Abstract
TH17 cells are proposed to play a role in the pathology of asthma, including steroid-resistant (SR) disease. We previously identified a steroid-enhancing function of vitamin D in patients with SR asthma in restoring the impaired response to steroids for production of the anti-inflammatory cytokine IL-10.
Publication information
Nanzer AM, Chambers ES, Corrigan C, Hawrylowizc CM et al 'Enhanced production of IL-17A in patients with severe asthma is inhibited by 1a,25- dihydroxyvitamin D3 in a glucocortico-independent fashion' Journal of Allergy and Clinical Immunology 2013 Aug;132(2):297-304.e3