The chronic respiratory failure consortium within the NIHR Royal Brompton Respiratory BRU has sought to increase recognition of physical performance as a measurable aspect of COPD.
Physical performance, and its impairment, is important to patients but is not currently accepted as an outcome measure for drug development or labelling claims. This is particularly important for a new generation of anabolic drugs which may have the potential to improve exercise capacity without changing lung function in COPD as indeed in other lung diseases.
With funding from NIHR and the MRC the research team have pioneered the use of tests of physical frailty in pulmonary medicine which are in common use in gerontology. In particular they have established that tests comprising the short physical performance battery are feasible, responsive to change, relate to muscle structure and have started to develop minimally clinical important differences (MCID) for components of this test.
The research team are also undertaking work on the more established test of the six minute walk to evaluate its role in stratification and to determine the MCID.
To find out more about this study please contact Dr Will Man or Professor Michael Polkey
Back to BRU news