Publications

The CTEU has produced a large number of abstracts for presentation at national and international scientific meetings and has publications in many peer-reviewed journals including The Lancet, European Heart Journal, British Medical Journal and Circulation as well as book chapters.

List of CTEU publications  

 2013

• Pepper JR.  The acquired cardiac disease domain: the next 5 years. Eur J Cardiothorac Surg. 2013;43:223-225
• Stanger O, Pepper J.  Should iatrogenic type A aortic dissection in patients with previous cardiac surgery be managed conservatively? J Thorac Cardiovasc Surg 2013; 145(2):612-613
• Stanger O, Pepper J. Letter and reply to T.Timek. J.Thorac.Cardiovasc.Surg. 2013; 145: 612-613
• Lexow J; Poggioli T; Rosenthal N; Santini MP. (Jan 2013). Combinatorial Therapies for Cardiac Regeneration. Rec Pat Regen Med. 2013,3:34-46.
• Kotecha D, Manzano L, Altman DG, Krum H, Erdem G, Williams N, Flather MD on behalf of the Beta-Blockers in Heart Failure Collaborative Group. Individual patient data meta-analysis of beta-blockers in heart failure: rationale and design. Systematic Reviews 2013, 2:7

   

2012

• Chan JKM, Punjabi PP, Flather M, Wage R, Symmonds K, Roussin I, Rahman-Haley S, Pennell DJ, Kilner PJ, Dreyfus GD and Pepper JR. Coronary Artery Bypass Surgery With or Without Mitral Valve Annuloplasty in Moderate Functional Ischemic Mitral Regurgitation Final Results of the Randomized Ischemic Mitral Evaluation (RIME) Trial. Circulation 2012;126:2502-2510

• Erdem G,  Bakhai  A,   Taneja  AK,  Collinson J,  Banya W,  Flather MD. Rates and Causes of Death from Non-ST elevation Acute Coronary Syndromes: Ten year follow up of the PRAIS-UK Registry (in press)

• Mulder BA, van Veldhuisen DJ, Crijns HJGM, Bohm M, Cohen-Solal A, Babalis D, Roughton M, Flather MD, Coats AJS, aVan Gelder IC. Effect of nebivolol on outcome in elderly patients with heart failure and atrial fibrillation: insights from SENIORS. Eur J Heart Fail 2012; 14: 1171–1178

• Treasure T, Pepper J, Golesworthy T, Mohiaddin R, Anderson RH. External aortic root support:  NICE Guidance. Heart 2012;98:65-8

• Angeloni E, Melina G, Pibarot P, Benedetto U, Refice S, Ciavarella GM, Roscitano A, Sinatra R, Pepper JR. Impact of prosthesis-patient mismatch on the regression of secondary mitral regurgitation after isolated aortic valve replacement with a bioprosthetic valve in patients with severe aortic stenosis. Circ Cardiovasc Imaging 2012;5(1):36-42

• K.M. John Chan; John R Pepper. Mitral valve annuloplasty in addition to CABG improves functional capacity and promotes reverse MV remodelling:  preliminary results of the Randomized Ischemic Mitral Evaluation (RIME) Trial. AHA Emerging Science Webinar – 29.2.12

• Hausenloy DJ, Candilio L, Laing C, Kunst G, Pepper J, Kolvekar S, Evans R, Robertson S, Knight R, Ariti C, Clayton T, Yellon DM; The ERICCA Trial Investigators. Effect of remote ischemic preconditioning on clinical outcomes in patients undergoing coronary artery bypass graft surgery (ERICCA): rationale and study design of a multi-centre randomized double-blinded controlled clinical trial. Clin Res Cardiol. 2012;101(5):339-348

• Kotecha D, New G, Collins P, Eccleston D, Krum H, Pepper J, Flather MD. Radial artery pulse wave analysis for non-invasive assessment of coronary artery disease.  Int J Cardiol. 2012 Apr 4

• Pepper JR. Update on mechanical circulatory support in heart failure. Heart 2012;98(8):663-9

• Quarto C, Dweck MR, Murigu T, Joshi S, Melina G, Angeloni E, Prasad SK, Pepper JR. Late gadolinium enhancement as a potential marker of increased perioperative risk in aortic valve replacement. Interact Cardiovasc Thorac Surg. 2012 Apr 17

• Pepper J, Jaggar SI, Mason MJ, Finney SJ, Dusmet M. Schwatz Rounds: reviving compassion in modern healthcare. J R Soc Med 2012;105:94-95

• Treasure T, Crowe S, Chan KMJ, Ranasinghe A, Attia R, Lees B, Utley M, Golesworthy T, Pepper J. A method for early evaluation of a recently introduced technology by deriving a comparative group from existing clinical data: a case study in external support of the Marfan aortic root. BMJ Open 2012;2:e000725. doi:10.1136/ bmjopen-2011-000725

• Kotecha D, New G, Flather MD, Eccleston D, Pepper J, Krum H

  Five-minute heart rate variability can predict obstructive angiographic coronary disease. Heart 2012;98:395-401 doi:10.1136/heartjnl-2011-300033

• Treasure T, Fallowfield L, Lees B, Farewell V. Pulmonary metastasectomy in colorectal cancer: the PulMiCC trial. Thorax 2012;67:185e188. doi:10.1136/thoraxjnl-2011-200015

2011

• Erdem G, Flather M. Assessing Bleeding Risk in Acute Coronary Syndromes. Rev Esp Cardiol. 2011 Nov 4. [Epub ahead of print]    

• Krzych LJ, Lees B, Nugara F, Banya W, Bochenek A, Cook J, Taggart D, Flather MD. Assessment of data quality in an international multi-centre randomised trial of coronary artery surgery. Trials 2011, 12:212 doi:10.1186/1745-6215-12-21

• Flather MD, Babalis D, Booth J, Bardaji A, Machecourt J, Opolski G, Ottani F, Bueno H, Banya W, Brady AR, Bojestig M, Lindahl B. Cluster-randomised trial to evaluate the effects of a quality improvement programme on management of non-ST elevation acute coronary syndromes: The EQUIP-ACS project results. Am. Heart J 2011, Oct;162(4):700-707.e1

•  Alexander JH, Lopes RD, James S, Kilaru R, He Y, Mohan P, Bhatt DL, Goodman S, Verheugt FW, Flather M, Huber K, Liaw D, Husted SE, Lopez-Sendon J, De Caterina R, Jansky P, Darius H, Vinereanu D, Cornel JH, Cools F, Atar D, Leiva-Pons JL, Keltai M, Ogawa H, Pais P, Parkhomenko A, Ruzyllo W, Diaz R, White H, Ruda M, Geraldes M, Lawrence J, Harrington RA, Wallentin L on behalf of the APPRAISE-2 Investigators.Apixaban with Antiplatelet Therapy After Acute Coronary Syndrome. N Engl J Med. 2011 Aug 25;365(8):699-708. Epub 2011 Jul 24.

• Kotecha D, Ngo K, Walters JAE, Manzano L, Palazzuoli A, Flather M. Erythropoietin as a Treatment for Anemia in Heart Failure: Systematic Review of Randomized Trials.  Am Heart J. 2011 May;161(5):822-831.e2.

• Htun P, Fateh-Moghadam S, Bischofs C, Banya W, Muller K, Bigalke B, Stellos K, May AE, Flather M, Gawaz M and Geisler T.  Low Responsiveness to Clopidogrel Increases Risk among CKD Patients Undergoing Coronary Intervention.  J Am Soc Nephrol. 2011 Jan 27. [Epub ahead of print].

• Stansby S, Mister R, Fowkes G, Roughton M, Nugara  F, Brittenden J, Bradbury B, Ashley S, Shearman C, Hannon R and Flather M on behalf of the PREPARED (Prospective Registry and Evaluation of Peripheral Arterial Risks, Events and Distribution) Investigators.  High Risk of Peripheral Arterial Disease in the United Kingdom: 2-Year Results of a Prospective Registry.  Angiology. 2011 Feb;62(2):111-8.

• Goodacre SW, Bradburn M, Cross E, Collinson P, Gray A, Hall AS; RATPAC Research Team. The Randomised Assessment of Treatment using Panel Assay of Cardiac Markers (RATPAC) trial: a randomised controlled trial of point-of-care cardiac markers in the emergency department. Heart. 2011 Feb;97(3):190-6.

• Manzano L, Babalis D, Roughton M., Shibata M., Anker S.D, Ghio S., van Veldhuisen D.J, Cohen-Solal A., Coats A.J., Poole-Wilson P, Flather M, SENIORS Investigators. Predictors of Clinical Outcomes in Elderly Patients with Heart Failure. Eur J Heart Fail. 2011 May;13(5):528-36. Epub 2011 Mar 30.
• Ambrosio G, Flather MD, Böhm M, Cohen-Solal A, Murrone A, Mascagni F, Spinucci G, Conti MG, van Veldhuisen DJ, Tavazzi L, Coats AJ. ß-blockade with nebivolol for prevention of acute ischaemic events in elderly patients with heart failure.  Heart 2011 97: 209-214

2010

• Godsland IF, Pavitt D, Okoturo O, Edwards RJ, Rubens MB, Feher MD, Flather MD, Elkeles RS; for the PREDICT Study Group.Can protein biomarkers provide an index of coronary artery calcification in patients with Type 2 diabetes? Atherosclerosis 2010;213: 570–572

• Cholesterol Treatment Trialists’ (CTT) Collaboration, Baigent C, Blackwell L, Emberson J, Holland LE, Reith C, Bhala N, Peto R, Barnes EH, Keech A, Simes J, Collins R. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials.  Lancet. 2010 Nov 13;376(9753):1670-81. Epub 2010 Nov 8.

• Babu-Narayan SV, Uebing A, Davlouros PA, Kemp M, Davidson S, Dimopoulos K, Bayne S, Pennell DJ, Gibson DG, Flather M, Kilner PJ, Li W, Gatzoulis MA.  Randomised trial of ramipril in repaired tetralogy of Fallot and pulmonary regurgitation The APPROPRIATE study (Ace inhibitors for Potential PRevention Of the deleterious effects of Pulmonary Regurgitation In Adults with repaired TEtralogy of Fallot). Int J Cardiol. 2010 Oct 20. [Epub ahead of print]

• Dimopoulos K, Dudek D, Piscione F, Mielecki W, Savonitto S, Borgia F, Murena E, Manari A, Gaspardone A, Ochala A, Zmudka K, Bolognese L, Steg PG, Flather M, Di Mario C; on behalf of the CARESS-in-AMI (Combined Abciximab RE-teplase Stent Study in Acute Myocardial Infarction) Investigators (All Investigators and Committees are listed in the Appendix). Timing of events in STEMI patients treated with immediate PCI or standard medical therapy: Implications on optimisation of timing of treatment from the CARESS-in-AMI trial.. Int J Cardiol. 2010 Oct 18. [Epub ahead of print]

• De Caterina R, Connolly SJ, Pogue J, Chrolavicius S, Budaj A, Morais J, Renda G, Yusuf S; ACTIVE Investigators.  Mortality predictors and effects of antithrombotic therapies in atrial fibrillation: insights from ACTIVE-W.  Eur Heart J. 2010 Sep;31(17):2133-40. Epub 2010 Aug 4.

• Flaker GC, Pogue J, Yusuf S, Pfeffer MA, Goldhaber SZ, Granger CB, Anand IS, Hart R, Connolly SJ; Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE) Investigators.  Cognitive function and anticoagulation control in patients with atrial fibrillation.  Circ Cardiovasc Qual Outcomes. 2010 May;3(3):277-83. Epub 2010 Mar 16.

• Topol EJ, Bousser MG, Fox KA, Creager MA, Despres JP, Easton JD, Hamm CW, Montalescot G, Steg PG, Pearson TA, Cohen E, Gaudin C, Job B, Murphy JH, Bhatt DL; CRESCENDO Investigators. Rimonabant for prevention of cardiovascular events (CRESCENDO): a randomised, multicentre, placebo-controlled trial. Lancet. 2010 Aug 14;376(9740):517-23.

• Mehta SR, Tanguay J-F, Eikelboom JW, Jolly SS, Campbell D Joyner CD, Granger CB, Faxon DP, Rupprecht H-J, Budaj A, Avezum A, Widimsky P, Steg PG, Bassand J-P, Montalescot,G, Macaya C, Di Pasquale G, Niemela K, Ajani AE, White HD, Chrolavicius S, Gao P, Fox KAA, Yusuf S, on behalf of the CURRENT-OASIS 7 trial investigators. Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial.  Lancet Published Online September 1, 2010 DOI:10.1016/S0140- 6736(10)61088-4
• The CURRENT–OASIS 7 Investigators. Dose Comparisons of Clopidogrel and Aspirin in Acute Coronary Syndromes. N Engl J Med 2010;363:930-42.
• Goto S, Ogawa H, Takeuchi M, Flather MD, Bhatt  DL on behalf of the J-LANCELOT (Japanese-Lesson from Antagonizing the Cellular Effect of Thrombin) Investigators Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary artery disease.  Eur Heart J 2010, doi: 10.1093/eurheartj/ehq320
• Taggart DP, Altman DG, Gray AM, Lees B, Nugara F, Yu LM, Campbell H, Flather M on behalf of the ART Investigators Randomised Trial to Compare Bilateral Versus Single Internal Mammary Coronary Artery Bypass Grafting: One Year Results of the Arterial Revascularisation Trial (ART).  Eur Heart J. 2010 Oct;31(20):2470-81 doi:10.1093/eurheartj/ehq318.
• Kotecha D, Flather M, McGrady M, Pepper J, Gishel N, Krum H, Eccleston D Contemporary predictors of coronary artery disease in patients referred for angiography.  Eur J Cardiovasc Prev Rehabil. 2010 Jun;17(3):280-8
• Perera D, Stables R, Thomas M, Booth J, Pitt M, Blackman D, de Belder A, Redwood S, for the BCIS-1 Investigators.Elective Intra-aortic Balloon Counterpulsation During High-Risk Percutaneous Coronary Intervention A Randomized Controlled Trial.  JAMA. 2010;304(8):867-874
• Müller K, Aichele S, Herkommer M, Bigalke B, Stellos K, Htun P, Fateh-Moghadam S, May AE, Flather M, Gawaz M, Geisler T. Impact of inflammatory markers on platelet inhibition and cardiovascular outcome including stent thrombosis in patients with symptomatic coronary artery disease.  Atherosclerosis. 2010 Nov;213(1):256-62. Epub 2010 Jul 27i
• Treasure, T, Fallowfield F, Lees B.  Pulmonary Metastasectomy in Colorectal Cancer, the PulMiCC Trial. J Thorac Oncol. 2010;5: S203–S206
• Geisler T, Gawaz M, Steinhubl SR, Bhatt DL, Storey RF, Flather M. Current strategies in antiplatelet therapy--does identification of risk and adjustment of therapy contribute to more effective, personalized medicine in cardiovascular disease? Pharmacol Ther. 2010 Aug;127(2):95-107.
• Geisler T, Mueller K, Aichele S, Bigalke B, Stellos K, Htun P, Ninci E, Fateh-Moghadam S, May AE, Gawaz M. Impact of inflammatory state and metabolic control on responsiveness to dual antiplatelet therapy in type 2 diabetics after PCI: prognostic relevance of residual platelet aggregability in diabetics undergoing coronary interventions. Clin Res Cardiol. 2010 Jun 6. [Epub ahead of print]
• de Boer RA, Doehner W, van der Horst IC, Anker SD, Babalis D, Roughton M, Coats AJ, Flather MD, van Veldhuisen DJ; SENIORS Investigators. Influence of diabetes mellitus and hyperglycemia on prognosis in patients > or =70 years old with heart failure and effects of nebivolol (data from the Study of Effects of Nebivolol Intervention on Outcomes and Rehospitalization in Seniors with heart failure [SENIORS]). Am J Cardiol. 2010 Jul 1;106(1):78-86.e1.
• Ngo K, Kotecha D, Walters JA, Manzano L, Palazzuoli A, van Veldhuisen DJ, Flather M.  Erythropoiesis-stimulating agents for anaemia in chronic heart failure patients.  Cochrane Database Syst Rev. 2010 Jan 20;(1):CD007613.
• Flather MD, Booth J, Babalis D, Bueno H, Steg PG, Opolski G, Ottani F, Machecourt J, Bardaji A, Bojestig M, Brady AR, Lindahl B. Improving the management of non-ST elevation acute coronary syndromes: systematic evaluation of a quality improvement programme European QUality Improvement Programme for Acute Coronary Syndrome: The EQUIP-ACS project protocol. Trials. 2010 Jan 14;11(1):5.
• Wallentin L, Yusuf S, Ezekowitz MD, Alings M, Flather M, Franzosi MG, Pais P, Dans A, Eikelboom J, Oldgren J, Pogue J, Reilly PA, Yang S, Connolly SJ; RE-LY investigators. Efficacy and safety of dabigatran compared with warfarin at different levels of international normalised ratio control for stroke prevention in atrial fibrillation: an analysis of the RE-LY trial. Lancet. 2010 Sep 18;376(9745):975-83.
• Barth JH, Jackson BM, Farrin AJ, Efthymiou M, Worthy G, Copeland J, Bailey KM, Romaine SP, Balmforth AJ, McCormack T, Whitehead A, Flather MD, Nixon J, Hall AS; SPACE ROCKET Trial Group. Change in serum lipids after acute coronary syndromes: secondary analysis of SPACE ROCKET study data and a comparative literature review. Clin Chem. 2010 Oct;56(10):1592-8. Epub 2010 Aug 20.
• Boden WE, Flather MD, Bhatt DL. Role of dual antiplatelet therapy in symptomatic patients with established vascular disease: putting the CHARISMA trial into therapeutic perspective.Cardiovasc Drugs Ther. 2010 Jun;24(3):207-16.
• Erdem G, Geisler T, Flather MD. What goes into a major acute coronary syndrome trial and what will future trials look like? Curr Cardiol Rep. 2010 Jul;12(4):348-55.
• Bailey KM, Romaine SP, Jackson BM, Farrin AJ, Efthymiou M, Barth JH, Copeland J, McCormack T, Whitehead A, Flather MD, Samani NJ, Nixon J, Hall AS, Balmforth AJ; SPACE ROCKET Trial Group. Hepatic metabolism and transporter gene variants enhance response to rosuvastatin in patients with acute myocardial infarction: the GEOSTAT-1 Study. Circ Cardiovasc Genet. 2010 Jun 1;3(3):276-85. Epub 2010 Mar 5.
• Kapur A, Bartolini D, Finlay MC, Qureshi AC, Flather M, Strange JW, Hall RJ. The Bypass Angioplasty Revascularization in Type 1 and Type 2 Diabetes Study: 5-year follow-up of revascularization with percutaneous coronary intervention versus coronary artery bypass grafting in diabetic patients with multivessel disease. J Cardiovasc Med (Hagerstown). 2010 Jan;11(1):26-33.

2009

• Hall AS, Jackson BM, Farrin AJ, Efthymiou M, Barth JH, Copeland J, Bailey KM, Romaine SP, Balmforth AJ, McCormack T, Whitehead A, Flather MD, Nixon J; SPACE ROCKET Trial Group. A randomized, controlled trial of simvastatin versus rosuvastatin in patients with acute myocardial infarction: the Secondary Prevention of Acute Coronary Events--Reduction of Cholesterol to Key European Targets Trial. Eur J Cardiovasc Prev Rehabil. 2009 Dec;16(6):712-21.
• Perera D, Stables R, Booth J, Thomas M, Redwood S; BCIS-1 Investigators.  The balloon pump-assisted coronary intervention study (BCIS-1): rationale and design. Am Heart J. 2009 Dec;158(6):910-916.e2.  
• Kapur A, Hall RJ, Malik IS, Qureshi AC, Butts J, de Belder M, Baumbach A, Angelini G, de Belder A, Oldroyd KG, Flather M, Roughton M, Nihoyannopoulos P, Bagger JP, Morgan K, Beatt KJ.  Randomized Comparison of Percutaneous Coronary Intervention With Coronary Artery Bypass Grafting in Diabetic Patients: 1-Year Results of the CARDia (Coronary Artery Revascularization in Diabetes) Trial.  J. Am. Coll. Cardiol. published online Nov 25, 2009;  doi:10.1016/j.jacc.2009.10.014
• Connolly SJ, Ezekowitz, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Paul A. Reilly PA, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis BS, Darius H, Diener HC, Joyner CD,., Wallentin L, and the RE-LY Steering Committee and Investigators*.  Dabigatran versus Warfarin in Patients with Atrial Fibrillation. N Engl J Med 2009;361.
• Cohen-Solal A, Kotecha K, van Veldhuisen DJ, Babalis D, Böhm M, Coats AJ, Roughton M, Poole-Wilson P, Tavazzi L, Flather M and on behalf of the SENIORS Investigators: Efficacy and safety of nebivolol in elderly heart failure patients with impaired renal function: insights from the SENIORS trial. European Journal of Heart Failure Advance Access published on August 1, 2009. doi:10.1093/eurjhf/hfp104  
• Serebruany VL, Kogushi M, Dastros-Pitei D, Flather M, Bhatt DL. The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease.  Thromb Haemost. 2009 Jul;102(1):111-9.
• Perez de Arenaza D^,, Pepper J, Lees B, Rubinstein, F, Nugara F, Roughton M, Jasinski M, Bazzino O, Flather M on behalf of the ASSERT (Aortic Stentless versus Stented valve assessed by Echocardiography Randomised Trial) InvestigatorsPreoperative 6 Minute Walk Test Adds Prognostic Information to Euroscore in Patients Undergoing Aortic Valve Replacement.. Heart 2009 28 June 2009, 10.1136/hrt.2008.161174  
• Sculpher MJ, Lozano-Ortega G, Sambrook J, Palmer S, Ormanidhi O, Bakhai A, Flather M, Steg PG, Mehta SR, Weintraub W.  Fondaparinux versus Enoxaparin in non-ST-elevation acute coronary syndromes: short-term cost and long-term cost-effectiveness using data from the Fifth Organization to Assess Strategies in Acute Ischemic Syndromes Investigators (OASIS-5) trial.  Am Heart J. 2009 May;157(5):845-52.  
• Van Veldhuisen DJ, Cohen-Solal AC, Bohm M, Anker SD, Babalis D, Roughton M, Coats AJS, Poole-Wilson PA, Flather MD. Beta-Blockade With Nebivolol in Elderly Heart Failure Patients With Impaired and Preserved Left Ventricular Ejection Fraction: Data From SENIORS. JACC 2009; 53;23:2150-8  
• Chan KMJ, Amirak E, Zakkar M, Flather M, Pepper JR, Punjabi PP.  Ischaemic Mitral Regurgitation: In search of the best treatment for a common condition.  Prog in Cardiovascular Diseases 2009;51:460-71.
• Hlatky MA, Boothroyd DB, Bravata DM, Boersma E, Booth J, Brooks MM, Carrié D, Clayton TC, Danchin N, Flather M, Hamm CW, Hueb WA, Kähler J, Kelsey SF, King SB, Kosinski AS, Lopes N, McDonald KM, Rodriguez A, Serruys P, Sigwart U, Stables RH, Owens DK, Pocock SJ. Coronary artery bypass surgery compared with percutaneous coronary interventions for multivessel disease: a collaborative analysis of individual patient data from ten randomised trials. Lancet. 2009 Apr 4; 373 (9670): 1190-7
• Treasure T, Fallowfield L, Farewell V, Ferry D, Lees B, Leonard P, Macbeth F, Utley M and For the Pulmonary Metastasectomy in Colorectal Cancer (PulMiCC) trial development group.  Pulmonary metastasectomy in colorectal cancer: Time for a trial. Eur J Surg Oncol 2009;35:686-9. 

2008

• Mehta SR, Boden WE, Eikelboom JW, Flather M, Steg PG, Avezum A, Afzal R, Piegas LS, Faxon DP, Widimsky P, Budaj A, Chrolavicius S, Rupprecht HJ, Jolly S, Granger CB, Fox KA, Bassand JP, Yusuf S; OASIS 5 and 6 Investigators. Antithrombotic therapy with fondaparinux in relation to interventional management strategy in patients with ST- and non-ST-segment elevation acute coronary syndromes: an individual patient-level combined analysis of the Fifth and Sixth Organization to Assess Strategies in Ischemic Syndromes (OASIS 5 and 6) randomized trials.Circulation. 2008 Nov 11;118(20):2038-46. Epub 2008 Oct 27.
• Daemen J, Boersma E, Flather M, Booth J, Stables R, Rodriguez A, Rodriguez-Granillo G, Hueb WA, Lemos PA, Serruys PW.Long-term safety and efficacy of percutaneous coronary intervention with stenting and coronary artery bypass surgery for multivessel coronary artery disease: a meta-analysis with 5-year patient-level data from the ARTS, ERACI-II, MASS-II, and SoS trials.Circulation. 2008 Sep 9;118(11):1146-54. Epub 2008 Aug 25.
• Dey S, Flather MD, Devlin GP, Brieger D, Gurfinkel EP, Steg PG, Fitzgerald G, Jackson EA, Eagle KA. Sex-related differences in the presentation, treatment and outcomes among patients with acute coronary syndromes. The Global Registry of Acute Coronary Events.Heart. 2008 May 7. [Epub ahead of print]
• Jones I, Flather M, Johnson M, Barrow S, Thompson D.A description of the characteristics of patients with non-ST elevation acute coronary syndromes admitted to different settings in the 1990s.Intensive Crit Care Nurs. 2008 Oct;24(5):286-94. Epub 2008 Apr 3.
• Di Mario C, Dudek D, Piscione F, Mielecki W, Savonitto S, Murena E, Dimopoulos K, Manari A, Gaspardone A, Ochala A, Zmudka K, Bolognese L, Steg PG, Flather M; CARESS-in-AMI (Combined Abciximab RE-teplase Stent Study in Acute Myocardial Infarction) Investigators.Immediate angioplasty versus standard therapy with rescue angioplasty after thrombolysis in the Combined Abciximab REteplase Stent Study in Acute Myocardial Infarction (CARESS-in-AMI): an open, prospective, randomised, multicentre trial.Lancet. 2008 Feb 16;371(9612):559-68.
• Booth J, Clayton T, Pepper J, Nugara F, Flather M, Sigwart U, Stables RH. Randomized, Controlled Trial of Coronary Artery Bypass Surgery Versus Percutaneous Coronary Intervention in Patients With Multivessel Coronary Artery Disease. Six-Year Follow-Up From the Stent or Surgery Trial (SoS). Circulation, 2008 Jul 7
• Yao G, Freemantle N, Flather M, Tharmanathan P, Coats A, Poole-Wilson PA; SENIORS Investigators; Long-term cost-effectiveness analysis of nebivolol compared with standard care in elderly patients with heart failure: an individual patient-based simulation model. Pharmacoeconomics. 2008;26(10):879-89.
• Crossman DC, Morton AC, Gunn JP, Greenwood JP, Hall AS, FoxKAA, Lucking AJ, Flather MD, Lees B, Foley CE. Investigation of the effect of Interleukin-1 receptor antagonist (IL-1ra) on markers of inflammation in non-ST elevation acute coronary syndromes (The MRC-ILA-HEART Study). Trials 2008, 9:8
• Elkeles RS, Godsland IF, Feher MD, Rubens MB, Roughton M, Nugara F, Humphries SE, Richmond W,  Flather MD. Coronary calcium measurement improves prediction of cardiovascular events in asymptomatic patients with type 2 diabetes: the PREDICT study. Eur Heart J. 2008 Jun 23

2007

• Bhatt DL; Flather MD; Hacke W; Berger PB; Black HR; Boden WE; Cacoub P; Cohen EA; Creager MA; Easton JD; et al. (2007). Patients with prior myocardial infarction, stroke, or symptomatic peripheral arterial disease in the CHARISMA trial. J Am Coll Cardiol. 49:1982-1988.
• Elkeles RS, Godsland IF, Rubens MB, Feher MD, Nugara F, Flather MD. The progress of coronary heart disease in Type 2 diabetes as measured by coronary calcium score from electron beam computed tomography (EBCT): The PREDICT study. Atherosclerosis. 2007 Oct 4

• Flather M; Rubens M; Godsland I; Feher M; Nugara F; Richmond W; Elkeles R. (Jun 2007). Predictors of progression of coronary artery calcium in type 2 diabetes: The PREDICT Study. Heart. 93:A62-A62.
• Goldberg RJ; Spencer FA; Steg PG; Flather M; Montalescot G; Gurfinkel EP; Kennelly BM; Goodman SG; Dedrick R; Gore JM. (10 Sep 2007). Increasing use of single and combination medical therapy in patients hospitalized for acute myocardial infarction in the 21st century - A multinational perspective. Arch Intern Med. 167:1766-1773.
• Khan S; Flather M; Mister R; Delahunty N; Fowkes G; Bradbury A; Stansby G. (Apr 2007). Characteristics and treatments of patients with peripheral arterial disease referred to UK vascular clinics: Results of a prospective registry. Eur J Vasc Endovasc. 33:442-450. DOI.
• Stables R; Booth J; Pepper J; Clayton T; Flather M; Nugara F; Sigwart U. (Jun 2007). The Stent or Surgery long-term follow-up. Heart. 93:A7-A7.

2006

• Balfour-Lynn IM, Lees B, HallP, Phillips G, Khan M, Flather M, Elborn JS on behalf of the CF WISE (Withdrawal of Inhaled Steroids Evaluation) Investigators. Multicenter randomized controlled trial of withdrawal of inhaled corticosteroids in cystic fibrosis. Am J Respir Crit Care Med 2006;173:1356-1362.

• Booth J; Delahunty N; Newlands P; Nugara F; Bakhai A; Khan M; Fox K; Adgey J; Taneja A; Mallick U; et al. (May 2006). A randomised study to evaluate the impact of an education programme on use of evidence based treatments in patients with non-st elevation acute coronary syndromes: PROMIS UK. Heart. 92:A32-A32.
• Booth J; Delahunty N; Fox K; Adgey J; Taneja A; Nugara F; Newlands P; Flather M; PROMIS-UK Investigators. (Aug 2006). A randomised study to evaluate the impact of an education programme on use of evidence based treatments in patients with non-ST elevation acute coronary syndromes: PROMIS UK. Eur Heart J. 27:389-389.
• Booth J; Stables R; Pepper J; Clayton T; Flather M; Nugara F; Sigwart U; SoS Investigators. (Aug 2006). The stent or surgery trial longer term follow up. Eur Heart J. 27:574-575.

• Collins P, Flather M, Lees B, Mister R, Proudler AJ, Stevenson JC on behalf of the WHISP (Women’s Hormone Intervention Secondary Prevention Study) Pilot Study Investigators. Randomised trial of effects of continuous combined HRT on markers of lipids and coagulation in women with acute coronary syndromes (WHISP Pilot Study). Eur Heart J 2006;17:2046-53.

• de Arenaza DP; Flather M; Lees B; Rubinstein F; Nugara F; Cagide A; Bazzino O; Pepper J. (31 Oct 2006). Role of preoperative 6 minute walk test in the assessment and prognosis of patients with severe aortic stenosis undergoing aortic valve replacement. Circulation. 114:478-478.
• Flather M; Collinson J. (Apr 2006). First line treatment with colchicine reduced recurrent pericarditis. Evid Based Med. 11:44-44. Publisher weblink DOI.
• Flather M; Collinson J. (Mar 2006). First-line treatment with colchicine reduced recurrent pericarditis. ACP J Club. 144:31-31. Publisher weblink.
• Flather M; Delahunty N; Collinson J. (2006). Generalizing results of randomized trials to clinical practice: reliability and cautions. Clin Trials. 3:508-512. Publisher weblink DOI.
• Fox KA; Bhatt DL; Topol EJ; Steg PG; Boden W; Cacoub P; Hu T; Flather M. (31 Oct 2006). CHARISMA (long-term dual anti-platelet therapy): The impact of risk status, prior history, and proximity to recent cardiovascular events. Circulation. 114:650-650.
• Godsland IF, Elkeles RS, Feher MD, Nugara F, Rubens MB, Richmond W, Khan M, Donovan J, Anyaoku V, Flather MD. Coronary calcification, homocysteine, C-reactive protein and the metabolic syndrome in Type 2 diabetes: the Prospective Evaluation of Diabetic Ischaemic Heart Disease by Coronary Tomography (PREDICT) Study. Diabet Med. 2006 Nov ;23 (11):1192-1200

• Hoyles RK, Ellis RW, Wellsbury J, Lees B, Newlands P, Goh N, Roberts C, Desai S, Herrick AL, McHugh NJ, Foley NM, Pearson SB, Emery P, Veale DJ, Denton CP, Wells AU, Black CM, Du Bois RM. Fibrosing Alveolitis in Scleroderma Trial (FAST) – a multi-centre, prospective, randomised, double-blind, placebo-controlled trial of treatment with corticosteroids and intravenous cyclophosphamide followed by oral azathioprine. Arthritis Rheum 2006;54:3962-3970.
• Kapur A; Butts J; Malik I; Mayet J; Flather M; Hall RJ; Beatt KJ; Nihoyannopoulos P. (Aug 2006). Myocardial function improves equally in diabetes following both multivessel PCI and CABG. Results from a CARDia trial substudy. EUR HEART J. 27:88-89.
• Karnon J; Bakhai A; Brennan A; Pandor A; Flather M; Warren E; Gray D; Akehurst R. (24 May 2006). A cost-utility analysis of clopidogrel in patients with non-ST-segment-elevation acute coronary syndromes in the UK. Int J Cardiol. 109:307-316. DOI.
• Taggart DP, Lees B, Gray A, Altman DG, Flather M, Channon K on behalf of the ART Investigators.  Protocol for the Arterial Revascularisation Trial (ART). A randomised trial to compare survival following bilateral versus single internal mammary grafting in coronary revascularisation [ISRCTN46552265]. Trials 2006;7:7.

• Taneja A; Van Veldhuisen D; Lechat P; Shibata M; Cohen-Solal A; Poole-Wilson P; Flather M. (May 2006). Are beta blockers effective in elderly patients wiih heart failure and preserved ejection fraction? Results from the randomised, multinational SENIORS trial. Heart. 92:A87-A88.
• Zhang Z, Mahoney EM, Spertus JA, Booth J, Nugara F, Kolm P, Stables RH, Weintraub WS. The impact of age on outcomes after coronary artery bypass surgery versus stent-assisted percutaneous coronary intervention: one-year results from the Stent or Surgery (SoS) trial. Am Heart J. 2006 Dec ;152 (6):1153-60

2005

• Al-Azzawi F, Lees B, Thompson J, Stevenson J. Bone mineral density in postmenopausal women treated with a vaginal ring delivering systemic doses of estradiol acetate. Menopause 2005;12:331-339.
• Bakhai A, Booth J, Delahunty N, Nugara F, Clayton T, McNeill J, Davies SW, Cumberland DC, Stables RH. The SV stent study: a prospective, multicentre, angiographic evaluation of the BiodivYsio phosphorylcholine coated small vessel stent in small coronary vessels. Int J Cardiol. 2005 Jun 22;102:95-102

• Daubeney PEF; Wang D; Delany DJ; Keeton BR; Anderson RH; Slavik Z; Flather M; Webber SA; UK Ireland Collaborative Study Pul. (Oct 2005). Pulmonary atresia with intact ventricular septum: Predictors of early and medium-term outcome in a population-based study. J Thorac Cardiovascular Surg. 130:1071-1078. DOI.
• de Arenaza DP; Lees B; Flather M; Nugara F; Khan M; Pepper J. (May 2005). A randomised comparison of stentless versus stented valves for aortic stenosis. Heasrt. 91:A18-A18.
• Flather MD; Shibata MC; Coats AJ; Van Veldhuisen DJ; Parkhomenko A; Borbola J; Cohen-Solal A; Dumitrascu D; Ferrari R; Lechat P; et al. (2005). Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS). Eur Heart J. 26:215-225.
• Flather M; Van Veldhuisen DJ; Lechat P; Shibata M; Cohen-Solal A; Poole-Wilson P; Coats AJS; SENIORS Investigators. (Sep 2005). Influence of age and ejection fraction on the effects of nebivolol in elderly patients with heart failure. Eur Heart J. 26:74-74.
• Gödicke J, Flather M, Noc M, Gyöngyösi M, Arntz H-R, Grip L, Gabriel HM, Huber K, Nugara F, Schröder J, Svensson L, Wang D, Zorman S, Montalescot G. Early versus periprocedural administration of abciximab for primary angioplasty: A pooled analysis of 6 studies. Am Heart J. 2005 Nov ;150 (5):1015.e11-1015.e17

• Iqbal MB; Taneja AK; Lip GY; Flather M. (29 Jan 2005). Recent developments in atrial fibrillation. BMJ. 330:238-243. Publisher weblink DOI.
• Khan S; Cleanthis M; Smout J; Flather M; Stansby G. (Jan 2005). Life-style modification in peripheral arterial disease. Eur J Vasc Endovasc. 29:2-9. DOI.
• Khan S; Cleanthis M; Smout J; Flather M; Stansby G. (Jun 2005). Regarding 'Life-style modification in peripheral arterial disease' - Response. EUR J VASC ENDOVASC. 29:655-655. DOI.
• Mallick U; Flather M; Bakhai A; Dorobantu M; Spircu T. (Apr 2005). Investigating risk factors for coronary artery disease in an Eastern European economy with a rising burden of cardiovascular diseases. Atherosclerosis Supp. 6:160-160.
• Perez de Arenaza D, Lees B, Flather M, Nugara F, Khan M, Pepper J on behalf of the ASSERT Investigators. A Randomised Comparison of Stentless Versus Stented Valves for Aortic Stenosis: Effects on Left Ventricular Mass. Circulation 2005;112:2696-2702.

• Robinson M; Palmer S; Sculpher M; Philips Z; Ginnelly L; Bowens A; Golder S; Alfakih K; Bakhai A; Packham C; et al. (Jul 2005). Cost-effectiveness of alternative strategies for the initial medical management of non-ST elevation acute coronary syndrome: systematic review and decision-analytical modelling. Health Technol Asses. 9:1
• Zhang Z, Spertus JA, Mahoney EM, Booth J, Nugara F, Stables RH, Weintraub WS. The impact of acute coronary syndrome on clinical, economic, and cardiac-specific health status after coronary artery bypass surgery versus stent-assisted percutaneous coronary intervention: 1-year results from the stent or surgery (SoS) trial. Am Heart J. 2005 Jul ;150 (1):175-81