Details of all our active research studies which are looking for volunteers, with more information about what each project entails and what kind of volunteers would be most suitable.
The ACTIVELY study
This is an observational multicentre study which aims to evaluate exercise testing practices and physical activity in children and adolescents who are diagnosed with inherited arrhythmias.
Epidemiology and prognosis in acute myocarditis
Myocarditis is a disease heart muscle caused by inflammation. This study aims to provide a contemporary, population-level assessment of the true clinical burden of myocarditis and how this may have changed over the last 20 years.
Active research studies
Safety and allegenicity of new vaccine for cat allergy
Study
An open label, safety and allergenicity Phase 0 study of a new hypoallergenic plant-derived cat dander vaccine in adult cat allergic subjects
IRAS no
1006294
Study contact information
Name: Gil Jimenez
Email: A.Eifan@rbht.nhs.uk
Principal investigator
Dr Guy Scadding
Rhythm or rate control for CRT: the RHYTHMIC study
Study
Rhythm or rate control for CRT: the RHYTHMIC study
IRAS no
265388
Study contact information
Name: Sara Salmi
Email: s.salmi@rbht.nhs.uk
Principal investigator
Dr Vias Markides
Click here for more information
BACKBEAT Trial
Study
BradycArdia paCemaKer with AV interval modulation for Blood prEssure treAtmenT (BACKBEAT Trial)
IRAS no
337061
Study contact information
Name: Maria Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk
Principal investigator
Professor Tom Wong
Click here for more information
AVEIR LP UK Registry
Study
AVEIR Leadless Pacemaker (LP) UK Registry
IRAS no
340241
Study contact information
Name: Maria Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk
Principal investigator
Professor Tom Wong
MODESA
Study
Mitochondrial dysfunction of eosinophils as a driving force for its activation in eosinophilic severe asthma
IRAS no
293693
Study contact information
Name: Sally Meah
Email: S.Meah@rbht.nhs.uk
Principal investigator
Professor Fan Chung
Click here for more information
TRECOS
Study
A 12 week double-blind, multicentre, randomised, active-controlled, 2-arm, parallel-group clinical trial to evaluate the safety of CHF5993 pMDI 200/6/12.5 µg HFA-152a, compared to CHF5993 pMDI 200/6/12.5 µg HFA-134a, in subjects with asthma
IRAS no
1008211
Study contact information
Name: Dr David Watchorn
Email: d.watchorn@rbht.nhs.uk
Principal investigator
Dr David Watchorn
Click here for more information
Nasal epithelial cells of healthy and asthmatic participants
Study
Study of the inflammatory properties of the nasal epithelial cells of healthy and asthmatic participants to define molecular phenotypes of severe asthma
IRAS no
336588
Study contact information
Name: Professor Fan Chung
Email: k.chung@rbht.nhs.uk
Principal investigator
Professor Fan Chung
Click here for more information
Pattern of chronic cough
Study
Measuring the pattern of cough in participants with chronic cough using Hyfe Cough monitor
IRAS no
329667
Study contact information
Name: Sally Meah
Email: sally.meah@imperial.ac.uk
Principal investigator
Professor Fan Chung
Click here for more information
TRECOS
Study
A 12 week double-blind, multicentre, randomised, active-controlled, 2-arm, parallel-group clinical trial to evaluate the safety of CHF5993 pMDI 200/6/12.5 µg HFA-152a, compared to CHF5993 pMDI 200/6/12.5 µg HFA-134a, in subjects with asthma
IRAS no
1008211
Study contact information
Name: Maria Fernandes
Email: m.fernandes@rbht.nhs.uk
Principal investigator
Dr David Watchorn
Click here for more information
Study to Assess the Efficacy and Safety of AZD5718 in Moderate-to-Severe Uncontrolled Asthma
Study
A Phase 2, Randomised, Double-Blind, Placebo and Active Comparator-Controlled Study to Assess Efficacy and Safety of Multiple Dose Levels of AZD5718 Given Orally Once Daily for Twelve Weeks in Adults with Moderate-to-Severe Uncontrolled Asthma
IRAS no
1005185
Study contact information
Name: Sankari Nagarajan
Email: s.nagarajan@rbht.nhs.uk
Principal investigator
Dr William Man
Click here for more information
Time and Motion (T&M) study to quantify time and resources associated with the management and administration of injectable biologics to treat patients with Severe Asthma (SA) and/or Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)
Study
Time and Motion (T&M) study to quantify time and resources associated with the management and administration of injectable biologics to treat patients with Severe Asthma (SA) and/or Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)
IRAS no
340292
Study contact information
Name: Irene Berrar Torre
Email: i.berrartorre@rbht.nhs.uk
Principal investigator
Ms Irene Berrar Torre
TEZEBIO – 3TR ABC
Study
Biomarkers and mechanisms of asthma remission following treatment with Tezepelumab in adults with severe asthma – 3TR ABC
IRAS no
323812
Study contact information
Name: Michel Dave Villamor
Email: m.villamor@rbht.nhs.uk
Principal investigator
Professor Salman Siddiqui
ReCETT-AF
Study
Realistic Computational Electrophysiology Simulations for Targeted Treatment of Atrial Fibrillation
IRAS no
285221
Study contact information
Name: Dr Shouvik Haldar
Email: s.haldar@rbht.nhs.uk
Principal investigator
Dr Shouvik Haldar
Click here for more information
REMEDY-PILOT
Study
Reducing microvascular dysfunction in patients with angina, ischaemia and unobstructed coronary arteries – a pilot study (REMEDY-PILOT)
IRAS no
295523
Study contact information
Name: Carmen Chan
Email: l.chan2@rbht.nhs.uk
Principal investigator
Dr Ranil De Silva
Click here for more information
ANT-010
Study
A Phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of abelacimab in high-risk patients with atrial fibrillation who have been deemed unsuitable for oral anticoagulation.
IRAS no
1007115
Study contact information
Name: Deirdre Flannery
Email: d.flannery@rbht.nhs.uk
Principal investigator
Dr John Foran
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MATRIX2
Study
Monotherapy with a P2Y12 inhibitor followed by a direct-acting oral anticoagulant in patients with ATRial fIbrillation undergoing suprafleX Cruz coronary stent implantation (MATRIX-2)
IRAS no
1009574
Study contact information
Name: Hayley Meyrick
Email: h.meyrick@rbht.nhs.uk
Principal investigator
Dr Mohammed Akhtar
SECURE (BWI_2019_05)
Study
An observational post-marketing study for evaluation of ongoing safety and effectiveness of catheter mapping and ablation using commercially approved BWI medical devices for the treatment of patients with cardiac arrhythmias
IRAS no
291077
Study contact information
Name: Maria Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk
Principal investigator
Professor Tom Wong
Safety and efficacy of PC945 for the treatment of refractory invasive pulmonary aspergillosis
Study
A double-blind, randomized, placebo-controlled study to assess the safety and efficacy of nebulized PC945 when added to systemic antifungal therapy for the treatment of refractory invasive pulmonary aspergillosis
IRAS no
1004474
Study contact information
Name: Dr Anna Reed
Email: a.reed@rbht.nhs.uk
Principal investigator
Dr Anna Reed
Click here for more information
GREAT-2 -GRemubamab ErAdication Trial
Study
GRemubamab ErAdication Trial (GREAT-2) A phase 2 trial of Gremubamab compared to placebo in participants with bronchiectasis and chronicPseudomonas aeruginosa infection
IRAS no
1005993
Study contact information
Name: Vladimir Domi
Email: v.domi@rbht.nhs.uk
Principal investigator
Professor Michael Loebinger
Click here for more information
EMILE
Study
Evaluation of the effect of Microbial dysbiosis upon anti-viral Immunity in bronchiEctasis
IRAS no
330984
Study contact information
Name: Dr Justin Garner
Email: j.garner@rbht.nhs.uk
Principal investigator
Dr Justin Garner
Click here for more information
ERS-AMR-CRC
Study
Mapping antimicrobial resistance in chronic infectious lung disease: A European Respiratory Society Antimicrobial Resistance Clinical Research Collaborative
IRAS no
327747
Study contact information
Name: Dr Anand Shah
Email: a.shah2@rbht.nhs.uk
Principal investigator
Dr Anand Shah
Click here for more information
Impact of Chronic Pulmonary Aspergillosis (CPA) on health status and wellbeing
Study
Impact of Chronic Pulmonary Aspergillosis (CPA) on health status and wellbeing
IRAS no
327492
Study contact information
Name: Dr Anand Shah
Email: a.shah2@rbht.nhs.uk
Principal investigator
Dr Anand Shah
Click here for more information
SBIVA
Study
Impact of Chronic Pulmonary Aspergillosis (CPA) on health status and wellbeing
IRAS no
1007537
Study contact information
Name: Dr Ricardo Jose
Email: r.jose@rbht.nhs.uk
Principal investigator
Professor Michael Loebinger
PRIVILEGE
Study
PRospective cohort study to understand Impact of VIraL infEction in chronic lunG diseasE
IRAS no
336487
Study contact information
Name: Patrick Senior
Email: p.senior@rbht.nhs.uk
Principal investigator
Dr Anand Shah
Therapeutic Outcomes in ABPA_retrospective data
Study
Therapeutic outcomes in Allergic Bronchopulmonary Aspergillosis: retrospective data
IRAS no
346410
Study contact information
Name: Lisa Nwankwo
Email: e.nwankwo@rbht.nhs.uk
Principal investigator
Ms Lisa Nwankwo
Click here for more information
Diagnosis and endotyping of fungal airways diseases
Study
Development of a precision diagnostic framework and endotyping (sub-typing) for chronic and allergic fungal airway diseases with a focus on aspergillosis
IRAS no
345119
Study contact information
Name: Ali Nuh
Email: a.nuh@rbht.nhs.uk
Principal investigator
Mr Ali Nuh
HNEi Phase I/IIa
Study
A randomised, double-blind, placebo-controlled study to investigate the safety, tolerability, and pharmacokinetics of inhaled CHF6333 after single ascending doses in healthy volunteers and one single dose in adult subjects with bronchiectasis
IRAS no
1008057
Study contact information
Name: Arvin Fernando
Email: a.fernando@rbht.nhs.uk
Principal investigator
Professor Michael Loebinger
Click here for more information
PRESIDE
Study
Prospective study of antimicrobial resistance in chronic lung disease
IRAS no
346303
Study contact information
Name: Dr Anand Shah
Email: a.shah2@rbht.nhs.uk
Principal investigator
Dr Anand Shah
PRC015 - Snipe First in Human Study
Study
A prospective, open label, multi centre, single arm, first in human study to assess the safety and initial performance of eas1 system for irreversible electroporation (ire) ablation of lung cancer in subjects eligible for tumour resection
IRAS no
342510
Study contact information
Name: Elif Agaoglu
Email: e.agaoglu@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
There are currently no active studies
UK lung volume reduction
Study
UK lung volume reduction - multicentre observational
IRAS no
190196
Study contact information
Name: Sara Buttery
Email: S.Buttery@rbht.nhs.uk
Principal investigator
Dr Nicholas Hopkinson
Click here for more information
AIRFLOW-3
Study
A Multicenter, Randomised, Sham-controlled Study to Evaluate Safety and Efficacy After Treatment with the Nuvaira Lung Denervation System in Subjects with Chronic Obstructive Pulmonary Disease (COPD).
IRAS no
253708
Study contact information
Name: Dr Ashish Karir
Email: a.karir@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
The WHAM Study
Study
Randomised controlled feasibility study of Maintaining the benefits of Pulmonary Rehabilitation with Harmonies and Melodies via Singing for Lung Health.
IRAS no
293580
Study contact information
Name: Peter Jung
Email: p.jung@rbht.nhs.uk
Principal investigator
Dr Adam Lewis
Click here for more information
The ON-PACE trial
Study
Dietary nitrate supplementation to enhance daily physical activity in hypoxic COPD: a randomised controlled trial
IRAS no
315107
Study contact information
Name: Alexis Perkins
Email: a.perkins@rbht.nhs.uk
Principal investigator
Dr Nicholas Hopkinson
Click here for more information
SPRAY-CB
Study
A Sham Controlled Prospective Randomized Clinical Trial of the RejuvenAir System for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease with Chronic Bronchitis
IRAS no
304514
Study contact information
Name: Dr Ashish Karir
Email: a.karir@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
AI in PRImary Care spirometry for diagnosis of Lung Disease (APRIL)
Study
Real-world evaluation of an Artificial-Intelligence support software (ArtiQ.Spiro) in Primary Care spirometry pathways for the detection of Lung Disease.
IRAS no
324175
Study contact information
Name: Dr William Man
Email: w.man@rbht.nhs.uk
Principal investigator
Dr William Man
Click here for more information
BREATH-2
Study
Bronchoscopic Release of Air Trapped in Hyperinflated Emphysematous Lung
IRAS no
326148
Study contact information
Name: Dr Ashish Karir
Email: a.karir@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
The Hyper-COPD Study
Study
Breathing Vigilance in a COPD population with hyperinflation
IRAS no
321477
Study contact information
Name: Dr Justin Garner
Email: j.garner@rbht.nhs.uk
Principal investigator
Dr Justin Garner
Click here for more information
ATHLOSS
Study
A Double-Blind, Multicentre, Randomized, Three-Period, Three-Treatment, Cross-Over Study to Evaluate the Effect of BGF MDI, BFF MDI, and Placebo MDI on Exercise Parameters in Participants with Chronic Obstructive Pulmonary Disease
IRAS no
1007637
Study contact information
Name: Camilla Goulsbra
Email: c.goulsbra@rbht.nhs.uk
Principal investigator
Professor Michael Polkey
Click here for more information
Ryme Medical TLD Pilot Study
Study
Targeted lung denervation (TLD) with the Ryme Medical Lung Denervation System in patients with chronic obstructive pulmonary disease (COPD)
IRAS no
337994
Study contact information
Name: Dr Anand Tana
Email: a.tana@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
Click here for more information
CONVERT II
Study
An Evaluation of the AeriSeal System® for CONVERTing Collateral Ventilation Status in Patients with Severe Emphysema: The CONVERT II Trial
IRAS no
336595
Study contact information
Name: Dr Ashish Karir
Email: a.karir@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
FADE UK
Study
Analysing Fungal Disease Epidemiology in the UK
IRAS no
300045
Study contact information
Name: Dr Anand Shah
Email: A.Shah2@rbht.nhs.uk
Principal investigator
Dr Anand Shah
Clinical Artificial Intelligence Fetal Echocardiography (CAIFE)
Study
Development of Clinical Artificial Intelligence Models in Fetal Echocardiography for the Detection of Congenital Heart Defects
IRAS no
317510
Study contact information
Name: Julene Carvalho
Email: j.carvalho@rbht.nhs.uk
Principal investigator
Dr Olga Patey
Click here for more information
Developing and validating a Health-related Quality-of-Life (HRQoL) measure for adults with congenital heart disease and heart failure (ACHD-HF HRQoL measure): Patient and clinician perspectives
Study
Developing and validating a Health-related Quality-of-Life (HRQoL) measure for adults with congenital heart disease and heart failure (ACHD-HF HRQoL measure): Patient and clinician perspectives
IRAS no
332895
Study contact information
Name: Hajar Habibi
Email: h.habibi@rbht.nhs.uk
Principal investigator
Professor Michael Gatzoulis
CF start
Study
The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF
IRAS no
211995
Study contact information
Name: Dr Siobhan Carr
Email: s.carr@rbht.nhs.uk
Principal investigator
Dr Siobhan Carr
Click here for more information
Targeting Immunotherapy for Fungal Infection in Cystic Fibrosis
Study
TrIFIC: Targeting Immunotherapy for Fungal Infection in Cystic Fibrosis
IRAS no
270828
Study contact information
Name: Maria Nunez
Email: M.Nunez@rbht.nhs.uk
Principal investigator
Dr James Darius-Armstrong
Click here for more information
Clinical Outcomes With Novel Modifier Therapy Combination (RECOVER)
Study
Real World Clinical Outcomes With Novel Modifier Therapy Combinations in People with CF
IRAS no
296928
Study contact information
Name: Clare Saunders
Email: c.saunders2@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
Clinimetric properties of Oxygen-Enhanced MRI
Study
Determining the clinimetric properties of structural and functional outputs of oxygen-enhanced magnetic resonance imaging in children and adults with cystic fibrosis (CF) and chronic suppurative lung disease (CSLD)
IRAS no
294686
Study contact information
Name: Cristopher Short
Email: C.Short@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Subjects
Study
A Phase 3 Open-label Study Evaluating the Long‑term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor Triple Combination Therapy in Cystic Fibrosis Subjects 2 Years and Older
IRAS no
1004766
Study contact information
Name: Jessie Matthews
Email: j.matthews@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
A Phase 3 Study of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Heterozygous
Study
A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for F508del and a Minimal Function Mutation (F/MF)
IRAS no
1003950
Study contact information
Name: Jessie Matthews
Email: j.matthews@rbht.nhs.uk
Principal investigator
Dr Nicholas Simmonds
Click here for more information
A Phase 1/2 Dose-escalation Study Evaluating the Safety, Tolerability, and Efficacy of VX-522 in Subjects 18 Years of Age and Older With Cystic Fibrosis and a CFTR Genotype Not Responsive to CFTR Modulator Therapy
Study
A Phase 1/2 Dose-escalation Study Evaluating the Safety, Tolerability, and Efficacy of VX-522 in Subjects 18 Years of Age and Older With Cystic Fibrosis and a CFTR Genotype Not Responsive to CFTR Modulator Therapy
IRAS no
1005878
Study contact information
Name: Clare Saunders
Email: c.saunders2@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
Skyline Open label Extension - VX20-121-104
Study
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy in Subjects With Cystic Fibrosis
IRAS no
1005889
Study contact information
Name: Dr Nicholas Simmonds
Email: n.simmonds@rbht.nhs.uk
Principal investigator
Dr Nicholas Simmonds
Click here for more information
A Randomised, Double-Blind, Placebo Controlled, Two-Part Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of a Repeat Dose of Inhaled ETD001 in People with Cystic Fibrosis
Study
A Randomised, Double-Blind, Placebo Controlled, Two-Part Study to Evaluate the Efficacy, Safety, Tolerability and Pharmacokinetics of a Repeat Dose of Inhaled ETD001 in People with Cystic Fibrosis
IRAS no
1008079
Study contact information
Name: Yasmine Needham
Email: y.needham@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
CFTR c.3874-4522A>G's impact on cystic fibrosis severity
Study
Investigating the possible association between expression of the CFTR: c.3874-4522A>G deep intronic variant and phenotype severity in patients with Cystic Fibrosis
IRAS no
335624
Study contact information
Name: Anna Lockhart
Email: a.lockhart@rbht.nhs.uk
Principal investigator
Dr Deborah Morris-Rosendahl
Click here for more information
ENHANCE
Study
Establishing Natural History in an Advanced New CF Care Era
IRAS no
332109
Study contact information
Name: Clare Saunders
Email: c.saunders2@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
YOGA-CF
Study
Yoga Outcomes Get Assessed in Cystic Fibrosis (YOGA-CF)
IRAS no
303898
Study contact information
Name: Gemma Stanford
Email: g.stanford@rbht.nhs.uk
Principal investigator
Gemma Stanford
Click here for more information
CHOICES
Study
A Phase IIb, Multicentre, Randomised, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Efficacy and Safety of irocaftor/Posenacaftor/Nesolicaftor in Subjects with Cystic Fibrosis Aged 18 Years or Older (CHOICES)
IRAS no
1005882
Study contact information
Name: Yasmine Needham
Email: y.needham@rbht.nhs.uk
Principal investigator
Dr Nicholas Simmonds
Click here for more information
Lenticlair TM 1
Study
A seamless Phase I/II trial with an initial open-label dose escalation part and a subsequent randomised, double-blind, placebo-controlled expansion part to evaluate the safety, tolerability, and efficacy of a single dose of BI 3720931, an inhaled lentivir
IRAS no
1008470
Study contact information
Name: Clare Saunders
Email: c.saunders2@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Closed-loop for people living with Cystic Fibrosis related diabetes
Study
An open-label, multi-centre, randomised, two arm single period parallel study to assess the efficacy, safety and utility of hybrid closed-loop glucose control compared to standard insulin therapy combined with continuous glucose monitoring in young people
IRAS no
315792
Study contact information
Name: Clare Saunders
Email: c.saunders2@rbht.nhs.uk
Principal investigator
Dr Imogen Felton
Click here for more information
Lenticlair TM-ON
Study
A clinical trial to evaluate the long-term safety and durability of efficacy of BI 3720931, an inhaled lentiviral vector gene therapy, after single dose administration in a previous clinical trial, and to evaluate the safety and efficacy of BI 3720931
IRAS no
1008580
Study contact information
Name: Clare Saunders
Email: c.saunders2@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Natural History Dilated Cardiomyopathy Associated with BAG3 Mutations
Study
A prospective multinational study of the natural history of participants with BAG3 mutation associated dilated cardiomyopathy
IRAS no
321187
Study contact information
Name: Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk
Principal investigator
Dr Antonis Pantazis
Click here for more information
The SMARTER-CM Study
Study
Genetics, Imaging And Artificial Intelligence for Precision Care in Cardiomyopathy
IRAS no
313058
Study contact information
Name: Dr Upasana Tayal
Email: u.tayal@rbht.nhs.uk
Principal investigator
Dr Upasana Tayal
Go DCM
Study
Defining the genetics, biomarkers and outcomes for dilated cardiomyopathy: a prospective multi-centre observational study
IRAS no
237880
Study contact information
Name: Teijo Palovaara
Email: T.Palovaara@rbht.nhs.uk
Principal investigator
Dr James Ware
Click here for more information
HEART - ACS V1.0
Study
The HarEfield Acute MyocaRdial InfarcTion Cohort
IRAS no
259087
Study contact information
Name: Laura Barker
Email: L.Barker2@rbht.nhs.uk
Principal investigator
Dr Miles Dalby
Click here for more information
Epidemiology and Prognosis in Acute Myocarditis
Study
Epidemiological trends and outcomes of hospital admissions for acute myocarditis and dilated cardiomyopathy in the National Health Service of England from 1998 onwards.
IGARD reference number
DARS-NIC-144568-D7G6V
Study contact information
Name: Amrit Lota
Email: A.Lota@rbht.nhs.uk
Principal investigator
Professor Sanjay Prasad
Click here for more information
A possible new treatment for elevated Lp(a) in CVD - HORIZON
Study
A randomised double-blind, placebo-controlled, multicenter trial assessing the impact of lipoprotein (a) lowering with TQJ230 on major cardiovascular events in patients with established cardiovascular disease (CVD).
IRAS no
267092
Study contact information
Name: Alkida Bucaj
Email: A.Bucaj@rbht.nhs.uk
Principal investigator
Professor Mahmoud Barbir
Click here for more information
Olpasiran trials of Cardiovascular Events And LipoproteiN(a) reduction – Outcomes trial
Study
A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Olpasiran on Major Cardiovascular Events in Patients with Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein (a)
IRAS no
1006924
Study contact information
Name: Sankari Nagarajan
Email: s.nagarajan@rbht.nhs.uk
Principal investigator
Dr Tina Khan
Click here for more information
CE-MARC 3
Study
A pragmatic approach to the investigation of stable chest pain: a UK, multi-centre, randomised trial to improve patient experience, outcomes and NHS cost efficiency
IRAS no
302218
Study contact information
Name: Dr Chiara Bucciarelli-Ducchi
Email: c.bucciarelli-ducci@rbht.nhs.uk
Principal investigator
Dr Ciara Bucciarelli-Ducchi
Click here for more information
VICTORION REAL v01
Study
An international prospective Real-world study to evaluate the Effectiveness and Adherence of incLisiran plus standard of care lipid-lowering therapy compared to standard of care therapy alone in patients with primary hypercholesterolemia or mixed dyslipidemia
IRAS no
317604
Study contact information
Name: Susshmitha Ramesh
Email: s.ramesh2@rbht.nhs.uk
Principal investigator
Dr Barbir Mahmoud
Click here for more information
BRITISH: Using CMR scar as risk indication tool in NICM and severe LVSD
Study
Using cardiovascular magnetic resonance identified scar as the Benchmark Risk Indication Tool for Implantable cardioverter defibrillators in patients with Non-Ischemic Cardiovascular and Severe systolic Heart failure
IRAS no
280862
Study contact information
Name: Annashyl West
Email: a.west@rbht.nhs.uk
Principal investigator
Professor Sanjay Prasad
Click here for more information
TRED-HF2
Study
A randomised trial examining therapy to maintain remission in dilated cardiomyopathy
IRAS no
1006543
Study contact information
Name: Saad Javed
Email: s.javed@rbht.nhs.uk
Principal investigator
Dr Brian Halliday
Click here for more information
HER-SAFE
Study
Randomised Control Trial for the Safety of Withdrawal of Pharmacological Treatment for Recovered HER2 Targeted Therapy Related Cardiac Dysfunction
IRAS no
312432
Study contact information
Name: Dr Alexander Lyon
Email: a.lyon@rbht.nhs.uk
Principal investigator
Dr Alexander Lyon
Click here for more information
Low QRS voltages in young healthy individuals and athletes
Study
The prevalence and significance of low QRS voltages in young healthy individuals and athletes
IRAS no
283055
Study contact information
Name: Dr Nirmitha Jayaratne
Email: n.jayaratne@rbht.nhs.uk
Principal investigator
Dr Sabiha Gati
Click here for more information
TN-401-0011
Study
Seroprevalence Study of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV) in Patients with Plakophilin 2 (PKP2)-associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
IRAS no
323224
Study contact information
Name: Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk
Principal investigator
Dr Antonis Pantazis
Click here for more information
Cardiac cachexia in advanced heart failure – a prospective cohort study investigating prevalence and outcome
Study
Cardiac cachexia in advanced heart failure – a prospective cohort study investigating prevalence and outcome
IRAS no
334613
Study contact information
Name: Dr Mansimran Singh Dulay
Email: m.singhdulay@rbht.nhs.uk
Principal investigator
Dr Owais Dar
Click here for more information
MAPLE-HCM
Study
A Phase 3, Multi-center, Randomized, Double-blind Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol in Adults with Symptomatic Obstructive Hypertrophic Cardiomyopathy
IRAS no
1007788
Study contact information
Name: Dr Antonis Pantazis
Email: a.pantazis@rbht.nhs.uk
Principal investigator
Dr Antonis Pantazis
Click here for more information
Euro-CRAFT Registry
Study
Prospective evaluation of the impact of coronary themodilution on clinical outcomes in chronic coronary syndromes
IRAS no
315345
Study contact information
Name: Maria Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk
Principal investigator
Dr Ranil De Silva
Click here for more information
BalanceD-HF
Study
A Phase III, Randomised, Double-blind Study to Evaluate the Effect of Balcinrenone/Dapagliflozin, Compared to Dapagliflozin, on the Risk of Heart Failure Events and Cardiovascular Death in Patients with Heart Failure and Impaired Kidney Function
IRAS no
1009392
Study contact information
Name: Melinda Holden
Email: m.holden@rbht.nhs.uk
Principal investigator
Dr Owais Dar
Click here for more information
The Acorai Study
Study
A single-site prospective observational study to assess the value of the data harvested by the Acorai intracardiac pressure monitoring (ICPM) system in predicting outcomes in patients ready for discharge from hospital following an admission with decompens
IRAS no
334837
Study contact information
Name: Ramey Assaf
Email: r.assaf@rbht.nhs.uk
Principal investigator
Dr Owais Dar
Click here for more information
PRIMARY
Study
Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥65 Year-olds (PRIMARY)
IRAS no
318625
Study contact information
Name: Maria Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk
Principal investigator
Mr Anthony C De Souza
Click here for more information
A Study to Assess Multidomain Endpoints of an ECG Patch (D1840M00072)
Study
Clinical observational study of remote, non-invasive, multidomain endpoints in patients recovering from acute decompensated heart failure
IRAS no
330309
Study contact information
Name: Dr Owais Dar
Email: o.dar@rbht.nhs.uk
Principal investigator
Dr Owais Dar
Click here for more information
VAD WEAN study
Study
Participation in an international registry of patients supported with a left ventricular assist device until recovery of natural heart function
IRAS no
339534
Study contact information
Name: Dr Fernando Riesgo Gil
Email: f.riesgogil@rbht.nhs.uk
Principal investigator
Dr Fernando Riesgo Gil
Click here for more information
Randomised, double-blind, placebo-controlled study to investigate a single administration of BI 765845 on top of standard of care in patients with acute myocardial infarction
Study
Randomised, double-blind, placebo-controlled study to investigate a single administration of BI 765845 on top of standard of care in patients with acute myocardial infarction
IRAS no
1008094
Study contact information
Name: Sankari Nagarajan
Email: s.nagarajan@rbht.nhs.uk
Principal investigator
Dr Vasileios Panoulas
GenePHIT: Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects with Non-Ischemic NYHA Class III Heart Failure
Study
A Phase 2, adaptive, double-blinded, placebo-controlled, randomized, multi-centre trial to evaluate the efficacy, safety and tolerability of intracoronary infusion of AB-1002 in adult subjects with New York Heart Association (NYHA) Class III heart failure
IRAS no
1009799
Study contact information
Name: Maria Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk
Principal investigator
Dr Alexander Lyon
Click here for more information
PROTECT IV
Study
Impella®-Supported PCI in High-Risk Patients with Complex Coronary Artery Disease and Reduced Left Ventricular Function
IRAS no
320316
Study contact information
Name: Melinda Holden
Email: m.holden@rbht.nhs.uk
Principal investigator
Dr Vasileios Panoulas
Progressive Fibrosing Lung Disease (PROFOUND)
Study
Identifying progressive fibrosing lung disease: a study of genetic and environmental interactions: an observational cohort study.
IRAS no
279948
Study contact information
Name: Jessica Wallen
Email: j.wallen@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
A Phase 2 study of RXC007 in patients with IPF
Study
A Multi-Cohort, Randomized, Placebo-Controlled Phase 2a Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Ascending Doses of RXC007 in Patients with Idiopathic Pulmonary Fibrosis.
IRAS no
1005138
Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
NAL03-202 - Trevi Therapeutics, Inc. - Idiopathic Pulmonary Fibrosis - 4318/0010
Study
A Randomised, Double-Blind, Placebo-Controlled, Parallel, 4-Arm Dose Ranging Study of the Safety and Efficacy of NAL ER Tablets for the Treatment of Cough in Idiopathic Pulmonary Fibrosis (IPF)
IRAS no
1008035
Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk
Principal investigator
Professor Philip Molyneaux
Click here for more information
Efzo-Fit Study
Study
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Intravenous Efzofitimod in Patients with Pulmonary Sarcoidosis
IRAS no
1006104
Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk
Principal investigator
Dr Vasilis Kouranos
Click here for more information
IM027-068
Study
A multicenter, randomized, double-blind, placebo-controlled, Phase 3 Study to evaluate the efficacy, safety, and tolerability of BMS-986278 in participants with idiopathic pulmonary fibrosis (IPF)
IRAS no
1008043
Study contact information
Name: Deirdre Flannery
Email: d.flannery@rbht.nhs.uk
Principal investigator
Professor Philip Molyneaux
Click here for more information
Treatment of idiopathic pulmonary fibrosis (IPF)
Study
A randomised, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of PLN-74809 bexotegrast) for the treatment of idiopathic pulmonary fibrosis (BEACON)
IRAS no
1008893
Study contact information
Name: Abigail Hamilton
Email: a.hamilton@rbht.nhs.uk
Principal investigator
Professor Philip Molyneaux
Click here for more information
FIBRONEER™-ON
Study
An open-label extension trial of the long-term safety and efficacyof BI 1015550 taken orally in patients with idiopathic pulmonaryfibrosis (IPF) and progressive pulmonary fibrosis (PPF)(FIBRONEER™-ON)
IRAS no
1009187
Study contact information
Name: Abigail Hamilton
Email: a.hamilton@rbht.nhs.uk
Principal investigator
Professor Philip Molyneaux
Click here for more information
Study 220929
Study
A Phase 2, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of GSK3915393 in participants with IPF
IRAS no
1004917
Study contact information
Name: Abigail Hamilton
Email: a.hamilton@rbht.nhs.uk
Principal investigator
Professor Philip Molyneaux
A randomised, double-blind, placebo-controlled, dose-finding study evaluating efficacy, safety and tolerability of different oral doses of BI 1819479 over at least 24 weeks in patients with IPF
Study
A randomised, double-blind, placebo-controlled, dose-finding study evaluating efficacy, safety and tolerability of different oral doses of BI 1819479 over at least 24 weeks in patients with idiopathic pulmonary fibrosis (IPF)
IRAS no
1009970
Study contact information
Name: Abigail Hamilton
Email: a.hamilton@rbht.nhs.uk
Principal investigator
Professor Philip Molyneaux
Click here for more information
A Phase IIa/IIb study to examine the efficacy and safety of BI 1839100 administered orally twice daily over a 12-week treatment period in patients with idiopathic pulmonary fibrosis or progressive pulmonary fibrosis with clinically significant cough
Study
A Phase IIa/IIb, randomised, double blind, placebo-controlled,parallel group dose-finding study to examine the efficacy and safetyof BI 1839100 administered orally twice daily over a 12-weektreatment period in patients with idiopathic pulmonary fibrosis
IRAS no
1009832
Study contact information
Name: Dr Richard Hewitt
Email: r.hewitt@rbht.nhs.uk
Principal investigator
Dr Richard Hewitt
PROPELLER
Study
PROgressive lung fibrosis and 68Ga-FAPi-PET Longitudinal evaLuation for Early disease activity Readout
IRAS no
347179
Study contact information
Name: Leda Yazbeck
Email: l.yazbeck@rbht.nhs.uk
Principal investigator
Professor Philip Molyneaux
There are currently no active studies
Transmural myocardial perfusion with hypertension, HCM and HCM phenocopies with CMR
Study
The measurement of transmural myocardial perfusion in normal subjects and patients with hypertension, hypertrophic cardiomyopathy (HCM) and HCM phenocopies with Cardiovascular Magnetic Resonance (CMR)
IRAS no
171258
Study contact information
Name: Brian Halliday
Email: B.Halliday@rbht.nhs.uk
Principal investigator
Dr Sanjay Prasad
CY 6022
Study
An open-label study of CK-3773274 for patients with Symptomatic Hypertrophic Cardiomyopathy (HCM)
IRAS no
1005788
Study contact information
Name: Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk
Principal investigator
Dr Antonis Pantazis
Click here for more information
Mavacamten in non-obstructive HCM
Study
A randomised, double-blind, placebo-controlled clinical study to evaluate mavacamten in adults with symptomatic non-obstructive hypertrophic cardiomyopathy
IRAS no
1006306
Study contact information
Name: Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk
Principal investigator
Dr Brian Halliday
Click here for more information
CY 6033 - Cytokinetics - Symptomatic Non-obstructive Hypertrophic Cardiomyopathy - 0771/0069
Study
A phase 3, multi-center, randomized, double-blind trial to evaluate the efficacy and safety of aficamten compared to placebo in adults with symptomatic non-obstructive hypertrophic cardiomyopathy
IRAS no
1008323
Study contact information
Name: Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk
Principal investigator
Dr Antonis Pantazis
GenOMICC
Study
Genetics of susceptibility and mortality in critical care (GenOMICC)
IRAS no
269326
Study contact information
Name: Dr Brijesh Patel
Email: B.Patel4@rbht.nhs.uk
Principal investigator
Dr Brijesh Patel
Click here for more information
HERACLES
Study
HEmodynamic effects of Reducing lv Afterload with impella or intra-aortic balloon CounterpuLsation during veno-arterial Extracorporeal membrane oxygenation in cardiogenic Shock
IRAS no
300145
Study contact information
Name: Professor Susanna Price
Email: s.price@rbht.nhs.uk
Principal investigator
Professor Susanna Price & Dr Vasileios Panoulas
Click here for more information
GOlDilOCS: Genomic determinants of outcome in cardiogenic shock
Study
Prospective observational study investigating genomic determinants of outcome from cardiogenic shock
IRAS no
290406
Study contact information
Name: Keir Stirrat
Email: k.stirrat@rbht.nhs.uk
Principal investigator
Dr Brijesh Patel
Click here for more information
Indications, efficacy and safety profiles of dual treatment with Levosimendan and Sildenafil in critically ill adult patients
Study
Indications, efficacy and safety profiles of dual treatment with Levosimendan and Sildenafil in critically ill adult patients
IRAS no
326729
Study contact information
Name: Dr Sundeep Kaul
Email: s.kaul@rbht.nhs.uk
Principal investigator
Dr Sundeep Kaul
GuARDS
Study
Glucocorticoids in adults with Acute Respiratory Distress Syndrome: Arandomised, parallel-group, allocation-concealed, open label, pragmatic,group sequential design, clinical and cost- effectiveness trial withinternal pilot
IRAS no
1007694
Study contact information
Name: Victor Jardim
Email: v.jardim@rbht.nhs.uk
Principal investigator
Dr Brijesh Patel
RESTORE
Study
A randomised trial of surgery versus no treatment to RESTORE cardiopulmonary function in severe pectus excavatum.
IRAS no
331910
Study contact information
Name: Paulo De Sousa
Email: p.desousa@rbht.nhs.uk
Principal investigator
Sofina Begum
Click here for more information
BIOMiCS
Study
Identification of optimal markers to assess bleeding and thrombosis risk in patients on mechanical circulatory support
IRAS no
345732
Study contact information
Name: Victor Galusko
Email: v.galusko@rbht.nhs.uk
Principal investigator
Professor Diana Gorog
Click here for more information
E-CLAD UK Long-term
Study
Extracorporeal Photopheresis in the treatment of Chronic Lung Allograft Dysfunction: Long-Term Follow-Up Study
IRAS no
338850
Study contact information
Name: Binu Raj
Email: b.raj@rbht.nhs.uk
Principal investigator
Dr Martin Carby
I-FILE
Study
An international patient-led registry in fibrotic interstitial lung diseases using eHealth technology
IRAS no
291393
Study contact information
Name: Victor Jardim
Email: v.jardim@rbht.nhs.uk
Principal investigator
Dr Philip Molyneaux
Click here for more information
ILD-DNA
Study
Interstitial Lung Disease DNA Study
IRAS no
316318
Study contact information
Name: Mr Philip Molyneaux
Email: p.molyneaux@rbht.nhs.uk
Principal investigator
Mr Philip Molyneaux
Click here for more information
1305-0023: Phase III PoCC pivotal trial #1 BI 1015550 - PDE4 inhibitor in AF experienced PF-ILD
Study
Phase III PoCC pivotal trial #1 BI 1015550 - PDE4 inhibitor in AF experienced PF-ILD
IRAS no
1006258
Study contact information
Name: Maria Nunez
Email: m.nunez@rbht.nhs.uk
Principal investigator
Mr Philip Molyneaux
Click here for more information
ILD: Health Outcomes in Remote Digital Monitoring versus Usual Care
Study
Comparison of health outcomes in a remote monitoring programme versus usual care in Interstitial Lung Disease
IRAS no
301636
Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk
Principal investigator
Professor Philip Molyneaux
Click here for more information
ALOFT-PPF
Study
A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants with Progressive Pulmonary Fibrosis
IRAS no
1008044
Study contact information
Name: Abigail Hamilton
Email: a.hamilton@rbht.nhs.uk
Principal investigator
Professor Philip Molyneaux
Click here for more information
SRF201
Study
Platform Clinical Study for Conquering Scleroderma: A Multicenter, Double-Blind, Randomized, Placebo-Controlled, Phase 2b Platform Clinical Study to Evaluate the Safety and Efficacy of Investigational Products in Participants with Interstitial Lung Diseas
IRAS no
1008913
Study contact information
Name: Abigail Hamilton
Email: a.hamilton@rbht.nhs.uk
Principal investigator
Professor Philip Molyneaux
ICSAVA
Study
Inhaled Corticosteroids and Vascular Ageing
IRAS no
1010334
Study contact information
Name: Dr Koralia Paschalaki
Email: k.paschalaki@rbht.nhs.uk
Principal investigator
Dr Koralia Paschalaki
Click here for more information
A Phase 2/3, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of belimumab administered subcutaneously in adults with interstitial lung disease (ILD) associated with connective tissue disease (CTD)
Study
A Phase 2/3, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of belimumab administered subcutaneously in adults with interstitial lung disease (ILD) associated with connective tissue disease (CTD)
IRAS no
1010296
Study contact information
Name: Joselle Ntumba
Email: j.ntumba@rbht.nhs.uk
Principal investigator
Dr Maria Kokosi
Tracking no small cell lung cancer evaluation
Study
Tracking non small cell lung cancer evolution through therapy (Rx)
IRAS no
138871
Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk
Principal investigator
Mr Eric Lim
Click here for more information
Lung nodule Imaging Biobank for Radiomics and AI research (LIBRA)
Study
Lung nodule Imaging Biobank for Radiomics and AI research (LIBRA)
IRAS no
274775
Study contact information
Name: Professor Anand Devaraj
Email: A.Devaraj@rbht.nhs.uk
Principal investigator
Professor Anand Devaraj
Click here for more information
AI-SONAR
Study
AI & radiomics for Stratification Of lung Nodules After Radically treated cancer
IRAS no
300424
Study contact information
Name: Professor Anand Devaraj
Email: A.Devaraj@rbht.nhs.uk
Principal investigator
Professor Anand Devaraj
ADAURA2
Study
Phase III, Double-blind, Randomized, Placebo-Controlled, International Study to assess the Efficacy and Safety of Adjuvant Osimertinib versus Placebo in Patients with EGFR mutation-positive Stage IA2-IA3 Non-small Cell Lung Cancer, following Complete Tumoour removal.
IRAS no
1004224
Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk
Principal investigator
Professor Eric Lim
Click here for more information
F4S-2
Study
Fit 4 Surgery 2: A randomised controlled trial to investigate an App-based, motivation-theory grounded, personalised, comprehensive, prehabilitation programme in addition to usual care versus usual care alone to enhance recovery of physical function
IRAS no
317416
Study contact information
Name: Paulo De Sousa
Email: P.DeSousa@rbht.nhs.uk
Principal investigator
Professor Eric Lim
Click here for more information
RA Assessment in Surgical Coronary Revascularisation
Study
Radial Artery Assessment in Surgical Coronary Revascularisation
IRAS no
333847
Study contact information
Name: Gianluca Adinolfi
Email: g.adinolfi@rbht.nhs.uk
Principal investigator
Mr Gianluca Adinolfi
ARTEMIS
Study
Effects of ziltivekimab versus placebo on cardiovascular outcomes in patients with acute myocardial infarction
IRAS no
1009307
Study contact information
Name: Geraldine Sloane
Email: g.sloane@rbht.nsh.uk
Principal investigator
Dr Tina Khan
Click here for more information
COMPLETE-2
Study
A randomized trial of physiology-guided versus angiography-guided nonculpritlesion (NCL) complete revascularization strategies and a large-scaleobservational study of Optical Coherence Tomography in patients withacute myocardial infarction and multivessel
IRAS no
328136
Study contact information
Name: Melinda Holden
Email: m.holden@rbht.nhs.uk
Principal investigator
Dr Mohammed Akhtar
There are currently no active studies
Treating severe paediatric asthma; the TREAT trial
Study
Treating severe paediatric asthma; a randomised controlled trial of mepolizumab and omalizumab (TREAT trial)
IRAS no
252084
Study contact information
Name: Professor Sejal Saglani
Email: S.Saglani@rbht.nhs.uk
Principal investigator
Professor Sejal Saglani
Click here for more information
ICONIK
Study
Inherited Cardiac cONditions In Kids Understanding the Genetics and Outcomes of Paediatric Inherited Cardiac Conditions
IRAS no
288514
Study contact information
Name: Dr Andres Rico-Armada
Email: a.rico-armada@rbht.nhs.uk
Principal investigator
Dr Andres Rico-Armada
Click here for more information
GASTRIC-PICU
Study
A randomised controlled trial of no routine gastric residual monitoring to guide enteral feeding in paediatric intensive care units
IRAS no
322370
Study contact information
Name: Laura Tous Sampol
Email: l.toussampol@rbht.nhs.uk
Principal investigator
Dr Justin Wang
Paediatric FH Register Study
Study
Estimating appropriate lipid lowering management in the United Kingdom Paediatric Familial Hypercholesterolaemia Register
IRAS no
324246
Study contact information
Name: Emma Neves
Email: e.neves@rbht.nhs.uk
Principal investigator
Lorraine Priestley-Barnham
Click here for more information
VX22-445-122
Study
A Phase 3, Open-label Study Evaluating the Pharmacokinetics, Safety, and Tolerability of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Subjects 12 to Less Than 24 Months of Age
IRAS no
1007349
Study contact information
Name: Clare Saunders
Email: c.saunders2@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
Natural History Study in Pediatric Patients with MYBPC3
Study
A Prospective and Retrospective Registry and Biomarker Study to Evaluate the Natural History of Pediatric Patients with Cardiomyopathy due to MYBPC3 Mutations
IRAS no
304240
Study contact information
Name: Annashyl West
Email: a.west@rbht.nhs.uk
Principal investigator
Dr Janice Till
Click here for more information
PDA study v 1.2
Study
A multicenter, international, prospective and retrospective, post marketing clinical follow-up study to evaluate the efficacy and safety of the occlutech patent ductus arteriosus occluder (the occlutech pda occluder) in patient with patent ductus arterios
IRAS no
318495
Study contact information
Name: Karl Evangelista
Email: k.evangelista@rbht.nhs.uk
Principal investigator
Professor Alain Fraisse
Click here for more information
VICTORION-PEDS-OLE
Study
An open-label, single arm, multicenter extension study to evaluate long-term safety and tolerability of inclisiran in participants with heterozygous or homozygous familial hypercholesterolemia who have completed the adolescent ORION-16 or ORION-13 studies
IRAS no
1007316
Study contact information
Name: Sankari Nagarajan
Email: s.nagarajan@rbht.nhs.uk
Principal investigator
Dr Mahmoud Barbir
Click here for more information
ARDS in Children and ECMO strategies impact on Neuro-Development
Study
ARDS in Children and ECMO initiation strategies impact on Neuro-Development (ASCEND)
IRAS no
292537
Study contact information
Name: Justin Wang
Email: q.wang@rbht.nhs.uk
Principal investigator
Angela Aramburo
Click here for more information
VX22-445-123
Study
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Subjects 12 Months of Age and Older
IRAS no
1010177
Study contact information
Name: Clare Saunders
Email: c.saunders2@rbht.nhs.uk
Principal investigator
Professor Jane Davies
Click here for more information
FAAR
Study
Identification of Future Asthma Attack Risk in Children with Clinical Tests
IRAS no
337100
Study contact information
Name: Samantha Irving
Email: s.irving@rbht.nhs.uk
Principal investigator
Professor Sejal Saglani
Click here for more information
The ACTIVELY Study
Study
Observational, prospective, cross sectional, multicentre study for evaluation of free-living physical activity and the assessment tools used to support pharmacological therapy titration and exercise prescription in children and adolescents diagnosed with inherited arrhythmias.
IRAS no
341211
Study contact information
Name: Catherine Renwick
Email: c.renwick@rbht.nhs.uk
Principal investigator
Ms Catherine Renwick
Machine learning to diagnose PCD
Study
Improving Primary Ciliary Dyskinesia diagnosis using artificial intelligence
IRAS no
259067
Study contact information
Name: Thomas Burgoyne
Email: T.Burgoyne@rbht.nhs.uk
Principal investigator
Professor Claire Hogg
Click here for more information
RCT1100-102
Study
A Phase 1b, Single-Center, Open-label Study to Assess the Safety, Tolerability, Ciliary Rescue, and Pharmacodynamics of RCT1100 in Adults with Primary Ciliary Dyskinesia Caused by Pathogenic Mutations in the DNAI1 Gene
IRAS no
1009008
Study contact information
Name: Arvin Fernando
Email: a.fernando@rbht.nhs.uk
Principal investigator
Professor Michael Loebinger
Acceleron
Study
An Open-Label Long-term Follow-up Study to Evaluate the Effects of Sotatercept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH
IRAS no
1003791
Study contact information
Name: Joy Pinguel
Email: a.pinguel@rbht.nhs.uk
Principal investigator
Dr Stephen John Wort
Click here for more information
A011-14
Study
A Phase 3, Randomized, Double-Blind, PlaceboControlled Study to Evaluate Sotatercept When Added to Maximum Tolerated Background Therapy in Participants With Pulmonary Arterial Hypertension (PAH) World Health Organization (WHO) Functional Class (FC) III or FC IV at High Risk of Mortality.
IRAS no
1004073
Study contact information
Name: Joy Pinguel
Email: a.pinguel@rbht.nhs.uk
Principal investigator
Dr Stephen John Wort
Click here for more information
IMPAHCT Phase 2b/3 Study of AV-101 for Pulmonary Arterial Hypertension
Study
A Phase 2b/3, Randomized, Double-Blind, Placebo-Controlled, 24-Week Dose Ranging and Confirmatory Study to Evaluate the Safety and Efficacy of AV-101 in Patients with Pulmonary Arterial Hypertension (PAH)
IRAS no
299052
Study contact information
Name: Victor Jardim
Email: v.jardim@rbht.nhs.uk
Principal investigator
Dr Colm McCabe
Click here for more information
CLTP002A12201 PAH
Study
A randomized, participant- and investigator-blinded, placebo-controlled study to investigate efficacy, safety and tolerability of LTP001 in participants with pulmonary arterial hypertension
IRAS no
1004298
Study contact information
Name: Apple Joy Pinguel
Email: a.pinguel@rbht.nhs.uk
Principal investigator
Dr John Wort Stephen
Click here for more information
Real-World Comparative Effectiveness Study of TYVASO Inhaled Treprostinil) in the Treatment of PH-ILD
Study
Real-World Comparative Effectiveness Study of TYVASO Inhaled Treprostinil) in the Treatment of PH-ILD
IRAS no
335576
Study contact information
Name: Victor Jardim
Email: v.jardim@rbht.nhs.uk
Principal investigator
Dr Laura Price
Re-PHIRE
Study
A Phase IIb Randomised, Double-blind, Placebo-controlled, Multi-centre, Dose-ranging Study of AZD3427 in Participants with Heart Failure and Pulmonary Hypertension due to Left Heart Disease (WHO Group 2)
IRAS no
1007304
Study contact information
Name: Keir Stirrat
Email: k.stirrat@rbht.nhs.uk
Principal investigator
Dr Ali Vazir
Click here for more information
GB002-3101 Efficacy and Safety of Seralutinib in Adult Subjects with PAH
Study
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Oral Inhalation of Seralutinib for the Treatment of Pulmonary Arterial Hypertension (PAH)
IRAS no
1007953
Study contact information
Name: Apple Joy Pinguel
Email: a.pinguel@rbht.nhs.uk
Principal investigator
Dr Colm McCabe
Click here for more information
PHoenix
Study
A multicentre randomised cross-over trial of disease specific therapy in patients with Pulmonary Arterial Hypertension (PAH) implanted with pulmonary artery pressure and cardiac rhythm monitoring devices (CardioMEMS/Confirm Rx)
IRAS no
325120
Study contact information
Name: Meriel Woodruff
Email: m.woodruff@rbht.nhs.uk
Principal investigator
Dr Stephen John Wort
Click here for more information
StratosPHere 2
Study
A response-adaptive randomised placebo-controlled Phase II trial to evaluate hydroxychloroquine and phenylbutyrate in pulmonary arterial hypertension caused by mutations in BMPR2
IRAS no
1003631
Study contact information
Name: Apple Joy Pinguel
Email: a.pinguel@rbht.nhs.uk
Principal investigator
Dr Laura Price
Click here for more information
MK-7962-024
Study
A Phase 2, Multicenter, Single-blinded, Randomized Study to Evaluate the Pharmacokinetics and Safety of Sotatercept (MK-7962) Administered Using Either a Weight-based or Weight-banded Approach in Participants With Pulmonary Arterial Hypertension (PAH)
IRAS no
1010520
Study contact information
Name: Victor Jardim
Email: v.jardim@rbht.nhs.uk
Principal investigator
Dr Stephen John Wort
Click here for more information
FIT-PH
Study
Feasibility of Novel Clinical Trial Infrastructure, Design and Technology for Early Phase Studies in Patients with Pulmonary Hypertension
IRAS no
269248
Study contact information
Name: Dr Stephen John Wort
Email: s.wort@rbht.nhs.uk
Principal investigator
Dr Stephen John Wort
There are currently no active studies
The role of conventional and advanced imaging modalities in formulating an optimal risk stratification strategy in patients with suspected cardiac sarcoidosis
Study
The role of conventional and advanced imaging modalities in formulating an optimal risk stratification strategy in patients with suspected cardiac sarcoidosis
IRAS no
310314
Study contact information
Name: Raheel Ahmed
Email: r.ahmed2@rbht.nhs.uk
Principal investigator
Dr Vasilis Kouranos
There are currently no active studies
Avr Thrombosis OutcoMe study (ATOM)
Study
Can thrombosis and fibrinolysis markers in patients undergoing aortic valve replacement predict outcome
IRAS no
259805
Study contact information
Name: Michelle Rackham
Email: M.Rackham@rbht.nhs.uk
Principal investigator
Dr Vasileios Panoulas
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RESOLVE MR
Study
Real World Study of the Tendyne™ Mitral Valve System to Treat Mitral Regurgitation (Tendyne™ PMCF Study)
IRAS no
304570
Study contact information
Name: Anelise Catelan Zborowski
Email: a.catelanzborowski@rbht.nhs.uk
Principal investigator
Dr Alison Mary Duncan
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STRESS-MR - Haemodynamics of Mitral Regurgitation Reduction
Study
Comparative STudy chaRacterising the physiological changEs induced by Surgical and tranScatheter Mitral Regurgitation reduction - STRESS-MR
IRAS no
293585
Study contact information
Name: Dr Robert Smith
Email: r.smith@rbht.nhs.uk
Principal investigator
Dr Robert Smith
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Acorai MLG study
Study
A Multi-Site Observational Clinical Investigation to Collect Non-invasive Sensor Data During a Right Heart Catheterization and Train Machine Learning Models to Estimate Intracardiac Hemodynamic Parameters
IRAS no
328221
Study contact information
Name: Dr Owais Dar
Email: o.dar@rbht.nhs.uk
Principal investigator
Dr Owais Dar
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APOLLO-EU study
Study
Transcatheter Mitral Valve Replacement with the Medtronic IntrepidTM TMVR Transfemoral System in patients with severe symptomatic mitral regurgitation
IRAS no
319225
Study contact information
Name: Abigail Watson
Email: a.watson2@rbht.nhs.uk
Principal investigator
Dr Alison Mary Duncan
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ET-TEER
Study
Changes in Exercise capacity, right ventricular function, activity levels and quality of life following transcatheter edge to edge repair in patients with severe tricuspid regurgitation.
IRAS no
340757
Study contact information
Name: Dr Robert Smith
Email: r.smith@rbht.nhs.uk
Principal investigator
Dr Robert Smith
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Predicting the outcome of FET repair through computational modelling
Study
Development of a novel Aortic Dissection REpair Simulator System (ADRESS) to model clinical outcome prior to type Aaortic dissection repair
IRAS no
340336
Study contact information
Name: Dr Saeed Mirsadraee
Email: s.mirsadraee@rbht.nhs.uk
Principal investigator
Dr Saeed Mirsadraee
BigpAK-2
Study
Biomarker- guided intervention to prevent acute kidney injury after major non-cardiac surgery - the prospective multicenter randomized controlled interventional trial
IRAS no
299561
Study contact information
Name: Alessandra Verzelloni
Email: a.verzellonisef@rbht.nhs.uk
Principal investigator
Dr Nandor Marczin
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STAR Registry
Study
Safe and Timely Antithrombotic Removal (STAR REGISTRY): International registry on the use of CytoSorb for removal of antithrombotic agents in the acute hospital setting.
IRAS no
301571
Study contact information
Name: Jovile Kazileviciute
Email: j.kazileviciute@rbht.nhs.uk
Principal investigator
Dr Nandor Marczin
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CHIP-BCIS3
Study
Controlled trial of High-risk coronary Intervention with Percutaneous left ventricular unloading
IRAS no
290599
Study contact information
Name: Laura Barker
Email: l.barker2@rbht.nhs.uk
Principal investigator
Dr Vasileios Panoulas
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The ROMA Trial
Study
Randomised comparison of the clinical Outcome of single versus Multiple Arterial grafts
IRAS no
321239
Study contact information
Name: Maria Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk
Principal investigator
Mr Cesare Quarto
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PANDOS
Study
Pain and opioids after surgery (PANDOS)
IRAS no
276689
Study contact information
Name: Dr Nandor Marczin
Email: N.Marczin@rbht.nhs.uk
Principal investigator
Dr Nandor Marczin
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THERMIC-4 Version 1.0
Study
Normothermic versus Hypothermic Cardiopulmonary Bypass in Adult Cardiac Surgery: a Multicentre Feasibility Randomised Controlled Trial (THERMIC-4)
IRAS no
325522
Study contact information
Name: Ricky Vaja
Email: r.vaja@rbht.nhs.uk
Principal investigator
Mr Cesare Quarto
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Biodosimetric assessment of radiation during endovascular procedures
Study
Biodosimetric assessment of radiation exposure during endovascular procedures in patients and operators
IRAS no
168743
Study contact information
Name: Dr Kshama Wechalekar
Email: k.wechalekar@rbht.nhs.uk
Principal investigator
Dr Kshama Wechalekar
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EuroSCORE 3
Study
EuroSCORE 3: recalibration of the EuroSCORE cardiac surgery risk model
IRAS no
300893
Study contact information
Name: Cesare Quarto
Email: c.quarto@rbht.nhs.uk
Principal investigator
Mr Cesare Quarto
VDyne VISTA
Study
Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment of Tricuspid Regurgitation
IRAS no
329175
Study contact information
Name: Maria Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk
Principal investigator
Dr Alison Mary Duncan
4D Flow CMR in Lung Transplant Assessment
Study
4D Flow Cardiovascular Magnetic Resonance analysis of the right ventricle in lung transplant assessment
IRAS no
270554
Study contact information
Name: Dr Joyce Wong
Email: J.Wong@rbht.nhs.uk
Principal investigator
Dr Joyce Wong
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Statins for Improving Organ Outcome in Transplantation (SIGNET)
Study
An evaluation of the benefits of a single dose of Simvastatin given to potential organ donors declared dead by neurological criteria on outcomes in organ recipients
IRAS no
288722
Study contact information
Name: Kamal Liyanage
Email: k.liyanage@rbht.nhs.uk
Principal investigator
Dr Hatem Soliman Aboumarie & Dr Sian Jaggar
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E-CLAD UK
Study
Extracorporeal Photopheresis in the treatment of Chronic Lung Allograft Dysfunction: a randomised controlled trial
IRAS no
1005642
Study contact information
Name: Dr Martin Carby
Email: m.carby@rbht.nhs.uk
Principal investigator
Dr Martin Carby
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Experience and Concerns in Organ Procurement and Transplantation
Study
An Insight into Perioperative Practitioners' Learning Experience and Concerns when Assisting Heart and Lung Organ Procurement and Transplantation
IRAS no
324868
Study contact information
Name: Ms Yi Wang
Email: y.wang@rbht.nhs.uk
Principal investigator
Ms Yi Wang
Sentinel skin flap in lung transplant RCT
Study
Efficacy and mechanism of sentinel skin flap reduction of solid organ (lung) transplant rejection: A randomised controlled trial
IRAS no
318347
Study contact information
Name: Hayley Meyrick
Email: h.meyrick@rbht.nhs.uk
Principal investigator
Dr Anna Reed
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Coronary artery disease in hearts donated for transplantation
Study
Coronary angiographic assessment of hearts donated for transplantation declined on the grounds of visible/palpable coronary artery disease at the time of retrieval
IRAS no
332977
Study contact information
Name: Christopher Bowles
Email: c.bowles@rbht.nhs.uk
Principal investigator
Mr Mohamed Osman
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PET CT in heart transplant a diagnostic accuracy study
Study
A prospective blinded pilot study evaluating the sensitivity and specificity of 18F Fluorodeoxyglucose PET CT imaging (a non-invasive imaging tool) for the diagnosis of rejection in heart transplant recipients
IRAS no
335590
Study contact information
Name: Dr Mansimran Singh Dulay
Email: m.singhdulay@rbht.nhs.uk
Principal investigator
Dr Owais Dar
Lung Health Check Biomarker Study
Study
Lung Health Check Biomarker Study
IRAS no
258696
Study contact information
Name: Dr Benjamin Hunter
Email: B.Hunter@rbht.nhs.uk
Principal investigator
Professor Anand Devaraj
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Tool Placement in Pulmonary Nodule using a Robotic Bronchoscopy System
Study
A Prospective Investigation to Assess the Accurate Tool Placement in Pulmonary Nodule(s) using a Robotic
Navigational Bronchoscopy System with Adjunct Real-time Imaging
IRAS no
308868
Study contact information
Name: Professor Pallav Shah
Email: p.shah@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
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The Physiotherapy Assessment of Breathing Pattern Dysfunction (PHAB)
Study
An evaluation of physiotherapy assessment: A mixed methods study to evaluate the physiotherapy assessment of Breathing Pattern Disorder
IRAS no
315897
Study contact information
Name: Lizzie Grillo
Email: l.grillo@rbht.nhs.uk
Principal investigator
Lizzie Grillo
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Microbiome and Metabolome in Healthy Volunteers (MATINEE Study)
Study
Investigating the stool and saliva microbiome and metabolome in healthy volunteers (The MATINEE Study). An observational cohort study
IRAS no
322270
Study contact information
Name: David Smith
Email: d.smith22@rbht.nhs.uk
Principal investigator
Professor Philip Molyneaux
RACE-MATE Trial
Study
A RAndomised Placebo Controlled Trial - to Explore the Efficacy and Mechanism of Action of Tezepelumab in EGPA (RACEMATE Trial)
IRAS no
1007564
Study contact information
Name: Harry Wilson-Morkeh
Email: h.wilsonmorkeh@rbht.nhs.uk
Principal investigator
Dr Pujan Patel