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MRC fellowship awarded to cardiovascular BRU clinical research fellow

Clinical research fellow, Dr Upasana Tayal, is one of only two Trust fellows to be awarded a prestigious three year, Medical Research Council Clinical Research Training Fellowship. 


Upasana’s project:  “Defining the Functional Effects of Titin Gene Mutations on the Pathophysiology of Dilated Cardiomyopathy and their Clincal Significance” will investigate patients with dilated cardiomyopathy (DCM) – the second most common cause of heart failure and the leading indication for heart transplantation in the UK.  This study will characterise the significance of mutations in the titin (TTN) gene in patients with DCM using advanced cardiovascular magnetic resonance (CMR). 

Dr Upasana Tayal

Dr Tayal trained as a CMR clinical fellow at the Trust which has the largest clinical CMR department in the world with over 6500 scans performed per year. It has an excellent track record in nurturing fellows in CMR with a well-respected and structured training programme.


The research will be supported by the imaging and genetics research teams within our cardiovascular biomedical research unit. Together, Imperial College London and Royal Brompton & Harefield NHS Foundation Trust form the largest specialist heart and lung centre in the UK. They have an internationally renowned research reputation and are best placed to conduct this research. Dr Tayal’s supervisors are Dr Sanjay Prasad, Professor Stuart Cook and Dr Piers Daubeney. Professor Cook’s collaborative work in the discovery of the abnormal gene (TTN) forms a key part of this research.


October 2014



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