Details of all our active research studies which are looking for volunteers, with more information about what each project entails and what kind of volunteers would be most suitable.
The ACTIVELY study
This is an observational multicentre study which aims to evaluate exercise testing practices and physical activity in children and adolescents who are diagnosed with inherited arrhythmias.
Epidemiology and prognosis in acute myocarditis
Myocarditis is a disease heart muscle caused by inflammation. This study aims to provide a contemporary, population-level assessment of the true clinical burden of myocarditis and how this may have changed over the last 20 years.
Active research studies
Safety and allegenicity of new vaccine for cat allergy
Study
An open label, safety and allergenicity Phase 0 study of a new hypoallergenic plant-derived cat dander vaccine in adult cat allergic subjects
IRAS no
1006294
Study contact information
Name: Aarif Eifan
Email: aarifomar.eifan@nhs.net
Principal investigator
Dr Guy Scadding
Rhythm or rate control for CRT: the RHYTHMIC study
Study
Rhythm or rate control for CRT: the RHYTHMIC study
IRAS no
265388
Study contact information
Name: Vias Markides
Email: v.markides@nhs.net
Principal investigator
Dr Vias Markides
Click here for more information
BACKBEAT Trial
Study
BradycArdia paCemaKer with AV interval modulation for Blood prEssure treAtmenT (BACKBEAT Trial)
IRAS no
337061
Study contact information
Name: Maria Teresa Pfyl
Email: maria.pfyl1@nhs.net
Principal investigator
Professor Tom Wong
Click here for more information
AVEIR LP UK Registry
Study
AVEIR Leadless Pacemaker (LP) UK Registry
IRAS no
340241
Study contact information
Name: Maria Teresa Pfyl
Email: maria.pfyl1@nhs.net
Principal investigator
Professor Tom Wong
Click here for more information
AI-ECG Accessory Pathway Localisation Study
Study
AI-ECG Accessory Pathway Localisation Study
IRAS no
347921
Study contact information
Name: Gamith Adasuriya
Email: gamith.adasuriya@nhs.net
Principal investigator
Professor Tom Wong
TRECOS
Study
A 12 week double-blind, multicentre, randomised, active-controlled, 2-arm, parallel-group clinical trial to evaluate the safety of CHF5993 pMDI 200/6/12.5 µg HFA-152a, compared to CHF5993 pMDI 200/6/12.5 µg HFA-134a, in subjects with asthma
IRAS no
1008211
Study contact information
Name: Dr David Watchorn
Email: david.watchorn2@nhs.net
Principal investigator
Dr David Watchorn
Click here for more information
Nasal epithelial cells of healthy and asthmatic participants
Study
Study of the inflammatory properties of the nasal epithelial cells of healthy and asthmatic participants to define molecular phenotypes of severe asthma
IRAS no
336588
Study contact information
Name: Professor Fan Chung
Email: kianfan.chung@nhs.net
Principal investigator
Professor Fan Chung
Click here for more information
Pattern of chronic cough
Study
Measuring the pattern of cough in participants with chronic cough using Hyfe Cough monitor
IRAS no
329667
Study contact information
Name: Professor Fan Chung
Email: kianfan.chung@nhs.net
Principal investigator
Professor Fan Chung
Click here for more information
TRECOS
Study
A 12 week double-blind, multicentre, randomised, active-controlled, 2-arm, parallel-group clinical trial to evaluate the safety of CHF5993 pMDI 200/6/12.5 µg HFA-152a, compared to CHF5993 pMDI 200/6/12.5 µg HFA-134a, in subjects with asthma
IRAS no
1008211
Study contact information
Name: Maria Fernandes
Email: maria.fernandes20@nhs.net
Principal investigator
Dr David Watchorn
Click here for more information
Study to Assess the Efficacy and Safety of AZD5718 in Moderate-to-Severe Uncontrolled Asthma
Study
A Phase 2, Randomised, Double-Blind, Placebo and Active Comparator-Controlled Study to Assess Efficacy and Safety of Multiple Dose Levels of AZD5718 Given Orally Once Daily for Twelve Weeks in Adults with Moderate-to-Severe Uncontrolled Asthma
IRAS no
1005185
Study contact information
Name: Sankari Nagarajan
Email: sankari.nagarajan1@nhs.net
Principal investigator
Dr William Man
Click here for more information
Time and Motion (T&M) study to quantify time and resources associated with the management and administration of injectable biologics to treat patients with Severe Asthma (SA) and/or Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)
Study
Time and Motion (T&M) study to quantify time and resources associated with the management and administration of injectable biologics to treat patients with Severe Asthma (SA) and/or Chronic Rhinosinusitis with Nasal Polyps (CRSwNP)
IRAS no
340292
Study contact information
Name: Irene Berrar Torre
Email: i.berrartorre@nhs.net
Principal investigator
Ms Irene Berrar Torre
TEZEBIO – 3TR ABC
Study
Biomarkers and mechanisms of asthma remission following treatment with Tezepelumab in adults with severe asthma – 3TR ABC
IRAS no
323812
Study contact information
Name: Salman Siddiqui
Email: salman.siddiqui10@nhs.net
Principal investigator
Professor Salman Siddiqui
Click here for more information
PRISM 2 Effects of Benralizumab and Tezepelumab in severe asthma
Study
Analysis of how the antibody treatments, Benralizumab and Tezepelumab,work in severe asthma participants: PRISM 2 study
IRAS no
354503
Study contact information
Name: Rosemarie Bolla
Email: rosemarie.bolla2@nhs.net
Principal investigator
Professor Kian Fan Chung
Click here for more information
REACH2
Study
A Randomised, Double-Blind, Placebo Controlled, Parallel-Arm Pilot Evaluation - to Investigate the Efficacy and Safety of SC0032, a Magnesium Salt Oral Spray, in Adults with Refractory or Unexplained Chronic Cough
IRAS no
366449
Study contact information
Name: Kian Fan Chung
Email: f.chung@imperial.ac.uk
Principal investigator
Professor Kian Fan Chung
ReCETT-AF
Study
Realistic Computational Electrophysiology Simulations for Targeted Treatment of Atrial Fibrillation
IRAS no
285221
Study contact information
Name: Dr Shouvik Haldar
Email: shouvik.haldar1@nhs.net
Principal investigator
Dr Shouvik Haldar
Click here for more information
REMEDY-PILOT
Study
Reducing microvascular dysfunction in patients with angina, ischaemia and unobstructed coronary arteries – a pilot study (REMEDY-PILOT)
IRAS no
295523
Study contact information
Name: Carmen Chan
Email: carmen.chan8@nhs.net
Principal investigator
Dr Ranil De Silva
Click here for more information
ANT-010
Study
A Phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the efficacy and safety of abelacimab in high-risk patients with atrial fibrillation who have been deemed unsuitable for oral anticoagulation.
IRAS no
1007115
Study contact information
Name: Deirdre Flannery
Email: deirdre.flannery@nhs.net
Principal investigator
Dr John Foran
Click here for more information
MATRIX2
Study
Monotherapy with a P2Y12 inhibitor followed by a direct-acting oral anticoagulant in patients with ATRial fIbrillation undergoing suprafleX Cruz coronary stent implantation (MATRIX-2)
IRAS no
1009574
Study contact information
Name: Hayley Meyrick
Email: hayley.meyrick@nhs.net
Principal investigator
Dr Mohammed Akhtar
SECURE (BWI_2019_05)
Study
An observational post-marketing study for evaluation of ongoing safety and effectiveness of catheter mapping and ablation using commercially approved BWI medical devices for the treatment of patients with cardiac arrhythmias
IRAS no
291077
Study contact information
Name: Maria Teresa Pfyl
Email: maria.pfyl1@nhs.net
Principal investigator
Professor Tom Wong
Click here for more information
CRAAFT-HF
Study
CRAAFT-HF: Cryoballoon/Radiofrequency Ablation of Atrial Fibrillation versus Medical Treatment for Heart Failure
IRAS no
281142
Study contact information
Name: Laura Barker
Email: l.barker12@nhs.net
Principal investigator
Dr Shouvik Haldar
Click here for more information
AFFECT
Study
Optimum therapy for those with Atrial Fibrillation aFtEr Completing miTral valve repair surgery - The AFFECT trial
IRAS no
1009448
Study contact information
Name: Mr Sunil Bhudia
Email: s.bhudia@nhs.net
Principal investigator
Mr Sunil Bhudia
COSIRA-II
Study
Efficacy of the COronary SInus Reducer in Patients with Refractory Angina II (COSIRA-II)
IRAS no
353498
Study contact information
Name: Maria Teresa Pfyl
Email: maria.pfyl1@nhs.net
Principal investigator
Dr Ranil De Silva
REMOTE AF-2
Study
REMOTE AF-2: Precision detection and prediction of atrial arrhythmias using artificial intelligence and consumer wearable devices.
IRAS no
354811
Study contact information
Name: Shouvik Haldar
Email: shouvik.haldar1@nhs.net
Principal investigator
Dr Shouvik Haldar
Safety and efficacy of PC945 for the treatment of refractory invasive pulmonary aspergillosis
Study
A double-blind, randomized, placebo-controlled study to assess the safety and efficacy of nebulized PC945 when added to systemic antifungal therapy for the treatment of refractory invasive pulmonary aspergillosis
IRAS no
1004474
Study contact information
Name: Dr Anna Reed
Email: annakatja.reed@nhs.net
Principal investigator
Dr Anna Reed
Click here for more information
GREAT-2 -GRemubamab ErAdication Trial
Study
GRemubamab ErAdication Trial (GREAT-2) A phase 2 trial of Gremubamab compared to placebo in participants with bronchiectasis and chronicPseudomonas aeruginosa infection
IRAS no
1005993
Study contact information
Name: Vladimir Domi
Email: v.domi@nhs.net
Principal investigator
Professor Michael Loebinger
Click here for more information
EMILE
Study
Evaluation of the effect of Microbial dysbiosis upon anti-viral Immunity in bronchiEctasis
IRAS no
330984
Study contact information
Name: Dr Justin Garner
Email: justin.garner1@nhs.net
Principal investigator
Dr Justin Garner
Click here for more information
ERS-AMR-CRC
Study
Mapping antimicrobial resistance in chronic infectious lung disease: A European Respiratory Society Antimicrobial Resistance Clinical Research Collaborative
IRAS no
327747
Study contact information
Name: Dr Anand Shah
Email: anand.shah10@nhs.net
Principal investigator
Dr Anand Shah
Click here for more information
Impact of Chronic Pulmonary Aspergillosis (CPA) on health status and wellbeing
Study
Impact of Chronic Pulmonary Aspergillosis (CPA) on health status and wellbeing
IRAS no
327492
Study contact information
Name: Dr Anand Shah
Email: anand.shah10@nhs.net
Principal investigator
Dr Anand Shah
Click here for more information
SBIVA
Study
Impact of Chronic Pulmonary Aspergillosis (CPA) on health status and wellbeing
IRAS no
1007537
Study contact information
Name: Dr Ricardo Jose
Email: ricardo.jose1@nhs.net
Principal investigator
Professor Michael Loebinger
PRIVILEGE
Study
PRospective cohort study to understand Impact of VIraL infEction in chronic lunG diseasE
IRAS no
336487
Study contact information
Name: Patrick Senior
Email: patrick.senior3@nhs.net
Principal investigator
Dr Anand Shah
Therapeutic Outcomes in ABPA_retrospective data
Study
Therapeutic outcomes in Allergic Bronchopulmonary Aspergillosis: retrospective data
IRAS no
346410
Study contact information
Name: Lisa Nwankwo
Email: elizabethchioma.nwankwo@nhs.net
Principal investigator
Ms Lisa Nwankwo
Click here for more information
Diagnosis and endotyping of fungal airways diseases
Study
Development of a precision diagnostic framework and endotyping (sub-typing) for chronic and allergic fungal airway diseases with a focus on aspergillosis
IRAS no
345119
Study contact information
Name: Ali Nuh
Email: ahmed.nuh@nhs.net
Principal investigator
Mr Ali Nuh
HNEi Phase I/IIa
Study
A randomised, double-blind, placebo-controlled study to investigate the safety, tolerability, and pharmacokinetics of inhaled CHF6333 after single ascending doses in healthy volunteers and one single dose in adult subjects with bronchiectasis
IRAS no
1008057
Study contact information
Name: Arvin Fernando
Email: arvin.fernando@nhs.net
Principal investigator
Professor Michael Loebinger
Click here for more information
PRESIDE
Study
Prospective study of antimicrobial resistance in chronic lung disease
IRAS no
346303
Study contact information
Name: Dr Anand Shah
Email: anand.shah10@nhs.net
Principal investigator
Dr Anand Shah
Click here for more information
Study of Ensifentrine in NCFBE
Study
A Phase II, Randomized, Double-Blind, Placebo-Controlled Study of Ensifentrine in Subjects with Non-Cystic Fibrosis Bronchiectasis
IRAS no
1010760
Study contact information
Name: Fatima Seidu
Email: f.seidu@nhs.net
Principal investigator
Professor Michael Loebinger
Click here for more information
Therapeutic Outcomes in ABPA
Study
Therapeutic outcomes in Allergic Bronchopulmonary Aspergillosis (ABPA)
IRAS no
327475
Study contact information
Name: Lisa Nwankwo
Email: elizabethchioma.nwankwo@nhs.net
Principal investigator
Ms Lisa Nwankwo
Click here for more information
AIR-NET
Study
A randomised, open-label, multifactorial, multicentre, platform trial using a range of repurposed anti-inflammatory treatments to improve outcomes in patients with bronchiectasis not due to cystic fibrosis, within the EMBARC international clinical research
IRAS no
1010124
Study contact information
Name: Joselle Ntumba
Email: joselle.ntumba@nhs.net
Principal investigator
Professor Michael Loebinger
The AIRTIVITY® Study: A study to find out whether BI 1291583 helps people with bronchiectasis
Study
A Phase III, randomised, double-blind, placebo-controlled study to assess the efficacy, safety, and tolerability of BI 1291583 2.5 mg administered once daily for up to 76 weeks in patients with bronchiectasis.
IRAS no
1011881
Study contact information
Name: Marie Somosierra
Email: m.somosierra@nhs.net
Principal investigator
Professor Michael Loebinger
Click here for more information
MR907-2502 - Rezafungin for treatment of chronic pulmonary aspergillosis (CPA)
Study
A phase 2, multicentre, open-label, single arm study to evaluate the effectiveness and safety of rezafungin (as acetate) in the treatment of chronic pulmonary aspergillosis (CPA) in patients with limited treatment options
IRAS no
1011377
Study contact information
Name: Darius Armstrong-James
Email: d.armstrong-james@nhs.net
Principal investigator
Darius Armstrong-James
Click here for more information
SBIVA - Mental Health Sub Study
Study
Seven versus Fourteen Days Antibiotics for Patients with Bronchiectasis Requiring Intravenous Antibiotics
IRAS no
350131
Study contact information
Name: Marie Somosierra
Email: marie.somosierra1@nhs.net
Principal investigator
Professor Michael Loebinger
ESCAPE trial
Study
Exacerbation and Symptom Control After Pseudomonas Eradication Treatment in Adult Bronchiectasis: a multicentre randomized controlled trial (ESCAPE)
IRAS no
1011311
Study contact information
Name: Adelolapo Adeleke
Email: adelolapo.adeleke@nhs.net
Principal investigator
Professor Michael Loebinger
PRC015 - Snipe First in Human Study
Study
A prospective, open label, multi centre, single arm, first in human study to assess the safety and initial performance of eas1 system for irreversible electroporation (ire) ablation of lung cancer in subjects eligible for tumour resection
IRAS no
342510
Study contact information
Name: Elif Agaoglu
Email: elif.agaoglu1@nhs.net
Principal investigator
Professor Pallav Shah
The STOP-MED CTRCD Trial
Study
A Multi-Centre Non-Inferiority Randomized Controlled Trial of STOPping Cardiac MEDications in Patients with Normalised Cancer Therapy Related Cardiac Dysfunction: The STOP-MED CTRCD Trial
IRAS no
340455
Study contact information
Name: Matilda Howe
Email: matilda.howe2@nhs.net
Principal investigator
Dr Alexander Lyon
There are currently no active studies
UK lung volume reduction
Study
UK lung volume reduction - multicentre observational
IRAS no
190196
Study contact information
Name: Sara Buttery
Email: saracatherine.buttery@nhs.net
Principal investigator
Dr Nicholas Hopkinson
Click here for more information
AIRFLOW-3
Study
A Multicenter, Randomised, Sham-controlled Study to Evaluate Safety and Efficacy After Treatment with the Nuvaira Lung Denervation System in Subjects with Chronic Obstructive Pulmonary Disease (COPD).
IRAS no
253708
Study contact information
Name: Dr Ashish Karir
Email: ashish.karir1@nhs.net
Principal investigator
Professor Pallav Shah
Click here for more information
The WHAM Study
Study
Randomised controlled feasibility study of Maintaining the benefits of Pulmonary Rehabilitation with Harmonies and Melodies via Singing for Lung Health.
IRAS no
293580
Study contact information
Name: Adam Lewis
Email: adam.lewis1984@nhs.net
Principal investigator
Dr Adam Lewis
Click here for more information
The ON-PACE trial
Study
Dietary nitrate supplementation to enhance daily physical activity in hypoxic COPD: a randomised controlled trial
IRAS no
315107
Study contact information
Name: Alexis Perkins
Email: alexis.perkins@nhs.net
Principal investigator
Dr Nicholas Hopkinson
Click here for more information
SPRAY-CB
Study
A Sham Controlled Prospective Randomized Clinical Trial of the RejuvenAir System for the Treatment of Moderate to Severe Chronic Obstructive Pulmonary Disease with Chronic Bronchitis
IRAS no
304514
Study contact information
Name: Dr Ashish Karir
Email: ashish.karir1@nhs.net
Principal investigator
Professor Pallav Shah
Click here for more information
AI in PRImary Care spirometry for diagnosis of Lung Disease (APRIL)
Study
Real-world evaluation of an Artificial-Intelligence support software (ArtiQ.Spiro) in Primary Care spirometry pathways for the detection of Lung Disease.
IRAS no
324175
Study contact information
Name: Dr William Man
Email: w.man@nhs.net
Principal investigator
Dr William Man
Click here for more information
BREATH-2
Study
Bronchoscopic Release of Air Trapped in Hyperinflated Emphysematous Lung
IRAS no
326148
Study contact information
Name: Dr Ashish Karir
Email: ashish.karir1@nhs.net
Principal investigator
Professor Pallav Shah
Click here for more information
The Hyper-COPD Study
Study
Breathing Vigilance in a COPD population with hyperinflation
IRAS no
321477
Study contact information
Name: Dr Justin Garner
Email: justin.garner1@nhs.net
Principal investigator
Dr Justin Garner
Click here for more information
ATHLOSS
Study
A Double-Blind, Multicentre, Randomized, Three-Period, Three-Treatment, Cross-Over Study to Evaluate the Effect of BGF MDI, BFF MDI, and Placebo MDI on Exercise Parameters in Participants with Chronic Obstructive Pulmonary Disease
IRAS no
1007637
Study contact information
Name: Camilla Goulsbra
Email: camilla.goulsbra@nhs.net
Principal investigator
Professor Michael Polkey
Click here for more information
Ryme Medical TLD Pilot Study
Study
Targeted lung denervation (TLD) with the Ryme Medical Lung Denervation System in patients with chronic obstructive pulmonary disease (COPD)
IRAS no
337994
Study contact information
Name: Dr Anand Tana
Email: anand.tana2@nhs.net
Principal investigator
Professor Pallav Shah
Click here for more information
CONVERT II
Study
An Evaluation of the AeriSeal System® for CONVERTing Collateral Ventilation Status in Patients with Severe Emphysema: The CONVERT II Trial
IRAS no
336595
Study contact information
Name: Dr Ashish Karir
Email: ashish.karir1@nhs.net
Principal investigator
Professor Pallav Shah
Click here for more information
AB1MALTISC-UK
Study
Assessment of the Safety and Performance of the AB1 Electrosurgical System for Bronchoscopic Microwave Ablation of Lung Tissue in Surgical Candidates (AB1MALTISC)
IRAS no
343239
Study contact information
Name: Dr Anand Tana
Email: anand.tana2@nhs.net
Principal investigator
Professor Pallav Shah
META AI
Study
A randomised controlled trial comparing performance of medical trainees in interpretation of pulmonary function tests with or without Artificial Intelligence Decision support software
IRAS no
349534
Study contact information
Name: George Edwards
Email: george.edwards5@nhs.net
Principal investigator
Professor William Man
Exacerbation Prevention in COPD-OSA (EPIC-OSA)
Study
Exacerbation Prevention in chronic obstructive pulmonary disease (COPD) – obstructive sleep apnoea (OSA) overlap syndrome: The clinical and health economic impact of treating patients with COPD-OSA overlap syndrome and a high risk of future exacerbations
IRAS no
332000
Study contact information
Name: Hayley Meyrick
Email: hayley.meyrick@nhs.net
Principal investigator
Professor William Man
Click here for more information
OPACE
Study
Optimising azithromycin prevention treatment in COPD to reduce exacerbations (OPACE): A double blind adaptive design pragmatic phase IV randomised controlled trial.
IRAS no
1006202
Study contact information
Name: Marie Somosierra
Email: marie.somosierra1@nhs.net
Principal investigator
Professor Michael Polkey
Click here for more information
BREATH-3
Study
Bronchoscopic Release of Air Trapped in Hyperinflated Emphysematous Lung
IRAS no
354379
Study contact information
Name: Dr Ashish Karir
Email: ashish.karir1@nhs.net
Principal investigator
Professor Pallav Shah
PHARM-PR
Study
The role of pharmacist-led medicine optimisation during pulmonary rehabilitation (PR) in people living with chronic respiratory disease: a qualitative study.
IRAS no
357751
Study contact information
Name: Professor William Man
Email: w.man@nhs.net
Principal investigator
Professor William Man
Ablation MOA
Study
Evaluation of Mechanism of Action of Novel Bronchoscopic Ablation Techniques
IRAS no
350533
Study contact information
Name: Harris Trainer
Email: h.trainer@rbht.nhs.uk
Principal investigator
Professor Pallav Shah
FADE UK
Study
Analysing Fungal Disease Epidemiology in the UK
IRAS no
300045
Study contact information
Name: Dr Anand Shah
Email: anand.shah10@nhs.net
Principal investigator
Dr Anand Shah
Clinical Artificial Intelligence Fetal Echocardiography (CAIFE)
Study
Development of Clinical Artificial Intelligence Models in Fetal Echocardiography for the Detection of Congenital Heart Defects
IRAS no
317510
Study contact information
Name: Julene Carvalho
Email: julene.carvalho@nhs.net
Principal investigator
Dr Olga Patey
Click here for more information
Developing and validating a Health-related Quality-of-Life (HRQoL) measure for adults with congenital heart disease and heart failure (ACHD-HF HRQoL measure): Patient and clinician perspectives
Study
Developing and validating a Health-related Quality-of-Life (HRQoL) measure for adults with congenital heart disease and heart failure (ACHD-HF HRQoL measure): Patient and clinician perspectives
IRAS no
332895
Study contact information
Name: Hajar Habibi
Email: h.habibi@nhs.net
Principal investigator
Professor Michael Gatzoulis
Understanding inequalities in Adult Congenital Heart Disease care
Study
Understanding inequalities in Adult Congenital Heart Disease (ACHD) care: improving surveillance for all – A Mixed Methods Study
IRAS no
363102
Study contact information
Name: Kostas Dimopoulos
Email: kostas.dimopoulos@nhs.net
Principal investigator
Professor Kostas Dimopoulos
CF start
Study
The cystic fibrosis (CF) anti-staphylococcal antibiotic prophylaxis trial (CF START); a randomised registry trial to assess the safety and efficacy of flucloxacillin as a longterm prophylaxis agent for infants with CF
IRAS no
211995
Study contact information
Name: Dr Siobhan Carr
Email: siobhan.carr@nhs.net
Principal investigator
Dr Siobhan Carr
Click here for more information
Targeting Immunotherapy for Fungal Infection in Cystic Fibrosis
Study
TrIFIC: Targeting Immunotherapy for Fungal Infection in Cystic Fibrosis
IRAS no
270828
Study contact information
Name: Maria Nunez
Email: maria.nunez5@nhs.net
Principal investigator
Dr James Darius-Armstrong
Click here for more information
Clinical Outcomes With Novel Modifier Therapy Combination (RECOVER)
Study
Real World Clinical Outcomes With Novel Modifier Therapy Combinations in People with CF
IRAS no
296928
Study contact information
Name: Clare Saunders
Email: c.saunders15@nhs.net
Principal investigator
Professor Jane Davies
Click here for more information
Clinimetric properties of Oxygen-Enhanced MRI
Study
Determining the clinimetric properties of structural and functional outputs of oxygen-enhanced magnetic resonance imaging in children and adults with cystic fibrosis (CF) and chronic suppurative lung disease (CSLD)
IRAS no
294686
Study contact information
Name: Cristopher Short
Email: christophermichael.short@nhs.net
Principal investigator
Professor Jane Davies
Click here for more information
Evaluation of Long-term Safety and Efficacy of ELX/TEZ/IVA in Cystic Fibrosis Subjects
Study
A Phase 3 Open-label Study Evaluating the Long‑term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor Triple Combination Therapy in Cystic Fibrosis Subjects 2 Years and Older
IRAS no
1004766
Study contact information
Name: Clare Saunders
Email: c.saunders15@nhs.net
Principal investigator
Professor Jane Davies
Click here for more information
A Phase 3 Study of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Heterozygous
Study
A Phase 3, Randomized, Double-blind, Controlled Study Evaluating the Efficacy and Safety of VX-121 Combination Therapy in Subjects With Cystic Fibrosis Who Are Heterozygous for F508del and a Minimal Function Mutation (F/MF)
IRAS no
1003950
Study contact information
Name: Clare Saunders
Email: c.saunders15@nhs.net
Principal investigator
Dr Nicholas Simmonds
Click here for more information
Skyline Open label Extension - VX20-121-104
Study
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of VX-121 Combination Therapy in Subjects With Cystic Fibrosis
IRAS no
1005889
Study contact information
Name: Dr Nicholas Simmonds
Email: nicholasjames.simmonds@nhs.net
Principal investigator
Dr Nicholas Simmonds
Click here for more information
CFTR c.3874-4522A>G's impact on cystic fibrosis severity
Study
Investigating the possible association between expression of the CFTR: c.3874-4522A>G deep intronic variant and phenotype severity in patients with Cystic Fibrosis
IRAS no
335624
Study contact information
Name: Anna Lockhart
Email: anna.lockhart1@nhs.net
Principal investigator
Dr Deborah Morris-Rosendahl
Click here for more information
ENHANCE
Study
Establishing Natural History in an Advanced New CF Care Era
IRAS no
332109
Study contact information
Name: Clare Saunders
Email: c.saunders15@nhs.net
Principal investigator
Professor Jane Davies
Click here for more information
YOGA-CF
Study
Yoga Outcomes Get Assessed in Cystic Fibrosis (YOGA-CF)
IRAS no
303898
Study contact information
Name: Gemma Stanford
Email: g.stanford16@imperial.ac.uk
Principal investigator
Gemma Stanford
Click here for more information
CHOICES
Study
A Phase IIb, Multicentre, Randomised, Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Efficacy and Safety of irocaftor/Posenacaftor/Nesolicaftor in Subjects with Cystic Fibrosis Aged 18 Years or Older (CHOICES)
IRAS no
1005882
Study contact information
Name: Yasmine Needham
Email: yasmine.needham1@nhs.net
Principal investigator
Dr Nicholas Simmonds
Click here for more information
Closed-loop for people living with Cystic Fibrosis related diabetes
Study
An open-label, multi-centre, randomised, two arm single period parallel study to assess the efficacy, safety and utility of hybrid closed-loop glucose control compared to standard insulin therapy combined with continuous glucose monitoring in young people
IRAS no
315792
Study contact information
Name: Clare Saunders
Email: c.saunders15@nhs.net
Principal investigator
Dr Imogen Felton
Click here for more information
Lenticlair TM-ON
Study
A clinical trial to evaluate the long-term safety and durability of efficacy of BI 3720931, an inhaled lentiviral vector gene therapy, after single dose administration in a previous clinical trial, and to evaluate the safety and efficacy of BI 3720931
IRAS no
1008580
Study contact information
Name: Clare Saunders
Email: c.saunders15@nhs.net
Principal investigator
Professor Jane Davies
Click here for more information
Maternal, Infant, Reproductive & Child Health in Cystic Fibrosis - MATRIARCH_CF
Study
An observational study to evaluate the impact of pregnancy and parenthood in females with Cystic Fibrosis and their offspring in the CFTR modulator era.
IRAS no
352398
Study contact information
Name: Yasmine Needham
Email: yasmine.needham1@nhs.net
Principal investigator
Dr Imogen Felton
The CF-Tracker study
Study
The CF-Tracker study: identifying the causes and risk factors of pulmonary exacerbations in cystic fibrosis
IRAS no
338539
Study contact information
Name: Clare Saunders
Email: c.saunders15@nhs.net
Principal investigator
Dr Nicholas Simmonds
Click here for more information
Joining the dots for CFSPID
Study
Joining the dots in Cystic Fibrosis Screen Positive Inconclusive Diagnosis (CFSPID) long-term outcomes
IRAS no
344976
Study contact information
Name: Clare Saunders
Email: c.saunders15@nhs.net
Principal investigator
Dr Rebecca Dobra
ADVANCE-CFTR
Study
Advanced Diagnostic Validation and Novel Clinical Evaluation across the CFTR spectrum: a prospective study of CFTR functional assays, including rectal organoids, to improve the accuracy of diagnosing cystic fibrosis
IRAS no
362887
Study contact information
Name: Dr Nicholas Simmonds
Email: nicholasjames.simmonds@nhs.net
Principal investigator
Dr Nicholas Simmonds
The PRECISION Partners Platform (P3) study
Study
The PRECISION Partners Platform (P3) study: a multi-centre, multi-sample-type approach to establish alternatives to sputum culture for detecting lung infections in cystic fibrosis, and better understand host/ microbe interactions
IRAS no
356585
Study contact information
Name: Clare Saunders
Email: c.saunders15@nhs.net
Principal investigator
Professor Jane Davies
Natural History Dilated Cardiomyopathy Associated with BAG3 Mutations
Study
A prospective multinational study of the natural history of participants with BAG3 mutation associated dilated cardiomyopathy
IRAS no
321187
Study contact information
Name: Teresa Pfyl
Email: maria.pfyl1@nhs.net
Principal investigator
Dr Antonis Pantazis
Click here for more information
The SMARTER-CM Study
Study
Genetics, Imaging And Artificial Intelligence for Precision Care in Cardiomyopathy
IRAS no
313058
Study contact information
Name: Dr Upasana Tayal
Email: upasana.tayal@nhs.net
Principal investigator
Dr Upasana Tayal
HEART - ACS V1.0
Study
The HarEfield Acute MyocaRdial InfarcTion Cohort
IRAS no
259087
Study contact information
Name: Laura Barker
Email: l.barker12@nhs.net
Principal investigator
Dr Miles Dalby
Click here for more information
Epidemiology and Prognosis in Acute Myocarditis
Study
Epidemiological trends and outcomes of hospital admissions for acute myocarditis and dilated cardiomyopathy in the National Health Service of England from 1998 onwards.
IGARD reference number
DARS-NIC-144568-D7G6V
Study contact information
Name: Amrit Lota
Email: a.lota@nhs.net
Principal investigator
Professor Sanjay Prasad
Click here for more information
A possible new treatment for elevated Lp(a) in CVD - HORIZON
Study
A randomised double-blind, placebo-controlled, multicenter trial assessing the impact of lipoprotein (a) lowering with TQJ230 on major cardiovascular events in patients with established cardiovascular disease (CVD).
IRAS no
267092
Study contact information
Name: Alkida Bucaj
Email: alkida.bucaj@nhs.net
Principal investigator
Professor Mahmoud Barbir
Click here for more information
Olpasiran trials of Cardiovascular Events And LipoproteiN(a) reduction – Outcomes trial
Study
A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing the Impact of Olpasiran on Major Cardiovascular Events in Patients with Atherosclerotic Cardiovascular Disease and Elevated Lipoprotein (a)
IRAS no
1006924
Study contact information
Name: Sankari Nagarajan
Email: sankari.nagarajan1@nhs.net
Principal investigator
Dr Tina Khan
Click here for more information
CE-MARC 3
Study
A pragmatic approach to the investigation of stable chest pain: a UK, multi-centre, randomised trial to improve patient experience, outcomes and NHS cost efficiency
IRAS no
302218
Study contact information
Name: Dr Chiara Bucciarelli-Ducchi
Email: chiara.bucciarelli-ducci1@nhs.net
Principal investigator
Dr Chiara Bucciarelli-Ducchi
Click here for more information
VICTORION REAL v01
Study
An international prospective Real-world study to evaluate the Effectiveness and Adherence of incLisiran plus standard of care lipid-lowering therapy compared to standard of care therapy alone in patients with primary hypercholesterolemia or mixed dyslipidemia
IRAS no
317604
Study contact information
Name: Susshmitha Ramesh
Email: susshmitha.ramesh@nhs.net
Principal investigator
Dr Barbir Mahmoud
Click here for more information
BRITISH: Using CMR scar as risk indication tool in NICM and severe LVSD
Study
Using cardiovascular magnetic resonance identified scar as the Benchmark Risk Indication Tool for Implantable cardioverter defibrillators in patients with Non-Ischemic Cardiovascular and Severe systolic Heart failure
IRAS no
280862
Study contact information
Name: Annashyl West
Email: annashyl.west1@nhs.net
Principal investigator
Professor Sanjay Prasad
Click here for more information
TRED-HF2
Study
A randomised trial examining therapy to maintain remission in dilated cardiomyopathy
IRAS no
1006543
Study contact information
Name: Saad Javed
Email: saad.javed4@nhs.net
Principal investigator
Dr Brian Halliday
Click here for more information
HER-SAFE
Study
Randomised Control Trial for the Safety of Withdrawal of Pharmacological Treatment for Recovered HER2 Targeted Therapy Related Cardiac Dysfunction
IRAS no
312432
Study contact information
Name: Dr Alexander Lyon
Email: alexander.lyon@nhs.net
Principal investigator
Dr Alexander Lyon
Click here for more information
Low QRS voltages in young healthy individuals and athletes
Study
The prevalence and significance of low QRS voltages in young healthy individuals and athletes
IRAS no
283055
Study contact information
Name: Dr Nirmitha Jayaratne
Email: nirmitha.jayaratne2@nhs.net
Principal investigator
Dr Sabiha Gati
Click here for more information
TN-401-0011
Study
Seroprevalence Study of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV) in Patients with Plakophilin 2 (PKP2)-associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
IRAS no
323224
Study contact information
Name: Teresa Pfyl
Email: maria.pfyl1@nhs.net
Principal investigator
Dr Antonis Pantazis
Click here for more information
Cardiac cachexia in advanced heart failure – a prospective cohort study investigating prevalence and outcome
Study
Cardiac cachexia in advanced heart failure – a prospective cohort study investigating prevalence and outcome
IRAS no
334613
Study contact information
Name: Dr Mansimran Singh Dulay
Email: m.dulay@nhs.net
Principal investigator
Dr Owais Dar
Click here for more information
MAPLE-HCM
Study
A Phase 3, Multi-center, Randomized, Double-blind Trial to Evaluate the Efficacy and Safety of Aficamten Compared to Metoprolol in Adults with Symptomatic Obstructive Hypertrophic Cardiomyopathy
IRAS no
1007788
Study contact information
Name: Dr Antonis Pantazis
Email: a.pantazis@nhs.net
Principal investigator
Dr Antonis Pantazis
Click here for more information
Euro-CRAFT Registry
Study
Prospective evaluation of the impact of coronary themodilution on clinical outcomes in chronic coronary syndromes
IRAS no
315345
Study contact information
Name: Maria Teresa Pfyl
Email: maria.pfyl1@nhs.net
Principal investigator
Dr Ranil De Silva
Click here for more information
BalanceD-HF
Study
A Phase III, Randomised, Double-blind Study to Evaluate the Effect of Balcinrenone/Dapagliflozin, Compared to Dapagliflozin, on the Risk of Heart Failure Events and Cardiovascular Death in Patients with Heart Failure and Impaired Kidney Function
IRAS no
1009392
Study contact information
Name: Melinda Holden
Email: melindaholden@nhs.net
Principal investigator
Dr Owais Dar
Click here for more information
The Acorai Study
Study
A single-site prospective observational study to assess the value of the data harvested by the Acorai intracardiac pressure monitoring (ICPM) system in predicting outcomes in patients ready for discharge from hospital following an admission with decompens
IRAS no
334837
Study contact information
Name: Ramey Assaf
Email: ramey.assaf2@nhs.net
Principal investigator
Dr Owais Dar
Click here for more information
PRIMARY
Study
Percutaneous or Surgical Repair In Mitral Prolapse And Regurgitation for ≥65 Year-olds (PRIMARY)
IRAS no
318625
Study contact information
Name: Maria Teresa Pfyl
Email: maria.pfyl1@nhs.net
Principal investigator
Mr Anthony C De Souza
Click here for more information
A Study to Assess Multidomain Endpoints of an ECG Patch (D1840M00072)
Study
Clinical observational study of remote, non-invasive, multidomain endpoints in patients recovering from acute decompensated heart failure
IRAS no
330309
Study contact information
Name: Dr Owais Dar
Email: o.dar@nhs.net
Principal investigator
Dr Owais Dar
Click here for more information
VAD WEAN study
Study
Participation in an international registry of patients supported with a left ventricular assist device until recovery of natural heart function
IRAS no
339534
Study contact information
Name: Dr Fernando Riesgo Gil
Email: fernando.riesgogil@nhs.net
Principal investigator
Dr Fernando Riesgo Gil
Click here for more information
Randomised, double-blind, placebo-controlled study to investigate a single administration of BI 765845 on top of standard of care in patients with acute myocardial infarction
Study
Randomised, double-blind, placebo-controlled study to investigate a single administration of BI 765845 on top of standard of care in patients with acute myocardial infarction
IRAS no
1008094
Study contact information
Name: Sankari Nagarajan
Email: sankari.nagarajan1@nhs.net
Principal investigator
Dr Vasileios Panoulas
GenePHIT: Phosphatase Inhibition by Intracoronary Gene Therapy in Subjects with Non-Ischemic NYHA Class III Heart Failure
Study
A Phase 2, adaptive, double-blinded, placebo-controlled, randomized, multi-centre trial to evaluate the efficacy, safety and tolerability of intracoronary infusion of AB-1002 in adult subjects with New York Heart Association (NYHA) Class III heart failure
IRAS no
1009799
Study contact information
Name: Maria Teresa Pfyl
Email: maria.pfyl1@nhs.net
Principal investigator
Dr Alexander Lyon
Click here for more information
AZURE-OUTCOMES
Study
A Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study to Assess the Effect of AZD0780 on Major Adverse Cardiovascular Events in High Risk Participants with Atherosclerotic Cardiovascular Disease and Elevated Low-Density Lipoprotein Cholesterol
IRAS no
1012003
Study contact information
Name: Melinda Holden
Email: melindaholden@nhs.net
Principal investigator
Dr Tina Khan
BMS
Study
Deliver Insights in Hypertrophic Cardiomyopathy and Observational Outcomes in Real World (DISCOVER-HCM): United States Prospective Registry Study
IRAS no
349402
Study contact information
Name: Ese Orhorhaghe
Email: e.orhorhaghe@nhs.net
Principal investigator
Dr Antonis Pantazis
Click here for more information
COMET-HF
Study
A Multi-Center, Double-Blind, Randomised, Placebo-Controlled Trial to Assess Efficacy and Safety of Omecamtiv Mecarbil in Patients with Symptomatic Heart Failure with Severely Reduced Ejection Fraction
IRAS no
1011618
Study contact information
Name: Hayley Meyrick
Email: hayley.meyrick@nhs.net
Principal investigator
Dr Owais Dar
Click here for more information
Myocardial structure and function in health
Study
Myocardial structure and function in health
IRAS no
354146
Study contact information
Name: Aaraby Ragavan
Email: aaraby.ragavan2@nhs.net
Principal investigator
Dr Brian Halliday
Click here for more information
A Phase 1/2 study of ALXN2350 in adult participants with BAG3-associated dilated cardiomyopathy
Study
A Phase 1/2, Open-Label, Multicenter, Dose Finding and Dose Expansion Study to Investigate the Safety, Tolerability, and Efficacy of ALXN2350 Gene Therapy in Adult Participants with BAG3 Mutation Associated Dilated Cardiomyopathy
IRAS no
1011568
Study contact information
Name: Maria Teresa Pfyl
Email: maria.pfyl1@nhs.net
Principal investigator
Dr Antonis Pantazis
Click here for more information
A Phase 2b study in Patients with Symptomatic Non-obstructive Hypertrophic Cardiomyopathy
Study
A Global Phase 2b, Randomized, Double-Blinded, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients with Symptomatic Non-Obstructive Hypertrophic Cardiomyopathy
IRAS no
1012709
Study contact information
Name: Maria Teresa Pfyl
Email: maria.pfyl1@nhs.net
Principal investigator
Dr Brian Halliday
KINSHIP-DCM
Study
A Phase 2b/3, Adaptive, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Assess the Efficacy and Safety of Danicamtiv in Participants with Symptomatic Genetic and Familial Dilated Cardiomyopathy
IRAS no
1012888
Study contact information
Name: Nikula Vicario
Email: nikula.vicario@nhs.net
Principal investigator
Dr Upasana Tayal
PhenoCONVERT
Study
Studying the natural history of cardiomyopathy in gene carriers using routine clinical data
IRAS no
362083
Study contact information
Name: Kevin Kirby
Email: kevin.kirby1@nhs.net
Principal investigator
Dr Brian Halliday
8212-Preserved
Study
Phase 2, Multicentre, Randomised, Double-blind, Placebo-controlled Safety and Efficacy Study of CDR132L on Reverse Cardiac Remodelling in Participants with Heart Failure with Preserved Ejection Fraction and Left Ventricular Hypertrophy
IRAS no
1011245
Study contact information
Name: Kevin Kirby
Email: kevin.kirby1@nhs.net
Principal investigator
Dr Brian Halliday
Click here for more information
CTQJ230A12301E1 HORIZON OLE
Study
A single arm, multicenter, open-label extension (OLE) trial to evaluate long-term safety and tolerability of pelacarsen (TQJ230) in participants who completed the parent Lp(a)HORIZON trial
IRAS no
1011654
Study contact information
Name: Sankari Nagarajan
Email: sankari.nagarajan1@nhs.net
Principal investigator
Dr Tina Khan
Click here for more information
ICECAP
Study
Intracoronary Cryotherapy Effect on Stabilization of Vulnerable Plaque in patients with Stable Angina or ACS – A traditional feasibility study
IRAS no
364136
Study contact information
Name: Maria Teresa Pfyl
Email: m.pfyl@rbht.nhs.uk
Principal investigator
Dr Ranil De Silva
A Phase 2 study of RXC007 in patients with IPF
Study
A Multi-Cohort, Randomized, Placebo-Controlled Phase 2a Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Ascending Doses of RXC007 in Patients with Idiopathic Pulmonary Fibrosis.
IRAS no
1005138
Study contact information
Name: Vladimir Domi
Email: v.domi@nhs.net
Principal investigator
Dr Philip Molyneaux
Click here for more information
Efzo-Fit Study
Study
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Intravenous Efzofitimod in Patients with Pulmonary Sarcoidosis
IRAS no
1006104
Study contact information
Name: Vladimir Domi
Email: v.domi@nhs.net
Principal investigator
Dr Vasilis Kouranos
Click here for more information
IM027-068
Study
A multicenter, randomized, double-blind, placebo-controlled, Phase 3 Study to evaluate the efficacy, safety, and tolerability of BMS-986278 in participants with idiopathic pulmonary fibrosis (IPF)
IRAS no
1008043
Study contact information
Name: Deirdre Flannery
Email: deirdre.flannery@nhs.net
Principal investigator
Professor Philip Molyneaux
Click here for more information
Treatment of idiopathic pulmonary fibrosis (IPF)
Study
A randomised, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of PLN-74809 bexotegrast) for the treatment of idiopathic pulmonary fibrosis (BEACON)
IRAS no
1008893
Study contact information
Name: Deirdre Flannery
Email: deirdre.flannery@nhs.net
Principal investigator
Professor Philip Molyneaux
Click here for more information
FIBRONEER™-ON
Study
An open-label extension trial of the long-term safety and efficacyof BI 1015550 taken orally in patients with idiopathic pulmonaryfibrosis (IPF) and progressive pulmonary fibrosis (PPF)(FIBRONEER™-ON)
IRAS no
1009187
Study contact information
Name: Deirdre Flannery
Email: deirdre.flannery@nhs.net
Principal investigator
Professor Philip Molyneaux
Click here for more information
Study 220929
Study
A Phase 2, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of GSK3915393 in participants with IPF
IRAS no
1004917
Study contact information
Name: Deirdre Flannery
Email: deirdre.flannery@nhs.net
Principal investigator
Professor Philip Molyneaux
PROPELLER
Study
PROgressive lung fibrosis and 68Ga-FAPi-PET Longitudinal evaLuation for Early disease activity Readout
IRAS no
347179
Study contact information
Name: Leda Yazbeck
Email: l.yazbeck@nhs.net
Principal investigator
Professor Philip Molyneaux
ASPIRE
Study
A randomized, double-blind, placebo-controlled, parallel group, multicenter trial evaluating the efficacy and safety of 2 doses of buloxibutid over 52 weeks in people with idiopathic pulmonary fibrosis.
IRAS no
1009572
Study contact information
Name: Deirdre Flannery
Email: deirdre.flannery@nhs.net
Principal investigator
Professor Philip Molyneaux
CHORUS
Study
CHORUS: A multi-centre double-blind randomised placebo-controlled group-sequential superiority trial to assess the effectiveness and cost-effectiveness of oral Corticosteroids in patients witH fibrOtic hypeRsensitivity pneUmonitiS
IRAS no
1010739
Study contact information
Name: Deirdre Flannery
Email: deirdre.flannery@nhs.net
Principal investigator
Professor Philip Molyneaux
Click here for more information
RETAIN Study
Study
Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung
IRAS no
322540
Study contact information
Name: Dr Richard Hewitt
Email: richard.hewitt7@nhs.net
Principal investigator
Dr Richard Hewitt
Click here for more information
WHISTLE-PF Trial
Study
A Phase 2, Multi-Center, Randomized, Double-Blind, Controlled Trial Evaluating the Safety and Efficacy of ENV-101 in Patients with Lung Fibrosis (WHISTLE-PF Trial)
IRAS no
1009869
Study contact information
Name: Arvin Fernando
Email: arvin.fernando@nhs.net
Principal investigator
Professor Philip Molyneaux
Click here for more information
AURORA
Study
A Randomised Double-Blind Trial to Evaluate the Efficacy and Safety of CAL101 in Patients with Idiopathic Pulmonary Fibrosis
IRAS no
1011201
Study contact information
Name: Arvin Fernando
Email: arvin.fernando@nhs.net
Principal investigator
Professor Philip Molyneaux
Click here for more information
RENEW: A Study of LTI-03 in Patients with Idiopathic Pulmonary Fibrosis
Study
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Tolerability and Efficacy of Caveolin-1- Scaffolding-Protein-Derived Peptide (LTI-03) in Patients with Idiopathic Pulmonary Fibrosis (RENEW)
IRAS no
1011923
Study contact information
Name: Marie Somosierra
Email: marie.somosierra1@nhs.net
Principal investigator
Professor Philip Molyneaux
AP02-003
Study
A Randomised, Double-Blind, Placebo-Controlled, Phase 2 Proof of Concept (POC) Study Evaluating the Safety, Tolerability, and Efficacy of Nintedanib Solution for Inhalation (AP02) in Participants with Idiopathic Pulmonary Fibrosis (IPF) (AURA-IPF)
IRAS no
1012881
Study contact information
Name: Deirdre Flannery
Email: deirdre.flannery@nhs.net
Principal investigator
Dr Richard Hewitt
M25-268 Treatment of Adult Subjects with Idiopathic Pulmonary Fibrosis
Study
A Phase 2a Multicenter Platform Study of Investigational Products for the Treatment of Adult Subjects with Idiopathic Pulmonary Fibrosis
IRAS no
1013104
Study contact information
Name: Marie Somosierra
Email: marie.somosierra1@nhs.net
Principal investigator
Professor Philip Molyneaux
REVIVE-TR
Study
Right Ventricular Remodelling Following Transcatheter Tricuspid Valve Intervention: A UK Multi-Centre Observational Imaging Study
IRAS no
369914
Study contact information
Name: Alison Mary Duncan
Email: alison.duncan14@nhs.net
Principal investigator
Dr Alison Mary Duncan
Multi-centre cardiac DTI in healthy volunteers (SIGNET
Study
Multi-centre Investigation of Cardiac Diffusion Tensor Imaging in Healthy Volunteers by SCMR Cardiac DiffusionSpecial Interest Group NETwork (SIGNET)
IRAS no
343837
Study contact information
Name: Dr Andrew Scott
Email: andrew.scott@imperial.ac.uk
Principal investigator
Dr Andrew Scott
Transmural myocardial perfusion with hypertension, HCM and HCM phenocopies with CMR
Study
The measurement of transmural myocardial perfusion in normal subjects and patients with hypertension, hypertrophic cardiomyopathy (HCM) and HCM phenocopies with Cardiovascular Magnetic Resonance (CMR)
IRAS no
171258
Study contact information
Name: Brian Halliday
Email: brian.halliday2@nhs.net
Principal investigator
Dr Sanjay Prasad
CY 6022
Study
An open-label study of CK-3773274 for patients with Symptomatic Hypertrophic Cardiomyopathy (HCM)
IRAS no
1005788
Study contact information
Name: Teresa Pfyl
Email: maria.pfyl1@nhs.net
Principal investigator
Dr Antonis Pantazis
Click here for more information
CY 6033 - Cytokinetics - Symptomatic Non-obstructive Hypertrophic Cardiomyopathy - 0771/0069
Study
A phase 3, multi-center, randomized, double-blind trial to evaluate the efficacy and safety of aficamten compared to placebo in adults with symptomatic non-obstructive hypertrophic cardiomyopathy
IRAS no
1008323
Study contact information
Name: Teresa Pfyl
Email: maria.pfyl1@nhs.net
Principal investigator
Dr Antonis Pantazis
Click here for more information
CY 6033 - Cytokinetics - Symptomatic Non-obstructive Hypertrophic Cardiomyopathy - 0771/0069
Study
MAP-HCM Mechanisms of Atrial Pathoelectrophysiology in HCM (MAP-HCM)
IRAS no
339394
Study contact information
Name: Dr Davide Fabbricatore
Email: davide.fabbricatore@nhs.net
Principal investigator
Dr Davide Fabbricatore
GenOMICC
Study
Genetics of susceptibility and mortality in critical care (GenOMICC)
IRAS no
269326
Study contact information
Name: Dr Brijesh Patel
Email: brijeshvipinchandra.patel@nhs.net
Principal investigator
Dr Brijesh Patel
Click here for more information
HERACLES
Study
HEmodynamic effects of Reducing lv Afterload with impella or intra-aortic balloon CounterpuLsation during veno-arterial Extracorporeal membrane oxygenation in cardiogenic Shock
IRAS no
300145
Study contact information
Name: Professor Susanna Price
Email: susanna.price2@nhs.net
Principal investigator
Professor Susanna Price & Dr Vasileios Panoulas
Click here for more information
GOlDilOCS: Genomic determinants of outcome in cardiogenic shock
Study
Prospective observational study investigating genomic determinants of outcome from cardiogenic shock
IRAS no
290406
Study contact information
Name: Keir Stirrat
Email: k.stirrat@nhs.net
Principal investigator
Dr Brijesh Patel
Click here for more information
Indications, efficacy and safety profiles of dual treatment with Levosimendan and Sildenafil in critically ill adult patients
Study
Indications, efficacy and safety profiles of dual treatment with Levosimendan and Sildenafil in critically ill adult patients
IRAS no
326729
Study contact information
Name: Dr Sundeep Kaul
Email: sundeep.kaul@nhs.net
Principal investigator
Dr Sundeep Kaul
GuARDS
Study
Glucocorticoids in adults with Acute Respiratory Distress Syndrome: Arandomised, parallel-group, allocation-concealed, open label, pragmatic,group sequential design, clinical and cost- effectiveness trial withinternal pilot
IRAS no
1007694
Study contact information
Name: Paulo De Sousa
Email: paulo.desousa@nhs.net
Principal investigator
Dr Brijesh Patel
RESTORE
Study
A randomised trial of surgery versus no treatment to RESTORE cardiopulmonary function in severe pectus excavatum.
IRAS no
331910
Study contact information
Name: Paulo De Sousa
Email: paulo.desousa@nhs.net
Principal investigator
Sofina Begum
Click here for more information
BIOMiCS
Study
Identification of optimal markers to assess bleeding and thrombosis risk in patients on mechanical circulatory support
IRAS no
345732
Study contact information
Name: Victor Galusko
Email: v.galusko@nhs.net
Principal investigator
Professor Diana Gorog
Click here for more information
E-CLAD UK Long-term
Study
Extracorporeal Photopheresis in the treatment of Chronic Lung Allograft Dysfunction: Long-Term Follow-Up Study
IRAS no
338850
Study contact information
Name: Binu Raj
Email: binu.raj@nhs.net
Principal investigator
Dr Martin Carby
Click here for more information
FEARLESS_ICU v1
Study
Fostering tEAmwork for ResiLiEnt Staff and Safe care: driving post-pandemic recovery and renewal in Intensive Care Units
IRAS no
335535
Study contact information
Name: Vicky Thwaites
Email: vicky.thwaites@nhs.net
Principal investigator
Laura Barker
Click here for more information
Optimising analgosedation in ECMO (ECMO-SED)
Study
Optimising analgosedation in extracorporeal membrane oxygenation (ECMO) using a co-designed analgosedation protocol
IRAS no
332457
Study contact information
Name: Haifa Lyster
Email: haifa.lyster@nhs.net
Principal investigator
Haifa Lyster
Optimising analgosedation in ECMO (ECMO-SED)
Study
Identifying the optimal IMT dose in ICU: A prospective, mixed methods, observational study to define a diaphragm-focussed and patient-acceptable IMT load (D-IMT) in difficult to wean, mechanically ventilated patients
IRAS no
357041
Study contact information
Name: Timothy Jenkins
Email: timothy.jenkins4@nhs.net
Principal investigator
Professor Michael Polkey
ROMEO
Study
Rest Or Moderate mechanical ventilation during ECMO support
IRAS no
351190
Study contact information
Name: Keir Stirrat
Email: k.stirrat@nhs.net
Principal investigator
Dr Ben Garfield
Understanding patients’ relatives’ role in icu decision-making
Study
Understanding patients' relatives' role in ICU decision-making: how the mental capacity act can lead to better outcomes for patients, their families, and health care professionals
IRAS no
345638
Study contact information
Name: Hayley Meyrick
Email: hayley.meyrick@nhs.net
Principal investigator
Hayley Meyrick
Click here for more information
BREATHE - Better Respiratory wEAning using Through physics-informed macHine learning for invasivE mechanical ventilation
Study
Better Respiratory wEAning using Through physics-informed macHine learning for invasivE mechanical ventilation
IRAS no
340376
Study contact information
Name: Murali Mayur
Email: mayur.murali@nhs.net
Principal investigator
Dr Brijesh Patel
I-FILE
Study
An international patient-led registry in fibrotic interstitial lung diseases using eHealth technology
IRAS no
291393
Study contact information
Name: Mr Philip Molyneaux
Email: philip.molyneaux3@nhs.net
Principal investigator
Dr Philip Molyneaux
Click here for more information
ILD-DNA
Study
Interstitial Lung Disease DNA Study
IRAS no
316318
Study contact information
Name: Mr Philip Molyneaux
Email: philip.molyneaux3@nhs.net
Principal investigator
Mr Philip Molyneaux
Click here for more information
ILD: Health Outcomes in Remote Digital Monitoring versus Usual Care
Study
Comparison of health outcomes in a remote monitoring programme versus usual care in Interstitial Lung Disease
IRAS no
301636
Study contact information
Name: Vladimir Domi
Email: v.domi@nhs.net
Principal investigator
Professor Philip Molyneaux
Click here for more information
ALOFT-PPF
Study
A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of BMS-986278 in Participants with Progressive Pulmonary Fibrosis
IRAS no
1008044
Study contact information
Name: Vladimir Domi
Email: v.domi@nhs.net
Principal investigator
Professor Philip Molyneaux
Click here for more information
ICSAVA
Study
Inhaled Corticosteroids and Vascular Ageing
IRAS no
1010334
Study contact information
Name: Dr Koralia Paschalaki
Email: koralia.paschalaki@nhs.net
Principal investigator
Dr Koralia Paschalaki
Click here for more information
A Phase 2/3, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of belimumab administered subcutaneously in adults with interstitial lung disease (ILD) associated with connective tissue disease (CTD)
Study
A Phase 2/3, randomized, double-blind, placebo-controlled, parallel group study to evaluate the efficacy and safety of belimumab administered subcutaneously in adults with interstitial lung disease (ILD) associated with connective tissue disease (CTD)
IRAS no
1010296
Study contact information
Name: Joselle Ntumba
Email: joselle.ntumba@nhs.net
Principal investigator
Dr Maria Kokosi
A Placebo-Controlled Study of Inhaled Pirfenidone in PPF
Study
A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study Evaluating the Safety and Efficacy of Pirfenidone Solution for Inhalation (AP01) in Subjects with Progressive Pulmonary Fibrosis (PPF)
IRAS no
1009856
Study contact information
Name: Vladimir Domi
Email: v.domi@nhs.net
Principal investigator
Dr Peter George
The prevalence and functional/prognostic impact of computed tomographic (CT) phenotypes in pulmonary sarcoidosis
Study
The prevalence and functional/prognostic impact of computed tomographic (CT) phenotypes in pulmonary sarcoidosis
IRAS no
335099
Study contact information
Name: Professor Sujal Desai
Email: sujal.desai2@nhs.net
Principal investigator
Professor Sujal Desai
DROP-FPF
Study
A double blind, randomized, placebo-controlled exploratory trial to investigate the efficacy and safety of nerandomilast over 24 months when administered in individuals with interstitial lung abnormalities and a family history of pulmonary fibrosis.
IRAS no
1012785
Study contact information
Name: Abigail Hamilton
Email: a.hamilton16@nhs.net
Principal investigator
Dr Richard Hewitt
SARC-Taper
Study
Corticosteroid tapering in sarcoidosis
IRAS no
367551
Study contact information
Name: Jessica Raja
Email: jessica.raja2@nhs.net
Principal investigator
Dr Vasilis Kouranos
GSK4527363 – First Time in Human Study
Study
A Phase 1, first-time-in-human, three-part study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and immunogenicity of GSK4527363 in healthy participants (Part A), participants with active systemic lupus erythematosus (Part B), and healthy participants of Chinese and Japanese descent (Part C).
IRAS no
1010205
Study contact information
Name: Abigail Hamilton
Email: a.hamilton16@nhs.net
Principal investigator
Professor Philip Molyneaux
Click here for more information
INDEX
Study
Interstitial Lung Disease Exacerbations Study
IRAS no
317419
Study contact information
Name: Dr Felix Chua
Email: felixjookiat.chua@nhs.net
Principal investigator
Dr Felix Chua
Tracking no small cell lung cancer evaluation
Study
Tracking non small cell lung cancer evolution through therapy (Rx)
IRAS no
138871
Study contact information
Name: Paulo De Sousa
Email: paulo.desousa@nhs.net
Principal investigator
Mr Eric Lim
Click here for more information
Lung nodule Imaging Biobank for Radiomics and AI research (LIBRA)
Study
Lung nodule Imaging Biobank for Radiomics and AI research (LIBRA)
IRAS no
274775
Study contact information
Name: Professor Anand Devaraj
Email: a.devaraj@nhs.net
Principal investigator
Professor Anand Devaraj
Click here for more information
AI-SONAR
Study
AI & radiomics for Stratification Of lung Nodules After Radically treated cancer
IRAS no
300424
Study contact information
Name: Professor Anand Devaraj
Email: a.devaraj@nhs.net
Principal investigator
Professor Anand Devaraj
ADAURA2
Study
Phase III, Double-blind, Randomized, Placebo-Controlled, International Study to assess the Efficacy and Safety of Adjuvant Osimertinib versus Placebo in Patients with EGFR mutation-positive Stage IA2-IA3 Non-small Cell Lung Cancer, following Complete Tumoour removal.
IRAS no
1004224
Study contact information
Name: Paulo De Sousa
Email: paulo.desousa@nhs.net
Principal investigator
Professor Eric Lim
Click here for more information
F4S-2
Study
Fit 4 Surgery 2: A randomised controlled trial to investigate an App-based, motivation-theory grounded, personalised, comprehensive, prehabilitation programme in addition to usual care versus usual care alone to enhance recovery of physical function
IRAS no
317416
Study contact information
Name: Paulo De Sousa
Email: paulo.desousa@nhs.net
Principal investigator
Professor Eric Lim
Click here for more information
INSIGHT
Study
Prospective Observational Study to Investigate the Management of Pulmonary Lesions in a Tertiary Hospital
IRAS no
363013
Study contact information
Name: Christopher Orton
Email: christopher.orton2@nhs.net
Principal investigator
Dr Christopher Orton
ARTEMIS
Study
Effects of ziltivekimab versus placebo on cardiovascular outcomes in patients with acute myocardial infarction
IRAS no
1009307
Study contact information
Name: Geraldine Sloane
Email: geraldine.sloane1@nhs.net
Principal investigator
Dr Tina Khan
Click here for more information
COMPLETE-2
Study
A randomized trial of physiology-guided versus angiography-guided nonculpritlesion (NCL) complete revascularization strategies and a large-scaleobservational study of Optical Coherence Tomography in patients withacute myocardial infarction and multivessel
IRAS no
328136
Study contact information
Name: Melinda Holden
Email: melindaholden@nhs.net
Principal investigator
Dr Mohammed Akhtar
Click here for more information
NORSHOCK
Study
Clinical Outcome and Cost-effectiveness of Reduced Noradrenaline by Using a Lower Blood Pressure Target in Patients with Cardiogenic Shock from Acute Myocardial Infarction
IRAS no
354410
Study contact information
Name: Laura Barker
Email: l.barker12@nhs.net
Principal investigator
Dr Vasileios Panoulas
SleepImage in ALS / Accuracy of SleepImage for detecting respiratory failure in ALS
Study
Diagnostic accuracy of SleepImage technology for detecting respiratory failure in patients with amyotrophic lateral sclerosis
IRAS no
365043
Study contact information
Name: Professor Michael Polkey
Email: mike.polkey@nhs.net
Principal investigator
Professor Michael Polkey
Treating severe paediatric asthma; the TREAT trial
Study
Treating severe paediatric asthma; a randomised controlled trial of mepolizumab and omalizumab (TREAT trial)
IRAS no
252084
Study contact information
Name: Professor Sejal Saglani
Email: sejal.saglani2@nhs.net
Principal investigator
Professor Sejal Saglani
Click here for more information
ICONIK
Study
Inherited Cardiac cONditions In Kids Understanding the Genetics and Outcomes of Paediatric Inherited Cardiac Conditions
IRAS no
288514
Study contact information
Name: Dr Andres Rico-Armada
Email: andres.ricoarmada@nhs.net
Principal investigator
Dr Andres Rico-Armada
Click here for more information
GASTRIC-PICU
Study
A randomised controlled trial of no routine gastric residual monitoring to guide enteral feeding in paediatric intensive care units
IRAS no
322370
Study contact information
Name: Laura Tous Sampol
Email: l.toussampol@nhs.net
Principal investigator
Dr Justin Wang
Paediatric FH Register Study
Study
Estimating appropriate lipid lowering management in the United Kingdom Paediatric Familial Hypercholesterolaemia Register
IRAS no
324246
Study contact information
Name: Emma Neves
Email: emma.neves@nhs.net
Principal investigator
Lorraine Priestley-Barnham
Click here for more information
Natural History Study in Pediatric Patients with MYBPC3
Study
A Prospective and Retrospective Registry and Biomarker Study to Evaluate the Natural History of Pediatric Patients with Cardiomyopathy due to MYBPC3 Mutations
IRAS no
304240
Study contact information
Name: Annashyl West
Email: annashyl.west1@nhs.net
Principal investigator
Dr Janice Till
Click here for more information
PDA study v 1.2
Study
A multicenter, international, prospective and retrospective, post marketing clinical follow-up study to evaluate the efficacy and safety of the occlutech patent ductus arteriosus occluder (the occlutech pda occluder) in patient with patent ductus arterios
IRAS no
318495
Study contact information
Name: Karl Evangelista
Email: k.evangelista@nhs.net
Principal investigator
Professor Alain Fraisse
Click here for more information
VICTORION-PEDS-OLE
Study
An open-label, single arm, multicenter extension study to evaluate long-term safety and tolerability of inclisiran in participants with heterozygous or homozygous familial hypercholesterolemia who have completed the adolescent ORION-16 or ORION-13 studies
IRAS no
1007316
Study contact information
Name: Sankari Nagarajan
Email: sankari.nagarajan1@nhs.net
Principal investigator
Dr Mahmoud Barbir
Click here for more information
ARDS in Children and ECMO strategies impact on Neuro-Development
Study
ARDS in Children and ECMO initiation strategies impact on Neuro-Development (ASCEND)
IRAS no
292537
Study contact information
Name: Justin Wang
Email: qwang@nhs.net
Principal investigator
Angela Aramburo
Click here for more information
VX22-445-123
Study
A Phase 3, Open-label Study Evaluating the Long-term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Cystic Fibrosis Subjects 12 Months of Age and Older
IRAS no
1010177
Study contact information
Name: Clare Saunders
Email: c.saunders15@nhs.net
Principal investigator
Professor Jane Davies
Click here for more information
FAAR
Study
Identification of Future Asthma Attack Risk in Children with Clinical Tests
IRAS no
337100
Study contact information
Name: Samantha Irving
Email: samantha.irving3@nhs.net
Principal investigator
Professor Sejal Saglani
Click here for more information
The ACTIVELY Study
Study
Observational, prospective, cross sectional, multicentre study for evaluation of free-living physical activity and the assessment tools used to support pharmacological therapy titration and exercise prescription in children and adolescents diagnosed with inherited arrhythmias.
IRAS no
341211
Study contact information
Name: Catherine Renwick
Email: crenwick2@nhs.net
Principal investigator
Ms Catherine Renwick
Click here for more information
The Mucoactive study
Study
The use of mucoactive agents in paediatric intensive care (MAP Study)
IRAS no
348970
Study contact information
Name: Jennifer Balls
Email: jenniferelizabeth.balls@nhs.net
Principal investigator
Jennifer Balls
PICU Physiotherapy-led lung ultrasound (PICU PLUS)
Study
Lung ultrasound score as a measure of change in lung aeration following respiratory physiotherapy in children who are mechanically ventilated
IRAS no
349111
Study contact information
Name: Jennifer Balls
Email: jenniferelizabeth.balls@nhs.net
Principal investigator
Jennifer Balls
Machine learning to diagnose PCD
Study
Improving Primary Ciliary Dyskinesia diagnosis using artificial intelligence
IRAS no
259067
Study contact information
Name: Thomas Burgoyne
Email: thomas.burgoyne@nhs.net
Principal investigator
Professor Claire Hogg
PHoenix
Study
A multicentre randomised cross-over trial of disease specific therapy in patients with Pulmonary Arterial Hypertension (PAH) implanted with pulmonary artery pressure and cardiac rhythm monitoring devices (CardioMEMS/Confirm Rx)
IRAS no
325120
Study contact information
Name: Meriel Woodruff
Email: merielhelen.woodruff@nhs.net
Principal investigator
Dr Stephen John Wort
Click here for more information
StratosPHere 2
Study
A response-adaptive randomised placebo-controlled Phase II trial to evaluate hydroxychloroquine and phenylbutyrate in pulmonary arterial hypertension caused by mutations in BMPR2
IRAS no
1003631
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Laura Price
Click here for more information
FIT-PH
Study
Feasibility of Novel Clinical Trial Infrastructure, Design and Technology for Early Phase Studies in Patients with Pulmonary Hypertension
IRAS no
269248
Study contact information
Name: Dr Stephen John Wort
Email: s.wort@nhs.net
Principal investigator
Dr Stephen John Wort
Click here for more information
RVT-2301
Study
A Phase 2, Randomized, Placebo-Controlled Trial to Assess the Efficacy and Safety of Mosliciguat in Participants with Pulmonary Hypertension associated with Interstitial Lung Disease
IRAS no
1010435
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Laura Price
Click here for more information
Extension Study of Sotatercept for Weight-banded Approach in Participants With PAH
Study
An Open-label Extension Study to Evaluate Safety and Tolerability of Sotatercept (MK-7962) Administered Using a Weight-banded Approach in Participants With Pulmonary Arterial Hypertension (PAH) on Standard of Care (LIGHTRAY EXTENSION)
IRAS no
1011310
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Stephen John Wort
AP13CP02
Study
A Phase 2, Multicenter, Open-Label Trial to Evaluate APL-9796 in Adult Participants with Pulmonary Hypertension (PH)
IRAS no
1010577
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Colm McCabe
Click here for more information
Aortic intervention in Pulmonary hypertension (AIM-PH)
Study
Evaluation of right ventricular performance in response to aortic balloon inflation in pulmonary hypertension using pressure volume loop analysis
IRAS no
355511
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Colm McCabe
Validity of FROM-16 in family members of patients with pulmonary hypertension
Study
Impact of Pulmonary Hypertension on the Quality of Life of Patients and Their Family Members/Partners: A Validation Study of the FROM-16 Tool
IRAS no
365711
Study contact information
Name: Dr Stephen John Wort
Email: s.wort@nhs.net
Principal investigator
Dr Stephen John Wort
CLTP001A12202
Study
A randomised, double-blind, placebo-controlled study to evaluate the safety, tolerability and pharmacokinetics of single and multiple ascending doses of LTP001 in healthy adult participants (Part A) and to evaluate the efficacy and safety of LTP001 in PAH
IRAS no
1011875
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Stephen John Wort
Click here for more information
Re-Spire (L606-301) PH-ILD
Study
A Phase 3, Multicenter, Randomized, Double-Blinded, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Liposomal Treprostinil Inhalation Suspension (L606) in Patients with Pulmonary Hypertension Associated with Interstitial Lung Disease (WHO Group 3)
IRAS no
1012758
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Laura Price
Click here for more information
PPVD Biobank
Study
Prospective study of patients with pulmonary vascular disease + Exhaled volatile organic compounds in pulmonary hypertension: A prospective, multicentre, non-interventional study
IRAS no
210461
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Stephen John Wort
Click here for more information
Phoenix
Study
A multicentre randomised cross-over trial of disease specific therapy in patients with Pulmonary Arterial Hypertension (PAH) implanted with pulmonary artery pressure and cardiac rhythm monitoring devices (CardioMEMS/Confirm Rx)
IRAS no
325120
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Stephen John Wort
Click here for more information
StratosPHere 2
Study
Phase II: A response-adaptive randomised placebo-controlled Phase II trial to evaluate hydroxychloroquine and phenylbutyrate in pulmonary arterial hypertension caused by mutations in BMPR2
IRAS no
1003631
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Laura Price
Click here for more information
FIT-PH
Study
Feasibility of Novel Clinical Trial Infrastructure, Design and Technology for Early Phase Studies in Patients with Pulmonary Hypertension
IRAS no
20422
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Stephen John Wort
Aim-PH
Study
Evaluation of right ventricular performance in response to aortic balloon inflation in pulmonary hypertension using pressure volume loop analysis
IRAS no
355511
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Colm McCabe
Click here for more information
FROM-16
Study
A single-centre, prospective study to assess the validity of a novel quality-of-life questionnaire, the Family Reported Outcome Measure (FROM-16), in family members of patients with pulmonary arterial hypertension
IRAS no
365711
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Stephen John Wort
CLTP001A12202 (Part B)
Study
A randomised, double-blind, placebo-controlled study to evaluate the safety, tolerability and pharmacokinetics of single and multiple ascending doses of LTP001 in healthy adult participants (Part A) and to evaluate the efficacy and safety of LTP001 for the treatment of participants with pulmonary arterial hypertension (Part B)
IRAS no
1011875
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Stephen John Wort
Click here for more information
ViTAL-PH (AP13CP02)
Study
A Phase 2, Multicentre, Open-Label Trial to Evaluate APL-9796 in Adult Participants with Pulmonary Hypertension (ViTAL-PH)
IRAS no
1010577
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Colm McCabe
Click here for more information
RVT-2301-201
Study
A Phase 2, Randomized, Placebo-Controlled Trial to Assess the Efficacy and Safety of Mosliciguat in Participants with Pulmonary Hypertension Associated with Interstitial Lung Disease
IRAS no
1010435
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Laura Price
Click here for more information
Lightray OLE (MK7963-031)
Study
An Open-label Extension Study to Evaluate Safety and Tolerability of Sotatercept (MK-7962) Administered Using a Weight-banded Approach in Participants With Pulmonary Arterial Hypertension (PAH) on Standard of Care
IRAS no
1011310
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Stephen John Wort
Click here for more information
MK7962-038 (Soteria)
Study
An Open-label Long-term Follow-up Study to Evaluate the Effects of Sotatarcept When Added to Background Pulmonary Arterial Hypertension (PAH) Therapy for the Treatment of PAH
IRAS no
1012109
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Stephen John Wort
Click here for more information
Ralinepag 303_ROR-PH-303
Study
Phase 3 Open-label extension study to evaluate the long-term safety & efficacy of Ralinepag in subjects with WHO Group 1 PAH
IRAS no
255904
Study contact information
Name: Stefania Sguera
Email: stefania.sguera1@nhs.net
Principal investigator
Dr Colm McCabe
There are currently no active studies
The role of conventional and advanced imaging modalities in formulating an optimal risk stratification strategy in patients with suspected cardiac sarcoidosis
Study
The role of conventional and advanced imaging modalities in formulating an optimal risk stratification strategy in patients with suspected cardiac sarcoidosis
IRAS no
310314
Study contact information
Name: Raheel Ahmed
Email: raheel.ahmed3@nhs.net
Principal investigator
Dr Vasilis Kouranos
There are currently no active studies
Avr Thrombosis OutcoMe study (ATOM)
Study
Can thrombosis and fibrinolysis markers in patients undergoing aortic valve replacement predict outcome
IRAS no
259805
Study contact information
Name: Michelle Rackham
Email: michelle.rackham1@nhs.net
Principal investigator
Dr Vasileios Panoulas
Click here for more information
STRESS-MR - Haemodynamics of Mitral Regurgitation Reduction
Study
Comparative STudy chaRacterising the physiological changEs induced by Surgical and tranScatheter Mitral Regurgitation reduction - STRESS-MR
IRAS no
293585
Study contact information
Name: Dr Robert Smith
Email: robert.smith119@nhs.net
Principal investigator
Dr Robert Smith
Click here for more information
Acorai MLG study
Study
A Multi-Site Observational Clinical Investigation to Collect Non-invasive Sensor Data During a Right Heart Catheterization and Train Machine Learning Models to Estimate Intracardiac Hemodynamic Parameters
IRAS no
328221
Study contact information
Name: Dr Owais Dar
Email: o.dar@nhs.net
Principal investigator
Dr Owais Dar
Click here for more information
APOLLO-EU study
Study
Transcatheter Mitral Valve Replacement with the Medtronic IntrepidTM TMVR Transfemoral System in patients with severe symptomatic mitral regurgitation
IRAS no
319225
Study contact information
Name: Vladimir Domi
Email: v.domi@nhs.net
Principal investigator
Dr Alison Mary Duncan
Click here for more information
ET-TEER
Study
Changes in Exercise capacity, right ventricular function, activity levels and quality of life following transcatheter edge to edge repair in patients with severe tricuspid regurgitation.
IRAS no
340757
Study contact information
Name: Dr Robert Smith
Email: robert.smith119@nhs.net
Principal investigator
Dr Robert Smith
Click here for more information
Predicting the outcome of FET repair through computational modelling
Study
Development of a novel Aortic Dissection REpair Simulator System (ADRESS) to model clinical outcome prior to type Aaortic dissection repair
IRAS no
340336
Study contact information
Name: Dr Saeed Mirsadraee
Email: saeed.mirsadraee@nhs.net
Principal investigator
Dr Saeed Mirsadraee
BigpAK-2
Study
Biomarker- guided intervention to prevent acute kidney injury after major non-cardiac surgery - the prospective multicenter randomized controlled interventional trial
IRAS no
299561
Study contact information
Name: Alessandra Verzelloni
Email: alessandra.verzellonisef@nhs.net
Principal investigator
Dr Nandor Marczin
Click here for more information
STAR Registry
Study
Safe and Timely Antithrombotic Removal (STAR REGISTRY): International registry on the use of CytoSorb for removal of antithrombotic agents in the acute hospital setting.
IRAS no
301571
Study contact information
Name: Nandor Marczin
Email: nandor.marczin@nhs.net
Principal investigator
Dr Nandor Marczin
Click here for more information
CHIP-BCIS3
Study
Controlled trial of High-risk coronary Intervention with Percutaneous left ventricular unloading
IRAS no
290599
Study contact information
Name: Laura Barker
Email: l.barker12@nhs.net
Principal investigator
Dr Vasileios Panoulas
Click here for more information
The ROMA Trial
Study
Randomised comparison of the clinical Outcome of single versus Multiple Arterial grafts
IRAS no
321239
Study contact information
Name: Maria Teresa Pfyl
Email: maria.pfyl1@nhs.net
Principal investigator
Mr Cesare Quarto
Click here for more information
PANDOS
Study
Pain and opioids after surgery (PANDOS)
IRAS no
276689
Study contact information
Name: Dr Nandor Marczin
Email: nandor.marczin@nhs.net
Principal investigator
Dr Nandor Marczin
Click here for more information
THERMIC-4 Version 1.0
Study
Normothermic versus Hypothermic Cardiopulmonary Bypass in Adult Cardiac Surgery: a Multicentre Feasibility Randomised Controlled Trial (THERMIC-4)
IRAS no
325522
Study contact information
Name: Ricky Vaja
Email: ricky.vaja2@nhs.net
Principal investigator
Mr Cesare Quarto
Click here for more information
EuroSCORE 3
Study
EuroSCORE 3: recalibration of the EuroSCORE cardiac surgery risk model
IRAS no
300893
Study contact information
Name: Cesare Quarto
Email: cesare.quarto@nhs.net
Principal investigator
Mr Cesare Quarto
STICH3-BCIS4
Study
A multicentre randomised trial of surgical versus percutaneous revascularisation of ischaemic left ventricular dysfunction (iLVSD) in the United Kingdom, with embedded internal pilot and health economic analysis
IRAS no
329409
Study contact information
Name: Mr Shahzad G Raja
Email: shahzad.raja1@nhs.net
Principal investigator
Mr Shahzad G Raja
Click here for more information
TREASURE
Study
A feasibiliTy study to exploRE the safety, Acceptability and potential cost effectiveness of Self-swabbing at home to obtain usable surgical wound cultURE swabs (TREASURE)
IRAS no
356847
Study contact information
Name: Karen Cariaga
Email: karen.cariaga1@nhs.net
Principal investigator
Mr Sunil Bhudia
Click here for more information
Methodology study in PO-AKI
Study
Methodology study in patients undergoing cardiac surgery with cardiopulmonary bypass to investigate mechanismsinvolved in post-operative acute kidney injury
IRAS no
343231
Study contact information
Name: Alessandra Verzellonisef
Email: alessandra.verzellonisef@nhs.net
Principal investigator
Dr Nandor Marczin
4D Flow CMR in Lung Transplant Assessment
Study
4D Flow Cardiovascular Magnetic Resonance analysis of the right ventricle in lung transplant assessment
IRAS no
270554
Study contact information
Name: Dr Joyce Wong
Email: joyce.wong4@nhs.net
Principal investigator
Dr Joyce Wong
Click here for more information
E-CLAD UK
Study
Extracorporeal Photopheresis in the treatment of Chronic Lung Allograft Dysfunction: a randomised controlled trial
IRAS no
1005642
Study contact information
Name: Dr Martin Carby
Email: martin.carby@nhs.net
Principal investigator
Dr Martin Carby
Click here for more information
Experience and Concerns in Organ Procurement and Transplantation
Study
An Insight into Perioperative Practitioners' Learning Experience and Concerns when Assisting Heart and Lung Organ Procurement and Transplantation
IRAS no
324868
Study contact information
Name: Ms Yi Wang
Email: yi.wang1@nhs.net
Principal investigator
Ms Yi Wang
Sentinel skin flap in lung transplant RCT
Study
Efficacy and mechanism of sentinel skin flap reduction of solid organ (lung) transplant rejection: A randomised controlled trial
IRAS no
318347
Study contact information
Name: Hayley Meyrick
Email: hayley.meyrick@nhs.net
Principal investigator
Dr Anna Reed
Click here for more information
Coronary artery disease in hearts donated for transplantation
Study
Coronary angiographic assessment of hearts donated for transplantation declined on the grounds of visible/palpable coronary artery disease at the time of retrieval
IRAS no
332977
Study contact information
Name: Christopher Bowles
Email: christopher.bowles2@nhs.net
Principal investigator
Mr Mohamed Osman
Click here for more information
PET CT in heart transplant a diagnostic accuracy study
Study
A prospective blinded pilot study evaluating the sensitivity and specificity of 18F Fluorodeoxyglucose PET CT imaging (a non-invasive imaging tool) for the diagnosis of rejection in heart transplant recipients
IRAS no
335590
Study contact information
Name: Dr Mansimran Singh Dulay
Email: m.dulay@nhs.net
Principal investigator
Dr Owais Dar
Click here for more information
F-CUSToS
Study
Feasibility study for Randomised Controlled Trial of CUstodiol-HTK vs St Thomas’ solution for cardioplegia and cold static Storage of UK donation after brainstem death hearts in cardiac transplantation
IRAS no
1007011
Study contact information
Name: Melinda Holden
Email: melindaholden@nhs.net
Principal investigator
Mr Mohamed Osman
Lung Health Check Biomarker Study
Study
Lung Health Check Biomarker Study
IRAS no
258696
Study contact information
Name: Anand Devaraj
Email: a.devaraj@nhs.net
Principal investigator
Professor Anand Devaraj
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Tool Placement in Pulmonary Nodule using a Robotic Bronchoscopy System
Study
A Prospective Investigation to Assess the Accurate Tool Placement in Pulmonary Nodule(s) using a Robotic
Navigational Bronchoscopy System with Adjunct Real-time Imaging
IRAS no
308868
Study contact information
Name: Professor Pallav Shah
Email: pallav.shah@nhs.net
Principal investigator
Professor Pallav Shah
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The Physiotherapy Assessment of Breathing Pattern Dysfunction (PHAB)
Study
An evaluation of physiotherapy assessment: A mixed methods study to evaluate the physiotherapy assessment of Breathing Pattern Disorder
IRAS no
315897
Study contact information
Name: Lizzie Grillo
Email: lizzie.grillo1@nhs.net
Principal investigator
Lizzie Grillo
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Microbiome and Metabolome in Healthy Volunteers (MATINEE Study)
Study
Investigating the stool and saliva microbiome and metabolome in healthy volunteers (The MATINEE Study). An observational cohort study
IRAS no
322270
Study contact information
Name: David Smith
Email: david.smith240@nhs.net
Principal investigator
Professor Philip Molyneaux
RACE-MATE Trial
Study
A RAndomised Placebo Controlled Trial - to Explore the Efficacy and Mechanism of Action of Tezepelumab in EGPA (RACEMATE Trial)
IRAS no
1007564
Study contact information
Name: Harry Wilson-Morkeh
Email: harold.wilson-morkeh@nhs.net
Principal investigator
Dr Pujan Patel
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LOWER
Study
Lomitapide Observational Worldwide Evaluation Registry
IRAS no
227605
Study contact information
Name: Julie Wagg
Email: j.wagg1@nhs.net
Principal investigator
Alison Pottle
LILITH
Study
Evaluation of the effect of lomitapide treatment on major adverse cardiovascular events (MACE) in patients with homozygous familial hypercholesterolemia
IRAS no
345905
Study contact information
Name: Alison Pottle
Email: apottle@nhs.net
Principal investigator
Alison Pottle
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Living with ICI-Heart Complications
Study
Exploring the Lived Experience of Patients with Cardiac Complications from Immune Checkpoint Inhibitors: A Qualitative Study
IRAS no
364146
Study contact information
Name: Dr Sohaib Nazir
Email: sohaib.nazir1@nhs.net
Principal investigator
Dr Sohaib Nazir
HELI-CLE
Study
Effect of Heliox on laryngeal closure during exercise
IRAS no
359694
Study contact information
Name: Zander Williams
Email: zander.williams1@nhs.net
Principal investigator
Dr James Hull
SEE-EILO
Study
Self-recorded Evaluation of Exercise-Induced Laryngeal Obstruction
IRAS no
361787
Study contact information
Name: Zander Williams
Email: zander.williams1@nhs.net
Principal investigator
Dr James Hull
Health Legacy
Study
Health legacy study
IRAS no
352127
Study contact information
Name: Laura Barker
Email: l.barker12@nhs.net
Principal investigator
Dr Vivat Baah
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Reducing and preventing unprofessional behaviour in the NHS
Study
Understanding how unprofessional behaviour in English NHS Trusts can be prevented and reduced: a mixed-methods study
IRAS no
352798
Study contact information
Name: Mark Bowers
Email: mark.bowers3@nhs.net
Principal investigator
Mr Mark Bowers