cystic fibrosis.
IRAS no
246187
Study contact information
Name: Nicky Murray
Email: N.Murray@rbht.nhs.uk
Principal investigator
Nicky Murray
Click here for more information
Measurement of novel indices of lung function in respiratory disease
Study
Measurement of novel indices of lung function in respiratory disease
IRAS no
208382
Study contact information
Name: Clare Saunders
Email: C.Saunders2@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
A study of the combined effects of three CFTR modulator medicines in people with cystic fibrosis aged 12 and older
Study
A Phase 3 study of the long-term safety of a triple combination therapy of VX-445, tezacaftor and ivacaftor in people with cystic fibrosis aged 12 and older.
IRAS no
269907
Study contact information
Name: Dr Sandra Scott
Email: s.scott@rbht.nhs.uk
Principal investigator
Dr Nicholas Simmonds
A study to learn more about a combination of CFTR modulator medicines in people with Cystic Fibrosis (VX 18 445 104)
Study
A study to evaluate the effectiveness and safety of VX 445/Tezacaftor/Ivacaftor in people with Cystic Fibrosis who are heterozygous for the F508del mutation and a gating or residual function mutation.
IRAS no
268820
Study contact information
Name: Dr Sandra Scott
Email: s.scott@rbht.nhs.uk
Principal investigator
Professor Jane Davies
A Phase 2 study of ABBV-3067 alone and in combination with ABBV-2222
Study
A Phase 2 study of ABBV-3067 alone and in combination with ABBV-2222 in Cystic Fibrosis subjects who are homozygous for the F508del mutation.
IRAS no
268446
Study contact information
Name: Dr Sandra Scott
Email: s.scott@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
VX18-445-110 VX-445/TEZ/IVA Open-label in CF (F/G and F/RF)
Study
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-445 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for the F508del Mutation and a Gating or Residual Function Mutation (F/G and F/RF Genotypes)
IRAS no
268821
Study contact information
Name: Dr Sandra Scott
Email: s.scott@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
Phase 3 Open-label Study of VX-445/TEZ/IVA in subjects 6 years & older
Study
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-445/TEZ/IVA Combination Therapy in Subjects With Cystic Fibrosis Who Are 6 Years of Age and Older
IRAS no
274499
Study contact information
Name: Dr Sandra Scott
Email: s.scott@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
Clinical Outcomes With Novel Modifier Therapy Combinations in CF
Study
Clinical Outcomes With Novel Modifier Therapy Combinations in CF
IRAS no
279116
Study contact information
Name: Dr Sandra Scott
Email: s.scott@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
Targeting Immunotherapy for Fungal Infection in Cystic Fibrosis
Study
TrIFIC: Targeting Immunotherapy for Fungal Infection in Cystic Fibrosis
IRAS no
270828
Study contact information
Name: Maria Nunez
Email: M.Nunez@rbht.nhs.uk
Principal investigator
Dr James Darius-Armstrong
VX20-445-119
Study
A Phase 3b Open-label Study Evaluating the Long-term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor Combination Therapy in Cystic Fibrosis Subjects Ages 6 Years and Older Who Are Heterozygous for the F508del Mutation and a Minimal Function Mutation (F/MF)"
IRAS no
1003390
Study contact information
Name: Dr Sandra Scott
Email: s.scott@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Clinical Outcomes With Novel Modifier Therapy Combination (RECOVER)
Study
Real World Clinical Outcomes With Novel Modifier Therapy Combinations in People with CF
IRAS no
296928
Study contact information
Name: Clare Saunders
Email: c.saunders2@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Clinimetric properties of Oxygen-Enhanced MRI
Study
Determining the clinimetric properties of structural and functional outputs of oxygen-enhanced magnetic resonance imaging in children and adults with cystic fibrosis (CF) and chronic suppurative lung disease (CSLD)
IRAS no
294686
Study contact information
Name: Cristopher Short
Email: C.Short@rbht.nhs.uk
Principal investigator
Professor Jane Davies
The Effects of Planned Intravenous Antibiotics on Activity and Sleep Quality in Cystic Fibrosis During the Post COVID-19 Lockdown Period.
Study
The Effects of Planned Intravenous Antibiotics on Activity and Sleep Quality in Cystic Fibrosis During the Post COVID-19 Lockdown Period
IRAS no
223350
Study contact information
Name: Dr Rishi Pabary
Email: R.Pabary@rbht.nhs.uk
Principal investigator
Dr Rishi Pabary
COVID-19 antibody responses in Cystic Fibrosis patients
Study
COVID-19 antibody responses in Cystic Fibrosis patients
IRAS no
294037
Study contact information
Name: Jessie Matthews
Email: J.Matthews@rbht.nhs.uk
Principal investigator
Dr Nicholas Simmonds
Click here for more information
Video game hearing tests for remote monitoring of ototoxicity
Study
Development and validation of the use of Video games and virtual reality to enable Autonomous Remote monitoring of OTotoxicity in high-risk population groups (VAROT).
IRAS no
298372
Study contact information
Name: Jamie Cheong
Email: j.cheong@rbht.nhs.uk
Principal investigator
Dr Anand Shah
Click here for more information
Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Subjects
Study
A Phase 3 Open-label Study Evaluating the Long‑term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor Triple Combination Therapy in Cystic Fibrosis Subjects 2 Years and Older
IRAS no
1004766
Study contact information
Name: Jessie Matthews
Email: j.matthews@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
A Phase 3 Study of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Heterozygous
Study
A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for F508del and a Minimal Function Mutation (F/MF)
IRAS no
1003950
Study contact information
Name: Jessie Matthews
Email: j.matthews@rbht.nhs.uk
Principal investigator
Dr Nicholas Simmonds
Click here for more information
VX20-121-103
Study
A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for F508del and a Minimal Function Mutation (F/MF)
IRAS no
1003951
Study contact information
Name: Sophie Pinnell
Email: s.pinnell@rbht.nhs.uk
Principal investigator
Dr Nicholas Simmonds
Click here for more information
RExA-CF
Study
Reproducibility of virtual exercise assessments versus face-to-face exercise testing in adults with cystic fibrosis – a pilot feasibility study
IRAS no
314914
Study contact information
Name: Gemma Stanford
Email: g.stanford@rbht.nhs.uk
Principal investigator
Gemma Stanford
Ilprost (Ventavis) in patients with Eisenmenger syndrome
Study
A single-centre, placebo-controlled, double-blinded, randomised, crossover study of Iloprost (Ventavis®) in patients with Eisenmenger syndrome
IRAS no
121948
Study contact information
Name: Dr Stephen John Wort
Email: s.wort@rbht.nhs.uk
Principal investigator
Dr Stephen John Wort
Molecular genetics of human birth defects
Study
Molecular genetics of human birth defects – mapping and gene identification
IRAS no
103488
Study contact information
Name: Dr Claire Hogg
Email: c.hogg@rbht.nhs.uk
Principal investigator
Dr Claire Hogg
Genetic linkage evaluation in inherited cardiac conditions
Study
Genetic linkage evaluation in inherited cardiac conditions
IRAS no
53663
Study contact information
Name: Dr Janice Till
Email: j.till@rbht.nhs.uk
Principal investigator
Dr Janice Till
ARRY-371797 (p38 MAP Kinase Inhibitor)
Study
A Phase 3, multinational, randomised, placebo-controlled study of ARRY-371797 in patients with Symptomatic Dilated Cardiomyopathy due to a Lamin A/C Gene Mutation
IRAS no
254544
Study contact information
Name: Dr James Ware
Email: J.Ware@rbht.nhs.uk
Principal investigator
Dr James Ware
Click here for more information
Natural History Dilated Cardiomyopathy Associated with BAG3 Mutations
Study
A prospective multinational study of the natural history of participants with BAG3 mutation associated dilated cardiomyopathy
IRAS no
321187
Study contact information
Name: Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk
Principal investigator
Dr Antonis Pantazis
CardioMEMS Heart Failure System
Study
CardioMEMS Heart Failure System
IRAS no
219676
Study contact information
Name: Angela Gallagher
Email: a.gallagher2@rbht.nhs.uk
Principal investigator
Professor Martin Cowie
Click here for more information
Factors influencing physical activity among individuals living with heart failure
Study
Factors influencing physical activity among individuals living with heart failure: a mixed-methods study
IRAS no
205050
Study contact information
Name: Professor Martin Cowie
Email: m.cowie@rbht.nhs.uk
Principal investigator
Professor Martin Cowie
Click here for more information
Assessing organisational readiness for heart failure remote monitoring
Study
Assessing Organisational Readiness for Heart Failure Remote Monitoring
IRAS no
236418
Study contact information
Name: Darshan Brahmbhatt
Email: d.brahmbhatt@rbht.nhs.uk
Principal investigator
Professor Martin Cowie
Click here for more information
BAROSTIM NEO
Study
BAROSTIM NEO ® - Baroreflex Activation Therapy® for Heart Failure
IRAS no
235110
Study contact information
Name: Ms Rebecca Lane
Email: r.lane@rbht.nhs.uk
Principal investigator
Ms Rebecca Lane
Click here for more information
IRONMAN
Study
Effectiveness of intravenous iron treatment vs standard care in patients with heart failure and iron deficiency: a randomised, open-label multicentre trial (IRONMAN)
IRAS no
191168
Study contact information
Name: Peng Zhang
Email: p.zhang@rbht.nhs.uk
Principal investigator
Ms Rebecca Lane
Click here for more information
The effects of inorganic nitrite on cardiac and skeletal muscle
Study
The Effects of inorganic nitrite on cardiac and skeletal muscle: Physiology, pharmacology, and therapeutic potential in patients with Chronic Heart Failure
IRAS no
87162
Study contact information
Name: Brodie Loudon
Email: B.Loudon@rbht.nhs.uk
Principal investigator
Dr Sanjay Prasad
Mitraclip device in heart failure
Study
Randomised investigation of the Mitraclip device in heart failure: 2nd trial in patients with clinically significant functional mitral regurgitation
IRAS no
220456
Study contact information
Name: Joanne Benton
Email: j.benton@rbht.nhs.uk
Principal investigator
Dr Robert Smith
Click here for more information
LCZ696 in paediatric patients
Study
Multicenter, open-label, single dose study to evaluate the safety, tolerability and pharmacokinetics of LCZ696 followed by randomised, double-blind, parallel group,active-controlled study to evaluate the efficacy and safety of LCZ696 in pediatric patients
IRAS no
206351
Study contact information
Name: Dr Piers Daubeney
Email: p.daubeney@rbht.nhs.uk
Principal investigator
Dr Piers Daubeney
AccuCinch® Ventriculoplasty System for Functional Mitral Regurgitation
Study
Safety and performance evaluation of the AccuCinch® Ventricular Repair System for the treatment of heart failure with or without Functional Mitral Regurgitation due to Dilated Ischaemic or Non-Ischaemic Cardiomyopathy.
IRAS no
230127
Study contact information
Name: Lauren Kelly
Email: L.Kelly2@rbht.nhs.uk
Principal investigator
Dr Robert Smith
The AMBITION
Study
Assessing mitochondrial bioenergetics in coronary heart disease; correlating cardiac magnetic resonance with the molecular processes that underpin myocardial dysfunction and left ventricular reverse remodelling.
IRAS no
247881
Study contact information
Name: Dr Richard Jones
Email: r.jones@rbht.nhs.uk
Principal investigator
Dr Sanjay Prasad
The REMIT-DCM study
Study
Reverse rEmodelling Markers In the serial evaluation of recenTonset Dilated CardioMyopathy
IRAS no
262962
Study contact information
Name: Dr Daniel Hammersley
Email: d.hammersley@rbht.nhs.uk
Principal investigator
Dr Sanjay Prasad
Click here for more information
PiCSO-AMI-I
Study
Pressure-controlled Intermittent Coronary Sinus Occlusion (PiCSO) in Acute Myocardial Infarction (PiCSO-AMI-I)
IRAS no
259683
Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk
Principal investigator
Dr Charles Ilsley
Click here for more information
Go DCM
Study
Defining the genetics, biomarkers and outcomes for dilated cardiomyopathy: a prospective multi-centre observational study
IRAS no
237880
Study contact information
Name: Teijo Palovaara
Email: T.Palovaara@rbht.nhs.uk
Principal investigator
Dr James Ware
ORBITA-2
Study
A placebo-controlled trial of percutaneous coronary intervention for the relief of stable angina
IRAS no
242451
Study contact information
Name: Meriel Woodruff
Email: M.Woodruff@rbht.nhs.uk
Principal investigator
Dr Vasileios Panoulas
Click here for more information
Sanofi Drug Utilisation Study of alirocumab
Study
A drug utilization study (DUS) of alirocumab in Europe to assess the effectiveness of the dosing recommendation to avoid very low LDL-C levels.
IRAS no
245146
Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk
Principal investigator
Dr Barbir Mahmoud
Click here for more information
HEART - ACS V1.0
Study
The HarEfield Acute MyocaRdial InfarcTion Cohort
IRAS no
259087
Study contact information
Name: Laura Barker
Email: L.Barker2@rbht.nhs.uk
Principal investigator
Dr Miles Dalby
The EURO-SHOCK Trial version 1
Study
EURO SHOCK Testing the value of novel strategy and its cost efficacy in order to improve the poor outcomes in Cardiogenic Shock
IRAS no
250403
Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk
Principal investigator
Dr Alex Rosenberg
Click here for more information
Epidemiology and Prognosis in Acute Myocarditis
Study
Epidemiological trends and outcomes of hospital admissions for acute myocarditis and dilated cardiomyopathy in the National Health Service of England from 1998 onwards.
IGARD reference number
DARS-NIC-144568-D7G6V
Study contact information
Name: Amrit Lota
Email: A.Lota@rbht.nhs.uk
Principal investigator
Professor Sanjay Prasad
Click here for more information
Diagnosis and risk stratification in myocarditis
Study
Diagnosis and risk stratification in myocarditis using cardiovascular magnetic resonance, detailed molecular markers and gene sequencing - a personalised approach.
IRAS no
220817
Study contact information
Name: Alma Iacob
Email: A.Iacob@rbht.nhs.uk
Principal investigator
Professor Sanjay Prasad
Click here for more information
MYK-491 in MYH7-DCM patients
Study
Open-Label, Baseline-Controlled, Two-Period, Exploratory Study of Safety, Tolerability and Pharmacodynamics of Oral MYK-491 in Stable Ambulatory Patients with Primary Dilated Cardiomyopathy Associated with MYH7 Mutation
IRAS no
277149
Study contact information
Name: Dr Brian Halliday
Email: B.Halliday@rbht.nhs.uk
Principal investigator
Dr Brian Halliday
Click here for more information
VIDEO-HF
Study
Evaluating Outpatient Video Consultations in Heart Failure: Clinician and Patient Perspectives.
IRAS no
284625
Study contact information
Name: Dr Arvind Singhal
Email: A.Singhal@rbht.nhs.uk
Principal investigator
Professor Martin Cowie
Click here for more information
Fish and Chips
Study
FFRCT In Stable Heart disease & CTA Helps Improve Patient care and Societal costs
IRAS no
285996
Study contact information
Name: Dr Edward Nicol
Email: E.Nicol@rbht.nhs.uk
Principal investigator
Dr Edward Nicol
Click here for more information
The DAPA-MI Study
Study
A Registry-based, Randomised, Double-blind, Placebo-Controlled Cardiovascular Outcomes Trial to Evaluate the Effect of Dapagliflozin on the Incidence of Heart Failure or Cardiovascular Death in Patients without Diabetes with Acute Myocardial Infarction at Increased Risk for Subsequent Development of Heart Failure
IRAS no
284188
Study contact information
Name: Heather Passmore
Email: H.Passmore@rbht.nhs.uk
Principal investigator
Dr Anthony Barron
Click here for more information
A possible new treatment for elevated Lp(a) in CVD - HORIZON
Study
A randomised double-blind, placebo-controlled, multicenter trial assessing the impact of lipoprotein (a) lowering with TQJ230 on major cardiovascular events in patients with established cardiovascular disease (CVD).
IRAS no
267092
Study contact information
Name: Alkida Bucaj
Email: A.Bucaj@rbht.nhs.uk
Principal investigator
Professor Mahmoud Barbir
Click here for more information
Genetic testing for DCM
Study
Examining the use and yield of genetic testing in clinical practice for patients with dilated cardiomyopathy.
IRAS no
280916
Study contact information
Name: Dr Brian Halliday
Email: B.Halliday@rbht.nhs.uk
Principal investigator
Dr Brian Halliday
Digital-HF
Study
Digital tools in Heart failure – a survey of patient usage
IRAS no
307636
Study contact information
Name: Kyle McBeath
Email: K.McBeath@rbht.nhs.uk
Principal investigator
Professor Martin Cowie
Click here for more information
ANTHEM
Study
Autonomic Regulation Therapy to Enhance Myocardial Function and Reduce Progression of Heart Failure with Heart Failure with Reduced Ejection Fraction
IRAS no
244390
Study contact information
Name: Antonio Barbera
Email: a.barbera@rbht.nhs.uk
Principal investigator
Professor Martin Cowie
Click here for more information
Examining the effect of mitochondrial oxidative stress in DCM
Study
Examining the role of mitochondrial oxidative stress in dilated cardiomyopathy
IRAS no
286376
Study contact information
Name: Katherine Smith
Email: k.smith@rbht.nhs.uk
Principal investigator
Dr Brian Halliday
Click here for more information
CY 6031- Cytokinetics - Cardiomyopathy 0771/0042
Study
A Phase 3, Multi-Center, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Efficacy and Safety of CK3773274 in Adults with Symptomatic Hypertrophic Cardiomyopathy and Left Ventricular Outflow Tract Obstruction
IRAS no
1005127
Study contact information
Name: Carmen Chan
Email: l.chan2@rbht.nhs.uk
Principal investigator
Dr Antonis Pantazis
Click here for more information
Study of Lipoprotein(a) Levels in Patients With a History of ASCVD
Study
A Multicenter, Cross-sectional Study to Characterize the Distribution of Lipoprotein(a)Levels Among Patients With Documented History of Atherosclerotic Cardiovascular Disease (ASCVD)
IRAS no
310751
Study contact information
Name: Laura Barker
Email: l.barker2@rbht.nhs.uk
Principal investigator
Dr Tina Khan
Click here for more information
CE-MARC 3
Study
A pragmatic approach to the investigation of stable chest pain: a UK, multi-centre, randomised trial to improve patient experience, outcomes and NHS cost efficiency
IRAS no
302218
Study contact information
Name: Dr Chiara Bucciarelli-Ducchi
Email: c.bucciarelli-ducci@rbht.nhs.uk
Principal investigator
Dr Ciara Bucciarelli-Ducchi
Click here for more information
Clinical Investigation of FIRE1 System in HF Patients – FUTURE HF
Study
First In Human Clinical Investigation of the FIRE1 System in Heart Failure Patients
IRAS no
316506
Study contact information
Name: Nikula Vicario
Email: n.vicario@rbht.nhs.uk
Principal investigator
Dr Ali Vazir
Click here for more information
QUAL-HF
Study
Digital tools in Heart failure – patient and clinician perspectives
IRAS no
321337
Study contact information
Name: Dr Ali Vazir
Email: a.vazir@rbht.nhs.uk
Principal investigator
Dr Ali Vazir
GSK3008348 in IPF patients using PET imaging
Study
A study of single doses to evaluate the safety, tolerability, pharmacokinetics and target engagement of nebulised GSK3008348 in Idiopathic Pulmonary Fibrosis patients, using positron emission tomography (PET) imaging
IRAS no
221453
Study contact information
Name: Lyn Paul
Email: L.Paul@rbht.nhs.uk
Principal investigator
Professor Toby Maher
Click here for more information
Muscle stimulation in advanced idiopathic pulmonary fibrosis (MUST-IPF)
Study
Neuromuscular electrical stimulation (NMES) is a portable hand-held muscle stimulator which allows the thigh muscles to be exercised whilst seated. The aims of this study are to 1) investigate whether NMES is acceptable to patients with IPF and healthcare/research staff and 2) identify if it can improve leg muscle strength and walking ability.
IRAS no
241055
Study contact information
Name: Claire Nolan
Email: c.nolan@rbht.nhs.uk
Principal investigator
Dr William Man
Click here for more information
A study to evaluate to efficacy and safety of BG00011
Study
A randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of BG00011 in patients with Idiopathic Pulmonary Fibrosis.
IRAS no
248312
Study contact information
Name: Lyn Paul
Email: l.paul@rbht.nhs.uk
Principal investigator
Professor Toby Maher
Click here for more information
Nintedanib in PF-ILD (extension)
Study
An open-label extension trial of the long-term safety of nintedanib in patients with Progressive Fibrosing Interstitial Lung Disease (PF-ILD)
IRAS no
252018
Study contact information
Name: Lyn Paul
Email: l.paul@rbht.nhs.uk
Principal investigator
Professor Toby Maher
Click here for more information
TR12 Ph 2 Study in Idiopathic Pulmonary Fibrosis-Nalbuphine ER Tablets
Study
A phase 2, double-blind, randomised, placebo-controlled, two-treatment, two-period crossover efficacy and safety study in Idiopathic Pulmonary Fibrosis (IPF) with Nalbuphine ER tablets for the treatment of cough.
IRAS no
262846
Study contact information
Name: Lyn Paul
Email: l.paul@rbht.nhs.uk
Principal investigator
Professor Toby Maher
GALACTIC-1 Phase 2b study in idiopathic pulmonary fibrosis
Study
GALACTIC-1 - A randomised, double-blind, multicentre, parallel, placebo controlled Phase 2b study in subjects with idiopathic pulmonary fibrosis (IPF) investigating the efficacy and safety of TD139, an inhaled galectin-3 inhibitor administered via a dry powder.
IRAS no
257627
Study contact information
Name: Lyn Paul
Email: l.paul@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
Changes in iOS in IPF
Study
Changes in impulse oscillometry measurements and outcomes in idiopathic pulmonary fibrosis
IRAS no
282567
Study contact information
Name: Suhani Patel
Email: S.Patel1@rbht.nhs.uk
Principal investigator
Dr William Man
Click here for more information
Reliability and vailidity of iOS in IPF
Study
Reliability and validity of impulse oscillometry measurements in idiopathic pulmonary fibrosis
IRAS no
280564
Study contact information
Name: Suhani Patel
Email: S.Patel1@rbht.nhs.uk
Principal investigator
Dr William Man
Click here for more information
PACIFY Cough
Study
PAciFy Cough: A multicentre, double blind, placebo controlled, crossover trial of morphine sulfate for the treatment of PulmonAry Fibrosis Cough
IRAS no
275034
Study contact information
Name: Zhe Wu
Email: Z.Wu@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
Progressive Fibrosing Lung Disease (PROFOUND)
Study
Identifying progressive fibrosing lung disease: a study of genetic and environmental interactions: an observational cohort study.
IRAS no
279948
Study contact information
Name: Jessica Wallen
Email: j.wallen@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
1305-0013 BI 1015550 in Idiopathic Pulmonary Fibrosis
Study
A randomised, double-blind, placebo-controlled parallel group study in IPF patients over 12 weeks evaluating efficacy, safety and tolerability of BI 1015550 taken orally.
IRAS no
280729
Study contact information
Name: Deirdre Flannery
Email: D.Flannery@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Phase 2 Study of the Efficacy and Safety of BMS-986278 in IPF
Study
A Multicenter, Randomised, Double-blind, Placebo-controlled, Phase 2 Study of the Efficacy and the Safety and Tolerability of BMS-986278 in Participants with Idiopathic Pulmonary Fibrosis (IM027-040)
IRAS no
1003409
Study contact information
Name: Natalie Dwyer
Email: N.Dwyer@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
TIPAL
Study
The effectiveness and risks of Treating people with Idiopathic Pulmonary fibrosis with the Addition of Lansoprazole (TIPAL): a randomised placebo-controlled multi-centre clinical trial
IRAS no
269050
Study contact information
Name: Natalie Dwyer
Email: N.Dwyer@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
C21 in IPF
Study
A Phase 2, Multi-Centre, Open-Label, Single-Arm Trial Investigating the Safety, Efficacy and Pharmacokinetics of C21 in Subjects with Idiopathic Pulmonary Fibrosis
IRAS no
282448
Study contact information
Name: Victor Jardim
Email: V.Jardim@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
Zephyrus II: A Phase 3 Study of Pamrevlumab in Subjects with IPF
Study
Zephyrus II: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study of Pamrevlumab in Subjects with Idiopathic Pulmonary Fibrosis (IPF)
IRAS no
271173
Study contact information
Name: Natalie Dwyer
Email: N.Dwyer@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
C21 in IPF
Study
A Phase 2, Multi-Centre, Open-Label, Single-Arm Trial Investigating the Safety, Efficacy and Pharmacokinetics of C21 in Subjects with Idiopathic Pulmonary Fibrosis
IRAS no
282448
Study contact information
Name: Victor Jardim
Email: V.Jardim@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
Outcomes in Idiopathic Inflammatory Myopathies
Study
Autoantibody Predictors of Long-Term Outcomes in Idiopathic Inflammatory Myopathy Associated Interstitial Lung Disease.
IRAS no
286985
Study contact information
Name: Dr Elizabeth Renzoni
Email: E.Renzoni@rbht.nhs.uk
Principal investigator
Dr Elizabeth Renzoni
Click here for more information
PLN-74809-IPF-202
Study
A randomized, double-blind, dose-ranging, placebo-controlled Phase 2a evaluation of the safety, tolerability and pharmacokinetics of PLN-74809 in participants with idiopathic pulmonary fibrosis (IPF).
IRAS no
277008
Study contact information
Name: Victor Jardim
Email: V.Jardim@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
STARSCAPE
Study
A phase iii randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of prm-151 in patients with Idiopathic Pulmonary Fibrosis.
IRAS no
291518
Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
A Phase 2 study of RXC007 in patients with IPF
Study
A Multi-Cohort, Randomized, Placebo-Controlled Phase 2a Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Ascending Doses of RXC007 in Patients with Idiopathic Pulmonary Fibrosis.
IRAS no
1005138
Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
Perspectives On Screening and early Treatment for Pulmonary Fibrosis: a qualitative study
Study
Perspectives On Screening and early Treatment for Pulmonary Fibrosis: a qualitative study
IRAS no
319409
Study contact information
Name: Dr Elizabeth Renzoni
Email: e.renzoni@rbht.nhs.uk
Principal investigator
Dr Elizabeth Renzoni
Randomised, Double-Blind, Placebo-Controlled, Dose Escalation, Safety, Tolerability & Pharmacodynamic Biomarker Study of Caveolin-1-Scaffolding-Protein-Derived Peptide (LTI-03)
Study
A Randomised, Double-Blind, Placebo-Controlled, Phase 1b, Dose Escalation, Safety, Tolerability and Pharmacodynamic Biomarker Study of Caveolin-1-Scaffolding-Protein-Derived Peptide (LTI-03) in Recently Diagnosed, Treatment Naïve Subjects with Idiopathic Pulmonary Fibrosis.
IRAS no
1006203
Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
CMR sequences for future clinical use
Study
Development of Cardiovascular Magnetic Resonance (CMR) sequences for future clinical use
IRAS no
33773
Study contact information
Name: Andy Scott
Email: a.scott07@imperial.ac.uk
Principal investigator
Professor David Firmin
Diffusion tensor CMR imaging of the myocardium
Study
Diffusion Tensor Cardiovascular Magnetic Resonance Imaging of the myocardium
IRAS no
136441
Study contact information
Name: Zohya Khalique
Email: Z.Khalique@rbht.nhs.uk
Principal investigator
Professor Dudley Pennell
Click here for more information
ORFAN
Study
The Oxford Risk Factors And Non-invasive imaging Study.
IRAS no
164361
Study contact information
Name: Dr Ciara Mahon
Email: C.Mahon@rbht.nhs.uk
Principal investigator
Dr Edward Nichol
Click here for more information
Quantitive analysis of the 4-dimensional motion of the ascending aorta
Study
Quantitive analysis of the 4-dimensional motion of the ascending aorta
IRAS no
281535
Study contact information
Name: Dr Christoph Nienaber
Email: C.Nienaber@rbht.nhs.uk
Principal investigator
Dr Christoph Nienaber
Diagnosis severity & prognosis evaluation using cardiothoracic CT & MR
Study
Diagnosis severity & prognosis evaluation using cardiothoracic CT & MR
IRAS no
296357
Study contact information
Name: Dr Anand Devaraj
Email: A.Devaraj@rbht.nhs.uk
Principal investigator
Mr Simon Padley
Transmural myocardial perfusion with hypertension, HCM and HCM phenocopies with CMR
Study
The measurement of transmural myocardial perfusion in normal subjects and patients with hypertension, hypertrophic cardiomyopathy (HCM) and HCM phenocopies with Cardiovascular Magnetic Resonance (CMR)
IRAS no
171258
Study contact information
Name: Brian Halliday
Email: B.Halliday@rbht.nhs.uk
Principal investigator
Dr Sanjay Prasad
Lifestyle and exercise in Hypertrophic Cardiomyopathy
Study
Lifestyle and exercise in Hypertrophic Cardiomyopathy
IRAS no
205294
Study contact information
Name: Carmen Chan
Email: L.Chan2@rbht.nhs.uk
Principal investigator
Dr James Ware
Click here for more information
Exploring the lived experiences of Familial Hypercholesterolaemia in childhood
Study
Exploring the lived experience of being diagnosed with genetically confirmed Familial Hypercholesterolaemia in childhood
IRAS no
269787
Study contact information
Name: Charis Browne
Email: C.Browne@rbht.nhs.uk
Principal investigator
Charis Browne
The DEPICT study
Study
Critically ill children and young people: Do national differences in access to emergency paediatric Intensive Care and care during transport affect clinical outcomes and patient experience? The DEPICT study
IRAS no
218569
Study contact information
Name: Angela Aramburo
Email: a.aramburocaragol@rbht.nhs.uk
Principal investigator
Ms Angela Aramburo
Rovaroxaban regimen in children with acute venous thromboembolism
Study
Multicentre, open-label, active-controlled, randomised study to evaluate the efficacy and safety of an age and body weight-adjusted rivaroxaban regimen in children with acute venous thromboembolism
IRAS no
155345
Study contact information
Name: Helena Sampaio
Email: m.fernandessampaio@rbht.nhs.uk
Principal investigator
Ms Angela Aramburo
Click here for more information
S-CAP study
Study
A molecular toolkit for the microbial investigation of severe community acquired pneumonia (S-CAP Study)
IRAS no
189915
Study contact information
Name: Natalie Dormand
Email: N.Dormand@rbht.nhs.uk
Principal investigator
Dr Brijesh Patel
Click here for more information
Haemostatic markers in ECMO (HAE) study
Study
Prospective cohort study of haemostatic activation markers and correlation with bleeding and thrombotic complications in patients receiving extracorporeal membrane oxygenation(ECMO)
IRAS no
235036
Study contact information
Name: Dr Deepa Arachchillage
Email: D.JayakodyArachchillage@rbht.nhs.uk
Principal investigator
Dr Deepa Arachchillage
Click here for more information
WAVE study - Weaning Algorithms for mechanical VEntilation
Study
Weaning from mechanical ventilation: comparison of open-loop decision support system and routine care in cardiothoracic patients.
IRAS no
239144
Study contact information
Name: Dr Brijesh Patel
Email: B.Patel4@rbht.nhs.uk
Principal investigator
Dr Brijesh Patel
Click here for more information
EAT-PK
Study
Does Extra-Corporeal Membrane Oxygenation alter anti-infectives therapy pharmacokinetics in adult critically ill patients?
IRAS no
228196
Study contact information
Name: Dr Anna Reed
Email: A.Reed@rbht.nhs.uk
Principal investigator
Dr Anna Reed
Click here for more information
Advanced echocardiography in critical care
Study
Advanced echocardiography in critical care
IRAS no
266247
Study contact information
Name: Professor Susanna Price
Email: S.Price@rbht.nhs.uk
Principal investigator
Professor Susanna Price
GenOMICC
Study
Genetics of susceptibility and mortality in critical care (GenOMICC)
IRAS no
269326
Study contact information
Name: Mahitha Gummadi
Email: M.Gummadi@rbht.nhs.uk
Principal investigator
Dr Brijesh Patel
Evaluating the nutritional impact of changing from 1% to 2% Propofol in a Cardiothoracic Adult Critical Care Unit
Study
Evaluating the nutritional impact of changing from 1% to 2% Propofol in a Cardiothoracic Adult Critical Care Unit
IRAS no
286229
Study contact information
Name: Chris Remmington
Email: C.Remmington@rbht.nhs.uk
Principal investigator
Chris Remmington
MUSCLE-ICU Study
Study
Acute muscle wasting in critical illness – an observational cohort study
IRAS no
285418
Study contact information
Name: Dr Brijesh Patel
Email: B.Patel4@rbht.nhs.uk
Principal investigator
Dr Brijesh Patel
Click here for more information
Nasal High-Flow Oxygen Therapy After Cardiac Surgery (NOTACS) study
Study
Nasal High-Flow Oxygen Therapy After Cardiac Surgery (NOTACS) Study: Effect of High-Flow Nasal Therapy on Patient-Centred Outcomes in Patients at High Risk of Postoperative Pulmonary Complications After Cardiac Surgery: A Multicentre Randomised Controlled Trial.
IRAS no
278290
Study contact information
Name: Dr Nicoletta Zimbler
Email: N.Zimbler@rbht.nhs.uk
Principal investigator
Dr Nicoletta Zimbler
Click here for more information
Aspergillosis in patients with severe influenza (AspiFlu)
Study
Incidence and Pathogenesis of Invasive Aspergillosis in Intensive Care Patients with Severe Influenza (AspiFLu)
IRAS no
271269
Study contact information
Name: Anelise Catelan Zborowski
Email: A.CatelanZborowski@rbht.nhs.uk
Principal investigator
Dr Darius Armstrong-James
Click here for more information
The HITEC study
Study
Haemostasis and Immunothrombosis in Extracorporeal Circuits
IRAS no
294477
Study contact information
Name: Dr Teresa Lee
Email: t.lee@rbht.nhs.uk
Principal investigator
Dr Brijesh Patel
Click here for more information
RASECAL-Bronchoscopic ambusampler RCT - safety and efficiency
Study
A Randomised controlled trial to Assess the Safety and Efficiency of a self-Contained sampling device /disposable bronchoscope system versus usual sAmpLing procedure.
IRAS no
289572
Study contact information
Name: Anelise Catelan Zborowski
Email: a.catelanzborowski@rbht.nhs.uk
Principal investigator
Dr Ben Garfield
Click here for more information
HERACLES
Study
HEmodynamic effects of Reducing lv Afterload with impella or intra-aortic balloon CounterpuLsation during veno-arterial Extracorporeal membrane oxygenation in cardiogenic Shock
IRAS no
300145
Study contact information
Name: Professor Susanna Price
Email: s.price@rbht.nhs.uk
Principal investigator
Professor Susanna Price & Dr Vasileios Panoulas
Click here for more information
PETRA-UK study
Study
PaEdiatric TRAnsfusion practices in PICU in UK (PETRA-UK study)
IRAS no
317209
Study contact information
Name: Dr Justin Wang
Email: q.wang@rbht.nhs.uk
Principal investigator
Dr Justin Wang
"Unclassifiable" ILD
Study
Phase II study of Pirfenidone vs placebo in patients with fibrotic ILD that cannot be classified with moderate or high confidence into any other category of fibrotic IP by Multidisciplinary Team (MDT) review (“unclassifiable” ILD).
IRAS no
218417
Study contact information
Name: Vladimir Domi
Email: V.Domi@rbht.nhs.uk
Principal investigator
Professor Toby Maher
Click here for more information
Systemic sclerosis associated with ILD
Study
A double blind, randomised, placebo-controlled trial evaluating efficacy and safety of oral nintedanib, 150 mg twice daily for 52 weeks (with follow up until last patient out up to a maximum of 2 years) in patients with systemic sclerosis associated interstitial lung disease
IRAS no
185104
Study contact information
Name: Deirdre Flannery
Email: D.Flannery@rbht.nhs.uk
Principal investigator
Professor Toby Maher
Click here for more information
RA associated ILD with UIP pattern
Study
A 52 week, double blind, randomised, placebo-controlled trial evaluating the effect of Nintedanib, 150 mg twice daily, on annual rate of decline in Forced Vital Capacity and safety in patients with RA associated ILD with UIP pattern
IRAS no
217658
Study contact information
Name: Vladimir Domi
Email: V.Domi@rbht.nhs.uk
Principal investigator
Professor Toby Maher
Click here for more information
Rituximab vs intravenous cyclophosphamide in connective tissue disease associated ILD
Study
A randomised, double blind controlled trial comparing rituximab against intravenous cyclophosphamide in connective tissue disease associated interstitial lung disease
IRAS no
98339
Study contact information
Name: Vladimir Domi
Email: V.Domi@rbht.nhs.uk
Principal investigator
Professor Toby Maher
Click here for more information
Open label extension study of nintedanib in SSc-ILD
Study
An open-label extension trial to assess the long term safety of nintedanib in patients with ‘Systemic Sclerosis associated Interstitial Lung Disease’ (SSc-ILD)
IRAS no
235678
Study contact information
Name: Professor Toby Maher
Email: T.Maher@rbht.nhs.uk
Principal investigator
Professor Toby Maher
Click here for more information
TRAIL1
Study
A Randomised, Double-Blind, Placebo-Controlled, Phase 2 Study of Safety, Tolerability and Efficacy of Pirfenidone in Patients with Rheumatoid Arthritis Interstitial Lung Disease
IRAS no
220334
Study contact information
Name: Professor Toby Maher
Email: T.Maher@rbht.nhs.uk
Principal investigator
Professor Toby Maher
Click here for more information
Deep learning for HRCT classification of fibrotic lung disease
Study
Deep learning for HRCT classification of fibrotic lung disease
IRAS no
234527
Study contact information
Name: Professor Toby Maher
Email: T.Maher@rbht.nhs.uk
Principal investigator
Professor Toby Maher
Click here for more information
Historical exposures in hypersensitivity pneumonitis
Study
A case-referent study of the exposure history of adults with hypersensitivity pneumonitis
IRAS no
245417
Study contact information
Name: Dr Johanna Feary
Email: J.Feary@rbht.nhs.uk
Principal investigator
Dr Johanna Feary
Click here for more information
FIBRINOX
Study
Fibrotic Interstitial Lung Disease and nocturnal oxygen - An observational study of the effects of nocturnal hypoxaemia on patients with fibrotic interstitial lung disease
IRAS no
234305
Study contact information
Name: Richard Mordi
Email: R.Mordi@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
Clustering and Phenotyping Interstitial Lung Disease
Study
Clustering and Phenotyping Interstitial Lung Disease
IRAS no
270865
Study contact information
Name: Dr Philip Molyneaux
Email: P.Molyneaux@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
POSTCODE
Study
POST COvid-19 interstitial lung DiseasE (POSTCODE) A study of genetic and environmental interactions: an observational cohort study.
IRAS no
297495
Study contact information
Name: Dr Philip Molyneaux
Email: P.Molyneaux@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
I-FILE
Study
An international patient-led registry in fibrotic interstitial lung diseases using eHealth technology
IRAS no
291393
Study contact information
Name: Victor Jardim
Email: v.jardim@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
IMPALA -2
Study
A randomized, double-blind, placebo-controlled clinical trial of once-daily inhaled molgramostim nebulizer solution in adult subjects with autoimmune pulmonary alveolar proteinosis (aPAP).
IRAS no
289012
Study contact information
Name: Rosemarie Bolla
Email: r.bolla@rbht.nhs.uk
Principal investigator
Dr Maria Kokosi
Click here for more information
ILD-DNA
Study
Interstitial Lung Disease DNA Study
IRAS no
316318
Study contact information
Name: Mr Philip Molyneaux
Email: p.molyneaux@rbht.nhs.uk
Principal investigator
Mr Philip Molyneaux
Click here for more information
1305-0023: Phase III PoCC pivotal trial #1 BI 1015550 - PDE4 inhibitor in AF experienced PF-ILD
Study
Phase III PoCC pivotal trial #1 BI 1015550 - PDE4 inhibitor in AF experienced PF-ILD
IRAS no
1006258
Study contact information
Name: Maria Nunez
Email: m.nunez@rbht.nhs.uk
Principal investigator
Mr Philip Molyneaux
Click here for more information
1305-0014: Phase III PoCC pivotal trial #1 BI 1015550 - PDE4 inhibitor in AF experienced PF-ILD
Study
A double blind, randomized, placebo-controlled trial evaluating the efficacy and safety of BI 1015550 over at least 52 weeks in patients with Idiopathic Pulmonary Fibrosis (IPF).
IRAS no
1006245
Study contact information
Name: Maria Nunez
Email: m.nunez@rbht.nhs.uk
Principal investigator
Mr Philip Molyneaux
Genetic determinants of Kawasaki disease
Study
Genetic determinants of Kawasaki disease for susceptibility and outcome
IRAS no
115933
Study contact information
Name: Dr Rodney Franklin
Email: r.franklin@rbht.nhs.uk
Principal investigator
Dr Rodney Franklin
Tracking no small cell lung cancer evaluation
Study
Tracking non small cell lung cancer evolution through therapy (Rx)
IRAS no
138871
Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk
Principal investigator
Mr Eric Lim
Click here for more information
Video assisted thoracoscopic lobectomy vs conventional Open LobEcTomy
Study
Video assisted thoracoscopic lobectomy versus conventional Open LobEcTomy for lung cancer, a multi-centre randomised controlled trial with an internal pilot
IRAS no
163516
Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk
Principal investigator
Mr Eric Lim
Click here for more information
Cancer recurrence in patients after lung cancer surgery
Study
The process of disclosure of the risk of cancer recurrence in patients following potentially curative lung cancer surgery: a multiple case study
IRAS no
168907
Study contact information
Name: Matthew Johnson
Email: M.Johnson@rbht.nhs.uk
Principal investigator
Mr Eric Lim
Click here for more information
Lung nodule Imaging Biobank for Radiomics and AI research (LIBRA)
Study
Lung nodule Imaging Biobank for Radiomics and AI research (LIBRA)
IRAS no
274775
Study contact information
Name: Professor Anand Devaraj
Email: A.Devaraj@rbht.nhs.uk
Principal investigator
Professor Anand Devaraj
2010 BTS Guideline evaluation
Study
An evaluation of surgical resection rates before and after the introduction of the 2010 British Thoracic Society Guidelines on Radical Management of Lung Cancer
IRAS no
295021
Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk
Principal investigator
Mr Eric Lim
Click here for more information
OCTAPUS AI
Study
Optimising cancer treatment surveillance and ascertaining cause of Pneumonitis using artificial intelligence
IRAS no
283611
Study contact information
Name: Dr Philip Molyneaux
Email: P.Molyneaux@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
AI-SONAR
Study
AI & radiomics for Stratification Of lung Nodules After Radically treated cancer
IRAS no
300424
Study contact information
Name: Professor Anand Devaraj
Email: A.Devaraj@rbht.nhs.uk
Principal investigator
Professor Anand Devaraj
ADAURA2
Study
Phase III, Double-blind, Randomized, Placebo-Controlled, International Study to assess the Efficacy and Safety of Adjuvant Osimertinib versus Placebo in Patients with EGFR mutation-positive Stage IA2-IA3 Non-small Cell Lung Cancer, following Complete Tumoour removal.
IRAS no
1004224
Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk
Principal investigator
Professor Eric Lim
Click here for more information
Investigating Management of Lung Nodules
Study
Investigating management of lung nodules, and the impact of pre-diagnostic surveillance on health and economic outcomes
IRAS no
301177
Study contact information
Name: Professor Anand Devaraj
Email: A.Devaraj@rbht.nhs.uk
Principal investigator
Professor Anand Devaraj
Diffusion Tensor Imaging in ST-elevation Myocardial Infarction
Study
Investigation of Post-Myocardial Infarction Left Ventricular Remodelling By Diffusion Tensor Cardiac Magnetic Resonance
IRAS no
259868
Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk
Principal investigator
Dr Ranil De Silva
Infarction NSTEMI v1.0
Study
Non-ST-segment elevation myocardial infarction Registry.
IRAS no
261605
Study contact information
Name: Paula Rogers
Email: p.rogers@rbht.nhs.uk
Principal investigator
Dr Vasileios Panoulas
Click here for more information
DanGer Shock
Study
Effect of mechanical circulatory support in acute myocardial infarction complicated by cardiogenic shock
IRAS no
286689
Study contact information
Name: Alcida Bucaj
Email: A.Bucaj@rbht.nhs.uk
Principal investigator
Dr Vasileios Panoulas
Click here for more information
ORBITA-COSMIC
Study
Coronary sinus reducer Objective impact on Symptoms, MRI Ischaemia and microvascular Resistance
IRAS no
288725
Study contact information
Name: Dr Ranil De Silva
Email: r.desilva2@rbht.nhs.uk
Principal investigator
Dr Ranil De Silva
Click here for more information
SERIAL Study
Study
Systematic Evaluation by Randomisation of Intracoronary physiological techniques for Assessing tandem Lesions
IRAS no
293563
Study contact information
Name: Kevin Cheng
Email: k.cheng@rbht.nhs.uk
Principal investigator
Dr Ranil De Silva
Pulmonary Non-Tuberculous Mycobacterial Disease
Study
A molecular approach to the diagnosis, assessment, monitoring and treatment of pulmonary non-Tuberculous Mycobacterial Disease.
IRAS no
212193
Study contact information
Name: Huw Ellis
Email: Huw.Ellis@rbht.nhs.uk
Principal investigator
Dr Michael Loebinger
Click here for more information
LAI in adult patients with NTM lung infections caused by MAC
Study
An open-label safety extension study to a multicenter study of liposomal amikacin for inhalation (LAI) in adult patients with non-Tuberculous Mycobacterial (NTM) lung infections caused by Mycobacterium avium complex (MAC) that are refractory to treatment
IRAS no
190666
Study contact information
Name: Najwa Soussi
Email: N.Soussi@rbht.nhs.uk
Principal investigator
Dr Michael Loebinger
Click here for more information
Metatranscriptomics in Non-Tuberculous Mycobacterial Pulmonary Disease
Study
Metatranscriptomics in Non-Tuberculous Mycobacterial Pulmonary Disease
IRAS no
296492
Study contact information
Name: Kartik Kumar
Email: K.Kumar2@rbht.nhs.uk
Principal investigator
Dr Michael Loebinger
Click here for more information
ENCORE - INS 416
Study
A Randomized, Double-Blind, Placebo-Controlled, Active Comparator, Multicenter Study to Evaluate the Efficacy and Safety of an Amikacin Liposome Inhalation Suspension (ALIS)-Based Regimen in Adult Subjects with Newly Diagnosed Nontuberculous Mycobacterial
IRAS no
1004406
Study contact information
Name: Camilla Goulsbra
Email: c.goulsbra@rbht.nhs.uk
Principal investigator
Dr Michael Loebinger
There are currently no active studies
NEURO-PACK
Study
NEURO-PACK: Neurologic prognosis after cardiac arrest in kids. An observational study of neurodevelopmental outcome after cardiac arrest in children admitted to paediatric intensive care
IRAS no
223292
Study contact information
Name: Dr Sandra Gala-Peralta
Email: s.gala-peralta@rbht.nhs.uk
Principal investigator
Dr Sandra Gala-Peralta
Click here for more information
Phase 3 - Edoxaban DU-176b in children
Study
An open-label randomised, parallel-group, multicenter, observational trial to evaluate the safety and efficacy of edoxaban tosylate in children from 38 weeks gestational age to less than 18 years of age with cardiac disease at risk of thromboembolic events.
IRAS no
238090
Study contact information
Name: Dr Piers Daubeney
Email: P.Daubeney@rbht.nhs.uk
Principal investigator
Dr Piers Daubeney
Click here for more information
Remote monitoring & gaming technology for children with CF
Study
Project Fizzyo: Remote monitoring and gaming technology for improving physiotherapy prescription, adherence and prediction of clinical outcomes in children with cystic fibrosis.
IRAS no
228625
Study contact information
Name: Ms Nicky Murray
Email: N.Murray@rbht.nhs.uk
Principal investigator
Ms Nicky Murray
Click here for more information
Novel electronic monitoring devices to monitor adherence in asthma
Study
A feasibility study to assess Novel Electronic Monitoring Devices (NEDM) for monitoring adherence in children with asthma.
IRAS no
239759
Study contact information
Name: Dr Louise Fleming
Email: L.Fleming@rbht.nhs.uk
Principal investigator
Dr Louise Fleming
Click here for more information
Severe Paediatric Asthma Collaborative in Europe (SPACE)
Study
Severe Paediatric Asthma Collaborative in Europe (SPACE).
IRAS no
230893
Study contact information
Name: Dr Louise Fleming
Email: L.Fleming@rbht.nhs.uk
Principal investigator
Dr Louise Fleming
Click here for more information
Fevipiprant
Study
A multicenter, open-label, 8 day treatment study to assess the pharmacokinetics, safety and tolerability of fevipiprant delivered via a once daily chewable tablet in children aged 6 to <12 years with asthma
IRAS no
264789
Study contact information
Name: Yvonne Bingham
Email: Y.Bingham@rbht.nhs.uk
Principal investigator
Dr Louise Fleming
Microbial ecology effects relating to childhood asthma (MEERCAT)
Study
Impact of premature birth on the gastrointestinal microbiota in early infancy and respiratory health at school age: a comparison of premature and term birth cohorts.
IRAS no
251418
Study contact information
Name: Yvonne Bingham
Email: Y.Bingham@rbht.nhs.uk
Principal investigator
Professor Sejal Saglani
A Phase 3b, randomised, placebo-controlled study evaluating the efficacy and safety of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis subjects 6-11 years of age who are heterozygous for the F508del mutation and a minimal function mutation (F/MF)
Study
A Phase 3b, randomised, placebo-controlled study evaluating the efficacy and safety of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis subjects 6-11 years of age who are heterozygous for the F508del mutation and a minimal function mutation (F/MF)
IRAS no
1003047
Study contact information
Name: Sandra Scott
Email: s.scott@rbht.nhs.uk
Principal investigator
Professor Jane Davies
PRAADA1 Study - Prenatal right aortic arch and double arch study - V1
Study
National Study of prenatally diagnosed right aortic arch and double arch: Incidence; associations and outcomes. A collaboration of the United Kingdom National Foetal Cardiology Working Group.
IRAS no
262525
Study contact information
Name: Victoria Doughty
Email: V.Doughty@rbht.nhs.uk
Principal investigator
Dr Julene Carvalho
Treating severe paediatric asthma; the TREAT trial
Study
Treating severe paediatric asthma; a randomised controlled trial of mepolizumab and omalizumab (TREAT trial)
IRAS no
252084
Study contact information
Name: Professor Sejal Saglani
Email: S.Saglani@rbht.nhs.uk
Principal investigator
Professor Sejal Saglani
Click here for more information
Retrospective review of lung function data in a paediatric centre
Study
Retrospective review of lung function data in a tertiary paediatric respiratory cohort
IRAS no
292859
Study contact information
Name: Dr Samantha Irving
Email: S.Irving@rbht.nhs.uk
Principal investigator
Dr Samantha Irving
CKJX839C12301: inclisiran in adolescents with HeFH
Study
Two part (double-blind inclisiran versus placebo [Year 1] followed by open-label inclisiran [Year 2]) randomized multicenter study to evaluate safety, tolerability, and efficacy of inclisiran in adolescents (12 to less than 18 years) with heterozygous familial hypercholesterolemia and elevated LDL-cholesterol (ORION-16)
IRAS no
1003480
Study contact information
Name: Dr Mahmoud Barbir
Email: M.Barbir@rbht.nhs.uk
Principal investigator
Dr Mahmoud Barbir
Click here for more information
The SPAR Study
Study
Exploration of a novel mathematical approach -Symmetric Projection Attractor Reconstruction (SPAR), to assist with clinical decision making in critically ill children.
IRAS no
301471
Study contact information
Name: Dr Duncan Macrae
Email: D.Macrae@rbht.nhs.uk
Principal investigator
Dr Duncan Macrae
The Fetal Aorta Study
Study
Echocardiographic Z-scores for Fetal Aortic Arch Dimensions
IRAS no
264724
Study contact information
Name: Victoria Doughty
Email: v.doughty@rbht.nhs.uk
Principal investigator
Dr Julene S Carvalho
Click here for more information
Childhood Home Asthma Monitoring Project (CHAMP)
Study
Childhood Home Asthma Monitoring Project: prospective observational study to explore the use of contactless home monitoring devices and analysis to predict asthma risk
IRAS no
282335
Study contact information
Name: Angela Jamalzadeh
Email: a.jamalzadeh@rbht.nhs.uk
Principal investigator
Dr Louise Fleming
Click here for more information
Remote monitoring in preschool wheeze
Study
Remote monitoring to predict and prevent asthma attacks in preschool children
IRAS no
307300
Study contact information
Name: Yvonne Bingham
Email: y.bingham@rbht.nhs.uk
Principal investigator
Dr Sejal Saglani
Click here for more information
Predicting Progression to School Aged Asthma
Study
Pre-school Wheeze: Predicting Progression to School Aged Asthma
IRAS no
290688
Study contact information
Name: Sormeh Salehian
Email: s.salehian@rbht.nhs.uk
Principal investigator
Dr Louise Fleming
Click here for more information
ICONIK
Study
Inherited Cardiac cONditions In Kids Understanding the Genetics and Outcomes of Paediatric Inherited Cardiac Conditions
IRAS no
288514
Study contact information
Name: Dr Andres Rico-Armada
Email: a.rico-armada@rbht.nhs.uk
Principal investigator
Dr Andres Rico-Armada
Click here for more information
Connecting breath and mind for CYP with post-COVID syndrome
Study
Connecting breath and mind: Development of an online holistic treatment Programme connecting psychological wellbeing and breathing techniques in children and young people with post-COVID syndrome
IRAS no
315063
Study contact information
Name: Dr Samatha Sonnappa
Email: s.sonnappa@rbht.nhs.uk
Principal investigator
Dr Samatha Sonnappa
Click here for more information
Care at the end of life in babies and children (NICU and PICU) WS3b
Study
End of Life Care for Infants, Children and Young People: a mixed methods evaluation of current practice in England and Wales. (Workstream 3 PART B: Prospective evaluation of care at the end of life in babies and children in NICU and PICU)
IRAS no
319728
Study contact information
Name: Laura Tous Sampol
Email: l.toussampol@rbht.nhs.uk
Principal investigator
Dr Justin Wang
Unexplained respiratory muscle weakness or respiratory failure
Study
Prevalence of Pompe’s disease amongst patients with unexplained respiratory muscle weakness or respiratory failure
IRAS no
184294
Study contact information
Name: Mike Apps
Email: M.Apps@rbht.nhs.uk
Principal investigator
Professor Michael Polkey
MRI in the assessment of CF and primary ciliary dyskinesia
Study
Use of MRI in the assessment of cystic fibrosis and primary ciliary dyskinesia - A clinical feasibility study
IRAS no
196228
Study contact information
Name: Dr Anand Devaraj
Email: a.devaraj@rbht.nhs.uk
Principal investigator
Dr Anand Devaraj
Click here for more information
Machine learning to diagnose PCD
Study
Improving Primary Ciliary Dyskinesia diagnosis using artificial intelligence
IRAS no
259067
Study contact information
Name: Thomas Burgoyne
Email: T.Burgoyne@rbht.nhs.uk
Principal investigator
Professor Claire Hogg
IN-PCD
Study
The Effects of Inhaled Corticosteroids on Inflammation and Infection in Primary Ciliary Dyskinesia.
IRAS no
256504
Study contact information
Name: Laura Gardner
Email: L.Gardner@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Patients with pulmonary vascular disease
Study
Prospective study in patients with pulmonary vascular disease
IRAS no
210461
Study contact information
Name: Eleanor Morris
Email: e.morris@rbht.nhs.uk
Principal investigator
Dr Stephen John Wort
Click here for more information
Idiopathic and heritable pulmonary arterial hypertension
Study
National cohort study of Idiopathic and Heritable Pulmonary Arterial Hypertension
IRAS no
123349
Study contact information
Name: Joy Pinguel
Email: A.Pinguel@rbht.nhs.uk
Principal investigator
Dr Stephen John Wort
Click here for more information
Quantitative MRI measures in PH (Version 1)
Study
Novel Quantitative Magnetic Resonance Imaging (MRI) Measures in the Assessment and Follow-up of patients with Pulmonary Hypertension (PH)
IRAS no
246688
Study contact information
Name: Mr Simon Padley
Email: S.Padley@rbht.nhs.uk
Principal investigator
Mr Simon Padley
Click here for more information
Utility of Emphasis-10 in Risk Stratification in Pulmonary Arterial Hypertension
Study
Utility of Emphasis-10 in Risk Stratification in Pulmonary Arterial Hypertension.
IRAS no
254446
Study contact information
Name: Dr John Wort
Email: S.Wort@rbht.nhs.uk
Principal investigator
Dr John Wort
Use of pulmonary arterial hypertension therapies in Fontan patients: Current practice across the UK
Study
Use of pulmonary arterial hypertension therapies in Fontan patients.
IRAS no
263589
Study contact information
Name: Dr Kostas Dimopoulos
Email: K.Dimopoulos@rbht.nhs.uk
Principal investigator
Dr Kostas Dimopoulos
PEX-NET
Study
Pulmonary Hemodynamics during Exercise - Research Network.
IRAS no
257879
Study contact information
Name: Dr Colm McCabe
Email: C.McCabe2@rbht.nhs.uk
Principal investigator
Dr Colm McCabe
ROR-PH-301 - APD811-301 A phase 3 study to evaluate ralinepag added to SOC in PAH
Study
ROR-PH-301 - A StuDy eVAluatiNg the EffiCacy and Safety of RalinEpag To Improve Treatment OUTCOMES in PAH Patients
IRAS no
255909
Study contact information
Name: Eleanor Morris
Email: e.morris@rbht.nhs.uk
Principal investigator
Dr Colm McCabe
Click here for more information
ROR-PH-303 - APD811-303-A phase 3 OLE ext to evaluate long term safety of ralinepag
Study
ROR-PH-303 - A StuDy EVAluatiNg the Long-Term EffiCacy and Safety of RalinEpag in Subjects with PAH via an Open-Label EXTENSION
IRAS no
255904
Study contact information
Name: Eleanor Morris
Email: e.morris@rbht.nhs.uk
Principal investigator
Dr Colm McCabe
Click here for more information
CPET and stress echocardiography following pulmonary embolism
Study
Utility of cardiopulmonary exercise testing and stress echocardiography in the assessment of breathlessness following pulmonary embolism: a pilot study
IRAS no
300840
Study contact information
Name: Dr Colm McCabe
Email: C.McCabe2@rbht.nhs.uk
Principal investigator
Dr Colm McCabe
STELLAR. A Phase 3 Study of Sotatercept for the Treatment of PAH
Study
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Compare the Efficacy and Safety of Sotatercept Versus Placebo When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH
IRAS no
1003529
Study contact information
Name: Joy Pinguel
Email: a.pinguel@rbht.nhs.uk
Principal investigator
Dr John Wort
Click here for more information
ELEVATE 2
Study
A Phase 2b, Dose-Ranging, Randomized, Double-Blind, Placebo Controlled, Multicenter Study of Rodatristat Ethyl in Patients with Pulmonary Arterial Hypertension
IRAS no
1003552
Study contact information
Name: Joy Pinguel
Email: a.pinguel@rbht.nhs.uk
Principal investigator
Dr John Wort
Click here for more information
GLP-1 agonist in acute pulmonary embolisms
Study
Efficacy of GLP-1 agonist Semaglutide in acute pulmonary embolisms: a biomarker-driven proof of concept open label phase II study
IRAS no
300440
Study contact information
Name: Joy Pinguel
Email: a.pinguel@rbht.nhs.uk
Principal investigator
Dr Colm McCabe
Positioning Imatinib for Pulmonary Arterial Hypertension (PIPAH)
Study
Identifying a safe and tolerated dose of Imatinib for patients with Pulmonary Arterial Hypertension (PAH)
IRAS no
274093
Study contact information
Name: Eleanor Morris
Email: e.morris@rbht.nhs.uk
Principal investigator
Dr John Wort
Click here for more information
Pulmonary hypertension in CHD
Study
Pulmonary hypertension in congenital heart disease
IRAS no
273383
Study contact information
Name: Dr Andrew Constantine
Email: a.constantine@rbht.nhs.uk
Principal investigator
Professor Kostas Dimopoulos
Click here for more information
Utility of sendaway NTproBNP
Study
Assessing the utility of capillary sendaway NT-proBNP in pulmonary hypertension across the UK.
IRAS no
299472
Study contact information
Name: Eleanor Morris
Email: e.morris@rbht.nhs.uk
Principal investigator
Dr Stephen John Wort
Acceleron
Study
An Open-Label Long-term Follow-up Study to Evaluate the Effects of Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH
IRAS no
1003791
Study contact information
Name: Joy Pinguel
Email: a.pinguel@rbht.nhs.uk
Principal investigator
Dr Stephen John Wort
Click here for more information
Hyperion
Study
A Phase 3, Randomized, Double-blind, Placebo-controlled study to Evaluate Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy in Newly Diagnosed Intermediate-and High-risk PAH Patients
IRAS no
1003773
Study contact information
Name: Joy Pinguel
Email: a.pinguel@rbht.nhs.uk
Principal investigator
Dr Colm McCabe
Click here for more information
A011-14
Study
A Phase 3, Randomized, Double-Blind, PlaceboControlled Study to Evaluate Sotatercept When Added to Maximum Tolerated Background Therapy in Participants With Pulmonary Arterial Hypertension (PAH) World Health Organization (WHO) Functional Class (FC) III or FC IV at High Risk of Mortality.
IRAS no
1004073
Study contact information
Name: Joy Pinguel
Email: a.pinguel@rbht.nhs.uk
Principal investigator
Dr Stephen John Wort
Click here for more information
AI in Chronic Lung Disease PH
Study
The role of artificial intelligence to detect the presence and severity of pulmonary hypertension in patients with chronic lung disease using non-invasive data
IRAS no
311484
Study contact information
Name: Dr Stephen John Wort
Email: s.wort@rbht.nhs.uk
Principal investigator
Dr Stephen John Wort
DeVENT
Study
Decision support system to evaluate VENTilation in ARDS (DeVENT)
IRAS no
266521
Study contact information
Name: Natalie Dormand
Email: N.Dormand@rbht.nhs.uk
Principal investigator
Dr Brij Patel
Reducer-I
Study
Reducer-I: An observational study of the Neovasc Reducer System
IRAS no
190140
Study contact information
Name: Debra Dempster
Email: D.Dempster@rbht.nhs.uk
Principal investigator
Dr Ranil De Silva
Click here for more information
PPCI
Study
Lived experiences of heart attack and primary angioplasty (PPCI)
IRAS no
224728
Study contact information
Name: Marina Nicholas
Email: m.nicholas@rbht.nhs.uk
Principal investigator
Ms Marina Nicholas
EBT in sarcoidosis
Study
Measure of exhaled breath temperature (EBT) in patients with sarcoidosis.
IRAS no
215820
Study contact information
Name: Professor Athol Wells
Email: RBHILD@rbht.nhs.uk
Principal investigator
Professor Athol Wells
Click here for more information
MAGNET-CS Version 1
Study
Improving Assessment of Diagnosis and Prognosis in Cardiac Sarcoidosis
IRAS no
287964
Study contact information
Name: Dr Alessia Azzu
Email: A.Azzu@rbht.nhs.uk
Principal investigator
Professor Dudley Pennell
PHASE Study
Study
A multicentre, randomised, double-blind, placebo-controlled study in participants with sarcoidosis-associated pulmonary hypertension (SAPH) to assess the efficacy and safety of oral selexipag
IRAS no
264526
Study contact information
Name: Silvia Zagalo
Email: S.Zagalo@rbht.nhs.uk
Principal investigator
Dr Vasilis Kouranos
Click here for more information
The role of conventional and advanced imaging modalities in formulating an optimal risk stratification strategy in patients with suspected cardiac sarcoidosis
Study
The role of conventional and advanced imaging modalities in formulating an optimal risk stratification strategy in patients with suspected cardiac sarcoidosis
IRAS no
310314
Study contact information
Name: Raheel Ahmed
Email: r.ahmed2@rbht.nhs.uk
Principal investigator
Dr Vasilis Kouranos
A Phase II study of CMK389 in patients with pulmonary sarcoidosis
Study
A subject and investigator blinded, randomized, placebo-controlled, repeat-dose, multicenter study to investigate efficacy, safety, and tolerability of CMK389 in patients with chronic pulmonary sarcoidosis
IRAS no
279463
Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk
Principal investigator
Dr Vasilis Kouranos
No studies at present
UK Mini Mitral
Study
Minimally invasive thoracoscopically-guided right minithoracotomy versus conventional sternotomy for mitral valve repair: a multicentre randomised controlled trial (UK Mini Mitral)
IRAS no
204506
Study contact information
Name: Claire Prendergast
Email: c.prendergast2@rbht.nhs.uk
Principal investigator
Mr Toufan Bahrami
Click here for more information
Blood flow patterns from 4D-flow MRI
Study
Can blood flow patterns from 4D-flow MRI be used to predict aortic wall degradation?
IRAS no
231355
Study contact information
Name: Yousuf Salmasi
Email: M.Salmasi@rbht.nhs.uk
Principal investigator
Professor John Pepper
Click here for more information
Avr Thrombosis OutcoMe study (ATOM)
Study
Can thrombosis and fibrinolysis markers in patients undergoing aortic valve replacement predict outcome
IRAS no
259805
Study contact information
Name: Michelle Rackham
Email: M.Rackham@rbht.nhs.uk
Principal investigator
Dr Vasileios Panoulas
Click here for more information
OSPREY-CR Version 2
Study
Optimising Secondary PRevention and quality of life following EarlY Cardiac Rehabilitation: OSPREY-CR
IRAS no
278371
Study contact information
Name: Heather Probert
Email: H.Probert@rbht.nhs.uk
Principal investigator
Heather Probert
Click here for more information
4D Motion-2
Study
4D Motion of the aorta in the chest and simulated wall stress distribution in relation to aortic events
IRAS no
284431
Study contact information
Name: Dr Christoph Nienaber
Email: c.nienaber@rbht.nhs.uk
Principal investigator
Dr Christoph Nienaber
RESOLVE MR
Study
Real World Study of the Tendyne™ Mitral Valve System to Treat Mitral Regurgitation (Tendyne™ PMCF Study)
IRAS no
304570
Study contact information
Name: Anelise Catelan Zborowski
Email: a.catelanzborowski@rbht.nhs.uk
Principal investigator
Dr Alison Mary Duncan
Click here for more information
Fingerprinting proteoglycan turnover by ADAMTS proteases
Study
Fingerprinting proteoglycan turnover by ADAMTS proteases in the cardiovasculature
IRAS no
296129
Study contact information
Name: Professor John Pepper
Email: j.pepper@rbht.nhs.uk
Principal investigator
Professor John Pepper
Click here for more information
STRESS-MR - Haemodynamics of Mitral Regurgitation Reduction
Study
Comparative STudy chaRacterising the physiological changEs induced by Surgical and tranScatheter Mitral Regurgitation reduction - STRESS-MR
IRAS no
293585
Study contact information
Name: Dr Robert Smith
Email: r.smith@rbht.nhs.uk
Principal investigator
Dr Robert Smith
Prevention HARP 2
Study
Prevention of post-operative complications by using HMG-CoA reductase inhibitor in patients undergoing oesophagectomy. A multicentre, randomised, double blind, placebo controlled trial (Prevention HARP 2)
IRAS no
180853
Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk
Principal investigator
Mr Eric Lim
Click here for more information
TOPIC 2: Thoracic Epidural and Paravertebral Blocks in reducing CPTP
Study
A randomised controlled trial to investigate the effectiveness of Thoracic Epidural and Paravertebral Blockade in reducing Chronic Post-Thoracotomy Pain: 2
IRAS no
248427
Study contact information
Name: Dr Nandor Marczin
Email: N.Marczin@rbht.nhs.uk
Principal investigator
Dr Nandor Marczin
Click here for more information
CYCLONE- LVAD
Study
CYtosorb modulation of surgiCal infLammatiON during LVAD insErtion (CYCLONE-LVAD) study
IRAS no
230919
Study contact information
Name: Louise Moss
Email: L.McBrearty@rbht.nhs.uk
Principal investigator
Dr Nandor Marczin
Click here for more information
Millipede Feasibility Study
Study
A Study to Evaluate the Feasibility and Safety of the Millipede Transcatheter Annuloplasty Ring System in Patients with Functional Mitral Regurgitation
IRAS no
285206
Study contact information
Name: Debra Dempster
Email: D.Dempster@rbht.nhs.uk
Principal investigator
Dr Robert Smith
Click here for more information
BigpAK-2
Study
Biomarker- guided intervention to prevent acute kidney injury after major non-cardiac surgery - the prospective multicenter randomized controlled interventional trial
IRAS no
299561
Study contact information
Name: Alessandra Verzelloni
Email: a.verzellonisef@rbht.nhs.uk
Principal investigator
Dr Nandor Marczin
Click here for more information
STAR Registry
Study
Safe and Timely Antithrombotic Removal (STAR REGISTRY): International registry on the use of CytoSorb for removal of antithrombotic agents in the acute hospital setting.
IRAS no
301571
Study contact information
Name: Jovile Kazileviciute
Email: j.kazileviciute@rbht.nhs.uk
Principal investigator
Dr Nandor Marczin
Click here for more information
Embolization coil systems: RETRACTA and HILAL
Study
Embolization coil systems: RETRACTA and HILAL
IRAS no
307387
Study contact information
Name: Dr Carole Ridge
Email: c.ridge@rbht.nhs.uk
Principal investigator
Dr Carole Ridge
Click here for more information
Target Wound Infection
Study
A Surgical Site Infection Risk Prediction Tool to Enable Targeted Infection Prevention Strategies in Adult Cardiac Surgery.
IRAS no
295054
Study contact information
Name: Melissa Rochon
Email: m.rochon@rbht.nhs.uk
Principal investigator
Dr Mario Petrou & Dr Sunil Bhudia
Click here for more information
CHIP-BCIS3
Study
Controlled trial of High-risk coronary Intervention with Percutaneous left ventricular unloading
IRAS no
290599
Study contact information
Name: Laura Barker
Email: l.barker2@rbht.nhs.uk
Principal investigator
Dr Vasileios Panoulas
Peak cough flow and respiratory function testing (spirometry)
Study
A cross sectional feasibility study examining the relationship between peak cough flow and respiratory function testing (spirometry) post bilateral sequential single lung transplantation, at a single centre cardiothoracic transplantation unit
IRAS no
218051
Study contact information
Name: Abigail Roberts
Email: A.Roberts@rbht.nhs.uk
Principal investigator
Dr Anna Reed
Click here for more information
LACTATE in OHT
Study
Significance of hyperlactataemia during heart transplantation.
IRAS no
259590
Study contact information
Name: Ms Ana Doce Hurtado
Email: A.HurtadoDoce@rbht.nhs.uk
Principal investigator
Ms Ana Doce Hurtado
PRIDEHEART 1.0
Study
PRImary graft Dysfunction Evaluation in HEART Transplantation (PRIDE-HEART) study
IRAS no
241344
Study contact information
Name: Mr Andre Simon
Email: A.Simon@rbht.nhs.uk
Principal investigator
Mr Andre Simon
Click here for more information
4D Flow CMR in Lung Transplant Assessment
Study
4D Flow Cardiovascular Magnetic Resonance analysis of the right ventricle in lung transplant assessment
IRAS no
270554
Study contact information
Name: Dr Joyce Wong
Email: J.Wong@rbht.nhs.uk
Principal investigator
Dr Joyce Wong
Click here for more information
Statins for Improving Organ Outcome in Transplantation (SIGNET)
Study
An evaluation of the benefits of a single dose of Simvastatin given to potential organ donors declared dead by neurological criteria on outcomes in organ recipients
IRAS no
288722
Study contact information
Name: Kamal Liyanage
Email: k.liyanage@rbht.nhs.uk
Principal investigator
Dr Hatem Soliman Aboumarie & Dr Sian Jaggar
Click here for more information
E-CLAD UK
Study
Extracorporeal Photopheresis in the treatment of Chronic Lung Allograft Dysfunction: a randomised controlled trial
IRAS no
1005642
Study contact information
Name: Dr Martin Carby
Email: m.carby@rbht.nhs.uk
Principal investigator
Dr Martin Carby
Molecular and cellular pathogenesis of bone marrow failure syndromes
Study
Investigation of the molecular and cellular pathogenesis of bone marrow failure syndromes
IRAS no
97361
Study contact information
Name: Mr Andreas Hoschtitzky
Email: A.Hoschtitzky@rbht.nhs.uk
Principal investigator
Mr Andreas Hoschtitzky
Multisystem and autonomic complications of NMD on NIV
Study
Growing up on non-invasive ventilation: assessment of multisystem and autonomic complications of neuromuscular and neurological disorders in young adults.
IRAS no
266270
Study contact information
Name: Lydia Spurr
Email: l.spurr@rbht.nhs.uk
Principal investigator
Professor Anita Simonds
Characterisation of Large Airway Collapse during Exercise (LACE)
Study
The Feasibility of Continuous Bronchoscopy During Exercise in Healthy Adults in Assessing Large Airways Collapse
IRAS no
268188
Study contact information
Name: Alexandros Mitropoulos
Email: A.Mitropoulos@rbht.nhs.uk
Principal investigator
Dr James Hull
Grenfell Firefighters Study
Study
The Grenfell firefighters study; establishing a cohort
IRAS no
265618
Study contact information
Name: Professor Paul Cullinan
Email: p.cullinan@imperial.ac.uk
Principal investigator
Professor Paul Cullinan
University of Cambridge NHS health data consent survey
Study
University of Cambridge NHS health data consent survey.
IRAS no
268811
Study contact information
Name: Sara Salmi
Email: S.Salmi@rbht.nhs.uk
Principal investigator
Sara Salmi
Lung Health Check Biomarker Study
Study
Lung Health Check Biomarker Study
IRAS no
258696
Study contact information
Name: Dr Benjamin Hunter
Email: B.Hunter@rbht.nhs.uk
Principal investigator
Professor Anand Devaraj
Click here for more information
PaD Strat Study
Study
PaD Strat Study
IRAS no
285609
Study contact information
Name: Melissa Rochon
Email: M.Rochon@rbht.nhs.uk
Principal investigator
Melissa Rochon
Measurement of ISDs and creatinine by LC-MS/MS in VAMS samples
Study
Development and validation of a method for measurement of tacrolimus, ciclosporin, and creatinine in whole blood via 2D turboflow HPLC coupled with tandem mass spectrometry, using VAMS micro sampling techniques.
IRAS no
302783
Study contact information
Name: Mr Zain Odho
Email: Z.Odho@rbht.nhs.uk
Principal investigator
Mr Zain Odho
Tool Placement in Pulmonary Nodule using a Robotic Bronchoscopy System
Study
A Prospective Investigation to Assess the Accurate Tool Placement in Pulmonary Nodule(s) using a Robotic
Navigational Bronchoscopy System with Adjunct Real-time Imaging
IRAS no
308868
Study contact information
Name: Professor Pallav Shah
Email: p.shah@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
The Physiotherapy Assessment of Breathing Pattern Dysfunction (PHAB)
Study
An evaluation of physiotherapy assessment: A mixed methods study to evaluate the physiotherapy assessment of Breathing Pattern Disorder
IRAS no
315897
Study contact information
Name: Lizzie Grillo
Email: l.grillo@rbht.nhs.uk
Principal investigator
Lizzie Grillo
Unreported secondary findings in diagnostic Next Generation Sequencing: A retrospective study
Study
Unreported secondary findings in diagnostic Next Generation Sequencing: A retrospective study
IRAS no
326738
Study contact information
Name: Dr Deborah Morris-Rosendahl
Email: d.morris-rosendahl@rbht.nhs.uk
Principal investigator
Dr Deborah Morris-Rosendahl